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Integrin β3/Akt signaling contributes to platelet-induced hemangioendothelioma growth.

Title: Integrin β3/Akt signaling contributes to platelet-induced hemangioendothelioma growth.
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Name(s): Gu, Rui, author
Sun, Xin, author
Chi, Yijie, author
Zhou, Qishuang, author
Xiang, Hongkai, author
Bosco, Dale B, author
Lai, Xinhe, author
Qin, Caixia, author
So, Kwok-Fai, author
Ren, Yi, author
Chen, Xiao-Ming, author
Type of Resource: text
Genre: Journal Article
Text
Date Issued: 2017-07-25
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Hemangioendothelioma (HE) is a type of angiomatous lesions that features endothelial cell proliferation. Understanding the mechanisms orchestrating HE angiogenesis can provide therapeutic insights. It has been shown that platelets can support normal and malignant endothelial cells during angiogenesis. Using the mouse endothelial-derived EOMA cell line as a model of HE, we explored the regulatory effect of platelets. We found that platelets stimulated EOMA proliferation but did not mitigate apoptosis. Furthermore, direct platelet-EOMA cell contact was required and the proliferation was mediated via integrin β3/Akt signaling in EOMA cells. SiRNA knockdown of integrin β3 and inhibition of Akt activity significantly abolished platelet-induced EOMA cell proliferation in vitro and tumor development in vivo. These results provide a new mechanism by which platelets support HE progression and suggest integrin β3 as a potential target to treat HE.
Identifier: FSU_pmch_28744026 (IID), 10.1038/s41598-017-06927-0 (DOI), PMC5527091 (PMCID), 28744026 (RID), 28744026 (EID), 10.1038/s41598-017-06927-0 (PII)
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527091.
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_pmch_28744026
Owner Institution: FSU
Is Part Of: Scientific reports.
2045-2322
Issue: iss. 1, vol. 7

Choose the citation style.
Gu, R., Sun, X., Chi, Y., Zhou, Q., Xiang, H., Bosco, D. B., … Chen, X. -M. (2017). Integrin β3/Akt signaling contributes to platelet-induced hemangioendothelioma growth. Scientific Reports. Retrieved from http://purl.flvc.org/fsu/fd/FSU_pmch_28744026