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Synthesis of "neoprofen", a rigidified analogue of ibuprofen, exemplifying synthetic methodology for altering the 3-D topology of pharmaceutical substances.
| Title: | Synthesis of "neoprofen", a rigidified analogue of ibuprofen, exemplifying synthetic methodology for altering the 3-D topology of pharmaceutical substances. |
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| Name(s): |
Ramsubhag, Ron R, author Massaro, Chelsea L, author Dadich, Christina M, author Janeczek, Andrew J, author Hoang, Tung T, author Mazzio, Elizabeth A, author Eyunni, Suresh, author Soliman, Karam F A, author Dudley, Gregory B, author |
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| Type of Resource: | text | |
| Genre: |
Journal Article Text |
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| Date Issued: | 2016-08-16 | |
| Physical Form: |
computer online resource |
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| Extent: | 1 online resource | |
| Language(s): | English | |
| Abstract/Description: | 3,3-Dimethylcyclopentanes (neopentylenes) are ubiquitous in Nature but largely absent from synthetic pharmaceutical libraries. Neopentylenes define a hydrophobic and rigid 3-D topology with distinct molecular pharmacology, as exemplified here with two neopentylene-fused analogues of the synthetic anti-inflammatory drug, ibuprofen. | |
| Identifier: | FSU_pmch_27492587 (IID), 10.1039/c6ob01351a (DOI), PMC5008855 (PMCID), 27492587 (RID), 27492587 (EID) | |
| Grant Number: | G12 MD007582, P20 MD006738 | |
| Publication Note: | This NIH-funded author manuscript originally appeared in PubMed Central at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008855. | |
| Subject(s): |
Anti-Inflammatory Agents, Non-Steroidal/chemical synthesis Anti-Inflammatory Agents, Non-Steroidal/chemistry Anti-Inflammatory Agents, Non-Steroidal/pharmacology Cyclooxygenase 2/metabolism Cyclooxygenase 2 Inhibitors/chemical synthesis Cyclooxygenase 2 Inhibitors/chemistry Cyclooxygenase 2 Inhibitors/pharmacology Humans Ibuprofen/analogs & derivatives Ibuprofen/chemistry Ibuprofen/pharmacology Molecular Structure |
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| Persistent Link to This Record: | http://purl.flvc.org/fsu/fd/FSU_pmch_27492587 | |
| Host Institution: | FSU | |
| Is Part Of: |
Organic & biomolecular chemistry. 1477-0539 |
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| Issue: | iss. 33, vol. 14 |
Ramsubhag, R. R., Massaro, C. L., Dadich, C. M., Janeczek, A. J., Hoang, T. T., Mazzio, E. A., … Dudley, G. B. (2016). Synthesis of "neoprofen", a rigidified analogue of ibuprofen, exemplifying synthetic methodology for altering the 3-D topology of pharmaceutical substances. Organic & Biomolecular Chemistry. Retrieved from http://purl.flvc.org/fsu/fd/FSU_pmch_27492587
