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Chromatin Structural Changes Linking Flavonoid Luteolin's Function to Genomic Targets

Title: Chromatin Structural Changes Linking Flavonoid Luteolin's Function to Genomic Targets.
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Name(s): Koerner, Joshua, author
Biological Science
Type of Resource: text
Genre: Text
Issuance: serial
Date Issued: 2012
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Many non-inherited factors play a role in the epidemiology of cancer. Several studies have suggested that a dietary increase in fruits and vegetables containing compounds such as Luteolin, used in this study, would reduce the new instances of cancer by 20% and potentially prevent 200,000 cancer-related deaths annually. One hallmark of cancer is the reorganization of DNA inside the cell. Each cell in the human body contains approximately four meters of DNA organized into a compartment, the nucleus, that is five one-hundredths of a millimeter. This almost unbelievable compaction is facilitated by the combination of negatively charged DNA with positively charged proteins to make a complex called chromatin. The organization of chromatin regulates access to DNA sequences. This project aimed to investigate factors that regulate the organization of chromatin, thereby regulating access to the genome. In this study we highlight five genomic locations where the structure of DNA changes in response to Luteolin treatment. We have potentially identified a new promoter region for the Abelson murine leukemia viral oncogene homolog 2, (ABL2) gene. Luteolin places a nucleosome in a transcriptionally active region of hydroxytryptamine receptor 2B (HTR2B) to inhibit the possible production of the gene product. Luteolin may be establishing transcriptional competence of cyclin-dependent kinase inhibitor 2A (CDKN2A) through regulation of chromatin structure around Sp1 binding sites in the promoter. Luteolin alters chromatin structure around the Sp1 binding sites in the promoter region of kisspeptin-1 (KiSS1), which could be a preliminary step to achieving transcriptional competence. Luteolin treatment alters the chromatin structure of the myelocytomatosis viral oncogene homolog (Myc) promoter in order to potentially re-establish steady state expression in a previously deregulated gene.
Identifier: FSU_migr_uhm-0079 (IID)
Keywords: Luteolin, Cancer, Chromatin Structure
Submitted Note: A Thesis submitted to the Department of Biological Science in partial fulfillment of the requirements for graduation with Honors in the Major.
Degree Awarded: Spring Semester, 2012.
Date of Defense: April 11, 2012.
Subject(s): Biology
Cancer
Oncology
Life sciences
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_migr_uhm-0079
Host Institution: FSU
Is Part of Series: Honors Theses.

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Koerner, J. (2012). Chromatin Structural Changes Linking Flavonoid Luteolin's Function to Genomic Targets. Retrieved from http://purl.flvc.org/fsu/fd/FSU_migr_uhm-0079