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COMT Val/Met polymorphism is associated with reading-related skills and consistent patterns of functional neural activation.

Title: The COMT Val/Met polymorphism is associated with reading-related skills and consistent patterns of functional neural activation.
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Name(s): Landi, Nicole, author
Frost, Stephen J, author
Mencl, W Einar, author
Preston, Jonathan L, author
Jacobsen, Leslie K, author
Lee, Maria, author
Yrigollen, Carolyn, author
Pugh, Kenneth R, author
Grigorenko, Elena L, author
Type of Resource: text
Genre: Text
Date Issued: 2013-01-01
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: In both children and adults there is large variability in reading skill, with approximately 5-10% of individuals characterized as having reading disability; these individuals struggle to learn to read despite adequate intelligence and opportunity. Although it is well established that a substantial portion of this variability is attributed to the genetic differences between individuals, specifics of the connections between reading and the genome are not understood. This article presents data that suggest that variation in the COMT gene, which has previously been associated with variation in higher-order cognition, is associated with reading and reading-related skills, at the level of both brain and behavior. In particular, we found that the COMT Val/Met polymorphism at rs4680, which results in the substitution of the ancestral Valine (Val) by Methionine (Met), was associated with better performance on a number of critical reading measures and with patterns of functional neural activation that have been linked to better readers. We argue that this polymorphism, known for its broad effects on cognition, may modulate (likely through frontal lobe function) reading skill.
Identifier: FSU_pmch_23278923 (IID), 10.1111/j.1467-7687.2012.01180.x (DOI), PMC3655431 (PMCID), 23278923 (RID), 23278923 (EID)
Grant Number: L30 HD054250, P01 HD 01994, P01 HD001994, P01 HD052120, P50 HD052120, R01 HD 048830, R01 HD040411, R01 HD048830, R03 HD053409, R03 HD053409
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655431.
Subject(s): Catechol O-Methyltransferase/genetics
Child
Cognition
Frontal Lobe/physiology
Genotype
Humans
Magnetic Resonance Imaging
Polymerase Chain Reaction
Polymorphism, Genetic/genetics
Reading
Verbal Behavior/physiology
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_pmch_23278923
Owner Institution: FSU
Is Part Of: Developmental science.
1467-7687
Issue: iss. 1, vol. 16

Choose the citation style.
Landi, N., Frost, S. J., Mencl, W. E., Preston, J. L., Jacobsen, L. K., Lee, M., … Grigorenko, E. L. (2013). The COMT Val/Met polymorphism is associated with reading-related skills and consistent patterns of functional neural activation. Developmental Science. Retrieved from http://purl.flvc.org/fsu/fd/FSU_pmch_23278923