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Genome-Wide Polygenic Scores Predict Reading Performance Throughout the School Years.

Title: Genome-Wide Polygenic Scores Predict Reading Performance Throughout the School Years.
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Name(s): Selzam, Saskia, author
Dale, Philip S, author
Wagner, Richard K, author
DeFries, John C, author
Cederlöf, Martin, author
O'Reilly, Paul F, author
Krapohl, Eva, author
Plomin, Robert, author
Type of Resource: text
Genre: Journal Article
Text
Date Issued: 2017-07-04
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: It is now possible to create individual-specific genetic scores, called genome-wide polygenic scores (GPS). We used a GPS for years of education () to predict reading performance assessed at UK National Curriculum Key Stages 1 (age 7), 2 (age 12) and 3 (age 14) and on reading tests administered at ages 7 and 12 in a UK sample of 5,825 unrelated individuals. GPS accounts for up to 5% of the variance in reading performance at age 14. GPS predictions remained significant after accounting for general cognitive ability and family socioeconomic status. Reading performance of children in the lowest and highest 12.5% of the GPS distribution differed by a mean growth in reading ability of approximately two school years. It seems certain that polygenic scores will be used to predict strengths and weaknesses in education.
Identifier: FSU_pmch_28706435 (IID), 10.1080/10888438.2017.1299152 (DOI), PMC5490720 (PMCID), 28706435 (RID), 28706435 (EID), 1299152 (PII)
Grant Number: G0901245, MR/M021475/1, R01 AG046938
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490720.
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_pmch_28706435
Owner Institution: FSU
Is Part Of: Scientific studies of reading : the official journal of the Society for the Scientific Study of Reading.
1088-8438
Issue: iss. 4, vol. 21

Choose the citation style.
Selzam, S., Dale, P. S., Wagner, R. K., DeFries, J. C., Cederlöf, M., O'Reilly, P. F., … Plomin, R. (2017). Genome-Wide Polygenic Scores Predict Reading Performance Throughout the School Years. Scientific Studies Of Reading : The Official Journal Of The Society For The Scientific Study Of Reading. Retrieved from http://purl.flvc.org/fsu/fd/FSU_pmch_28706435