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Title: “Des voix refuseront de se taire”: Women’s Voices in Léonora Miano’s Contours du jours qui vient.
Creator: Messay, Marda
Abstract/Description: Inspired by the phenomenon of “child witches” in the Democratic Republic of Congo, Léonora Miano’s second novel, Contours du jour qui vient (2006), reveals the psychological and physical violence children accused of witchcraft experience and its detrimental consequences. This article examines the manner in which Musango, the protagonist of the novel, reconstitutes her fragmented sense of self and reestablishes relationships with others after surviving her mother’s violence and her banishment...
Show moreInspired by the phenomenon of “child witches” in the Democratic Republic of Congo, Léonora Miano’s second novel, Contours du jour qui vient (2006), reveals the psychological and physical violence children accused of witchcraft experience and its detrimental consequences. This article examines the manner in which Musango, the protagonist of the novel, reconstitutes her fragmented sense of self and reestablishes relationships with others after surviving her mother’s violence and her banishment from home. After analyzing the extent of the damages Musango sustained within her own home and community, especially her trauma-induced mutism, I examine how an already fragile Musango witnesses the silencing of women in a human trafficking camp and in a community revivalist church. I show how this silencing engenders a resistance within Musango and sparks a desire to use her voice. Lastly, I study how this resistance is further cemented and refined by the women she meets in the second half of the novel. These women guide Musango in her transformation from a mute traumatized self to a self-assured vocal individual. Furthermore, these women show her the ability of women’s voices to not only transmit knowledge and values but to also change the community for the better. Ultimately, I demonstrate how Musango is able to affirm her self-worth, reconstruct her fragmented sense of self, establish a connection with others and become a guiding voice through her interactions with the women she meets in her journey to recovery.
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Date Issued: 2019-12-31
Identifier: FSU_libsubv1_scholarship_submission_1578591465_04254cb6
Format: Citation

Title: "Do unto others"? Distinct psychopathy facets predict reduced perception and tolerance of pain.
Creator: Brislin, Sarah J, Buchman-Schmitt, Jennifer M, Joiner, Thomas E, Patrick, Christopher J
Abstract/Description: Recent research has sought to understand how individuals high in psychopathic traits perceive pain in others (Decety, Skelly, & Kiehl, 2013; Marsh et al., 2013). Perception of pain in others is presumed to act as a prosocial signal, and underreactivity to others' pain may contribute to engagement in exploitative-aggressive behaviors among individuals high in psychopathic traits (Jackson, Meltzoff, & Decety, 2005). The current study tested for associations between facets of psychopathy as...
Show moreRecent research has sought to understand how individuals high in psychopathic traits perceive pain in others (Decety, Skelly, & Kiehl, 2013; Marsh et al., 2013). Perception of pain in others is presumed to act as a prosocial signal, and underreactivity to others' pain may contribute to engagement in exploitative-aggressive behaviors among individuals high in psychopathic traits (Jackson, Meltzoff, & Decety, 2005). The current study tested for associations between facets of psychopathy as defined by the triarchic model (Patrick, Fowles, & Krueger, 2009) and decreased sensitivity to pain in 105 undergraduates tested in a laboratory pain assessment. A pressure algometer was used to index pain tolerance, and participants also rated their perceptions of and reactivity to the algometer-induced pain during the assessment and again 3 days later. A unique positive relationship was found between pain tolerance and the meanness facet of psychopathy, which also predicted reduced fear of painful algometer stimulation. Other psychopathy facets (boldness, disinhibition) showed negative relations with fear of pain stimulation during testing and at follow-up. Findings from this study extend the nomological network surrounding callousness (meanness) and suggest that increased pain tolerance may be a mechanism contributing to insensitivity to expressions of discomfort in others. (PsycINFO Database Record
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Date Issued: 2016-07-01
Identifier: FSU_pmch_26950545, 10.1037/per0000180, PMC4929019, 26950545, 26950545, 2016-11415-001
Format: Citation

Title: "I don't want to grow up, I'm a [Gen X, Y, Me] kid": Increasing maturity fears across the decades..
Creator: Smith, April R, Bodell, Lindsay P, Holm-Denoma, Jill, Joiner, Thomas E, Gordon, Kathryn H, Perez, Marisol, Keel, Pamela K
Abstract/Description: The current studies examined the hypothesis that maturity fears are increasing among undergraduate men and women from the United States over time. Study 1 used a time-lag method to assess generational effects of maturity fears among a large sample (n = 3,291) of undergraduate men and women assessed in 1982, 1992, 2002, and 2012. Results revealed that both men and women reported significantly higher rates of maturity fears across time. Study 2 replicated these findings, and used a more...
Show moreThe current studies examined the hypothesis that maturity fears are increasing among undergraduate men and women from the United States over time. Study 1 used a time-lag method to assess generational effects of maturity fears among a large sample (n = 3,291) of undergraduate men and women assessed in 1982, 1992, 2002, and 2012. Results revealed that both men and women reported significantly higher rates of maturity fears across time. Study 2 replicated these findings, and used a more restricted time frame to more closely examine the rate of change. Undergraduate women (n = 554) were assessed in 2001, 2003, 2009, and 2012. Maturity fears were again found to increase from 2001 to 2012. Recent cohorts of emerging adults seem more reluctant to mature than previous cohorts. Many contributing factors may be at play, including challenging economic times, social pressures to remain youthful, and/or internal fears of assuming increased responsibility.
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Date Issued: 2017-11-01
Identifier: FSU_pmch_29225386, 10.1177/0165025416654302, PMC5718623, 29225386, 29225386
Format: Citation

Title: “Le corps petit, mais l’âme grande”: Voicing a Woman’s Ambition in Louise de Keralio.
Creator: Mistacco, Vicki
Abstract/Description: Historian, translator, publisher, novelist, and journalist, polemicist and political activist during the French Revolution, Louise de Keralio (1756–1822) challenged prevailing gender roles by her ambitious incursion into areas considered the sole province of men. Yet, in apparent contradiction with her bold actions, authoritative voice and ambitious writing projects, she also reiterated gender stereotypes and made antifeminist remarks, much to the perplexity of recent critics such as Annie...
Show moreHistorian, translator, publisher, novelist, and journalist, polemicist and political activist during the French Revolution, Louise de Keralio (1756–1822) challenged prevailing gender roles by her ambitious incursion into areas considered the sole province of men. Yet, in apparent contradiction with her bold actions, authoritative voice and ambitious writing projects, she also reiterated gender stereotypes and made antifeminist remarks, much to the perplexity of recent critics such as Annie Geffroy (“Louise de Kéralio-Robert, pionnière du républicanisme sexiste”). I argue that this contrast between her “masculine” endeavors and authoritative voice, on the one hand, and her espousal of normative femininity, on the other, may best be understood by analyzing the discursive strategies she adopts to express her gender-nonconforming ambitions. From her earliest writings, a fundamental dilemma pits her female body, her “corps petit,” viewed in Rousseauian terms as consigned to modesty and domesticity, against her “âme grande” with its ambitious longing to do something for the benefit of society as a whole, to publish and enact her equally Rousseauian progressive ideas. They reveal that, for Keralio, writing is enabled by the repetition of restrictive gender norms, even as it is undercut by them. Her attempt to substitute for this binary thinking of gender in terms of either/or a utopian logic of both/and ultimately results in the silencing of her female-gendered, yet powerful, male-coded political voice during the evolution. Even so, her ideal of both/and endures.
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Date Issued: 2019-12-31
Identifier: FSU_libsubv1_scholarship_submission_1578588553_f8cde7a6
Format: Citation

Title: “Ma voix se dégagea”: Music, Risk, and the Heroine’s Voice in George Sand’s Malgrétout.
Creator: Marcoline, Anne
Abstract/Description: In “‘Ma voix se dégagea’: Music, Risk, and the Heroine’s Voice in George Sand’s Malgrétout,” I argue that Sand’s 1870 novel Malgrétout offers a view of the complexity of Sand’s thinking about sound, whether in a child’s holistic and mythical understanding of nature and music, in an artist-hero’s exhausting performances of genius, or in the erosion of the restraint and pragmatism in the heroine’s musical production. Returning through the novel, as a fulcrum on which the heroine, Sarah,...
Show moreIn “‘Ma voix se dégagea’: Music, Risk, and the Heroine’s Voice in George Sand’s Malgrétout,” I argue that Sand’s 1870 novel Malgrétout offers a view of the complexity of Sand’s thinking about sound, whether in a child’s holistic and mythical understanding of nature and music, in an artist-hero’s exhausting performances of genius, or in the erosion of the restraint and pragmatism in the heroine’s musical production. Returning through the novel, as a fulcrum on which the heroine, Sarah, balances her relationship with violin virtuoso, Abel, is the little children’s song Sarah invented, “La Demoiselle.” I propose that “La Demoiselle,” which begins as a musical exercise for a child, becomes for Sarah a means to measure Abel’s commitment to their relationship through his interpretation, arrangement, and dissemination of the little song. At stake in the returns and reiterations of Sarah’s song is a reconceptualization of the Romantic artist story through the heroine’s narrative of the discovery of the sound of her own voice and soul. Moreover, drawing from feminist care ethics, Sand studies, and sound studies, I propose that Sand’s narrative of vibrating instrumental chords, shivering bodies, and trembling voices, which explores the intersubjective and relational nature of sound, articulates a vision and ethics of people as fundamentally and vitally relational beings.
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Date Issued: 2019-12-31
Identifier: FSU_libsubv1_scholarship_submission_1578589483_cf4b13dd
Format: Citation

