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Kallikreins are Associated with Secondary Progressive Multiple Sclerosis and Promote Neurodegeneration

Title: Kallikreins are Associated with Secondary Progressive Multiple Sclerosis and Promote Neurodegeneration.
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Name(s): Scarisbrick, Isobel, author
Linbo, Rachel, author
Vandell, Alexander, author
Keegan, Mark, author
Blaber, Sachiko, author
Blaber, Michael, author
Sneve, Diane, author
Lucchinetti, Claudia F., author
Rodriguez, Moses, author
Diamandis, Eleftherios P., author
Type of Resource: text
Genre: Text
Issuance: serial
Date Issued: 2008
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Tissue kallikrein KLK1 and the kallikrein-related peptidases KLK2-15 are a subfamily of serine proteases that have defined or proposed roles in a range of central nervous system (CNS) and non-CNS pathologies. To further understand their potential activity in multiple sclerosis (MS), serum levels of KLK1, 6, 7, 8 and 10 were determined in 35 MS patients and 62 controls by quantitative fluorometric ELISA. Serum levels were then correlated with Expanded Disability Status Scale (EDSS) scores determined at the time of serological sampling or at last clinical follow-up. Serum levels of KLK1 and KLK6 were elevated in MS patients (p
Identifier: FSU_migr_biomed_faculty_publications-0008 (IID)
Keywords: axon injury, kallikrein, prognosis, serine protease
Uncontrolled subjects: Adult, Biological Markers, Case-Control Studies, Female, Humans, Kallikreins, Male, Middle Aged, Multiple Sclerosis, Chronic Progressive, Multiple Sclerosis, Relapsing-Remitting, Neurodegenerative Diseases
Note: Originally published in Biological Chemistry
Citation: Scarisbrick, I.A., Linbo, R., Vandell, A.G., Keegan, M., Blaber, S.I., Blaber, M., Sneve, D., Lucchinetti, C.F., Rodriguez, M. and Diamandis, E. (2008). Kallikreins are associated with secondary progressive multiple sclerosis and promote neurodegeneration. Biol. Chem. 389, 739-745.
Subject(s): Biochemistry
Biophysics
Molecular biology
Cytology
Developmental biology
Clinical biochemistry
Medical sciences
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_migr_biomed_faculty_publications-0008
Owner Institution: FSU
Is Part of Series: Department of Biomedical Sciences Faculty Publications.
Is Part Of: Biological Chemistry.
Issue: 6, 389

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Scarisbrick, I., Linbo, R., Vandell, A., Keegan, M., Blaber, S., Blaber, M., … Diamandis, E. P. (2008). Kallikreins are Associated with Secondary Progressive Multiple Sclerosis and Promote Neurodegeneration. Biological Chemistry. Retrieved from http://purl.flvc.org/fsu/fd/FSU_migr_biomed_faculty_publications-0008