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Differential Expression of Neuron Glial Antigen 2 in a Subpopulation of Bone Marrow-Derived Macrophages
| Title: | Differential Expression of Neuron Glial Antigen 2 in a Subpopulation of Bone Marrow-Derived Macrophages. |
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| Name(s): | Broussard, Erynn Nicole, author | |
| Type of Resource: | text | |
| Genre: |
Text Bachelor Thesis |
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| Date Issued: | 2018-12-06 | |
| Physical Form: |
computer online resource |
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| Extent: | 1 online resource | |
| Language(s): | English | |
| Abstract/Description: | Neuron glial antigen 2 (NG2) is a transmembrane protein predominately expressed in certain central nervous system (CNS) cells. Among these cell types are oligodendrocyte precursor cells (OPCs) and astrocytes. The 250 kilodalton core protein undergoes extensive post-translational modification. The addition of chondroitin sulfate glycosaminoglycan chains and disulfide bonds allows for binding to a number of receptors and extracellular ligands which allows it to play a vital role in cell migration, survival, and angiogenesis. Although NG2 expression has been classically associated with CNS cell types, the presence of NG2 has been detected in immune cells in a variety of CNS pathologies. Following a spinal cord injury (SCI), a small population of bone marrow-derived macrophages (BMDMs) infiltrating the injured spinal cord have been reported to express NG2. While infiltrating macrophages in the injured spinal cord are considered pro-inflammatory, it is unclear whether NG2+ BMDMs are classically (pro-inflammatory) or alternatively activated (anti-inflammatory). In addition, much is still unknown regarding the immunological role of NG2+ macrophages. To determine the factors driving NG2 expression, we quantified protein expression following various activating stimuli. The findings suggest that NG2 upregulation is strongly associated with alternative (anti-inflammatory) activation. | |
| Identifier: | FSU_libsubv1_scholarship_submission_1544082780_9588a7c4 (IID) | |
| Keywords: | Neuron Glial Antigen 2 (NG2), Macrophage (BMDM), Transforming Growth Factor Beta 1 (TGF-β1), Glial Scar, Spinal Cord Injury (SCI) | |
| Persistent Link to This Record: | http://purl.flvc.org/fsu/fd/FSU_libsubv1_scholarship_submission_1544082780_9588a7c4 | |
| Owner Institution: | FSU |
Broussard, E. N. (2018). Differential Expression of Neuron Glial Antigen 2 in a Subpopulation of Bone Marrow-Derived Macrophages. Retrieved from http://purl.flvc.org/fsu/fd/FSU_libsubv1_scholarship_submission_1544082780_9588a7c4