Title: “Nous aussi nous sommes citoyennes”: Female Activism during the French Revolution.
Creator: Pédron, Anaïs
Abstract/Description: Marie-Madeleine Jodin and Olympe de Gouges were among the women who believed that the new state created by the French Revolution would offer equality to men and women. Both of them published political pamphlets arguing in favor of their sex: Vues législatives pour les femmes by Jodin in 1790 and (among other writings) Déclaration des Droits de la Femme in 1791 by Gouges. Jodin’s pamphlet shows the extent of her culture: she quotes philosophers, uses examples from history, and offers some...
Show moreMarie-Madeleine Jodin and Olympe de Gouges were among the women who believed that the new state created by the French Revolution would offer equality to men and women. Both of them published political pamphlets arguing in favor of their sex: Vues législatives pour les femmes by Jodin in 1790 and (among other writings) Déclaration des Droits de la Femme in 1791 by Gouges. Jodin’s pamphlet shows the extent of her culture: she quotes philosophers, uses examples from history, and offers some remarkable perspectives (on prostitution for instance). Gouges’ pamphlet, the most famous of all, is a clever pastiche of the 1789 Déclaration des Droits de l’Homme, and contains her thoughts on marriage,divorce, and illegitimate children. While neither one of them seems to have been truly active in women’s manifestations and clubs or developed contacts with the Assembly or other proto-feminists, both women participated in the Revolution and its events mainly through these writings. This paper explores Jodin’s and Gouges’ paradoxical participation (loud in print but silent in speech) and compares them to other female writers of the Revolution: was their participation atypical or did it represent the norm?
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Date Issued: 2019-12-31
Identifier: FSU_libsubv1_scholarship_submission_1578504204_cf0a4a66
Format: Citation

Title: (tco4-)-tc-99 Remediation By A Cationic Polymeric Network.
Creator: Li, Jie, Dai, Xing, Zhu, Lin, Xu, Chao, Zhang, Duo, Silver, Mark A., Li, Peng, Chen, Lanhua, Li, Yongzhong, Zuo, Douwen, Zhang, Hui, Xiao, Chengliang, Chen, Jing, Diwu, Juan,...
Show moreLi, Jie, Dai, Xing, Zhu, Lin, Xu, Chao, Zhang, Duo, Silver, Mark A., Li, Peng, Chen, Lanhua, Li, Yongzhong, Zuo, Douwen, Zhang, Hui, Xiao, Chengliang, Chen, Jing, Diwu, Juan, Farha, Omar K., Albrecht-Schmitt, Thomas E., Chai, Zhifang, Wang, Shuao
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Abstract/Description: Direct removal of (TcO4-)-Tc-99 from the highly acidic solution of used nuclear fuel is highly beneficial for the recovery of uranium and plutonium and more importantly aids in the elimination of Tc-99 discharge into the environment. However, this task represents a huge challenge given the combined extreme conditions of super acidity, high ionic strength, and strong radiation field. Here we overcome this challenge using a cationic polymeric network with significant TcO4- uptake capabilities...
Show moreDirect removal of (TcO4-)-Tc-99 from the highly acidic solution of used nuclear fuel is highly beneficial for the recovery of uranium and plutonium and more importantly aids in the elimination of Tc-99 discharge into the environment. However, this task represents a huge challenge given the combined extreme conditions of super acidity, high ionic strength, and strong radiation field. Here we overcome this challenge using a cationic polymeric network with significant TcO4- uptake capabilities in four aspects: the fastest sorption kinetics, the highest sorption capacity, the most promising uptake performance from highly acidic solutions, and excellent radiation-resistance and hydrolytic stability among all anion sorbent materials reported. In addition, this material is fully recyclable for multiple sorption/desorption trials, making it extremely attractive for waste partitioning and emergency remediation. The excellent TcO4- uptake capability is elucidated by X-ray absorption spectroscopy, solid-state NMR measurement, and density functional theory analysis on anion coordination and bonding.
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Date Issued: 2018-08-01
Identifier: FSU_libsubv1_wos_000440413500007, 10.1038/s41467-018-05380-5
Format: Citation

Title: 1.1-billion-year-old Porphyrins Establish A Marine Ecosystem Dominated By Bacterial Primary Producers.
Creator: Gueneli, N., McKenna, A. M., Ohkouchi, N., Boreham, C. J., Beghin, J., Javaux, E. J., Brocks, J. J.
Abstract/Description: The average cell size of marine phytoplankton is critical for the flow of energy and nutrients from the base of the food web to higher trophic levels. Thus, the evolutionary succession of primary producers through Earth's history is important for our understanding of the radiation of modern protists similar to 800 million years ago and the emergence of eumetazoan animals similar to 200 million years later. Currently, it is difficult to establish connections between primary production and the...
Show moreThe average cell size of marine phytoplankton is critical for the flow of energy and nutrients from the base of the food web to higher trophic levels. Thus, the evolutionary succession of primary producers through Earth's history is important for our understanding of the radiation of modern protists similar to 800 million years ago and the emergence of eumetazoan animals similar to 200 million years later. Currently, it is difficult to establish connections between primary production and the proliferation of large and complex organisms because the mid-Proterozoic (similar to 1,800-800 million years ago) rock record is nearly devoid of recognizable phytoplankton fossils. We report the discovery of intact porphyrins, the molecular fossils of chlorophylls, from 1,100-million-year-old marine black shales of the Taoudeni Basin (Mauritania), 600 million years older than previous findings. The porphyrin nitrogen isotopes (delta N-15(por) = 5.6-10.2 parts per thousand) are heavier than in younger sedimentary sequences, and the isotopic offset between sedimentary bulk nitrogen and porphyrins (epsilon(por) = -5.1 to -0.5 parts per thousand) points to cyanobacteria as dominant primary producers. Based on fossil carotenoids, anoxygenic green (Chlorobiacea) and purple sulfur bacteria (Chromatiaceae) also contributed to photosynthate. The low epsilon(por) values, in combination with a lack of diagnostic eukaryotic steranes in the time interval of 1,600-1,000 million years ago, demonstrate that algae played an insignificant role in mid-Proterozoic oceans. The paucity of algae and the small cell size of bacterial phytoplankton may have curtailed the flow of energy to higher trophic levels, potentially contributing to a diminished evolutionary pace toward complex eukaryotic ecosystems and large and active organisms.
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Date Issued: 2018-07-24
Identifier: FSU_libsubv1_wos_000439574700004, 10.1073/pnas.1803866115
Format: Citation

Title: 14-3-3 and aggresome formation: implications in neurodegenerative diseases..
Creator: Jia, Baohui, Wu, Yuying, Zhou, Yi
Abstract/Description: Protein misfolding and aggregation underlie the pathogenesis of many neurodegenerative diseases. In addition to chaperone-mediated refolding and proteasomal degradation, the aggresome-macroautophagy pathway has emerged as another defense mechanism for sequestration and clearance of toxic protein aggregates in cells. Previously, the 14-3-3 proteins were shown to be indispensable for the formation of aggresomes induced by mutant huntingtin proteins. In a recent study, we have determined that 14...
Show moreProtein misfolding and aggregation underlie the pathogenesis of many neurodegenerative diseases. In addition to chaperone-mediated refolding and proteasomal degradation, the aggresome-macroautophagy pathway has emerged as another defense mechanism for sequestration and clearance of toxic protein aggregates in cells. Previously, the 14-3-3 proteins were shown to be indispensable for the formation of aggresomes induced by mutant huntingtin proteins. In a recent study, we have determined that 14-3-3 functions as a molecular adaptor to recruit chaperone-associated misfolded proteins to dynein motors for transport to aggresomes. This molecular complex involves a dimeric binding of 14-3-3 to both the dynein-intermediate chain (DIC) and an Hsp70 co-chaperone Bcl-2-associated athanogene 3 (BAG3). As 14-3-3 has been implicated in various neurodegenerative diseases, our findings may provide mechanistic insights into its role in managing misfolded protein stress during the process of neurodegeneration.
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Date Issued: 2014-03-01
Identifier: FSU_pmch_24549097, PMC4189886, 24549097, 24549097, 28123
Format: Citation

