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Maternal residential exposure to agricultural pesticides and birth defects in a 2003 to 2005 North Carolina birth cohort.

Title: Maternal residential exposure to agricultural pesticides and birth defects in a 2003 to 2005 North Carolina birth cohort.
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Name(s): Rappazzo, Kristen M, author
Warren, Joshua L, author
Meyer, Robert E, author
Herring, Amy H, author
Sanders, Alison P, author
Brownstein, Naomi C, author
Luben, Thomas J, author
Type of Resource: text
Genre: Journal Article
Text
Date Issued: 2016-04-01
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Birth defects are responsible for a large proportion of disability and infant mortality. Exposure to a variety of pesticides have been linked to increased risk of birth defects. We conducted a case-control study to estimate the associations between a residence-based metric of agricultural pesticide exposure and birth defects. We linked singleton live birth records for 2003 to 2005 from the North Carolina (NC) State Center for Health Statistics to data from the NC Birth Defects Monitoring Program. Included women had residence at delivery inside NC and infants with gestational ages from 20 to 44 weeks (n = 304,906). Pesticide exposure was assigned using a previously constructed metric, estimating total chemical exposure (pounds of active ingredient) based on crops within 500 meters of maternal residence, specific dates of pregnancy, and chemical application dates based on the planting/harvesting dates of each crop. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals for four categories of exposure (<10(th) , 10-50(th) , 50-90(th) , and >90(th) percentiles) compared with unexposed. Models were adjusted for maternal race, age at delivery, education, marital status, and smoking status. We observed elevated ORs for congenital heart defects and certain structural defects affecting the gastrointestinal, genitourinary and musculoskeletal systems (e.g., OR [95% confidence interval] [highest exposure vs. unexposed] for tracheal esophageal fistula/esophageal atresia = 1.98 [0.69, 5.66], and OR for atrial septal defects: 1.70 [1.34, 2.14]). Our results provide some evidence of associations between residential exposure to agricultural pesticides and several birth defects phenotypes. Birth Defects Research (Part A) 106:240-249, 2016. © 2016 Wiley Periodicals, Inc.
Identifier: FSU_pmch_26970546 (IID), 10.1002/bdra.23479 (DOI), PMC4833532 (PMCID), 26970546 (RID), 26970546 (EID)
Keywords: GIS, Agriculture, Birth defects, Congenital anomalies, Pesticide exposure, Residential
Grant Number: P30 ES010126, T32ES007018, T32 ES007018, R01 ES020619, R01ES020619, P2C HD050924, P30ES010126
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833532.
Subject(s): Adult
Agriculture
Congenital Abnormalities/epidemiology
Congenital Abnormalities/etiology
Female
Humans
Maternal Exposure/adverse effects
North Carolina/epidemiology
Pesticides/adverse effects
Pregnancy
Retrospective Studies
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_pmch_26970546
Host Institution: FSU
Is Part Of: Birth defects research. Part A, Clinical and molecular teratology.
1542-0760
Issue: iss. 4, vol. 106

Choose the citation style.
Rappazzo, K. M., Warren, J. L., Meyer, R. E., Herring, A. H., Sanders, A. P., Brownstein, N. C., & Luben, T. J. (2016). Maternal residential exposure to agricultural pesticides and birth defects in a 2003 to 2005 North Carolina birth cohort. Birth Defects Research. Part A, Clinical And Molecular Teratology. Retrieved from http://purl.flvc.org/fsu/fd/FSU_pmch_26970546