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Title: "A Glimpse Into the Past": Communication, Cultural Tourism, and the Political Economy of Modern Gullah Preservation.
Creator: Graves, Brian
Date Issued: 2013-10-01
Identifier: FSU_libsubv1_scholarship_submission_1475787437
Format: Citation

Title: The "Demand Side" of General Education - A Review of the Literature: Technical Report Number 11.
Creator: Reardon, Robert C, Lenz, Janet G, Sampson, James P, Johnston, Joseph S, Kramer, Gary L
Abstract/Description: Much of the literature in general education is focused on the design or contents of the program, or the "supply side," while little attention has been given to students' understandings of and attitudes toward general education, the "demand side." This paper reviews literature on the "demand side" of general education by first providing a brief synopsis of the notion of general education and recent recommendations for reform, and next summarizing research on student knowledge of and attitudes...
Show moreMuch of the literature in general education is focused on the design or contents of the program, or the "supply side," while little attention has been given to students' understandings of and attitudes toward general education, the "demand side." This paper reviews literature on the "demand side" of general education by first providing a brief synopsis of the notion of general education and recent recommendations for reform, and next summarizing research on student knowledge of and attitudes toward higher education and general education. Because of the paucity of "demand side" research, the paper shifts focus to processes used in higher education to affect demand side questions, including teaching, recruitment and admissions, orientation, academic and career advising, and course scheduling. The paper ends with conclusions on the importance of attending to "demand side" issues in the improvement of general education programs.
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Date Issued: 1990-07-01
Identifier: FSU_libsubv1_scholarship_submission_1525887098_ce56a520, 10.17125/fsu.1525887098
Format: Citation

Title: “Des voix refuseront de se taire”: Women’s Voices in Léonora Miano’s Contours du jours qui vient.
Creator: Messay, Marda
Abstract/Description: Inspired by the phenomenon of “child witches” in the Democratic Republic of Congo, Léonora Miano’s second novel, Contours du jour qui vient (2006), reveals the psychological and physical violence children accused of witchcraft experience and its detrimental consequences. This article examines the manner in which Musango, the protagonist of the novel, reconstitutes her fragmented sense of self and reestablishes relationships with others after surviving her mother’s violence and her banishment...
Show moreInspired by the phenomenon of “child witches” in the Democratic Republic of Congo, Léonora Miano’s second novel, Contours du jour qui vient (2006), reveals the psychological and physical violence children accused of witchcraft experience and its detrimental consequences. This article examines the manner in which Musango, the protagonist of the novel, reconstitutes her fragmented sense of self and reestablishes relationships with others after surviving her mother’s violence and her banishment from home. After analyzing the extent of the damages Musango sustained within her own home and community, especially her trauma-induced mutism, I examine how an already fragile Musango witnesses the silencing of women in a human trafficking camp and in a community revivalist church. I show how this silencing engenders a resistance within Musango and sparks a desire to use her voice. Lastly, I study how this resistance is further cemented and refined by the women she meets in the second half of the novel. These women guide Musango in her transformation from a mute traumatized self to a self-assured vocal individual. Furthermore, these women show her the ability of women’s voices to not only transmit knowledge and values but to also change the community for the better. Ultimately, I demonstrate how Musango is able to affirm her self-worth, reconstruct her fragmented sense of self, establish a connection with others and become a guiding voice through her interactions with the women she meets in her journey to recovery.
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Date Issued: 2019-12-31
Identifier: FSU_libsubv1_scholarship_submission_1578591465_04254cb6
Format: Citation

Title: "Do unto others"? Distinct psychopathy facets predict reduced perception and tolerance of pain.
Creator: Brislin, Sarah J, Buchman-Schmitt, Jennifer M, Joiner, Thomas E, Patrick, Christopher J
Abstract/Description: Recent research has sought to understand how individuals high in psychopathic traits perceive pain in others (Decety, Skelly, & Kiehl, 2013; Marsh et al., 2013). Perception of pain in others is presumed to act as a prosocial signal, and underreactivity to others' pain may contribute to engagement in exploitative-aggressive behaviors among individuals high in psychopathic traits (Jackson, Meltzoff, & Decety, 2005). The current study tested for associations between facets of psychopathy as...
Show moreRecent research has sought to understand how individuals high in psychopathic traits perceive pain in others (Decety, Skelly, & Kiehl, 2013; Marsh et al., 2013). Perception of pain in others is presumed to act as a prosocial signal, and underreactivity to others' pain may contribute to engagement in exploitative-aggressive behaviors among individuals high in psychopathic traits (Jackson, Meltzoff, & Decety, 2005). The current study tested for associations between facets of psychopathy as defined by the triarchic model (Patrick, Fowles, & Krueger, 2009) and decreased sensitivity to pain in 105 undergraduates tested in a laboratory pain assessment. A pressure algometer was used to index pain tolerance, and participants also rated their perceptions of and reactivity to the algometer-induced pain during the assessment and again 3 days later. A unique positive relationship was found between pain tolerance and the meanness facet of psychopathy, which also predicted reduced fear of painful algometer stimulation. Other psychopathy facets (boldness, disinhibition) showed negative relations with fear of pain stimulation during testing and at follow-up. Findings from this study extend the nomological network surrounding callousness (meanness) and suggest that increased pain tolerance may be a mechanism contributing to insensitivity to expressions of discomfort in others. (PsycINFO Database Record
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Date Issued: 2016-07-01
Identifier: FSU_pmch_26950545, 10.1037/per0000180, PMC4929019, 26950545, 26950545, 2016-11415-001
Format: Citation

Title: The "Enneads" of Plotinus: A Commentary, vol 1.
Creator: Slaveva-Griffin, Svetla
Date Issued: 2016-06
Identifier: FSU_libsubv1_wos_000379544700005, 10.1515/agph-2016-0010
Format: Citation

Title: "Free to All": Library Publishing and the Challenge of Open Access.
Creator: Vandegrift, Micah, Bolick, Josh
Abstract/Description: There is a significant and important responsibility as libraries move into the role of publishing to retain our heritage of "access for all." Connecting and collaborating with colleagues in the publishing industry is essential, but should come with the understanding that the library as an organization is access-prone. This article discusses the complexities of navigating that relationship, and calls for libraries and publishers to embrace and respect the position from which we begin. Finally,...
Show moreThere is a significant and important responsibility as libraries move into the role of publishing to retain our heritage of "access for all." Connecting and collaborating with colleagues in the publishing industry is essential, but should come with the understanding that the library as an organization is access-prone. This article discusses the complexities of navigating that relationship, and calls for libraries and publishers to embrace and respect the position from which we begin. Finally, the article forecasts several possible characteristics of what "publishing" might look like if libraries press the principle of access in this growing area.
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Date Issued: 2014
Identifier: FSU_migr_library_faculty_publications-0011, 10.6084/m9.figshare.1088945
Format: Citation

Title: The "FSU Lives" Digitization Project.
Creator: Morris, Sammie, Smith, Plato
Abstract/Description: FSU Libraries Special Collections and Digital Library Center collaborated on development this presentation highlighting FSU Lives Class of 1955 digitization project along with digital preservation of faculty research as part of a guest lecture for Florida State University College of Communication & Information Spring 2011 Digital Libraries course (LIS5472) taught by Dr. Sanghee Oh.
Date Issued: 2011
Identifier: FSU_migr_digital_lib-0013
Format: Citation

Title: "Gimme Shelter"™: The Hidden Causes and Consequences of Internal Displacement.
Creator: Kelley, Kaitlyn N., Department of Political Science
Abstract/Description: What are the causes and consequences of internal displacement during civil conflicts? This project makes two general claims: First, internal displacement is often the intentional byproduct of territorial consolidation during civil wars. Second, internal displacement can create an unfortunate and heretofore undiscovered feedback loop: wide-scale displacement leads to increases in civil war duration as well as intensity, which thereby leads to increased displacement. This project examines these...
Show moreWhat are the causes and consequences of internal displacement during civil conflicts? This project makes two general claims: First, internal displacement is often the intentional byproduct of territorial consolidation during civil wars. Second, internal displacement can create an unfortunate and heretofore undiscovered feedback loop: wide-scale displacement leads to increases in civil war duration as well as intensity, which thereby leads to increased displacement. This project examines these claims through the use of unique micro-level data on the Colombian Civil War as well as cross-national investigations of internal displacement and civil war duration.
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Date Issued: 2015
Identifier: FSU_migr_undergradsymposium2015-0012
Format: Citation

