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Nutrient Sensing

Title: Nutrient Sensing: Another Chemosensitivity Of The Olfactory System.
Name(s): Julliard, A.-Karyn, author
Al Koborssy, Dolly, author
Fadool, Debra A., author
Palouzier-Paulignan, Brigitte, author
Type of Resource: text
Genre: Journal Article
Journal Article
Date Issued: 2017-07-12
Physical Form: computer
Physical Form: online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Olfaction is a major sensory modality involved in real time perception of the chemical composition of the external environment. Olfaction favors anticipation and rapid adaptation of behavioral responses necessary for animal survival. Furthermore, recent studies have demonstrated that there is a direct action of metabolic peptides on the olfactory network. Orexigenic peptides such as ghrelin and orexin increase olfactory sensitivity, which in turn, is decreased by anorexigenic hormones such as insulin and leptin. In addition to peptides, nutrients can play a key role on neuronal activity. Very little is known about nutrient sensing in olfactory areas. Nutrients, such as carbohydrates, amino acids, and lipids, could play a key role in modulating olfactory sensitivity to adjust feeding behavior according to metabolic need. Here we summarize recent findings on nutrient-sensing neurons in olfactory areas and delineate the limits of our knowledge on this topic. The present review opens new lines of investigations on the relationship between olfaction and food intake, which could contribute to determining the etiology of metabolic disorders.
Identifier: FSU_libsubv1_wos_000405365400001 (IID), 10.3389/fphys.2017.00468 (DOI)
Keywords: obesity, central-nervous-system, gated potassium channel, receptor, amino-acid transporter, anterior piriform cortex, blood-brain-barrier, fatty-acid, food intake, in-situ hybridization, nutrient sensing, olfaction, piriform cortex, receptor messenger-rna, regulates food-intake, sensitive k+ channels, transporter, type 2 diabetes
Publication Note: The publisher's version of record is available at
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Owner Institution: FSU
Is Part Of: Frontiers in Physiology.
Issue: vol. 8

Choose the citation style.
Julliard, A. -K., Al Koborssy, D., Fadool, D. A., & Palouzier-Paulignan, B. (2017). Nutrient Sensing: Another Chemosensitivity Of The Olfactory System. Frontiers In Physiology. Retrieved from