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Lexical decision as an endophenotype for reading comprehension

Title: Lexical decision as an endophenotype for reading comprehension: an exploration of an association.
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Name(s): Naples, Adam, author
Katz, Len, author
Grigorenko, Elena L, author
Type of Resource: text
Genre: Text
Date Issued: 2012-11-01
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Based on numerous suggestions in the literature, we evaluated lexical decision (LD) as a putative endophenotype for reading comprehension by investigating heritability estimates and segregation analyses parameter estimates for both of these phenotypes. Specifically, in a segregation analysis of a large sample of families, we established that there is little to no overlap between genes contributing to LD and reading comprehension and that the genetic mechanism behind LD derived from this analysis appears to be more complex than that for reading comprehension. We conclude that in our sample, LD is not a good candidate as an endophenotype for reading comprehension, despite previous suggestions from the literature. Based on this conclusion, we discuss the role and benefit of the endophenotype approach in studies of complex human cognitive functions.
Identifier: FSU_pmch_23062302 (IID), 10.1017/S0954579412000752 (DOI), PMC3541527 (PMCID), 23062302 (RID), 23062302 (EID), S0954579412000752 (PII)
Grant Number: DC007665, HD048830, HD052120, MH081756, NICHD01994, P01 HD001994, P50 HD052120, P50 MH081756, R01 DC007665, R01 HD048830, T32 MH018268
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541527.
Subject(s): Adolescent
Adult
Aged
Child
Cognition
Comprehension
Decision Making
Endophenotypes
Family
Female
Humans
Language Tests
Male
Middle Aged
Models, Genetic
Models, Psychological
Reading
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_pmch_23062302
Owner Institution: FSU
Is Part Of: Development and psychopathology.
1469-2198
Issue: iss. 4, vol. 24

Choose the citation style.
Naples, A., Katz, L., & Grigorenko, E. L. (2012). Lexical decision as an endophenotype for reading comprehension: an exploration of an association. Development And Psychopathology. Retrieved from http://purl.flvc.org/fsu/fd/FSU_pmch_23062302