Title: "His-Panic": Latin-American Poetry in Translation.
Creator: Ruiz, Daniel, Department of English
Abstract/Description: Though I learned it first, I no longer speak Spanish fluently. Wishing to reconnect myself to my language and my culture—my own interests also piqued by the romantic sound of the language and the sheer brilliance and precision of the Spanish-language poets I had read—I returned to the language through poetry translation in an attempt to morph what had become unfamiliar (Spanish) into the language with which I have become most familiar (English). The purpose of this presentation is to give...
Show moreThough I learned it first, I no longer speak Spanish fluently. Wishing to reconnect myself to my language and my culture—my own interests also piqued by the romantic sound of the language and the sheer brilliance and precision of the Spanish-language poets I had read—I returned to the language through poetry translation in an attempt to morph what had become unfamiliar (Spanish) into the language with which I have become most familiar (English). The purpose of this presentation is to give insight into processes—of writing, rewriting, translating poems from Spanish to English, and learning to confront and accept the unfamiliar. Over the summer, I traveled to Uruguay and Argentina, where I was forced to speak Spanish only, where even my limited Puerto Rican Spanish was foreign to the European-influenced Spanish of South America. Living in Tallahassee before and after my trip, I worked to improve my Spanish and focused my reading on poets from Latin-American countries and on the notable essays and books on translation that are considered paramount in the field. My period of focus is the twentieth century, and while English-language poets were writing about "The Everyday", their Latin-American counterparts, while still, as Emerson says, embracing "the common," often focused on the big issues of Life, Death, Time, and especially Love. My goal is this: I wish to relay the experience of working in two languages instead of one, and to show how the discourse between languages altered my writing and the way I think about language.
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Date Issued: 2013
Identifier: FSU_migr_undergradresearch-0004
Format: Citation

Title: "I Can Name that Bayesian Network in Two Matrixes!".
Creator: Almond, Russell
Abstract/Description: The traditional approach to building Bayesian networks is to build the graphical structure using a graphical editor and then add probabilities using a separate spreadsheet for each node. This can make it difficult for a design team to get an impression of the total evidence provided by an assessment, especially if the Bayesian network is split into many fragments to make it more manageable. Using the design patterns commonly used to build Bayesian networks for educational assessments, the...
Show moreThe traditional approach to building Bayesian networks is to build the graphical structure using a graphical editor and then add probabilities using a separate spreadsheet for each node. This can make it difficult for a design team to get an impression of the total evidence provided by an assessment, especially if the Bayesian network is split into many fragments to make it more manageable. Using the design patterns commonly used to build Bayesian networks for educational assessments, the collection of networks necessary can be specified using two matrixes. An inverse covariance matrix among the proficiency variables (the variables which are the target of interest) specifies the graphical structure and relation strength of the proficiency model. A Q-matrix — an incidence matrix whose rows represent observable outcomes from assessment tasks and whose columns represent proficiency variables — provides the graphical structure of the evidence models (graph fragments linking proficiency variables to observable outcomes). The Q-matrix can be augmented to provide details of relationship strengths and provide a high level overview of the kind of evidence available in the assessment. The representation of the model using matrixes means that the bulk of the specification work can be done using a desktop spreadsheet program and does not require specialized software, facilitating collaboration with external experts. The design idea is illustrated with some examples from prior assessment design projects.
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Date Issued: 2007-01-01
Identifier: FSU_libsubv1_scholarship_submission_1472579811
Format: Citation

Title: "I don't want to grow up, I'm a [Gen X, Y, Me] kid": Increasing maturity fears across the decades..
Creator: Smith, April R, Bodell, Lindsay P, Holm-Denoma, Jill, Joiner, Thomas E, Gordon, Kathryn H, Perez, Marisol, Keel, Pamela K
Abstract/Description: The current studies examined the hypothesis that maturity fears are increasing among undergraduate men and women from the United States over time. Study 1 used a time-lag method to assess generational effects of maturity fears among a large sample (n = 3,291) of undergraduate men and women assessed in 1982, 1992, 2002, and 2012. Results revealed that both men and women reported significantly higher rates of maturity fears across time. Study 2 replicated these findings, and used a more...
Show moreThe current studies examined the hypothesis that maturity fears are increasing among undergraduate men and women from the United States over time. Study 1 used a time-lag method to assess generational effects of maturity fears among a large sample (n = 3,291) of undergraduate men and women assessed in 1982, 1992, 2002, and 2012. Results revealed that both men and women reported significantly higher rates of maturity fears across time. Study 2 replicated these findings, and used a more restricted time frame to more closely examine the rate of change. Undergraduate women (n = 554) were assessed in 2001, 2003, 2009, and 2012. Maturity fears were again found to increase from 2001 to 2012. Recent cohorts of emerging adults seem more reluctant to mature than previous cohorts. Many contributing factors may be at play, including challenging economic times, social pressures to remain youthful, and/or internal fears of assuming increased responsibility.
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Date Issued: 2017-11-01
Identifier: FSU_pmch_29225386, 10.1177/0165025416654302, PMC5718623, 29225386, 29225386
Format: Citation

Title: "It's Not Gay if They Don't Touch": Challenging Heteronormative Empire and Countering the 'Closeting of History' Through Art.
Creator: Steel, Isabella, Department of Art
Abstract/Description: My project revolves around the "closeting of history", which is the phenomenon in which evidence that suggests gay or bisexual behavior is omitted from the narratives of important historical figures, thus allowing them to be imagined as heterosexual by future generations (and depriving young people of gay and bisexual icons). I wanted to create artwork that counters this phenomenon, by placing historical figures and popular characters in situations that complicate their sexuality, removing...
Show moreMy project revolves around the "closeting of history", which is the phenomenon in which evidence that suggests gay or bisexual behavior is omitted from the narratives of important historical figures, thus allowing them to be imagined as heterosexual by future generations (and depriving young people of gay and bisexual icons). I wanted to create artwork that counters this phenomenon, by placing historical figures and popular characters in situations that complicate their sexuality, removing them from the heterosexual narrative that they have been confined to. I first began to explore this concept with a series of drawings of several American presidents as drag queens, complete with drag names, such as Abraham "Babe" Lincoln. I want these and other art pieces of mine to challenge the idea of "normativity" as applied to sexuality by re-appropriating iconic figures such as presidents, who have been symbols of heterosexual masculinity and success, as tools for showing sexuality as a performance—something that is fluid rather than compartmentalized. I want key works to simultaneously tackle the discomfort associated with excessive femininity, particularly when that femininity is applied to powerful individuals, and to negate the idea of the effeminate as weak. My artwork consists primarily of colorful and playful drawings and paintings, inspired by the camp aesthetic and sense of humor. At the end of the day, I just want to confront people with fun images of gay male sexuality, so that they might question what it is about it that makes them uncomfortable, and whether their discomfort is truly warranted.
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Date Issued: 2013
Identifier: FSU_migr_undergradresearch-0003
Format: Citation

Title: "It's Really Overwhelming": Parent And Service Provider Perspectives Of Parents Aging Out Of Foster Care.
Creator: Radey, Melissa, Schelbe, Lisa, McWey, Lenore M., Holtrop, Kendal, Canto, Angela I.
Abstract/Description: Rates of pregnancy and parenthood among current and former foster youth are two to three times higher than non-foster youth peers. Repeat pregnancies among young mothers aging out of foster care also occur at higher rates than peers not involved with the child welfare system. Furthermore, mothers aging out of foster care demonstrate high levels of parenting stress and risk for child maltreatment. Indeed, this population is in significant need of help; however, beyond anecdotal evidence,...
Show moreRates of pregnancy and parenthood among current and former foster youth are two to three times higher than non-foster youth peers. Repeat pregnancies among young mothers aging out of foster care also occur at higher rates than peers not involved with the child welfare system. Furthermore, mothers aging out of foster care demonstrate high levels of parenting stress and risk for child maltreatment. Indeed, this population is in significant need of help; however, beyond anecdotal evidence, little is known about the needs and day-to day experiences of this population. In order to tailor interventions to meet the needs of parents aging out, the perspectives of stakeholders must be taken into account. Using qualitative data gathered from separate small group interviews with parents aging out and service providers, this study examined participants' perceptions of parents' daily experiences, strengths, and needs. Findings indicated that parents aging out face overwhelming adversity and stress with little outside financial, emotional, or parenting support from family or friends. Yet, parents also expressed motivation to be good parents, resilience, and the desire to gain effective parenting skills. Although similar themes arose among parent and provider interviews, perceptions differed. Parents expressed hope and optimism in providing for their children while providers expressed systemic failure in preparing parents for independent living. Based on these findings, we conclude that parenting interventions specific to parents aging out may need to address three fundamental and key components: basic needs, social support, and effective parenting techniques. Published by Elsevier Ltd.
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Date Issued: 2016-08
Identifier: FSU_libsubv1_wos_000381171100001, 10.1016/j.childyouth.2016.05.013
Format: Citation