Title: 14-3-3 protein targets misfolded chaperone-associated proteins to aggresomes.
Creator: Xu, Zhe, Graham, Kourtney, Foote, Molly, Liang, Fengshan, Rizkallah, Raed, Hurt, Myra, Wang, Yanchang, Wu, Yuying, Zhou, Yi
Abstract/Description: The aggresome is a key cytoplasmic organelle for sequestration and clearance of toxic protein aggregates. Although loading misfolded proteins cargos to dynein motors has been recognized as an important step in the aggresome formation process, the molecular machinery that mediates the association of cargos with the dynein motor is poorly understood. Here, we report a new aggresome-targeting pathway that involves isoforms of 14-3-3, a family of conserved regulatory proteins. 14-3-3 interacts...
Show moreThe aggresome is a key cytoplasmic organelle for sequestration and clearance of toxic protein aggregates. Although loading misfolded proteins cargos to dynein motors has been recognized as an important step in the aggresome formation process, the molecular machinery that mediates the association of cargos with the dynein motor is poorly understood. Here, we report a new aggresome-targeting pathway that involves isoforms of 14-3-3, a family of conserved regulatory proteins. 14-3-3 interacts with both the dynein-intermediate chain (DIC) and an Hsp70 co-chaperone Bcl-2-associated athanogene 3 (BAG3), thereby recruiting chaperone-associated protein cargos to dynein motors for their transport to aggresomes. This molecular cascade entails functional dimerization of 14-3-3, which we show to be crucial for the formation of aggresomes in both yeast and mammalian cells. These results suggest that 14-3-3 functions as a molecular adaptor to promote aggresomal targeting of misfolded protein aggregates and may link such complexes to inclusion bodies observed in various neurodegenerative diseases.
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Date Issued: 2013-09-15
Identifier: FSU_pmch_23843611, 10.1242/jcs.126102, PMC3772389, 23843611, 23843611, jcs.126102
Format: Citation

Title: 14-3-3 proteins are required for hippocampal long-term potentiation and associative learning and memory.
Creator: Qiao, Haifa, Foote, Molly, Graham, Kourtney, Wu, Yuying, Zhou, Yi
Abstract/Description: 14-3-3 is a family of regulatory proteins highly expressed in the brain. Previous invertebrate studies have demonstrated the importance of 14-3-3 in the regulation of synaptic functions and learning and memory. However, the in vivo role of 14-3-3 in these processes has not been determined using mammalian animal models. Here, we report the behavioral and electrophysiological characterization of a new animal model of 14-3-3 proteins. These transgenic mice, considered to be a 14-3-3 functional...
Show more14-3-3 is a family of regulatory proteins highly expressed in the brain. Previous invertebrate studies have demonstrated the importance of 14-3-3 in the regulation of synaptic functions and learning and memory. However, the in vivo role of 14-3-3 in these processes has not been determined using mammalian animal models. Here, we report the behavioral and electrophysiological characterization of a new animal model of 14-3-3 proteins. These transgenic mice, considered to be a 14-3-3 functional knock-out, express a known 14-3-3 inhibitor in various brain regions of different founder lines. We identify a founder-specific impairment in hippocampal-dependent learning and memory tasks, as well as a correlated suppression in long-term synaptic plasticity of the hippocampal synapses. Moreover, hippocampal synaptic NMDA receptor levels are selectively reduced in the transgenic founder line that exhibits both behavioral and synaptic plasticity deficits. Collectively, our findings provide evidence that 14-3-3 is a positive regulator of associative learning and memory at both the behavioral and cellular level.
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Date Issued: 2014-04-02
Identifier: FSU_pmch_24695700, 10.1523/JNEUROSCI.4393-13.2014, PMC3972712, 24695700, 24695700, 34/14/4801
Format: Citation

Title: 14-3-3 Proteins in Glutamatergic Synapses.
Creator: Zhang, Jiajing, Zhou, Yi
Abstract/Description: The 14-3-3 proteins are a family of proteins that are highly expressed in the brain and particularly enriched at synapses. Evidence accumulated in the last two decades has implicated 14-3-3 proteins as an important regulator of synaptic transmission and plasticity. Here, we will review previous and more recent research that has helped us understand the roles of 14-3-3 proteins at glutamatergic synapses. A key challenge for the future is to delineate the 14-3-3-dependent molecular pathways...
Show moreThe 14-3-3 proteins are a family of proteins that are highly expressed in the brain and particularly enriched at synapses. Evidence accumulated in the last two decades has implicated 14-3-3 proteins as an important regulator of synaptic transmission and plasticity. Here, we will review previous and more recent research that has helped us understand the roles of 14-3-3 proteins at glutamatergic synapses. A key challenge for the future is to delineate the 14-3-3-dependent molecular pathways involved in regulating synaptic functions.
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Date Issued: 2018-04-23
Identifier: FSU_pmch_29849571, 10.1155/2018/8407609, PMC5937437, 29849571, 29849571
Format: Citation

Title: 14-3-3 proteins in neurological disorders.
Creator: Foote, Molly, Zhou, Yi
Abstract/Description: 14-3-3 proteins were originally discovered as a family of proteins that are highly expressed in the brain. Through interactions with a multitude of binding partners, 14-3-3 proteins impact many aspects of brain function including neural signaling, neuronal development and neuroprotection. Although much remains to be learned and understood, 14-3-3 proteins have been implicated in a variety of neurological disorders based on evidence from both clinical and laboratory studies. Here we will...
Show more14-3-3 proteins were originally discovered as a family of proteins that are highly expressed in the brain. Through interactions with a multitude of binding partners, 14-3-3 proteins impact many aspects of brain function including neural signaling, neuronal development and neuroprotection. Although much remains to be learned and understood, 14-3-3 proteins have been implicated in a variety of neurological disorders based on evidence from both clinical and laboratory studies. Here we will review previous and more recent research that has helped us understand the roles of 14-3-3 proteins in both neurodegenerative and neuropsychiatric diseases.
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Date Issued: 2012-01-01
Identifier: FSU_pmch_22773956, PMC3388734, 22773956, 22773956
Format: Citation

Title: 14-3-3τ promotes surface expression of Cav2.2 (α1B) Ca2+ channels.
Creator: Liu, Feng, Zhou, Qin, Zhou, Jie, Sun, Hao, Wang, Yan, Zou, Xiuqun, Feng, Lingling, Hou, Zhaoyuan, Zhou, Aiwu, Zhou, Yi, Li, Yong
Abstract/Description: Surface expression of voltage-gated Ca(2+) (Cav) channels is important for their function in calcium homeostasis in the physiology of excitable cells, but whether or not and how the α1 pore-forming subunits of Cav channels are trafficked to plasma membrane in the absence of the known Cav auxiliary subunits, β and α2δ, remains mysterious. Here we showed that 14-3-3 proteins promoted functional surface expression of the Cav2.2 α1B channel in transfected tsA-201 cells in the absence of any known...
Show moreSurface expression of voltage-gated Ca(2+) (Cav) channels is important for their function in calcium homeostasis in the physiology of excitable cells, but whether or not and how the α1 pore-forming subunits of Cav channels are trafficked to plasma membrane in the absence of the known Cav auxiliary subunits, β and α2δ, remains mysterious. Here we showed that 14-3-3 proteins promoted functional surface expression of the Cav2.2 α1B channel in transfected tsA-201 cells in the absence of any known Cav auxiliary subunit. Both the surface to total ratio of the expressed α1B protein and the current density of voltage step-evoked Ba(2+) current were markedly suppressed by the coexpression of a 14-3-3 antagonist construct, pSCM138, but not its inactive control, pSCM174, as determined by immunofluorescence assay and whole cell voltage clamp recording, respectively. By contrast, coexpression with 14-3-3τ significantly enhanced the surface expression and current density of the Cav2.2 α1B channel. Importantly, we found that between the two previously identified 14-3-3 binding regions at the α1B C terminus, only the proximal region (amino acids 1706-1940), closer to the end of the last transmembrane domain, was retained by the endoplasmic reticulum and facilitated by 14-3-3 to traffic to plasma membrane. Additionally, we showed that the 14-3-3/Cav β subunit coregulated the surface expression of Cav2.2 channels in transfected tsA-201 cells and neurons. Altogether, our findings reveal a previously unidentified regulatory function of 14-3-3 proteins in promoting the surface expression of Cav2.2 α1B channels.
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Date Issued: 2015-01-30
Identifier: FSU_pmch_25516596, 10.1074/jbc.M114.567800, PMC4317001, 25516596, 25516596, M114.567800
Format: Citation

