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Differential Expression of Neuron Glial Antigen 2 in a Subpopulation of Bone Marrow-Derived Macrophages

Title: Differential Expression of Neuron Glial Antigen 2 in a Subpopulation of Bone Marrow-Derived Macrophages.
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Name(s): Broussard, Erynn Nicole, author
Type of Resource: text
Genre: Text
Bachelor Thesis
Date Issued: 2018-12-06
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Neuron glial antigen 2 (NG2) is a transmembrane protein predominately expressed in certain central nervous system (CNS) cells. Among these cell types are oligodendrocyte precursor cells (OPCs) and astrocytes. The 250 kilodalton core protein undergoes extensive post-translational modification. The addition of chondroitin sulfate glycosaminoglycan chains and disulfide bonds allows for binding to a number of receptors and extracellular ligands which allows it to play a vital role in cell migration, survival, and angiogenesis. Although NG2 expression has been classically associated with CNS cell types, the presence of NG2 has been detected in immune cells in a variety of CNS pathologies. Following a spinal cord injury (SCI), a small population of bone marrow-derived macrophages (BMDMs) infiltrating the injured spinal cord have been reported to express NG2. While infiltrating macrophages in the injured spinal cord are considered pro-inflammatory, it is unclear whether NG2+ BMDMs are classically (pro-inflammatory) or alternatively activated (anti-inflammatory). In addition, much is still unknown regarding the immunological role of NG2+ macrophages. To determine the factors driving NG2 expression, we quantified protein expression following various activating stimuli. The findings suggest that NG2 upregulation is strongly associated with alternative (anti-inflammatory) activation.
Identifier: FSU_libsubv1_scholarship_submission_1544082780_9588a7c4 (IID)
Keywords: Neuron Glial Antigen 2 (NG2), Macrophage (BMDM), Transforming Growth Factor Beta 1 (TGF-β1), Glial Scar, Spinal Cord Injury (SCI)
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_libsubv1_scholarship_submission_1544082780_9588a7c4
Owner Institution: FSU

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Broussard, E. N. (2018). Differential Expression of Neuron Glial Antigen 2 in a Subpopulation of Bone Marrow-Derived Macrophages. Retrieved from http://purl.flvc.org/fsu/fd/FSU_libsubv1_scholarship_submission_1544082780_9588a7c4