Title: "Keeping Them Off the Streets": Examining the Media's Discussion of Youth Agriculture Projects.
Creator: Philips, Allison, Boggs, George
Date Issued: 2016-04-12
Identifier: FSU_libsubv1_scholarship_submission_1460471829
Format: Citation

Title: “Le corps petit, mais l’âme grande”: Voicing a Woman’s Ambition in Louise de Keralio.
Creator: Mistacco, Vicki
Abstract/Description: Historian, translator, publisher, novelist, and journalist, polemicist and political activist during the French Revolution, Louise de Keralio (1756–1822) challenged prevailing gender roles by her ambitious incursion into areas considered the sole province of men. Yet, in apparent contradiction with her bold actions, authoritative voice and ambitious writing projects, she also reiterated gender stereotypes and made antifeminist remarks, much to the perplexity of recent critics such as Annie...
Show moreHistorian, translator, publisher, novelist, and journalist, polemicist and political activist during the French Revolution, Louise de Keralio (1756–1822) challenged prevailing gender roles by her ambitious incursion into areas considered the sole province of men. Yet, in apparent contradiction with her bold actions, authoritative voice and ambitious writing projects, she also reiterated gender stereotypes and made antifeminist remarks, much to the perplexity of recent critics such as Annie Geffroy (“Louise de Kéralio-Robert, pionnière du républicanisme sexiste”). I argue that this contrast between her “masculine” endeavors and authoritative voice, on the one hand, and her espousal of normative femininity, on the other, may best be understood by analyzing the discursive strategies she adopts to express her gender-nonconforming ambitions. From her earliest writings, a fundamental dilemma pits her female body, her “corps petit,” viewed in Rousseauian terms as consigned to modesty and domesticity, against her “âme grande” with its ambitious longing to do something for the benefit of society as a whole, to publish and enact her equally Rousseauian progressive ideas. They reveal that, for Keralio, writing is enabled by the repetition of restrictive gender norms, even as it is undercut by them. Her attempt to substitute for this binary thinking of gender in terms of either/or a utopian logic of both/and ultimately results in the silencing of her female-gendered, yet powerful, male-coded political voice during the evolution. Even so, her ideal of both/and endures.
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Date Issued: 2019-12-31
Identifier: FSU_libsubv1_scholarship_submission_1578588553_f8cde7a6
Format: Citation

Title: “Ma voix se dégagea”: Music, Risk, and the Heroine’s Voice in George Sand’s Malgrétout.
Creator: Marcoline, Anne
Abstract/Description: In “‘Ma voix se dégagea’: Music, Risk, and the Heroine’s Voice in George Sand’s Malgrétout,” I argue that Sand’s 1870 novel Malgrétout offers a view of the complexity of Sand’s thinking about sound, whether in a child’s holistic and mythical understanding of nature and music, in an artist-hero’s exhausting performances of genius, or in the erosion of the restraint and pragmatism in the heroine’s musical production. Returning through the novel, as a fulcrum on which the heroine, Sarah,...
Show moreIn “‘Ma voix se dégagea’: Music, Risk, and the Heroine’s Voice in George Sand’s Malgrétout,” I argue that Sand’s 1870 novel Malgrétout offers a view of the complexity of Sand’s thinking about sound, whether in a child’s holistic and mythical understanding of nature and music, in an artist-hero’s exhausting performances of genius, or in the erosion of the restraint and pragmatism in the heroine’s musical production. Returning through the novel, as a fulcrum on which the heroine, Sarah, balances her relationship with violin virtuoso, Abel, is the little children’s song Sarah invented, “La Demoiselle.” I propose that “La Demoiselle,” which begins as a musical exercise for a child, becomes for Sarah a means to measure Abel’s commitment to their relationship through his interpretation, arrangement, and dissemination of the little song. At stake in the returns and reiterations of Sarah’s song is a reconceptualization of the Romantic artist story through the heroine’s narrative of the discovery of the sound of her own voice and soul. Moreover, drawing from feminist care ethics, Sand studies, and sound studies, I propose that Sand’s narrative of vibrating instrumental chords, shivering bodies, and trembling voices, which explores the intersubjective and relational nature of sound, articulates a vision and ethics of people as fundamentally and vitally relational beings.
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Date Issued: 2019-12-31
Identifier: FSU_libsubv1_scholarship_submission_1578589483_cf4b13dd
Format: Citation

Title: “Nous aussi nous sommes citoyennes”: Female Activism during the French Revolution.
Creator: Pédron, Anaïs
Abstract/Description: Marie-Madeleine Jodin and Olympe de Gouges were among the women who believed that the new state created by the French Revolution would offer equality to men and women. Both of them published political pamphlets arguing in favor of their sex: Vues législatives pour les femmes by Jodin in 1790 and (among other writings) Déclaration des Droits de la Femme in 1791 by Gouges. Jodin’s pamphlet shows the extent of her culture: she quotes philosophers, uses examples from history, and offers some...
Show moreMarie-Madeleine Jodin and Olympe de Gouges were among the women who believed that the new state created by the French Revolution would offer equality to men and women. Both of them published political pamphlets arguing in favor of their sex: Vues législatives pour les femmes by Jodin in 1790 and (among other writings) Déclaration des Droits de la Femme in 1791 by Gouges. Jodin’s pamphlet shows the extent of her culture: she quotes philosophers, uses examples from history, and offers some remarkable perspectives (on prostitution for instance). Gouges’ pamphlet, the most famous of all, is a clever pastiche of the 1789 Déclaration des Droits de l’Homme, and contains her thoughts on marriage,divorce, and illegitimate children. While neither one of them seems to have been truly active in women’s manifestations and clubs or developed contacts with the Assembly or other proto-feminists, both women participated in the Revolution and its events mainly through these writings. This paper explores Jodin’s and Gouges’ paradoxical participation (loud in print but silent in speech) and compares them to other female writers of the Revolution: was their participation atypical or did it represent the norm?
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Date Issued: 2019-12-31
Identifier: FSU_libsubv1_scholarship_submission_1578504204_cf0a4a66
Format: Citation

Title: “One Must Actually Take Facts as They Are”: Information Value and Information Behavior in the Miss Marple Novels.
Creator: Kazmer, Michelle M.
Abstract/Description: One perspective not often brought to the study of detective fiction is that from the field of information science. Among other topics, information science is concerned with information behavior, or how people behave with respect to information: needing, seeking, accidentally encountering, avoiding, evaluating, storing and so forth. Examining the solving of a mystery as an information behavior has potential for insights into the genre and into our twenty-first century readings of detective...
Show moreOne perspective not often brought to the study of detective fiction is that from the field of information science. Among other topics, information science is concerned with information behavior, or how people behave with respect to information: needing, seeking, accidentally encountering, avoiding, evaluating, storing and so forth. Examining the solving of a mystery as an information behavior has potential for insights into the genre and into our twenty-first century readings of detective fiction. Current audiences are accustomed to modern information technology and the information behaviors afforded by it: amateur sleuths hack computer systems or professional detectives analyze trace evidence for DNA. Highly technologized contemporary information environments leave us to ask: in what ways do the manipulation of information value, and the sophistication of the information behaviors, in novels written by Agatha Christie in the early- to mid-twentieth century, continue to enthrall readers in the twenty-first?
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Date Issued: 2016
Identifier: FSU_libsubv1_scholarship_submission_1457717673
Format: Citation