Title: The 2.8 Angstrom Electron Microscopy Structure Of Adeno-associated Virus-dj Bound By A Heparinoid Pentasaccharide.
Creator: Xie, Qing, Spear, John M., Noble, Alex J., Sousa, Duncan R., Meyer, Nancy L., Davulcu, Omar, Zhang, Fuming, Linhardt, Robert J., Stagg, Scott M., Chapman, Michael S.
Abstract/Description: Atomic structures of adeno-associated virus (AAV)-DJ, alone and in complex with fondaparinux, have been determined by cryoelectron microscopy at 3 angstrom resolution. The gene therapy vector, AAV-DJ, is a hybrid of natural serotypes that was previously derived by directed evolution, selecting for hepatocyte entry and resistance to neutralization by human serum. The structure of AAV-DJ differs from that of parental serotypes in two regions where neutralizing antibodies bind, so immune escape...
Show moreAtomic structures of adeno-associated virus (AAV)-DJ, alone and in complex with fondaparinux, have been determined by cryoelectron microscopy at 3 angstrom resolution. The gene therapy vector, AAV-DJ, is a hybrid of natural serotypes that was previously derived by directed evolution, selecting for hepatocyte entry and resistance to neutralization by human serum. The structure of AAV-DJ differs from that of parental serotypes in two regions where neutralizing antibodies bind, so immune escape appears to have been the primary driver of AAV-DJ's directed evolution. Fondaparinux is an analog of cell surface heparan sulfate to which several AAVs bind during entry. Fondaparinux interacts with viral arginines at a known heparin binding site, without the large conformational changes whose presence was controversial in low-resolution imaging of AAV2-heparin complexes. The glycan density suggests multimodal binding that could accommodate sequence variation and multivalent binding along a glycan polymer, consistent with a role in attachment, prior to more specific interactions with a receptor protein mediating entry.
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Date Issued: 2017-06
Identifier: FSU_libsubv1_wos_000406299600001, 10.1016/j.omtm.2017.02.004
Format: Citation

Title: The 2.8 Å Electron Microscopy Structure of Adeno-Associated Virus-DJ Bound by a Heparinoid Pentasaccharide.
Creator: Xie, Qing, Spear, John M, Noble, Alex J, Sousa, Duncan R, Meyer, Nancy L, Davulcu, Omar, Zhang, Fuming, Linhardt, Robert J, Stagg, Scott M, Chapman, Michael S
Abstract/Description: Atomic structures of adeno-associated virus (AAV)-DJ, alone and in complex with fondaparinux, have been determined by cryoelectron microscopy at 3 Å resolution. The gene therapy vector, AAV-DJ, is a hybrid of natural serotypes that was previously derived by directed evolution, selecting for hepatocyte entry and resistance to neutralization by human serum. The structure of AAV-DJ differs from that of parental serotypes in two regions where neutralizing antibodies bind, so immune escape appears...
Show moreAtomic structures of adeno-associated virus (AAV)-DJ, alone and in complex with fondaparinux, have been determined by cryoelectron microscopy at 3 Å resolution. The gene therapy vector, AAV-DJ, is a hybrid of natural serotypes that was previously derived by directed evolution, selecting for hepatocyte entry and resistance to neutralization by human serum. The structure of AAV-DJ differs from that of parental serotypes in two regions where neutralizing antibodies bind, so immune escape appears to have been the primary driver of AAV-DJ's directed evolution. Fondaparinux is an analog of cell surface heparan sulfate to which several AAVs bind during entry. Fondaparinux interacts with viral arginines at a known heparin binding site, without the large conformational changes whose presence was controversial in low-resolution imaging of AAV2-heparin complexes. The glycan density suggests multi-modal binding that could accommodate sequence variation and multivalent binding along a glycan polymer, consistent with a role in attachment, prior to more specific interactions with a receptor protein mediating entry.
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Date Issued: 2017-03-08
Identifier: FSU_pmch_28480299, 10.1016/j.omtm.2017.02.004, PMC5415311, 28480299, 28480299, S2329-0501(17)30044-X
Format: Citation

Title: 3'-UTR and microRNA-24 regulate circadian rhythms by repressing PERIOD2 protein accumulation.
Creator: Yoo, Seung-Hee, Kojima, Shihoko, Shimomura, Kazuhiro, Koike, Nobuya, Buhr, Ethan D, Furukawa, Tadashi, Ko, Caroline H, Gloston, Gabrielle, Ayoub, Christopher, Nohara, Kazunari,...
Show moreYoo, Seung-Hee, Kojima, Shihoko, Shimomura, Kazuhiro, Koike, Nobuya, Buhr, Ethan D, Furukawa, Tadashi, Ko, Caroline H, Gloston, Gabrielle, Ayoub, Christopher, Nohara, Kazunari, Reyes, Bryan A, Tsuchiya, Yoshiki, Yoo, Ook-Joon, Yagita, Kazuhiro, Lee, Choogon, Chen, Zheng, Yamazaki, Shin, Green, Carla B, Takahashi, Joseph S
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Abstract/Description: We previously created two PER2::LUCIFERASE (PER2::LUC) circadian reporter knockin mice that differ only in the 3'-UTR region: , which retains the endogenous 3'-UTR and , where the endogenous 3'-UTR was replaced by an SV40 late poly(A) signal. To delineate the in vivo functions of 3'-UTR, we analyzed circadian rhythms of mice. Interestingly, mice displayed more than threefold stronger amplitude in bioluminescence rhythms than mice, and also exhibited lengthened free-running periods (∼24.0 h),...
Show moreWe previously created two PER2::LUCIFERASE (PER2::LUC) circadian reporter knockin mice that differ only in the 3'-UTR region: , which retains the endogenous 3'-UTR and , where the endogenous 3'-UTR was replaced by an SV40 late poly(A) signal. To delineate the in vivo functions of 3'-UTR, we analyzed circadian rhythms of mice. Interestingly, mice displayed more than threefold stronger amplitude in bioluminescence rhythms than mice, and also exhibited lengthened free-running periods (∼24.0 h), greater phase delays following light pulse, and enhanced temperature compensation relative to Analysis of the 3'-UTR sequence revealed that miR-24, and to a lesser degree miR-30, suppressed PER2 protein translation, and the reversal of this inhibition in augmented PER2::LUC protein level and oscillatory amplitude. Interestingly, mRNA and protein oscillatory amplitude as well as CRY1 protein oscillation were increased in mice, suggesting rhythmic overexpression of PER2 enhances expression of and other core clock genes. Together, these studies provide important mechanistic insights into the regulatory roles of 3'-UTR, miR-24, and PER2 in expression and core clock function.
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Date Issued: 2017-10-17
Identifier: FSU_pmch_28973913, 10.1073/pnas.1706611114, PMC5651750, 28973913, 28973913, 1706611114
Format: Citation

Title: 5 Numbers Women with Diabetes Should Know Before Pregnancy.
Creator: Bush, Suzanne Yancey, Ambler, Laura
Abstract/Description: Pregnancies with diabetes are increasing in the United States. Much has been written for the physician about the importance of medical care before a woman becomes pregnant to achieve the best results for both mom and baby. Physicians refer to the care before pregnancy as preconception counseling. Many countries as well as the US, have guidelines for the care of women with diabetes. These guidelines agree that preconception counseling should be routine for all women with both Type 1 and Type 2...
Show morePregnancies with diabetes are increasing in the United States. Much has been written for the physician about the importance of medical care before a woman becomes pregnant to achieve the best results for both mom and baby. Physicians refer to the care before pregnancy as preconception counseling. Many countries as well as the US, have guidelines for the care of women with diabetes. These guidelines agree that preconception counseling should be routine for all women with both Type 1 and Type 2 diabetes mellitus, but some studies have found that only 50% of women receive this vital care. We propose a simple way that a woman with diabetes can advocate for a healthy pregnancy by knowing 5 Numbers. These 5 Numbers can make a positive difference in the mothers health and that of her unborn baby. Although these 5 numbers are not all there is to being ready to become pregnant, knowing these 5 numbers can help start the conversation with her physicians and begin the journey to the very best she can be before a pregnancy.
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Date Issued: 2015
Identifier: FSU_libsubv1_scholarship_submission_1605811437_a0d7a2c3, 10.17125/plaid.2015.53
Format: Citation

Title: À contre-silence: Articulating a Taxonomy of Maternal Grief in Maïssa Bey’s Puisque mon coeur est mort (2010).
Creator: McIlvanney, Siobhán
Abstract/Description: The following article examines the role of sound and silence in the work of the Franco-Algerian author Maïssa Bey, Puisque mon coeur est mort (2010). The text takes the form of an epistolary novel written by a mother, Aïda, to her murdered son, Nadir. Despite the acutely personal histoire which acts as a catalyst for the act of writing, Bey’s protagonist endeavours to speak out for the maternally dispossessed in Algeria—and elsewhere—in order to give voice to a more public Histoire: the...
Show moreThe following article examines the role of sound and silence in the work of the Franco-Algerian author Maïssa Bey, Puisque mon coeur est mort (2010). The text takes the form of an epistolary novel written by a mother, Aïda, to her murdered son, Nadir. Despite the acutely personal histoire which acts as a catalyst for the act of writing, Bey’s protagonist endeavours to speak out for the maternally dispossessed in Algeria—and elsewhere—in order to give voice to a more public Histoire: the textual emphasis on the importance of audibly speaking to her son through her written letters encompasses a political objective of speaking out for all those who have lost a child in Algeria’s bloody décennie noire, leaving a compte rendu of a mother’s profound grief. That account is most vividly conveyed through the many sounds and noises which made up Aïda’s daily life with Nadir and to which she returns repeatedly throughout the work as a source of comfort and strength. She refuses to succumb to both sonic and writerly silence, but seeks to disturb the enforced silence imposed by the Algerian authorities following the execution of Nadir by ‘loudly’ bearing witness to private and political truths. This article argues that the much-quoted adage ‘Speech is silver, but silence is golden’ is both meaningless and politically noxious for those women for whom freedom of expression is denied.
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Date Issued: 2019-12-31
Identifier: FSU_libsubv1_scholarship_submission_1578591117_7b9ed528
Format: Citation

