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Age-related changes of gene expression in the neocortex

Title: Age-related changes of gene expression in the neocortex: preliminary data on RNA-Seq of the transcriptome in three functionally distinct cortical areas.
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Name(s): Naumova, Oksana Yu, author
Palejev, Dean, author
Vlasova, Natalia V, author
Lee, Maria, author
Rychkov, Sergei Yu, author
Babich, Olga N, author
M Vaccarino, Flora, author
Grigorenko, Elena L, author
Type of Resource: text
Genre: Text
Date Issued: 2012-11-01
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: The study of gene expression (i.e., the study of the transcriptome) in different cells and tissues allows us to understand the molecular mechanisms of their differentiation, development and functioning. In this article, we describe some studies of gene-expression profiling for the purposes of understanding developmental (age-related) changes in the brain using different technologies (e.g., DNA-Microarray) and the new and increasingly popular RNA-Seq. We focus on advancements in studies of gene expression in the human brain, which have provided data on the structure and age-related variability of the transcriptome in the brain. We present data on RNA-Seq of the transcriptome in three distinct areas of the neocortex from different ages: mature and elderly individuals. We report that most age-related transcriptional changes affect cellular signaling systems, and, as a result, the transmission of nerve impulses. In general, the results demonstrate the high potential of RNA-Seq for the study of distinctive features of gene expression among cortical areas and the changes in expression through normal and atypical development of the central nervous system.
Identifier: FSU_pmch_23062308 (IID), 10.1017/S0954579412000818 (DOI), PMC3539811 (PMCID), 23062308 (RID), 23062308 (EID), S0954579412000818 (PII)
Grant Number: DC007665, P50 HD052120, P50 HD052120, R01 DC007665
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539811.
Subject(s): Adult
Aged
Aging/genetics
Aging/metabolism
Female
Frontal Lobe/metabolism
Gene Expression Profiling
Gene Expression Regulation, Developmental
Humans
Neocortex/metabolism
Oligonucleotide Array Sequence Analysis
Sequence Analysis, RNA
Temporal Lobe/metabolism
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_pmch_23062308
Owner Institution: FSU
Is Part Of: Development and psychopathology.
1469-2198
Issue: iss. 4, vol. 24

Choose the citation style.
Naumova, O. Y., Palejev, D., Vlasova, N. V., Lee, M., Rychkov, S. Y., Babich, O. N., … Grigorenko, E. L. (2012). Age-related changes of gene expression in the neocortex: preliminary data on RNA-Seq of the transcriptome in three functionally distinct cortical areas. Development And Psychopathology. Retrieved from http://purl.flvc.org/fsu/fd/FSU_pmch_23062308