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Tissue-Intrinsic Tumor Hotspots

Title: Tissue-Intrinsic Tumor Hotspots: Terroir for Tumorigenesis.
Name(s): Tamori, Yoichiro, author
Deng, Wu-Min, author
Type of Resource: text
Genre: Journal Article
Date Issued: 2017-04-01
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Epithelial tissues are highly organized systems with a remarkable homeostatic ability to maintain morphology through regulation of cellular proliferation and tissue integrity. This robust self-organizing system is progressively disrupted during tumor development. Recent studies of conserved tumor-suppressor genes in Drosophila showed how protumor cells deviate from the robustly organized tissue microenvironment to take the first steps into becoming aggressive tumors. Here we review the 'tumor hotspot' hypothesis that explains how the tissue-intrinsic local microenvironment has a pivotal role in the initial stage of tumorigenesis in Drosophila epithelia and discuss comparable mechanisms in mammalian tissues.
Identifier: FSU_pmch_28718438 (IID), 10.1016/j.trecan.2017.03.003 (DOI), PMC5518481 (PMCID), 28718438 (RID), 28718438 (EID), S2405-8033(17)30058-4 (PII)
Grant Number: R01 GM072562
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at
Subject(s): Animals
Cell Proliferation
Drosophila Proteins/genetics
Persistent Link to This Record:
Owner Institution: FSU
Is Part Of: Trends in cancer.
Issue: iss. 4, vol. 3

Choose the citation style.
Tamori, Y., & Deng, W. -M. (2017). Tissue-Intrinsic Tumor Hotspots: Terroir for Tumorigenesis. Trends In Cancer. Retrieved from