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Automated Analysis of Protein Side Chain Spectra

Title: Automated Analysis of Protein Side Chain Spectra.
Name(s): Hart, Andrew, author
Department of Chemistry and Biochemistry
Type of Resource: text
Genre: Text
Issuance: serial
Date Issued: 2013
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Manual Nuclear Magnetic Resonance (NMR) spectral analysis of proteins is a time intensive effort with methods often specific to each analysis. The method described in this thesis automates the resonance assignment of protein side chains using a TOCSY (Totally Correlated Spectroscopy) NMR experiment. The system under study is Ubiquitin (8.6 kDa). 54 of the 70 available amino acid side chains were identified by a single TOCSY spectrum in less than 5 min of local computer runtime using the algorithms described. Automation of spectral analysis can enhance reproducibility and create standards of spectral analysis.
Identifier: FSU_migr_uhm-0244 (IID)
Keywords: Automated, Analysis, Protein, Ubiquitin, Bio Informatics, NMR
Submitted Note: A Thesis submitted to the Department of Chemistry in partial fulfillment of the requirements for graduation with Honors in the Major.
Degree Awarded: Summer Semester, 2013.
Date of Defense: May 31, 2013.
Subject(s): Chemistry, Analytic
Nuclear physics
Chemistry, Physical and theoretical
Molecular biology
Numerical analysis
Quantum theory
Persistent Link to This Record:
Restrictions on Access:
Host Institution: FSU
Is Part of Series: Honors Theses.

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Hart, A. (2013). Automated Analysis of Protein Side Chain Spectra. Retrieved from