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δ/ω-Plectoxin-Pt1a
| Title: | δ/ω-Plectoxin-Pt1a: An Excitatory Spider Toxin with Actions on both Ca(2+) and Na(+) Channels. |
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| Name(s): |
Zhou, Yi, author Zhao, Mingli, author Fields, Gregg B., author Wu, Chun-Fang, author Branton, W., author |
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| Type of Resource: | text | |
| Genre: | Text | |
| Issuance: | serial | |
| Date Issued: | 2013 | |
| Physical Form: | computer | |
| Physical Form: | online resource | |
| Extent: | 1 online resource | |
| Language(s): | English | |
| Abstract/Description: | The venom of spider Plectreurys tristis contains a variety of peptide toxins that selectively target neuronal ion channels. O-palmitoylation of a threonine or serine residue, along with a characteristic and highly constrained disulfide bond structure, are hallmarks of a family of toxins found in this venom. Here, we report the isolation and characterization of a new toxin, δ/ω-plectoxin-Pt1a, from this spider venom. It is a 40 amino acid peptide containing an O-palmitoylated Ser-39. Analysis of δ/ω-plectoxin-Pt1a cDNA reveals a small precursor containing a secretion signal sequence, a 14 amino acid N-terminal propeptide, and a C-terminal amidation signal. The biological activity of δ/ω-plectoxin-Pt1a is also unique. It preferentially blocks a subset of Ca(2+) channels that is apparently not required for neurotransmitter release; decreases threshold for Na(+) channel activation; and slows Na(+) channel inactivation. As δ/ω-plectoxin-Pt1a enhances synaptic transmission by prolonging presynaptic release of neurotransmitter, its effects on Na(+) and Ca(2+) channels may act synergistically to sustain the terminal excitability. | |
| Identifier: | FSU_migr_biomed_faculty_publications-0044 (IID) | |
| Subject(s): |
Biochemistry Biophysics Molecular biology Neurobiology Neurosciences |
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| Persistent Link to This Record: | http://purl.flvc.org/fsu/fd/FSU_migr_biomed_faculty_publications-0044 | |
| Owner Institution: | FSU | |
| Is Part of Series: | Department of Biomedical Sciences Faculty Publications. | |
| Is Part Of: | PLoS One. | |
| Issue: | 5, 8 |
Zhou, Y., Zhao, M., Fields, G. B., Wu, C. -F., & Branton, W. (2013). δ/ω-Plectoxin-Pt1a: An Excitatory Spider Toxin with Actions on both Ca(2+) and Na(+) Channels. Plos One. Retrieved from http://purl.flvc.org/fsu/fd/FSU_migr_biomed_faculty_publications-0044