Title: Ab initio Folding of a Trefoil-fold Motif Reveals Structural similarity with a β-propeller Blade Motif.
Creator: Tenorio, Connie, Longo, Liam, Parker, Joseph, Lee, Jihun, Blaber, Michael
Abstract/Description: Many protein architectures exhibit evidence of internal rotational symmetry postulated to be the result of gene duplication/fusion events involving a primordial polypeptide motif. A common feature of such structures is a domain-swapped arrangement at the interface of the N- and C-termini motifs and postulated to provide cooperative interactions that promote folding and stability. De novo designed symmetric protein architectures have demonstrated an ability to accommodate circular permutation...
Show moreMany protein architectures exhibit evidence of internal rotational symmetry postulated to be the result of gene duplication/fusion events involving a primordial polypeptide motif. A common feature of such structures is a domain-swapped arrangement at the interface of the N- and C-termini motifs and postulated to provide cooperative interactions that promote folding and stability. De novo designed symmetric protein architectures have demonstrated an ability to accommodate circular permutation of the N- and C-termini in the overall architecture; however, the folding requirement of the primordial motif are poorly understood, and tolerance to circular permutation is essentially unknown. The β-trefoil protein fold is a threefold symmetric architecture where the repeating ~42-mer “trefoil-fold” motif assembles via a domain-swapped arrangement. The trefoil-fold structure in isolation exposes considerable hydrophobic area that is otherwise buried in the intact β-trefoil trimeric assembly. The trefoil-fold sequence is not predicted to adopt the trefoil-fold architecture in ab initio folding studies; rather, the predicted fold is closely related to a compact “blade” motif from the β-propeller architecture. Expression of a trefoil-fold sequence and circular permutants shows that only the wild-type N-terminal motif definition yields an intact β-trefoil trimeric assembly, while permutants yield monomers. The results elucidate the folding requirements of the primordial trefoil-fold motif, and also suggest that this motif may sample a compact conformation that limits hydrophobic residue exposure, contains key trefoil-fold structural features, but is more structurally homologous to a β-propeller blade motif.
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Date Issued: 2020-03-03
Identifier: FSU_libsubv1_scholarship_submission_1583283654_54e07068, 10.1002/pro.3850
Format: Citation

Title: Absence Of Dirac States In Baznbi2 Induced By Spin-orbit Coupling.
Creator: Ren, Weijun, Wang, Aifeng, Graf, D., Liu, Yu, Zhang, Zhidong, Yin, Wei-Guo, Petrovic, C.
Abstract/Description: We report magnetotransport properties of BaZnBi2 single crystals. Whereas electronic structure features Dirac states, such states are removed from the Fermi level by spin-orbit coupling (SOC) and consequently electronic transport is dominated by the small hole and electron pockets. Our results are consistent with not only three-dimensional, but also with quasi-two-dimensional portions of the Fermi surface. The SOC-induced gap in Dirac states is much larger when compared to isostructural...
Show moreWe report magnetotransport properties of BaZnBi2 single crystals. Whereas electronic structure features Dirac states, such states are removed from the Fermi level by spin-orbit coupling (SOC) and consequently electronic transport is dominated by the small hole and electron pockets. Our results are consistent with not only three-dimensional, but also with quasi-two-dimensional portions of the Fermi surface. The SOC-induced gap in Dirac states is much larger when compared to isostructural SrMnBi2. This suggests that not only long-range magnetic order, but also mass of the alkaline-earth atoms A in ABX(2) (A = alkaline-earth, B = transition-metal, and X = Bi/Sb) are important for the presence of low-energy states obeying the relativistic Dirac equation at the Fermi surface.
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Date Issued: 2018-01-22
Identifier: FSU_libsubv1_wos_000423341500001, 10.1103/PhysRevB.97.035147
Format: Citation

Title: The Absence Of Specific Yeast Heat-shock Proteins Leads To Abnormal Aggregation And Compromised Autophagic Clearance Of Mutant Huntingtin Proteins.
Creator: Higgins, Ryan, Kabbaj, Marie-Helene, Hatcher, Alexa, Wang, Yanchang
Abstract/Description: The functionality of a protein depends on its correct folding, but newly synthesized proteins are susceptible to aberrant folding and aggregation. Heat shock proteins (HSPs) function as molecular chaperones that aid in protein folding and the degradation of misfolded proteins. Trinucleotide (CAG) repeat expansion in the Huntingtin gene (HTT) results in the expression of misfolded Huntingtin protein (Htt), which contributes to the development of Huntington's disease. We previously found that...
Show moreThe functionality of a protein depends on its correct folding, but newly synthesized proteins are susceptible to aberrant folding and aggregation. Heat shock proteins (HSPs) function as molecular chaperones that aid in protein folding and the degradation of misfolded proteins. Trinucleotide (CAG) repeat expansion in the Huntingtin gene (HTT) results in the expression of misfolded Huntingtin protein (Htt), which contributes to the development of Huntington's disease. We previously found that the degradation of mutated Htt with polyQ expansion (Htt103QP) depends on both ubiquitin proteasome system and autophagy. However, the role of heat shock proteins in the clearance of mutated Htt remains poorly understood. Here, we report that cytosolic Hsp70 (Ssa family), its nucleotide exchange factors (Sse1 and Fes1), and a Hsp40 co-chaperone (Ydj1) are required for inclusion body formation of Htt103QP proteins and their clearance via autophagy. Extended induction of Htt103QPGFP leads to the formation of a single inclusion body in wild-type yeast cells, but mutant cells lacking these HSPs exhibit increased number of Htt103QP aggregates. Most notably, we detected more aggregated forms of Htt103QP in sse1 Delta. mutant cells using an agarose gel assay. Increased protein aggregates are also observed in these HSP mutants even in the absence Htt103QP overexpression. Importantly, these HSPs are required for autophagy- mediated Htt103QP clearance, but are less critical for proteasome-dependent degradation. These findings suggest a chaperone network that facilitates inclusion body formation of misfolded proteins and the subsequent autophagic clearance.
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Date Issued: 2018-01-18
Identifier: FSU_libsubv1_wos_000422749500056, 10.1371/journal.pone.0191490
Format: Citation

Title: The absence of specific yeast heat-shock proteins leads to abnormal aggregation and compromised autophagic clearance of mutant Huntingtin proteins.
Creator: Higgins, Ryan, Kabbaj, Marie-Helene, Hatcher, Alexa, Wang, Yanchang
Abstract/Description: The functionality of a protein depends on its correct folding, but newly synthesized proteins are susceptible to aberrant folding and aggregation. Heat shock proteins (HSPs) function as molecular chaperones that aid in protein folding and the degradation of misfolded proteins. Trinucleotide (CAG) repeat expansion in the Huntingtin gene (HTT) results in the expression of misfolded Huntingtin protein (Htt), which contributes to the development of Huntington's disease. We previously found that...
Show moreThe functionality of a protein depends on its correct folding, but newly synthesized proteins are susceptible to aberrant folding and aggregation. Heat shock proteins (HSPs) function as molecular chaperones that aid in protein folding and the degradation of misfolded proteins. Trinucleotide (CAG) repeat expansion in the Huntingtin gene (HTT) results in the expression of misfolded Huntingtin protein (Htt), which contributes to the development of Huntington's disease. We previously found that the degradation of mutated Htt with polyQ expansion (Htt103QP) depends on both ubiquitin proteasome system and autophagy. However, the role of heat shock proteins in the clearance of mutated Htt remains poorly understood. Here, we report that cytosolic Hsp70 (Ssa family), its nucleotide exchange factors (Sse1 and Fes1), and a Hsp40 co-chaperone (Ydj1) are required for inclusion body formation of Htt103QP proteins and their clearance via autophagy. Extended induction of Htt103QP-GFP leads to the formation of a single inclusion body in wild-type yeast cells, but mutant cells lacking these HSPs exhibit increased number of Htt103QP aggregates. Most notably, we detected more aggregated forms of Htt103QP in sse1Δ mutant cells using an agarose gel assay. Increased protein aggregates are also observed in these HSP mutants even in the absence Htt103QP overexpression. Importantly, these HSPs are required for autophagy-mediated Htt103QP clearance, but are less critical for proteasome-dependent degradation. These findings suggest a chaperone network that facilitates inclusion body formation of misfolded proteins and the subsequent autophagic clearance.
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Date Issued: 2018-01-18
Identifier: FSU_pmch_29346421, 10.1371/journal.pone.0191490, PMC5773196, 29346421, 29346421, PONE-D-17-24723
Format: Citation

