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Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.

Title: Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.
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Name(s): Okbay, Aysu, author
Baselmans, Bart M L, author
De Neve, Jan-Emmanuel, author
Turley, Patrick, author
Nivard, Michel G, author
Fontana, Mark Alan, author
Meddens, S Fleur W, author
Linnér, Richard Karlsson, author
Rietveld, Cornelius A, author
Derringer, Jaime, author
Gratten, Jacob, author
Lee, James J, author
Liu, Jimmy Z, author
de Vlaming, Ronald, author
Ahluwalia, Tarunveer S, author
Buchwald, Jadwiga, author
Cavadino, Alana, author
Frazier-Wood, Alexis C, author
Furlotte, Nicholas A, author
Garfield, Victoria, author
Geisel, Marie Henrike, author
Gonzalez, Juan R, author
Haitjema, Saskia, author
Karlsson, Robert, author
van der Laan, Sander W, author
Ladwig, Karl-Heinz, author
Lahti, Jari, author
van der Lee, Sven J, author
Lind, Penelope A, author
Liu, Tian, author
Matteson, Lindsay, author
Mihailov, Evelin, author
Miller, Michael B, author
Minica, Camelia C, author
Nolte, Ilja M, author
Mook-Kanamori, Dennis, author
van der Most, Peter J, author
Oldmeadow, Christopher, author
Qian, Yong, author
Raitakari, Olli, author
Rawal, Rajesh, author
Realo, Anu, author
Rueedi, Rico, author
Schmidt, Börge, author
Smith, Albert V, author
Stergiakouli, Evie, author
Tanaka, Toshiko, author
Taylor, Kent, author
Thorleifsson, Gudmar, author
Wedenoja, Juho, author
Wellmann, Juergen, author
Westra, Harm-Jan, author
Willems, Sara M, author
Zhao, Wei, author
, author
Amin, Najaf, author
Bakshi, Andrew, author
Bergmann, Sven, author
Bjornsdottir, Gyda, author
Boyle, Patricia A, author
Cherney, Samantha, author
Cox, Simon R, author
Davies, Gail, author
Davis, Oliver S P, author
Ding, Jun, author
Direk, Nese, author
Eibich, Peter, author
Emeny, Rebecca T, author
Fatemifar, Ghazaleh, author
Faul, Jessica D, author
Ferrucci, Luigi, author
Forstner, Andreas J, author
Gieger, Christian, author
Gupta, Richa, author
Harris, Tamara B, author
Harris, Juliette M, author
Holliday, Elizabeth G, author
Hottenga, Jouke-Jan, author
De Jager, Philip L, author
Kaakinen, Marika A, author
Kajantie, Eero, author
Karhunen, Ville, author
Kolcic, Ivana, author
Kumari, Meena, author
Launer, Lenore J, author
Franke, Lude, author
Li-Gao, Ruifang, author
Liewald, David C, author
Koini, Marisa, author
Loukola, Anu, author
Marques-Vidal, Pedro, author
Montgomery, Grant W, author
Mosing, Miriam A, author
Paternoster, Lavinia, author
Pattie, Alison, author
Petrovic, Katja E, author
Pulkki-Råback, Laura, author
Quaye, Lydia, author
Räikkönen, Katri, author
Rudan, Igor, author
Scott, Rodney J, author
Smith, Jennifer A, author
Sutin, Angelina R, author
Trzaskowski, Maciej, author
Vinkhuyzen, Anna E, author
Yu, Lei, author
Zabaneh, Delilah, author
Attia, John R, author
Bennett, David A, author
Berger, Klaus, author
Bertram, Lars, author
Boomsma, Dorret I, author
Snieder, Harold, author
Chang, Shun-Chiao, author
Cucca, Francesco, author
Deary, Ian J, author
van Duijn, Cornelia M, author
Eriksson, Johan G, author
Bültmann, Ute, author
de Geus, Eco J C, author
Groenen, Patrick J F, author
Gudnason, Vilmundur, author
Hansen, Torben, author
Hartman, Catharine A, author
Haworth, Claire M A, author
Hayward, Caroline, author
Heath, Andrew C, author
Hinds, David A, author
Hyppönen, Elina, author
Iacono, William G, author
Järvelin, Marjo-Riitta, author
Jöckel, Karl-Heinz, author
Kaprio, Jaakko, author
Kardia, Sharon L R, author
