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Mapping of Glucagon-like Peptide-1 Receptor Expression in the Developing Mouse Brain

Title: Mapping of Glucagon-like Peptide-1 Receptor Expression in the Developing Mouse Brain.
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Name(s): Madkour, Haley, author
Type of Resource: text
Genre: Text
Bachelor Thesis
Date Issued: 2020-12-01
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Studying the role of glucagon-like peptide-1 (GLP-1) and GLP-1 receptor (GLP-1R) in the mouse brain has been a subject of emergent relevance in recent years due to its presence in the central and peripheral nervous systems, as well as the gut. Previous examination of GLP-1R location in the adult mouse brain has been widely beneficial, however the ontogeny of GLP-1R in the developing mouse brain has not been thoroughly observed. I examined the pattern of expression of Glp1rmRNA in the central nervous system using in-situ hybridization across multiple stages of mouse development, embryonic and postnatal. Glp1rmRNA expression was found across all ages in the hippocampus, lateral septum, medial septal nucleus, amygdala, bed nucleus of the stria terminalis, thalamus, nucleus accumbens, cerebral cortex, caudate putamen, regions of the midbrain, and hypothalamus. Embryonic brains displayed higher and more widespread expression than postnatal brains, which could signify the importance of GLP-1R during development. Early postnatal expression of Glp1rmRNA was more restricted than embryonic patterns, but still expressed in specific brain regions and circuits not found in adult expression patterns, including the medial septal nucleus, thalamus and somatosensory cortex. These data contribute to the study of GLP-1R development in the mouse brain, the investigation of treatment of mood disorders, diabetes and obesity with GLP-1R agonists, and possible further implications to treat pregnant women that have these diseases.
Identifier: FSU_libsubv1_scholarship_submission_1606854707_22f9685e (IID)
Keywords: GLP-1R, glucagon-like-peptide-1, development, brain mapping, embryonic, in-situ hybridization
Publication Note: Date of defense was 11/23/2020.
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_libsubv1_scholarship_submission_1606854707_22f9685e
Host Institution: FSU

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Madkour, H. (2020). Mapping of Glucagon-like Peptide-1 Receptor Expression in the Developing Mouse Brain. Retrieved from http://purl.flvc.org/fsu/fd/FSU_libsubv1_scholarship_submission_1606854707_22f9685e