Title: Academic Achievement Among Juvenile Detainees.
Creator: Grigorenko, Elena L, Macomber, Donna, Hart, Lesley, Naples, Adam, Chapman, John, Geib, Catherine F, Chart, Hilary, Tan, Mei, Wolhendler, Baruch, Wagner, Richard
Abstract/Description: The literature has long pointed to heightened frequencies of learning disabilities (LD) within the population of law offenders; however, a systematic appraisal of these observations, careful estimation of these frequencies, and investigation of their correlates and causes have been lacking. Here we present data collected from all youth (1,337 unique admissions, mean age 14.81, 20.3% females) placed in detention in Connecticut (January 1, 2010-July 1, 2011). All youth completed a computerized...
Show moreThe literature has long pointed to heightened frequencies of learning disabilities (LD) within the population of law offenders; however, a systematic appraisal of these observations, careful estimation of these frequencies, and investigation of their correlates and causes have been lacking. Here we present data collected from all youth (1,337 unique admissions, mean age 14.81, 20.3% females) placed in detention in Connecticut (January 1, 2010-July 1, 2011). All youth completed a computerized educational screener designed to test a range of performance in reading (word and text levels) and mathematics. A subsample (n = 410) received the Wide Range Achievement Test, in addition to the educational screener. Quantitative (scale-based) and qualitative (grade-equivalence-based) indicators were then analyzed for both assessments. Results established the range of LD in this sample from 13% to 40%, averaging 24.9%. This work provides a systematic exploration of the type and severity of word and text reading and mathematics skill deficiencies among juvenile detainees and builds the foundation for subsequent efforts that may link these deficiencies to both more formal, structured, and variable definitions and classifications of LD, and to other types of disabilities (e.g., intellectual disability) and developmental disorders (e.g., ADHD) that need to be conducted in future research.
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Date Issued: 2015-07-01
Identifier: FSU_pmch_24064502, 10.1177/0022219413500991, PMC5064284, 24064502, 24064502, 0022219413500991
Format: Citation

Title: Accommodation Request Strategies among Employees with Disabilities: Impacts and Associated Factors.
Creator: Dong, Shengli, Geyer, Paul, Hinton, Tameisha, Chin, Arizona
Abstract/Description: The purpose of this study is to examine the prevalence of different workplace accommodation request strategies, the effectiveness of different request approaches, and situational and individual factors associated with different request strategies for individuals with disabilities. Common action plans of accommodation requests may vary depending on decisions about mentioning the ADA (or not) and whether a formal (or informal) request is submitted, though past literature has focused primarily...
Show moreThe purpose of this study is to examine the prevalence of different workplace accommodation request strategies, the effectiveness of different request approaches, and situational and individual factors associated with different request strategies for individuals with disabilities. Common action plans of accommodation requests may vary depending on decisions about mentioning the ADA (or not) and whether a formal (or informal) request is submitted, though past literature has focused primarily on formal accommodation requests made under the auspices of the ADA. Participants (n=408) were recruited from rehabilitation agencies and organizations serving people with disabilities in the United States. The results indicated that informal requests without mentioning the ADA were found most often, followed by formal requests while not mentioning the ADA, formal requests while mentioning the ADA, and informal requests while mentioning the ADA. The odds of acquiring the requested accommodation were significantly higher, relative to other strategies, for requests made informally without mentioning the ADA. A variety of individual attributes capable of discerning when participants chose one strategy over another were observed; these included self-efficacy and outcome expectancy, negative affect, and an array of situational and personal attributes. Implications for research and practice were discussed.
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Date Issued: 2019-03-06
Identifier: FSU_libsubv1_scholarship_submission_1580330719_ecc5eb25, 10.1177/0034355219834630
Format: Citation

Title: Accountability, Efficiency, and Effectiveness in Corrections: Shining a Light on the Black Box of Prison Systems.
Creator: Mears, Daniel P.
Date Issued: 2008-02-19
Identifier: FSU_libsubv1_scholarship_submission_1548443439_cf2a5672, 10.1111/j.1745-9133.2008.00497.x
Format: Citation

Title: Acculturation and career development of international and domestic college students.
Creator: Hou, P-C. C., Osborn, Debra S., Sampson, James P.
Abstract/Description: The authors examined the relationships between career and cultural characteristics among 53 international and 54 domestic students at a large university in the southeastern United States. One-way multivariate analysis of variance results showed an overall significant difference between groups for mainstream acculturation, but not for vocational identity, dysfunctional career thoughts, goal instability, or heritage acculturation. Regression results indicated that 71% of the variance in...
Show moreThe authors examined the relationships between career and cultural characteristics among 53 international and 54 domestic students at a large university in the southeastern United States. One-way multivariate analysis of variance results showed an overall significant difference between groups for mainstream acculturation, but not for vocational identity, dysfunctional career thoughts, goal instability, or heritage acculturation. Regression results indicated that 71% of the variance in vocational identity of domestic college students was explained by dysfunctional career thoughts and acculturation, whereas dysfunctional career thoughts were the only significant predictor of vocational identity for international college students. Thus, a key implication from this study is for career practitioners to address and challenge the dysfunctional thinking of all students to improve their vocational identity. Future researchers should also explore how other potential moderator variables (e.g., age, gender, race/ethnicity, parental education) may influence vocational identity, as well as include more qualitative approaches to better understand an individual’s worldview, including career and cultural characteristics.
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Date Issued: 2018
Identifier: FSU_libsubv1_scholarship_submission_1545150345_1a5bdb0d, 10.1002/cdq.12155
Format: Citation

Title: Acculturation Factors Related to Obesity of Latino American Men Nationwide.
Creator: Ai, Amy L, Appel, Hoa B, Lee, Jungup
Abstract/Description: Obesity is a public health epidemic, particularly among underrepresented populations. With a large proportion of immigrants, Latino Americans comprise the largest minority population in the United States. This study examined the association of acculturation factors with obesity among Latino American men ( n = 1,127) using the National Latino and Asian American Study. The result identified two acculturation-related factors (being U.S.-born and living in the United States for the longest period...
Show moreObesity is a public health epidemic, particularly among underrepresented populations. With a large proportion of immigrants, Latino Americans comprise the largest minority population in the United States. This study examined the association of acculturation factors with obesity among Latino American men ( n = 1,127) using the National Latino and Asian American Study. The result identified two acculturation-related factors (being U.S.-born and living in the United States for the longest period/5-10 years) as positive correlates. In contrast, a different study on obesity in Latino American women demonstrated discrimination, but not the above factors, as significant correlates. The men's pattern suggests that the Hispanic/Latino paradox might have greater implications for men with respect to weight issues. Furthermore, Mexican American and Other Latino American men presented a greater likelihood of being obese than Cuban and Puerto Rican men. The findings, if replicated in prospective research, suggest the need for gender- and ethnic-specific intervention for obesity in Latino American men, particularly for the largest subgroup, Mexican Americans.
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Date Issued: 2018-09-01
Identifier: FSU_pmch_27283432, 10.1177/1557988316653182, PMC6142145, 27283432, 27283432, 1557988316653182
Format: Citation