Keltikangas-Järvinen, Liisa, author
Kraft, Peter, author
Kubzansky, Laura D, author
Lehtimäki, Terho, author
Magnusson, Patrik K E, author
Martin, Nicholas G, author
McGue, Matt, author
Metspalu, Andres, author
Mills, Melinda, author
de Mutsert, Renée, author
Oldehinkel, Albertine J, author
Pasterkamp, Gerard, author
Pedersen, Nancy L, author
Plomin, Robert, author
Polasek, Ozren, author
Power, Christine, author
Rich, Stephen S, author
Rosendaal, Frits R, author
den Ruijter, Hester M, author
Schlessinger, David, author
Schmidt, Helena, author
Svento, Rauli, author
Schmidt, Reinhold, author
Alizadeh, Behrooz Z, author
Sørensen, Thorkild I A, author
Spector, Tim D, author
Starr, John M, author
Stefansson, Kari, author
Steptoe, Andrew, author
Terracciano, Antonio, author
Thorsteinsdottir, Unnur, author
Thurik, A Roy, author
Timpson, Nicholas J, author
Tiemeier, Henning, author
Uitterlinden, André G, author
Vollenweider, Peter, author
Wagner, Gert G, author
Weir, David R, author
Yang, Jian, author
Conley, Dalton C, author
Smith, George Davey, author
Hofman, Albert, author
Johannesson, Magnus, author
Laibson, David I, author
Medland, Sarah E, author
Meyer, Michelle N, author
Pickrell, Joseph K, author
Esko, Tõnu, author
Krueger, Robert F, author
Beauchamp, Jonathan P, author
Koellinger, Philipp D, author
Benjamin, Daniel J, author
Bartels, Meike, author
Cesarini, David, author
Type of Resource: text
Genre: Journal Article
Text
Date Issued: 2016-06-01
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is genetically correlated with both of these traits, has not yet been studied with genome-wide data. We conducted genome-wide association studies of three phenotypes: subjective well-being (n = 298,420), depressive symptoms (n = 161,460), and neuroticism (n = 170,911). We identify 3 variants associated with subjective well-being, 2 variants associated with depressive symptoms, and 11 variants associated with neuroticism, including 2 inversion polymorphisms. The two loci associated with depressive symptoms replicate in an independent depression sample. Joint analyses that exploit the high genetic correlations between the phenotypes (|ρ^| ≈ 0.8) strengthen the overall credibility of the findings and allow us to identify additional variants. Across our phenotypes, loci regulating expression in central nervous system and adrenal or pancreas tissues are strongly enriched for association.
Identifier: FSU_pmch_27089181 (IID), 10.1038/ng.3552 (DOI), PMC4884152 (PMCID), 27089181 (RID), 27089181 (EID), ng.3552 (PII)
Grant Number: R01 DA036216, G1001799, RF1 AG015819, U01 AG009740, MC_UU_12013/3, MC_QA137853, R01 AG017917, MR/J012165/1, R03 AG051960, UL1 TR000124, MR/K026992/1, MR/N01104X/1, P30 DK063491, P2C HD047879, MC_PC_15018, P30 AG010161, MC_UU_12013/1, MC_PC_U127561128, P01 AG005842, R37 DA005147, P30 AG012810, R01 AG042568, T32 AG000186, 647648
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4884152.
Subject(s): Anxiety Disorders/genetics
Bayes Theorem
Depression/genetics
Genome-Wide Association Study
Humans
Neuroticism
Phenotype
Polymorphism, Single Nucleotide
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_pmch_27089181
Owner Institution: FSU
Is Part Of: Nature genetics.
1546-1718
Issue: iss. 6, vol. 48

Choose the citation style.
Okbay, A., Baselmans, B. M. L., De Neve, J. -E., Turley, P., Nivard, M. G., Fontana, M. A., … Cesarini, D. (2016). Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses. Nature Genetics. Retrieved from http://purl.flvc.org/fsu/fd/FSU_pmch_27089181