You are here

Behavioral Immune System Activity Predicts Downregulation Of Chronic Basal Inflammation

Title: Behavioral Immune System Activity Predicts Downregulation Of Chronic Basal Inflammation.
Name(s): Gassen, Jeffrey, author
Prokosch, Marjorie L., author
Makhanova, Anastasia, author
Eimerbrink, Micah J., author
White, Jordon D., author
Leyva, Randi P. Proffitt, author
Peterman, Julia L., author
Nicolas, Sylis C., author
Reynolds, Tania A., author
Maner, Jon K., author
McNulty, James K., author
Eckel, Lisa A., author
Nikonova, Larissa, author
Brinkworth, Jessica F., author
Phillips, Melody D., author
Mitchell, Joel B., author
Boehm, Gary W., author
Hill, Sarah E., author
Type of Resource: text
Genre: Journal Article
Journal Article
Date Issued: 2018-09-20
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Here, we present a mechanistically grounded theory detailing a novel function of the behavioral immune system (BIS), the psychological system that prompts pathogen avoidance behaviors. We propose that BIS activity allows the body to downregulate basal inflammation, preventing resultant oxidative damage to DNA and promoting longevity. Study 1 investigated the relationship between a trait measure of pathogen avoidance motivation and in vitro and in vivo proinflammatory cytokine production. Study 2 examined the relationship between this same predictor and DNA damage often associated with prolonged inflammation. Results revealed that greater trait pathogen avoidance motivation predicts a) lower levels of spontaneous (but not stimulated) proinflammatory cytokine release by peripheral blood mononuclear cells (PBMCs), b) lower plasma levels of the proinflammatory cytokine interleukin-6 (IL-6), and c) lower levels of oxidative DNA damage. Thus, the BIS may promote health by protecting the body from the deleterious effects of inflammation and oxidative stress.
Identifier: FSU_libsubv1_wos_000445626400047 (IID), 10.1371/journal.pone.0203961 (DOI)
Keywords: symptoms, disease, personality, people, avoidance, oxidative stress, cytokines, free-radicals
Publication Note: The publisher’s version of record is available at
Persistent Link to This Record:
Owner Institution: FSU
Is Part Of: Plos One.
Issue: iss. 9, vol. 13

Choose the citation style.
Gassen, J., Prokosch, M. L., Makhanova, A., Eimerbrink, M. J., White, J. D., Leyva, R. P. P., … Hill, S. E. (2018). Behavioral Immune System Activity Predicts Downregulation Of Chronic Basal Inflammation. Plos One. Retrieved from