Title: The Accuracy Of Neutrophil To Lymphocyte Ratio And Platelet To Lymphocyte Ratio As A Marker For Gastrointestinal Malignancies.
Creator: Nora, Ian, Shridhar, Ravi, Huston, Jamie, Meredith, Kenneth
Abstract/Description: Background: Accurate predictors of locally advanced and recurrence disease in patients with gastrointestinal cancer are currently lacking. Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) have emerged as possible markers for predicting recurrence in these patients. In this study, we sought to evaluate the utility of NLR and PLR in predicting the presence of regional nodal disease, metastasis and systemic recurrence in patients with gastrointestinal malignancies....
Show moreBackground: Accurate predictors of locally advanced and recurrence disease in patients with gastrointestinal cancer are currently lacking. Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) have emerged as possible markers for predicting recurrence in these patients. In this study, we sought to evaluate the utility of NLR and PLR in predicting the presence of regional nodal disease, metastasis and systemic recurrence in patients with gastrointestinal malignancies. Methods: We queried a comprehensive gastrointestinal oncology database to identify patients who had undergone surgery for a GI malignancy. NLR and PLR values were determined via a complete blood count (CBC). In patients treated with neoadjuvant therapy (NT) the NLR and PLR were calculated from CBCs before and after NT and in patients proceeding to surgery within 2 weeks pre-operatively. The associations between NLR and PLR and the clinicopathologic parameters (sex, age, tumor size, differentiation, positive lymph nodes, and metastatic disease) were assessed via chi(2) or Fisher's exact tests where appropriate. All the tests were two-sided, and P<0.05 was considered statistically significant. Results: We identified 116 patients diagnosed with gastrointestinal malignancies. There were 76 (65.5%) males and 40 (34.5%) females with an average age of 69.4 +/- 10.7 years. The mean follow up was 14.1 +/- 15.5 months. We identified 49 (42.2%) esophageal, 34 (29.3%) pancreatic, 14 (12.1%) colorectal, 13 (11.2%) gastric, and 6 (5.2%) biliary cancers. There were 36 (31.0%) patients with node negative disease, 52 (44.8%) with node positive and 28 (24.2%) with metastatic disease at surgery. Of the metastatic patients 4 (3.4%) were found at staging laparoscopy and 24 (20.6%) were diagnosed pre-operatively. The median NLR for LN-patient's was 1.78 (0.23-8.2) and for LN+ and metastatic patients was 4.69 (2.27-36), P<0.001. The median PLR for LN-patient's was 123.03 (14-257.69) and for LN+ and metastatic patients was 212.42 (105.45-2,185.18), P<0.001. The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) for a NLR >2.25 was 98.8%, 72.2%, 89%, and 96% respectively. The sensitivity, specificity, PPV, and NPV for PLR >140 was 95%, 78%, 90%, and 88% respectively. Utilizing both NLR and PLR the sensitivity, specificity, PPV and NPV was increased. Conclusions: Elevation of NLR and PLR can be used to help identify patients with advanced disease GI malignancies and recurrences after surgery. Additionally, failure of normalization of NLR and PLR 3-month post-surgical resection may indicate early recurrence or persistent disease. Individually, NLR has a higher sensitivity and negative predictive value while PLR has a higher specificity and positive predictive value for distinguishing metastatic disease and node positivity. The combination of NLR and PLR has the highest accuracy of predicting advanced disease among all gastrointestinal malignancies.
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Date Issued: 2018-10-01
Identifier: FSU_libsubv1_wos_000445720200026, 10.21037/jgo.2018.08.05
Format: Citation

Title: Accurate Identification of Unknown and Known Metabolic Mixture Components by Combining 3D NMR with Fourier Transform Ion Cyclotron Resonance Tandem Mass Spectrometry.
Creator: Wang, Cheng, He, Lidong, Li, Da-Wei, Bruschweiler-Li, Lei, Marshall, Alan G, Brüschweiler, Rafael
Abstract/Description: Metabolite identification in metabolomics samples is a key step that critically impacts downstream analysis. We recently introduced the SUMMIT NMR/mass spectrometry (MS) hybrid approach for the identification of the molecular structure of unknown metabolites based on the combination of NMR, MS, and combinatorial cheminformatics. Here, we demonstrate the feasibility of the approach for an untargeted analysis of both a model mixture and E. coli cell lysate based on 2D/3D NMR experiments in...
Show moreMetabolite identification in metabolomics samples is a key step that critically impacts downstream analysis. We recently introduced the SUMMIT NMR/mass spectrometry (MS) hybrid approach for the identification of the molecular structure of unknown metabolites based on the combination of NMR, MS, and combinatorial cheminformatics. Here, we demonstrate the feasibility of the approach for an untargeted analysis of both a model mixture and E. coli cell lysate based on 2D/3D NMR experiments in combination with Fourier transform ion cyclotron resonance MS and MS/MS data. For 19 of the 25 model metabolites, SUMMIT yielded complete structures that matched those in the mixture independent of database information. Of those, seven top-ranked structures matched those in the mixture, and four of those were further validated by positive ion MS/MS. For five metabolites, not part of the 19 metabolites, correct molecular structural motifs could be identified. For E. coli, SUMMIT MS/NMR identified 20 previously known metabolites with three or more H spins independent of database information. Moreover, for 15 unknown metabolites, molecular structural fragments were determined consistent with their spin systems and chemical shifts. By providing structural information for entire metabolites or molecular fragments, SUMMIT MS/NMR greatly assists the targeted or untargeted analysis of complex mixtures of unknown compounds.
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Date Issued: 2017-10-06
Identifier: FSU_pmch_28795575, 10.1021/acs.jproteome.7b00457, PMC5663437, 28795575, 28795575
Format: Citation

Title: Achalasia: A case report on its effect during surgical decision making for laparoscopic sleeve gastrectomy in the young morbidly obese patient..
Creator: Oviedo, Rodolfo J, Sofiak, Chase W, Dixon, Bruce M
Abstract/Description: Achalasia is a condition that occurs when the lower esophageal sphincter (LES) fails to properly relax, combined with slowing/failure of esophageal peristalsis. This is seen clinically by not allowing solids and liquids to pass easily into the stomach. Achalasia is not historically associated with morbid obesity, yet dual treatment of morbid obesity and achalasia is becoming more prominent due to the worldwide obesity epidemic. Achalasia is typically a disease that affects non-obese adults...
Show moreAchalasia is a condition that occurs when the lower esophageal sphincter (LES) fails to properly relax, combined with slowing/failure of esophageal peristalsis. This is seen clinically by not allowing solids and liquids to pass easily into the stomach. Achalasia is not historically associated with morbid obesity, yet dual treatment of morbid obesity and achalasia is becoming more prominent due to the worldwide obesity epidemic. Achalasia is typically a disease that affects non-obese adults over the age of 55, which makes the discussion of this case report unique in that our patient is a 23 year-old woman who successfully underwent per-oral endoscopic myotomy (POEM) in preparation for a future laparoscopic sleeve gastrectomy. There is sparse literature on combining laparoscopic Heller myotomy (LHM) and partial fundoplication versus POEM with either restrictive or malabsorptive minimally invasive bariatric procedures. LHM and partial fundoplication have long been considered the gold standard surgical treatment for achalasia by disrupting both the longitudinal and circular muscle layers of the LES. The newer, less invasive, POEM technique will be compared to the gold standard LHM and Dor fundoplication in this uncharacteristically young morbidly obese achalasia patient. The decision to pursue a laparoscopic sleeve gastrectomy over a laparoscopic Roux-en-Y gastric bypass was multifactorial due to the patient's concerns regarding malabsorption of vitamins and nutrients in the event of a future pregnancy. The patient has already undergone a POEM procedure, which was chosen to maintain the gastric fundus, cardia, and gastroesophageal junction (GEJ) architecture as opposed to a LHM with Dor fundoplication, which would have altered the anatomy, thus making a concomitant laparoscopic sleeve gastrectomy an unfeasible option.
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Date Issued: 2016-01-01
Identifier: FSU_pmch_27423062, 10.1016/j.ijscr.2016.06.046, PMC4949807, 27423062, 27423062, S2210-2612(16)30230-9
Format: Citation

Title: Acknowledging Challenges And Embracing Innovative Instructional Practices In Response To Cultural And Linguistic Diversity.
Creator: Wood, Carla, Wofford, Mary Claire, Hassinger, Abby
Abstract/Description: Aims of the current study were to explore teachers' background, beliefs, attitudes, and sense of self-efficacy, as well as instructional supports and innovative practices in response to cultural and linguistic diversity in classrooms serving Spanish-English speaking children of migrant workers. A total of 22 teachers participated in semi-structured interviews regarding linguistic diversity in the classroom. Their responses were transcribed and qualitative analysis procedures were utilized to...
Show moreAims of the current study were to explore teachers' background, beliefs, attitudes, and sense of self-efficacy, as well as instructional supports and innovative practices in response to cultural and linguistic diversity in classrooms serving Spanish-English speaking children of migrant workers. A total of 22 teachers participated in semi-structured interviews regarding linguistic diversity in the classroom. Their responses were transcribed and qualitative analysis procedures were utilized to deconstruct units. Individual units were then clustered by similarities and differences into themes and subcategories of themes. Teacher responses to the interview questions produced themes: awareness of cultural and linguistic diversity, issues and challenges, and innovative instructional supports and practices. Participating teachers commented on general supports designed to assist communication between English Learners (EL) and the teacher or peers, facilitate communication with parents of ELs, and embrace and promote responsiveness to cultural linguistic diversity (CLD) in the classroom. Teachers identified specific supports to intensify instruction, including (a) employing multiple modalities, (b) increasing experience and exposure, and (c) providing individualized support. Additional resources and support are warranted to identify and disseminate effective practices to provide intensified instruction and support to ELs.
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Date Issued: 2018-04-17
Identifier: FSU_libsubv1_wos_000430338800001, 10.1177/2158244018771110
Format: Citation

