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Neurochemical Mediation of Affiliation and Aggression Associated With Pair-Bonding.
| Title: | Neurochemical Mediation of Affiliation and Aggression Associated With Pair-Bonding. |
 37 views 1 downloads |
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| Name(s): |
Gobrogge, Kyle L, author Jia, Xixi, author Liu, Yan, author Wang, Zuoxin, author |
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| Type of Resource: | text | |
| Genre: |
Journal Article Text |
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| Date Issued: | 2017-02-01 | |
| Physical Form: |
computer online resource |
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| Extent: | 1 online resource | |
| Language(s): | English | |
| Abstract/Description: | The neuropeptides vasopressin and corticotropin-releasing factor facilitate, while serotonin inhibits, aggression. How the brain is wired to coordinate interactions between these functionally opposed neurotransmitters to control behavioral states is poorly understood. Pair-bonded male prairie voles (Microtus ochrogaster) were infused with a retrograde tracer, Fluoro-Gold, and tested for affiliation and aggression toward a female partner or novel female subject. Subsequent immunocytochemical experiments examined neuronal activation using Fos and neurochemical/neuroreceptor profiles on brain areas involved in these social behaviors. Finally, a series of behavioral pharmacologic and real-time in vivo brain microdialysis experiments were performed on male prairie voles displaying affiliation or aggression. We localized a subpopulation of excitatory vasopressin neurons in the anterior hypothalamus that may gate corticotropin-releasing factor output from the amygdala to the anterior hypothalamus and then the lateral septum to modulate aggression associated with mate guarding. Conversely, we identified a subset of inhibitory serotonergic projection neurons in the dorsal raphe that project to the anterior hypothalamus and may mediate the spatiotemporal release of neuropeptides and their interactions in modulating aggression and affiliation. Together, this study establishes the medial extended amygdala as a major neural substrate regulating the switch between positive and negative affective states, wherein several neurochemicals converge and interact to coordinate divergent social behaviors. | |
| Identifier: | FSU_pmch_27129413 (IID), 10.1016/j.biopsych.2016.02.013 (DOI), PMC4992658 (PMCID), 27129413 (RID), 27129413 (EID), S0006-3223(16)00100-1 (PII) | |
| Keywords: | Anterior hypothalamus, Corticotropin-releasing factor, Dopamine, Medial amygdala, Serotonin, Vasopressin | |
| Grant Number: | F31 MH079600, F32 GM096591 | |
| Publication Note: | This NIH-funded author manuscript originally appeared in PubMed Central at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992658. | |
| Subject(s): |
Aggression/physiology Amygdala/metabolism Amygdala/physiology Animals Arvicolinae Brain/metabolism Brain/physiology Corticotropin-Releasing Hormone/metabolism Corticotropin-Releasing Hormone/physiology Dorsal Raphe Nucleus/metabolism Dorsal Raphe Nucleus/physiology Female Hypothalamus/metabolism Hypothalamus/physiology Male Neural Pathways/metabolism Neural Pathways/physiology Neurons/metabolism Neurons/physiology Neuropeptides/metabolism Proto-Oncogene Proteins c-fos/metabolism Receptor, Serotonin, 5-HT1A/physiology Septal Nuclei/metabolism Septal Nuclei/physiology Serotonergic Neurons/metabolism Serotonergic Neurons/physiology Serotonin/metabolism Serotonin/physiology Social Behavior Vasopressins/metabolism Vasopressins/physiology |
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| Persistent Link to This Record: | http://purl.flvc.org/fsu/fd/FSU_pmch_27129413 | |
| Host Institution: | FSU | |
| Is Part Of: |
Biological psychiatry. 1873-2402 |
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| Issue: | iss. 3, vol. 81 |
Gobrogge, K. L., Jia, X., Liu, Y., & Wang, Z. (2017). Neurochemical Mediation of Affiliation and Aggression Associated With Pair-Bonding. Biological Psychiatry. Retrieved from http://purl.flvc.org/fsu/fd/FSU_pmch_27129413