Title: "Poverty Porn": The Narratives of INGO Media Campaigns.
Creator: Costner, Monique, Kohli, Tanu
Abstract/Description: International non-governmental organizations (INGOs) have different strategies of raising awareness and funds for their causes. Sometimes however, these strategies can rely on the use of stereotypical or dehumanizing depictions of people from the developing world. We have all seen the images of hungry children with bloated stomachs, presumably from some African or Asian country. To what extent do these narratives present a grossly simplified version of the struggles people in poverty face?...
Show moreInternational non-governmental organizations (INGOs) have different strategies of raising awareness and funds for their causes. Sometimes however, these strategies can rely on the use of stereotypical or dehumanizing depictions of people from the developing world. We have all seen the images of hungry children with bloated stomachs, presumably from some African or Asian country. To what extent do these narratives present a grossly simplified version of the struggles people in poverty face? The term “poverty porn” has been coined to describe these kinds of shock-based images which reduce people to their vulnerability and helplessness. Narratives within INGO media campaigns can either contribute to, or combat stereotypical images of developing regions. The first section of this research will discuss representations of people from developing regions. Second, the research will examine strategies employed in several digital-based INGO media campaigns through their use of visual and verbal tools. Third, the research will analyze the ethical nature of media campaigns which contribute to or combat stereotypes. It is important for international non-governmental organizations and those within the field of international development to consider how communication strategies impact the understanding we have of developing regions. This research aims to look critically at INGO communications and provide best practices for organizations constructing their own media campaigns.
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Date Issued: 2018-05-04
Identifier: FSU_libsubv1_scholarship_submission_1525459187_d84adacc
Format: Citation

Title: "Poverty Porn": The Narratives of INGO Media Campaigns.
Creator: Costner, Monique, Kohli, Tanu
Abstract/Description: International non-governmental organizations (INGOs) have different strategies of raising awareness and funds for their causes. Sometimes however, these strategies can rely on the use of stereotypical or dehumanizing depictions of people from the developing world. We have all seen the images of hungry children with bloated stomachs, presumably from some African or Asian country. To what extent do these narratives present a grossly simplified version of the struggles people in poverty face?...
Show moreInternational non-governmental organizations (INGOs) have different strategies of raising awareness and funds for their causes. Sometimes however, these strategies can rely on the use of stereotypical or dehumanizing depictions of people from the developing world. We have all seen the images of hungry children with bloated stomachs, presumably from some African or Asian country. To what extent do these narratives present a grossly simplified version of the struggles people in poverty face? The term “poverty porn” has been coined to describe these kinds of shock-based images which reduce people to their vulnerability and helplessness. Narratives within INGO media campaigns can either contribute to, or combat stereotypical images of developing regions. The first section of this research will discuss representations of people from developing regions. Second, the research will examine strategies employed in several digital-based INGO media campaigns through their use of visual and verbal tools. Third, the research will analyze the ethical nature of media campaigns which contribute to or combat stereotypes. It is important for international non-governmental organizations and those within the field of international development to consider how communication strategies impact the understanding we have of developing regions. This research aims to look critically at INGO communications and provide best practices for organizations constructing their own media campaigns.
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Date Issued: 2018-05-04
Identifier: FSU_libsubv1_scholarship_submission_1525459546_a796c8ef
Format: Citation

Title: The "State" of Behavioral and Demographic Analysis of Longevity Risk: A State-Aggregated Approach to Studying the Inter-Related Effects of Financial Education and Financial Literacy.
Creator: Levine, Apple, Sirmans, Eleanor, Born, Patricia
Date Issued: 2016-04-12
Identifier: FSU_libsubv1_scholarship_submission_1460472288
Format: Citation

Title: "To Benefit the World by Whatever Means Possible": Adolescents' Constructions of Global Citizenship.
Creator: Myers, John
Abstract/Description: This article reports on the ways that 77 students in an international studies programme constructed meanings for global citizenship. The focus was on their personal meanings for the topic and how they articulated a global identity with their national civic beliefs. Data was collected from online discussion boards, written essays and 20 interviews. A key finding was that the students' political language for global citizenship, examined here in terms of purpose, membership and relationship with...
Show moreThis article reports on the ways that 77 students in an international studies programme constructed meanings for global citizenship. The focus was on their personal meanings for the topic and how they articulated a global identity with their national civic beliefs. Data was collected from online discussion boards, written essays and 20 interviews. A key finding was that the students' political language for global citizenship, examined here in terms of purpose, membership and relationship with national citizenship, was predominantly a moral commitment framed in universal language. A second finding was that the students understood global citizenship as a heterogeneous and complex affiliation shaped by a range of sources. The implication is that citizenship education emphasizing a narrow notion of patriotism may encourage students to disengage from civic life because it does not represent their lived experiences and identities. Insights for making citizenship education practices more inclusive are discussed., In this study, information about national identity and global citizenship were collected from 77 students enrolled in an international studies program through discussion boards, essays, and interviews. Results regarding global citizenship showed that participants’ language was often framed in moral and universal terms, and that students saw global citizenship as complex and drew from diverse sources to understand what it meant. The article also discussed how citizenship education needs to be broader and more inclusive than the traditional focus on patriotism.
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Date Issued: 2009
Identifier: FSU_migr_ste_faculty_publications-0007, 10.1080/01411920902989219
Format: Citation

Title: "Waiting to Fail" Redux: Understanding Inadequate Response to Intervention..
Creator: Al Otaiba, Stephanie, Wagner, Richard K, Miller, Brett
Abstract/Description: This introduction to the special issue provides an overview of the promise, but also the ongoing challenges, related to Response to Intervention (RTI) as a means of both prevention and identification of reading disabilities. We conclude by describing the articles in this special issue and considering their implications for future research.
Date Issued: 2014-08-01
Identifier: FSU_pmch_25422530, 10.1177/0731948714525622, PMC4240019, 25422530, 25422530
Format: Citation

Title: #IfTheyGunnedMeDown: Social Media Activism in Ferguson, Missouri.
Creator: Entralgo-Fernandez, Rebekah, Jones, Emilie, Carney, Sean
Abstract/Description: The study focuses on the race issues and increased police militarization in Ferguson, Missouri related to the recent murder of Michael Brown. This particular part of the study focuses on the popular trend of the hashtag If They Gunned Me Down. Young activists on Twitter post pictures of themselves, both positive and negative, to highlight the media's opinion of people of color in the news. The tag is meant to show the obvious bias in media portrayal of black victims of police violence through...
Show moreThe study focuses on the race issues and increased police militarization in Ferguson, Missouri related to the recent murder of Michael Brown. This particular part of the study focuses on the popular trend of the hashtag If They Gunned Me Down. Young activists on Twitter post pictures of themselves, both positive and negative, to highlight the media's opinion of people of color in the news. The tag is meant to show the obvious bias in media portrayal of black victims of police violence through personal images. During the study we studied these images and then complied a sample of 20 images per category (categories being aspects of their personality being highlighted). The tweets show two pictures per post, one negative and one positive, which we group together to find the most common traits presented. From these qualities we are hoping to gain an idea of the way the black community views the medias opinion of their worth. In addition to this information we are also qualitatively coding tweets related to race, black culture and marketing to find celebrities involvement and influence in the issue of police brutality of the black community.
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Date Issued: 2015
Identifier: FSU_migr_undergradsymposium2015-0036
Format: Citation

Title: β-lactam synthesis.
Creator: Holton, Robert A., Vu, Phong H.
Abstract/Description: The present invention is directed to a process for the preparation of β-lactams. Generally, an imine is cyclocondensed with a ketene acetal or enolate to form the β-lactam product in a “one pot” synthesis, this process is generally performed at a higher temperature than conventional processes.
Date Issued: 2009-06-02
Identifier: FSU_uspto_7541458, 7541458, 711524, 11/449462, 6c9256d97d167832cbab694dc904bd27
Format: Citation

Title: 'determinism' Is Just Fine: A Reply To Scott Sehon.
Creator: De Marco, Gabriel
Abstract/Description: Scott Sehon recently argued that the standard notion of determinism employed in the Consequence Argument makes it so that, if our world turns out to be deterministic, then an interventionist God is logically impossible. He further argues that because of this, we should revise our notion of determinism. In this paper I show that Sehon's argument for the claim that the truth of determinism, in this sense, would make an interventionist God logically impossible ultimately fails. I then offer and...
Show moreScott Sehon recently argued that the standard notion of determinism employed in the Consequence Argument makes it so that, if our world turns out to be deterministic, then an interventionist God is logically impossible. He further argues that because of this, we should revise our notion of determinism. In this paper I show that Sehon's argument for the claim that the truth of determinism, in this sense, would make an interventionist God logically impossible ultimately fails. I then offer and respond to a weaker version of the argument for the claim that we should revise our notion of determinism.
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Date Issued: 2016-06
Identifier: FSU_libsubv1_wos_000384551600015, 10.1007/s11406-016-9712-0
Format: Citation

