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application of the elastic net for an endophenotype analysis.

Title: An application of the elastic net for an endophenotype analysis.
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Name(s): Palejev, Dean, author
Hwang, Wookyeon, author
Landi, Nicole, author
Eastman, Maria, author
Frost, Stephen J, author
Fulbright, Robert K, author
Kidd, Judith R, author
Kidd, Kenneth K, author
Mason, Graeme F, author
Mencl, W Einar, author
Yrigollen, Carolyn, author
Pugh, Kenneth R, author
Grigorenko, Elena L, author
Type of Resource: text
Genre: Text
Date Issued: 2011-01-01
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: We provide an illustration of an application of the elastic net to a large number of common genetic variants in the context of the search for the genetic bases of an endophenotype conceivably related to individual differences in learning. GABA concentration in the occipital cortex, a critical area for reading, was obtained in a group (n = 76) of children aged 6-10 years. Two extreme groups, high and low, were selected for genotyping with the 650Y Illumina array chip (Ilmn650Y). An elastic net approach was applied to the resulting SNP dataset; 100 SNPs were identified for each chromosome as "interesting" based on having the highest absolute value coefficients. The analyses highlighted chromosomes 15 and 20, which contained 55 candidate genes. The STRING partner analyses of the associated proteins pointed to a number of related genes, most notably, GABA and NTRK receptors.
Identifier: FSU_pmch_21229297 (IID), 10.1007/s10519-011-9443-8 (DOI), PMC3613288 (PMCID), 21229297 (RID), 21229297 (EID)
Grant Number: AA009379, DC007665, GM057672, HD001994, HD048830, HD052120, HD053409, P01 HD001994, P50 HD052120, R01 DC007665, R01 HD048830, R01 HD048830-04, R01 TW008274, TW008274
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613288.
Subject(s): Algorithms
Child
Chromosomes, Human, Pair 15/genetics
Chromosomes, Human, Pair 20/genetics
Dyslexia/genetics
Dyslexia/physiopathology
Endophenotypes
Female
Genetic Variation/genetics
Genome-Wide Association Study/statistics & numerical data
Genotype
Humans
Magnetic Resonance Spectroscopy
Male
Models, Genetic
Occipital Lobe/physiopathology
Phenotype
Polymorphism, Single Nucleotide/genetics
gamma-Aminobutyric Acid/metabolism
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_pmch_21229297
Owner Institution: FSU
Is Part Of: Behavior genetics.
1573-3297
Issue: iss. 1, vol. 41

Choose the citation style.
Palejev, D., Hwang, W., Landi, N., Eastman, M., Frost, S. J., Fulbright, R. K., … Grigorenko, E. L. (2011). An application of the elastic net for an endophenotype analysis. Behavior Genetics. Retrieved from http://purl.flvc.org/fsu/fd/FSU_pmch_21229297