Title: The ‘True’ Juvenile Offender: Age Effects and Juvenile Court Sanctioning.
Creator: Mears, Daniel P., Cochran, Joshua C., Stults, Brian J., Greenman, Sarah J., Bhati, Avinash S., Greenwald, Mark A.
Abstract/Description: Age is the only factor used to demarcate the boundary between juvenile and adult justice. However, little research has examined how age guides the juvenile court in determining which youth within the juvenile justice system merit particular dispositions, especially those that reflect the court's emphasis on rehabilitation. Drawing on scholarship on the court's origins, attribution theory, and cognitive heuristics, we hypothesize that the court focuses on youth in the middle of the range of...
Show moreAge is the only factor used to demarcate the boundary between juvenile and adult justice. However, little research has examined how age guides the juvenile court in determining which youth within the juvenile justice system merit particular dispositions, especially those that reflect the court's emphasis on rehabilitation. Drawing on scholarship on the court's origins, attribution theory, and cognitive heuristics, we hypothesize that the court focuses on youth in the middle of the range of the court's age of jurisdiction—characterized in this article as “true” juveniles—who may be viewed as meriting more specialized intervention. We use data from Florida for court referrals in 2008 (N = 71,388) to examine the decision to proceed formally or informally and, in turn, to examine formally processed youth dispositions (dismissal, diversion, probation, commitment, and transfer) and informally processed youth dispositions (dismissal, diversion, and probation). The analyses provide partial support for the hypothesis. The very young were more likely to be informally processed; however, among the informally processed youth, the youngest, not “true” juveniles, were most likely to be diverted or placed on probation. By contrast, among formally processed youth, “true” juveniles were most likely to receive traditional juvenile court responses, such as diversion or probation.
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Date Issued: 2014-05-01
Identifier: FSU_libsubv1_scholarship_submission_1460380390, 10.1111/1745-9125.12034
Format: Citation

Title: (tco4-)-tc-99 Remediation By A Cationic Polymeric Network.
Creator: Li, Jie, Dai, Xing, Zhu, Lin, Xu, Chao, Zhang, Duo, Silver, Mark A., Li, Peng, Chen, Lanhua, Li, Yongzhong, Zuo, Douwen, Zhang, Hui, Xiao, Chengliang, Chen, Jing, Diwu, Juan,...
Show moreLi, Jie, Dai, Xing, Zhu, Lin, Xu, Chao, Zhang, Duo, Silver, Mark A., Li, Peng, Chen, Lanhua, Li, Yongzhong, Zuo, Douwen, Zhang, Hui, Xiao, Chengliang, Chen, Jing, Diwu, Juan, Farha, Omar K., Albrecht-Schmitt, Thomas E., Chai, Zhifang, Wang, Shuao
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Abstract/Description: Direct removal of (TcO4-)-Tc-99 from the highly acidic solution of used nuclear fuel is highly beneficial for the recovery of uranium and plutonium and more importantly aids in the elimination of Tc-99 discharge into the environment. However, this task represents a huge challenge given the combined extreme conditions of super acidity, high ionic strength, and strong radiation field. Here we overcome this challenge using a cationic polymeric network with significant TcO4- uptake capabilities...
Show moreDirect removal of (TcO4-)-Tc-99 from the highly acidic solution of used nuclear fuel is highly beneficial for the recovery of uranium and plutonium and more importantly aids in the elimination of Tc-99 discharge into the environment. However, this task represents a huge challenge given the combined extreme conditions of super acidity, high ionic strength, and strong radiation field. Here we overcome this challenge using a cationic polymeric network with significant TcO4- uptake capabilities in four aspects: the fastest sorption kinetics, the highest sorption capacity, the most promising uptake performance from highly acidic solutions, and excellent radiation-resistance and hydrolytic stability among all anion sorbent materials reported. In addition, this material is fully recyclable for multiple sorption/desorption trials, making it extremely attractive for waste partitioning and emergency remediation. The excellent TcO4- uptake capability is elucidated by X-ray absorption spectroscopy, solid-state NMR measurement, and density functional theory analysis on anion coordination and bonding.
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Date Issued: 2018-08-01
Identifier: FSU_libsubv1_wos_000440413500007, 10.1038/s41467-018-05380-5
Format: Citation

Title: .beta.-lactams as taxol intermediates N-acylated.
Creator: Holton, Robert A.
Abstract/Description: .beta.-lactam compounds which are reacted with a metal alkoxide for preparing N-acyl, N-sulfonyl and phosphoryl substituted isoserine esters.
Date Issued: 1996-07-23
Identifier: FSU_uspto_5539103, 5539103, 711524, 08/351532, 600b83161da1122888348587dc18798c
Format: Citation

Title: .beta.-lactams used in preparing taxol.
Creator: Holton, Robert A.
Abstract/Description: A .beta.-lactam of the formula: ##STR1## wherein R.sub.1 is aryl, substituted aryl, alkyl, alkenyl, or alkynyl; R.sub.2 is hydrogen, alkyl, acyl, acetal, ethoxyethyl, or other hydroxyl protecting group; and R.sub.3 is aryl, substituted aryl, alkyl, alkenyl, or alkynyl; and the enantiomers and diastereomers thereof.
Date Issued: 1996-11-12
Identifier: FSU_uspto_5574156, 5574156, 711524, 08/254561, 600b83161da1122888348587dc18798c
Format: Citation

Title: 1-deoxy baccatin III, 1-deoxy taxol and 1-deoxy taxol analogs and method for the preparation thereof.
Creator: Holton, Robert A., Somoza, Carmen, Liang, Feng, Tang, Suhan
Abstract/Description: 1-Deoxybaccatin III, 1-deoxytaxol and 1-deoxy taxol analogs and method for the preparation thereof.
Date Issued: 2003-04-08
Identifier: FSU_uspto_6545168, 6545168, 711524, 08/850942, 600b83161da1122888348587dc18798c
Format: Citation

Title: 1-deoxy taxol analogs.
Creator: Holton, Robert A., Somoza, Carmen, Liang, Feng, Tang, Suhan
Abstract/Description: 1-Deoxybaccatin III, 1-deoxytaxol and 1-deoxy taxol analogs and method for the preparation thereof.
Date Issued: 2006-03-28
Identifier: FSU_uspto_7019150, 7019150, 711524, 10/636017, 600b83161da1122888348587dc18798c
Format: Citation

Title: 1-s2.0-S2352827318300272-main.
Format: Citation

Title: 1.1-billion-year-old Porphyrins Establish A Marine Ecosystem Dominated By Bacterial Primary Producers.
Creator: Gueneli, N., McKenna, A. M., Ohkouchi, N., Boreham, C. J., Beghin, J., Javaux, E. J., Brocks, J. J.
Abstract/Description: The average cell size of marine phytoplankton is critical for the flow of energy and nutrients from the base of the food web to higher trophic levels. Thus, the evolutionary succession of primary producers through Earth's history is important for our understanding of the radiation of modern protists similar to 800 million years ago and the emergence of eumetazoan animals similar to 200 million years later. Currently, it is difficult to establish connections between primary production and the...
Show moreThe average cell size of marine phytoplankton is critical for the flow of energy and nutrients from the base of the food web to higher trophic levels. Thus, the evolutionary succession of primary producers through Earth's history is important for our understanding of the radiation of modern protists similar to 800 million years ago and the emergence of eumetazoan animals similar to 200 million years later. Currently, it is difficult to establish connections between primary production and the proliferation of large and complex organisms because the mid-Proterozoic (similar to 1,800-800 million years ago) rock record is nearly devoid of recognizable phytoplankton fossils. We report the discovery of intact porphyrins, the molecular fossils of chlorophylls, from 1,100-million-year-old marine black shales of the Taoudeni Basin (Mauritania), 600 million years older than previous findings. The porphyrin nitrogen isotopes (delta N-15(por) = 5.6-10.2 parts per thousand) are heavier than in younger sedimentary sequences, and the isotopic offset between sedimentary bulk nitrogen and porphyrins (epsilon(por) = -5.1 to -0.5 parts per thousand) points to cyanobacteria as dominant primary producers. Based on fossil carotenoids, anoxygenic green (Chlorobiacea) and purple sulfur bacteria (Chromatiaceae) also contributed to photosynthate. The low epsilon(por) values, in combination with a lack of diagnostic eukaryotic steranes in the time interval of 1,600-1,000 million years ago, demonstrate that algae played an insignificant role in mid-Proterozoic oceans. The paucity of algae and the small cell size of bacterial phytoplankton may have curtailed the flow of energy to higher trophic levels, potentially contributing to a diminished evolutionary pace toward complex eukaryotic ecosystems and large and active organisms.
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Date Issued: 2018-07-24
Identifier: FSU_libsubv1_wos_000439574700004, 10.1073/pnas.1803866115
Format: Citation

Title: 10-desacetoxytaxol derivatives.
Creator: Farina, Vittorio, Holton, Robert A., Chen, Shu-Hui
Abstract/Description: The present invention relates to 10-desacetoxytaxol and derivatives thereof, which are useful as antitumor agents. These compounds have the formula ##STR1## wherein R.sub.2 is hydrogen, hydroxy or a protected hydroxy group; R.sub.3 and R.sub.4 are independently hydrogen, hydroxy, a protected hydroxy group, methyl, --SH, --NH.sub.2, or --NR.sub.8 R.sub.9 ; R.sub.5 is R.sub.10, or --OR.sub.10 ; R.sub.6 and R.sub.7 are independently hydrogen, alkyl, or aryl; R.sub.8 and R.sub.9 are independently...
Show moreThe present invention relates to 10-desacetoxytaxol and derivatives thereof, which are useful as antitumor agents. These compounds have the formula ##STR1## wherein R.sub.2 is hydrogen, hydroxy or a protected hydroxy group; R.sub.3 and R.sub.4 are independently hydrogen, hydroxy, a protected hydroxy group, methyl, --SH, --NH.sub.2, or --NR.sub.8 R.sub.9 ; R.sub.5 is R.sub.10, or --OR.sub.10 ; R.sub.6 and R.sub.7 are independently hydrogen, alkyl, or aryl; R.sub.8 and R.sub.9 are independently hydrogen, alkyl, alkenyl, alkynyl, or aryl; and R.sub.10 is alkoxy, alkyl, alkenyl, alkynl, or aryl.
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Date Issued: 1994-09-27
Identifier: FSU_uspto_5350866, 5350866, 691280, 07/949449, 600b83161da1122888348587dc18798c
Format: Citation

Title: 14-3-3 and aggresome formation: implications in neurodegenerative diseases..
Creator: Jia, Baohui, Wu, Yuying, Zhou, Yi
Abstract/Description: Protein misfolding and aggregation underlie the pathogenesis of many neurodegenerative diseases. In addition to chaperone-mediated refolding and proteasomal degradation, the aggresome-macroautophagy pathway has emerged as another defense mechanism for sequestration and clearance of toxic protein aggregates in cells. Previously, the 14-3-3 proteins were shown to be indispensable for the formation of aggresomes induced by mutant huntingtin proteins. In a recent study, we have determined that 14...
Show moreProtein misfolding and aggregation underlie the pathogenesis of many neurodegenerative diseases. In addition to chaperone-mediated refolding and proteasomal degradation, the aggresome-macroautophagy pathway has emerged as another defense mechanism for sequestration and clearance of toxic protein aggregates in cells. Previously, the 14-3-3 proteins were shown to be indispensable for the formation of aggresomes induced by mutant huntingtin proteins. In a recent study, we have determined that 14-3-3 functions as a molecular adaptor to recruit chaperone-associated misfolded proteins to dynein motors for transport to aggresomes. This molecular complex involves a dimeric binding of 14-3-3 to both the dynein-intermediate chain (DIC) and an Hsp70 co-chaperone Bcl-2-associated athanogene 3 (BAG3). As 14-3-3 has been implicated in various neurodegenerative diseases, our findings may provide mechanistic insights into its role in managing misfolded protein stress during the process of neurodegeneration.
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Date Issued: 2014-03-01
Identifier: FSU_pmch_24549097, PMC4189886, 24549097, 24549097, 28123
Format: Citation

Title: 14-3-3 protein targets misfolded chaperone-associated proteins to aggresomes.
Creator: Xu, Zhe, Graham, Kourtney, Foote, Molly, Liang, Fengshan, Rizkallah, Raed, Hurt, Myra, Wang, Yanchang, Wu, Yuying, Zhou, Yi
Abstract/Description: The aggresome is a key cytoplasmic organelle for sequestration and clearance of toxic protein aggregates. Although loading misfolded proteins cargos to dynein motors has been recognized as an important step in the aggresome formation process, the molecular machinery that mediates the association of cargos with the dynein motor is poorly understood. Here, we report a new aggresome-targeting pathway that involves isoforms of 14-3-3, a family of conserved regulatory proteins. 14-3-3 interacts...
Show moreThe aggresome is a key cytoplasmic organelle for sequestration and clearance of toxic protein aggregates. Although loading misfolded proteins cargos to dynein motors has been recognized as an important step in the aggresome formation process, the molecular machinery that mediates the association of cargos with the dynein motor is poorly understood. Here, we report a new aggresome-targeting pathway that involves isoforms of 14-3-3, a family of conserved regulatory proteins. 14-3-3 interacts with both the dynein-intermediate chain (DIC) and an Hsp70 co-chaperone Bcl-2-associated athanogene 3 (BAG3), thereby recruiting chaperone-associated protein cargos to dynein motors for their transport to aggresomes. This molecular cascade entails functional dimerization of 14-3-3, which we show to be crucial for the formation of aggresomes in both yeast and mammalian cells. These results suggest that 14-3-3 functions as a molecular adaptor to promote aggresomal targeting of misfolded protein aggregates and may link such complexes to inclusion bodies observed in various neurodegenerative diseases.
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Date Issued: 2013-09-15
Identifier: FSU_pmch_23843611, 10.1242/jcs.126102, PMC3772389, 23843611, 23843611, jcs.126102
Format: Citation

Title: 14-3-3 proteins are required for hippocampal long-term potentiation and associative learning and memory.
Creator: Qiao, Haifa, Foote, Molly, Graham, Kourtney, Wu, Yuying, Zhou, Yi
Abstract/Description: 14-3-3 is a family of regulatory proteins highly expressed in the brain. Previous invertebrate studies have demonstrated the importance of 14-3-3 in the regulation of synaptic functions and learning and memory. However, the in vivo role of 14-3-3 in these processes has not been determined using mammalian animal models. Here, we report the behavioral and electrophysiological characterization of a new animal model of 14-3-3 proteins. These transgenic mice, considered to be a 14-3-3 functional...
Show more14-3-3 is a family of regulatory proteins highly expressed in the brain. Previous invertebrate studies have demonstrated the importance of 14-3-3 in the regulation of synaptic functions and learning and memory. However, the in vivo role of 14-3-3 in these processes has not been determined using mammalian animal models. Here, we report the behavioral and electrophysiological characterization of a new animal model of 14-3-3 proteins. These transgenic mice, considered to be a 14-3-3 functional knock-out, express a known 14-3-3 inhibitor in various brain regions of different founder lines. We identify a founder-specific impairment in hippocampal-dependent learning and memory tasks, as well as a correlated suppression in long-term synaptic plasticity of the hippocampal synapses. Moreover, hippocampal synaptic NMDA receptor levels are selectively reduced in the transgenic founder line that exhibits both behavioral and synaptic plasticity deficits. Collectively, our findings provide evidence that 14-3-3 is a positive regulator of associative learning and memory at both the behavioral and cellular level.
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Date Issued: 2014-04-02
Identifier: FSU_pmch_24695700, 10.1523/JNEUROSCI.4393-13.2014, PMC3972712, 24695700, 24695700, 34/14/4801
Format: Citation

Title: 14-3-3 Proteins in Glutamatergic Synapses.
Creator: Zhang, Jiajing, Zhou, Yi
Abstract/Description: The 14-3-3 proteins are a family of proteins that are highly expressed in the brain and particularly enriched at synapses. Evidence accumulated in the last two decades has implicated 14-3-3 proteins as an important regulator of synaptic transmission and plasticity. Here, we will review previous and more recent research that has helped us understand the roles of 14-3-3 proteins at glutamatergic synapses. A key challenge for the future is to delineate the 14-3-3-dependent molecular pathways...
Show moreThe 14-3-3 proteins are a family of proteins that are highly expressed in the brain and particularly enriched at synapses. Evidence accumulated in the last two decades has implicated 14-3-3 proteins as an important regulator of synaptic transmission and plasticity. Here, we will review previous and more recent research that has helped us understand the roles of 14-3-3 proteins at glutamatergic synapses. A key challenge for the future is to delineate the 14-3-3-dependent molecular pathways involved in regulating synaptic functions.
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Date Issued: 2018-04-23
Identifier: FSU_pmch_29849571, 10.1155/2018/8407609, PMC5937437, 29849571, 29849571
Format: Citation

Title: 14-3-3 proteins in neurological disorders.
Creator: Foote, Molly, Zhou, Yi
Abstract/Description: 14-3-3 proteins were originally discovered as a family of proteins that are highly expressed in the brain. Through interactions with a multitude of binding partners, 14-3-3 proteins impact many aspects of brain function including neural signaling, neuronal development and neuroprotection. Although much remains to be learned and understood, 14-3-3 proteins have been implicated in a variety of neurological disorders based on evidence from both clinical and laboratory studies. Here we will...
Show more14-3-3 proteins were originally discovered as a family of proteins that are highly expressed in the brain. Through interactions with a multitude of binding partners, 14-3-3 proteins impact many aspects of brain function including neural signaling, neuronal development and neuroprotection. Although much remains to be learned and understood, 14-3-3 proteins have been implicated in a variety of neurological disorders based on evidence from both clinical and laboratory studies. Here we will review previous and more recent research that has helped us understand the roles of 14-3-3 proteins in both neurodegenerative and neuropsychiatric diseases.
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Date Issued: 2012-01-01
Identifier: FSU_pmch_22773956, PMC3388734, 22773956, 22773956
Format: Citation

Title: 14-3-3τ promotes surface expression of Cav2.2 (α1B) Ca2+ channels.
Creator: Liu, Feng, Zhou, Qin, Zhou, Jie, Sun, Hao, Wang, Yan, Zou, Xiuqun, Feng, Lingling, Hou, Zhaoyuan, Zhou, Aiwu, Zhou, Yi, Li, Yong
Abstract/Description: Surface expression of voltage-gated Ca(2+) (Cav) channels is important for their function in calcium homeostasis in the physiology of excitable cells, but whether or not and how the α1 pore-forming subunits of Cav channels are trafficked to plasma membrane in the absence of the known Cav auxiliary subunits, β and α2δ, remains mysterious. Here we showed that 14-3-3 proteins promoted functional surface expression of the Cav2.2 α1B channel in transfected tsA-201 cells in the absence of any known...
Show moreSurface expression of voltage-gated Ca(2+) (Cav) channels is important for their function in calcium homeostasis in the physiology of excitable cells, but whether or not and how the α1 pore-forming subunits of Cav channels are trafficked to plasma membrane in the absence of the known Cav auxiliary subunits, β and α2δ, remains mysterious. Here we showed that 14-3-3 proteins promoted functional surface expression of the Cav2.2 α1B channel in transfected tsA-201 cells in the absence of any known Cav auxiliary subunit. Both the surface to total ratio of the expressed α1B protein and the current density of voltage step-evoked Ba(2+) current were markedly suppressed by the coexpression of a 14-3-3 antagonist construct, pSCM138, but not its inactive control, pSCM174, as determined by immunofluorescence assay and whole cell voltage clamp recording, respectively. By contrast, coexpression with 14-3-3τ significantly enhanced the surface expression and current density of the Cav2.2 α1B channel. Importantly, we found that between the two previously identified 14-3-3 binding regions at the α1B C terminus, only the proximal region (amino acids 1706-1940), closer to the end of the last transmembrane domain, was retained by the endoplasmic reticulum and facilitated by 14-3-3 to traffic to plasma membrane. Additionally, we showed that the 14-3-3/Cav β subunit coregulated the surface expression of Cav2.2 channels in transfected tsA-201 cells and neurons. Altogether, our findings reveal a previously unidentified regulatory function of 14-3-3 proteins in promoting the surface expression of Cav2.2 α1B channels.
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Date Issued: 2015-01-30
Identifier: FSU_pmch_25516596, 10.1074/jbc.M114.567800, PMC4317001, 25516596, 25516596, M114.567800
Format: Citation

Title: 14-hydrido-9β-hydroxytetracyclic taxanes.
Creator: Suzuki, Yukio, Holton, Robert A., Somoza, Carmen, Shindo, Mitsuru
Abstract/Description: Process for the preparation of a derivative or analog of baccatin III or 10-desacetyl baccatin III having a C9 substituent other than keto in which the C9 keto substituent of taxol, a taxol analog, baccatin III or 10-desacetyl baccatin III is selectively reduced to the corresponding hydroxy group.
Date Issued: 2005-04-12
Identifier: FSU_uspto_6878834, 6878834, 187776, 10/765692, 600b83161da1122888348587dc18798c
Format: Citation

Title: 19th Century Prisons in Practice.
Creator: Hertzler, Audrey, Criminology and Criminal Justice
Abstract/Description: There are many regulations for how a prison should work as a system according to the state, but the ones who actually have the most control over how the prison is run are the employees and officials who work in and manage the facility. These people have a stronger effect on how punishment is actually meted out. This project offers a longitudinal case study of Eastern State Penitentiary from 1829 to 1875. Through records kept by the prison administrators we can observe the decisions they made...
Show moreThere are many regulations for how a prison should work as a system according to the state, but the ones who actually have the most control over how the prison is run are the employees and officials who work in and manage the facility. These people have a stronger effect on how punishment is actually meted out. This project offers a longitudinal case study of Eastern State Penitentiary from 1829 to 1875. Through records kept by the prison administrators we can observe the decisions they made behind the scenes on a day-to-day basis and compare punishment in practice to the expectations of state regulations. We demonstrate that administrators and employees at Eastern State were willing to veer from the regulations and make their own decisions to benefit the public view of the prison. Specifically, the administrators' were guided by the need to protect the reputation of the prison, to make the prison appear to function well. Administrators sought to counter criticism over the prison's unique "separate system" of punishment in which prisoners were held in solitary confinement, a practice that attracted great criticism at the time. Our study demonstrates that many of the administrators' decisions were intended to maintain a positive image of Eastern State and to prevent criticism.
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Date Issued: 2015
Identifier: FSU_migr_undergradsymposium2015-0018
Format: Citation

Title: 1MHz scalable cascaded Z-source inverter using gallium nitride (GAN) device.
Creator: Li, Hui, Liu, Liming
Abstract/Description: The scalable cascaded Z-source inverter is able to interface flexibly different distributed renewable energy sources or storages in wide voltage change range, such as wind power, solar power, battery, fuel cell, Ultra-capacitor and so on. The invention facilitates the AC 1 MHz frequency output; therefore high power density can be reached. Z-source network is integrated in each inverter module to wide system operation range, improve high system efficiency, and enhance high system reliability....
Show moreThe scalable cascaded Z-source inverter is able to interface flexibly different distributed renewable energy sources or storages in wide voltage change range, such as wind power, solar power, battery, fuel cell, Ultra-capacitor and so on. The invention facilitates the AC 1 MHz frequency output; therefore high power density can be reached. Z-source network is integrated in each inverter module to wide system operation range, improve high system efficiency, and enhance high system reliability. The invention is applied for PV system to verify the performance.
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Date Issued: 2017-04-11
Identifier: FSU_uspto_9621073, 9621073, 1616461, 13/601364, 6c9256d97d167832cbab694dc904bd27
Format: Citation

Title: The 2.8 Angstrom Electron Microscopy Structure Of Adeno-associated Virus-dj Bound By A Heparinoid Pentasaccharide.
Creator: Xie, Qing, Spear, John M., Noble, Alex J., Sousa, Duncan R., Meyer, Nancy L., Davulcu, Omar, Zhang, Fuming, Linhardt, Robert J., Stagg, Scott M., Chapman, Michael S.
Abstract/Description: Atomic structures of adeno-associated virus (AAV)-DJ, alone and in complex with fondaparinux, have been determined by cryoelectron microscopy at 3 angstrom resolution. The gene therapy vector, AAV-DJ, is a hybrid of natural serotypes that was previously derived by directed evolution, selecting for hepatocyte entry and resistance to neutralization by human serum. The structure of AAV-DJ differs from that of parental serotypes in two regions where neutralizing antibodies bind, so immune escape...
Show moreAtomic structures of adeno-associated virus (AAV)-DJ, alone and in complex with fondaparinux, have been determined by cryoelectron microscopy at 3 angstrom resolution. The gene therapy vector, AAV-DJ, is a hybrid of natural serotypes that was previously derived by directed evolution, selecting for hepatocyte entry and resistance to neutralization by human serum. The structure of AAV-DJ differs from that of parental serotypes in two regions where neutralizing antibodies bind, so immune escape appears to have been the primary driver of AAV-DJ's directed evolution. Fondaparinux is an analog of cell surface heparan sulfate to which several AAVs bind during entry. Fondaparinux interacts with viral arginines at a known heparin binding site, without the large conformational changes whose presence was controversial in low-resolution imaging of AAV2-heparin complexes. The glycan density suggests multimodal binding that could accommodate sequence variation and multivalent binding along a glycan polymer, consistent with a role in attachment, prior to more specific interactions with a receptor protein mediating entry.
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Date Issued: 2017-06
Identifier: FSU_libsubv1_wos_000406299600001, 10.1016/j.omtm.2017.02.004
Format: Citation

Title: The 2.8 Å Electron Microscopy Structure of Adeno-Associated Virus-DJ Bound by a Heparinoid Pentasaccharide.
Creator: Xie, Qing, Spear, John M, Noble, Alex J, Sousa, Duncan R, Meyer, Nancy L, Davulcu, Omar, Zhang, Fuming, Linhardt, Robert J, Stagg, Scott M, Chapman, Michael S
Abstract/Description: Atomic structures of adeno-associated virus (AAV)-DJ, alone and in complex with fondaparinux, have been determined by cryoelectron microscopy at 3 Å resolution. The gene therapy vector, AAV-DJ, is a hybrid of natural serotypes that was previously derived by directed evolution, selecting for hepatocyte entry and resistance to neutralization by human serum. The structure of AAV-DJ differs from that of parental serotypes in two regions where neutralizing antibodies bind, so immune escape appears...
Show moreAtomic structures of adeno-associated virus (AAV)-DJ, alone and in complex with fondaparinux, have been determined by cryoelectron microscopy at 3 Å resolution. The gene therapy vector, AAV-DJ, is a hybrid of natural serotypes that was previously derived by directed evolution, selecting for hepatocyte entry and resistance to neutralization by human serum. The structure of AAV-DJ differs from that of parental serotypes in two regions where neutralizing antibodies bind, so immune escape appears to have been the primary driver of AAV-DJ's directed evolution. Fondaparinux is an analog of cell surface heparan sulfate to which several AAVs bind during entry. Fondaparinux interacts with viral arginines at a known heparin binding site, without the large conformational changes whose presence was controversial in low-resolution imaging of AAV2-heparin complexes. The glycan density suggests multi-modal binding that could accommodate sequence variation and multivalent binding along a glycan polymer, consistent with a role in attachment, prior to more specific interactions with a receptor protein mediating entry.
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Date Issued: 2017-03-08
Identifier: FSU_pmch_28480299, 10.1016/j.omtm.2017.02.004, PMC5415311, 28480299, 28480299, S2329-0501(17)30044-X
Format: Citation

Title: 20th Century Tall Tale Postcards.
Creator: Irwin, Sophia, Neal, Michael
Date Issued: 2016-04-06
Identifier: FSU_libsubv1_scholarship_submission_1459966710
Format: Citation

Title: 24/7 Access: Crafted in 2010 and Built to Last.
Creator: Rosasco, Robyn, Epstein, Susan A.
Abstract/Description: Objectives Our library has provided 24/7 access for student study space since 2010. This service has functioned as anticipated with minor policy breaches in 2010 and 2013. The purpose of this study was to determine how well 24/7 access to our library is working, obtain student feedback on security procedures, and solicit ideas from all stakeholders for future improvements. Methods Stakeholders for 24/7 access to our academic health sciences library include both the service providers (library,...
Show moreObjectives Our library has provided 24/7 access for student study space since 2010. This service has functioned as anticipated with minor policy breaches in 2010 and 2013. The purpose of this study was to determine how well 24/7 access to our library is working, obtain student feedback on security procedures, and solicit ideas from all stakeholders for future improvements. Methods Stakeholders for 24/7 access to our academic health sciences library include both the service providers (library, student affairs, and security/legal personnel) and the service users (first- and second-year medical students and biomedical graduate students). To evaluate the effectiveness of the library's 24/7 access service, the authors conducted a series of free-response interviews with several service provider and user stakeholders to solicit the most detailed feedback possible. The authors also administered a brief survey to determine if students were satisfied with unstaffed access to library study space. The results of stakeholder feedback were used to evaluate the value of our extensive planning for 24/7 access to the library, our thorough and consistent implementation, and our responsiveness to the needs of our students. Results: Our library director invited (via email) 14 student/staff stakeholders to be interviewed by the primary investigator (PI) and co-PI. Three students and three staff members agreed to be interviewed; five interviews were conducted face-to-face and one was conducted by phone. In addition, our library director sent an email invitation to complete a 10-question survey to approximately 500 students; 114 surveys were completed. From the interviews and the survey, shared themes as well as several unique feedback items emerged. In general, the overwhelming response was that the 24/7 service meets the needs of students, providing a secure, consistent study area for students who do not choose to study in another College of Medicine study space, in another campus library, at home, or at another location. Specifically, 90% of the students were not concerned about safety/security issues in the library during unstaffed hours, 82% indicated that the library environment was conducive to studying during unstaffed hours, and 83% felt that the library's orientation on 24/7 policies and procedures has met their needs. Conclusions: Collecting formal feedback on our 24/7 service has validated the time spent in planning, implementation, and responding to student needs, and has also elicited several ideas for improving the 24/7 service. We plan to continue interviewing and surveying 24/7 stakeholders on a yearly basis to solicit current feedback and continually improve the service.
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Date Issued: 2014
Identifier: FSU_migr_medlib_posters-0003
Format: Citation

Title: 3′-alkyl substituted taxanes and pharmaceutical compositions containing them.
Creator: Suzuki, Yukio, Holton, Robert A., Nadizadeh, Hossain, Chai, Ki-byung, Idmoumaz, Hamid
Abstract/Description: Taxane derivatives having an alkyl substituted C13 side chain.
Date Issued: 2003-02-18
Identifier: FSU_uspto_6521660, 6521660, 187776, 10/134762, 600b83161da1122888348587dc18798c
Format: Citation

Title: 3'-UTR and microRNA-24 regulate circadian rhythms by repressing PERIOD2 protein accumulation.
Creator: Yoo, Seung-Hee, Kojima, Shihoko, Shimomura, Kazuhiro, Koike, Nobuya, Buhr, Ethan D, Furukawa, Tadashi, Ko, Caroline H, Gloston, Gabrielle, Ayoub, Christopher, Nohara, Kazunari,...
Show moreYoo, Seung-Hee, Kojima, Shihoko, Shimomura, Kazuhiro, Koike, Nobuya, Buhr, Ethan D, Furukawa, Tadashi, Ko, Caroline H, Gloston, Gabrielle, Ayoub, Christopher, Nohara, Kazunari, Reyes, Bryan A, Tsuchiya, Yoshiki, Yoo, Ook-Joon, Yagita, Kazuhiro, Lee, Choogon, Chen, Zheng, Yamazaki, Shin, Green, Carla B, Takahashi, Joseph S
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Abstract/Description: We previously created two PER2::LUCIFERASE (PER2::LUC) circadian reporter knockin mice that differ only in the 3'-UTR region: , which retains the endogenous 3'-UTR and , where the endogenous 3'-UTR was replaced by an SV40 late poly(A) signal. To delineate the in vivo functions of 3'-UTR, we analyzed circadian rhythms of mice. Interestingly, mice displayed more than threefold stronger amplitude in bioluminescence rhythms than mice, and also exhibited lengthened free-running periods (∼24.0 h),...
Show moreWe previously created two PER2::LUCIFERASE (PER2::LUC) circadian reporter knockin mice that differ only in the 3'-UTR region: , which retains the endogenous 3'-UTR and , where the endogenous 3'-UTR was replaced by an SV40 late poly(A) signal. To delineate the in vivo functions of 3'-UTR, we analyzed circadian rhythms of mice. Interestingly, mice displayed more than threefold stronger amplitude in bioluminescence rhythms than mice, and also exhibited lengthened free-running periods (∼24.0 h), greater phase delays following light pulse, and enhanced temperature compensation relative to Analysis of the 3'-UTR sequence revealed that miR-24, and to a lesser degree miR-30, suppressed PER2 protein translation, and the reversal of this inhibition in augmented PER2::LUC protein level and oscillatory amplitude. Interestingly, mRNA and protein oscillatory amplitude as well as CRY1 protein oscillation were increased in mice, suggesting rhythmic overexpression of PER2 enhances expression of and other core clock genes. Together, these studies provide important mechanistic insights into the regulatory roles of 3'-UTR, miR-24, and PER2 in expression and core clock function.
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Date Issued: 2017-10-17
Identifier: FSU_pmch_28973913, 10.1073/pnas.1706611114, PMC5651750, 28973913, 28973913, 1706611114
Format: Citation

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