Title: Acoustic Measures of Voice and Physiologic Measures of Autonomic Arousal during Speech as a Function of Cognitive Load.
Creator: MacPherson, Megan K, Abur, Defne, Stepp, Cara E
Abstract/Description: This study aimed to determine the relationship among cognitive load condition and measures of autonomic arousal and voice production in healthy adults. A prospective study design was conducted. Sixteen healthy young adults (eight men, eight women) produced a sentence containing an embedded Stroop task in each of two cognitive load conditions: congruent and incongruent. In both conditions, participants said the font color of the color words instead of the word text. In the incongruent...
Show moreThis study aimed to determine the relationship among cognitive load condition and measures of autonomic arousal and voice production in healthy adults. A prospective study design was conducted. Sixteen healthy young adults (eight men, eight women) produced a sentence containing an embedded Stroop task in each of two cognitive load conditions: congruent and incongruent. In both conditions, participants said the font color of the color words instead of the word text. In the incongruent condition, font color differed from the word text, creating an increase in cognitive load relative to the congruent condition in which font color and word text matched. Three physiologic measures of autonomic arousal (pulse volume amplitude, pulse period, and skin conductance response amplitude) and four acoustic measures of voice (sound pressure level, fundamental frequency, cepstral peak prominence, and low-to-high spectral energy ratio) were analyzed for eight sentence productions in each cognitive load condition per participant. A logistic regression model was constructed to predict the cognitive load condition (congruent or incongruent) using subject as a categorical predictor and the three autonomic measures and four acoustic measures as continuous predictors. It revealed that skin conductance response amplitude, cepstral peak prominence, and low-to-high spectral energy ratio were significantly associated with cognitive load condition. During speech produced under increased cognitive load, healthy young adults show changes in physiologic markers of heightened autonomic arousal and acoustic measures of voice quality. Future work is necessary to examine these measures in older adults and individuals with voice disorders.
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Date Issued: 2017-07-01
Identifier: FSU_pmch_27939119, 10.1016/j.jvoice.2016.10.021, PMC6081741, 27939119, 27939119, S0892-1997(16)30302-2
Format: Citation

Title: Acquiring Science and Social Studies Knowledge in Kindergarten Through Fourth Grade: Conceptualization, Design, Implementation, and Efficacy Testing of Content-Area Literacy Instruction (CALI)..
Creator: Dombek, Jennifer, Crowe, Elizabeth C, Spencer, Mercedes, Tighe, Elizabeth L, Coffinger, Sean, Zargar, Elham, Wood, Taffeta, Petscher, Yaacov
Abstract/Description: With national focus on reading and math achievement, science and social studies have received less instructional time. Yet, accumulating evidence suggests that content knowledge is an important predictor of proficient reading. Starting with a design study, we developed Content Area Literacy Instruction (CALI), as an individualized (or personalized) instructional program for kindergarteners through fourth graders to build science and social studies knowledge. We developed CALI to be...
Show moreWith national focus on reading and math achievement, science and social studies have received less instructional time. Yet, accumulating evidence suggests that content knowledge is an important predictor of proficient reading. Starting with a design study, we developed Content Area Literacy Instruction (CALI), as an individualized (or personalized) instructional program for kindergarteners through fourth graders to build science and social studies knowledge. We developed CALI to be implemented in general education classrooms, over multiple iterations (n=230 students), using principles of design-based implementation research. The aims were to develop CALI as a usable and feasible instructional program that would, potentially, improve science and social studies knowledge, and could be implemented during the literacy block without negatively affecting students' reading gains (i.e., no opportunity cost). We then evaluated the efficacy of CALI in a randomized controlled field trial with 418 students in kindergarten through fourth grade. Results reveal that CALI demonstrates promise as a useable and feasible instructional individualized general education program, and is efficacious in improving social studies (=2.2) and science (=2.1) knowledge, with some evidence of improving oral and reading comprehension skills (=.125).
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Date Issued: 2017-04-01
Identifier: FSU_pmch_28479610, 10.1037/edu0000128, PMC5415842, 28479610, 28479610
Format: Citation

Title: Across the tree of life, radiation resistance is governed by antioxidant Mn, gauged by paramagnetic resonance.
Creator: Sharma, Ajay, Gaidamakova, Elena K, Grichenko, Olga, Matrosova, Vera Y, Hoeke, Veronika, Klimenkova, Polina, Conze, Isabel H, Volpe, Robert P, Tkavc, Rok, Gostinčar, Cene, Gunde...
Show moreSharma, Ajay, Gaidamakova, Elena K, Grichenko, Olga, Matrosova, Vera Y, Hoeke, Veronika, Klimenkova, Polina, Conze, Isabel H, Volpe, Robert P, Tkavc, Rok, Gostinčar, Cene, Gunde-Cimerman, Nina, DiRuggiero, Jocelyne, Shuryak, Igor, Ozarowski, Andrew, Hoffman, Brian M, Daly, Michael J
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Abstract/Description: Despite concerted functional genomic efforts to understand the complex phenotype of ionizing radiation (IR) resistance, a genome sequence cannot predict whether a cell is IR-resistant or not. Instead, we report that absorption-display electron paramagnetic resonance (EPR) spectroscopy of nonirradiated cells is highly diagnostic of IR survival and repair efficiency of DNA double-strand breaks (DSBs) caused by exposure to gamma radiation across archaea, bacteria, and eukaryotes, including fungi...
Show moreDespite concerted functional genomic efforts to understand the complex phenotype of ionizing radiation (IR) resistance, a genome sequence cannot predict whether a cell is IR-resistant or not. Instead, we report that absorption-display electron paramagnetic resonance (EPR) spectroscopy of nonirradiated cells is highly diagnostic of IR survival and repair efficiency of DNA double-strand breaks (DSBs) caused by exposure to gamma radiation across archaea, bacteria, and eukaryotes, including fungi and human cells. IR-resistant cells, which are efficient at DSB repair, contain a high cellular content of manganous ions (Mn) in high-symmetry (H) antioxidant complexes with small metabolites (e.g., orthophosphate, peptides), which exhibit narrow EPR signals (small zero-field splitting). In contrast, Mn ions in IR-sensitive cells, which are inefficient at DSB repair, exist largely as low-symmetry (L) complexes with substantially broadened spectra seen with enzymes and strongly chelating ligands. The fraction of cellular Mn present as H-complexes (H-Mn), as measured by EPR of live, nonirradiated Mn-replete cells, is now the strongest known gauge of biological IR resistance between and within organisms representing all three domains of life: Antioxidant H-Mn complexes, not antioxidant enzymes (e.g., Mn superoxide dismutase), govern IR survival. As the pool of intracellular metabolites needed to form H-Mn complexes depends on the nutritional status of the cell, we conclude that IR resistance is predominantly a metabolic phenomenon. In a cross-kingdom analysis, the vast differences in taxonomic classification, genome size, and radioresistance between cell types studied here support that IR resistance is not controlled by the repertoire of DNA repair and antioxidant enzymes.
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Date Issued: 2017-10-31
Identifier: FSU_pmch_29042516, 10.1073/pnas.1713608114, PMC5676931, 29042516, 29042516, 1713608114
Format: Citation

Title: An activity theoretic model for information quality change.
Creator: Stvilia, Besiki, Gasser, Les
Abstract/Description: To manage information quality (IQ) effectively, one needs to know how IQ changes over time, what causes it to change, and whether the changes can be predicted. In this paper we analyze the structure of IQ change in Wikipedia, an open, collaborative general encyclopedia. We found several patterns in Wikipedia’s IQ process trajectories and linked them to article types. Drawing on the results of our analysis, we develop a general model of IQ change that can be used for reasoning about IQ...
Show moreTo manage information quality (IQ) effectively, one needs to know how IQ changes over time, what causes it to change, and whether the changes can be predicted. In this paper we analyze the structure of IQ change in Wikipedia, an open, collaborative general encyclopedia. We found several patterns in Wikipedia’s IQ process trajectories and linked them to article types. Drawing on the results of our analysis, we develop a general model of IQ change that can be used for reasoning about IQ dynamics in many different settings, including traditional databases and information repositories.
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Date Issued: 2008-04-07
Identifier: FSU_libsubv1_scholarship_submission_1493896106_3601f514, 10.5210/fm.v13i4.2126
Format: Citation

Title: Acupoint Sensitization, Acupuncture Analgesia, Acupuncture on Visceral Functional Disorders, and Its Mechanism.
Creator: Yu, Xiaochun, Zhu, Bing, Lin, Zhixiu, Qiao, Haifa, Kong, Jian, Gao, Xinyan
Date Issued: 2015-01-01
Identifier: FSU_pmch_26300944, 10.1155/2015/171759, PMC4537726, 26300944, 26300944
Format: Citation

Title: Acute and timing effects of beta-hydroxy-beta-methylbutyrate (HMB) on indirect markers of skeletal muscle damage.
Creator: Wilson, Jacob M, Kim, Jeong-Su, Lee, Sang-Rok, Rathmacher, John A, Dalmau, Brett, Kingsley, J Derek, Koch, Heather, Manninen, Anssi H, Saadat, Raz, Panton, Lynn B
Abstract/Description: While chronic β-Hydroxy β-Methylbutyrate (HMB) supplementation (≥ 2 wk) lowers exercise induced muscle damage, its acute or timing effects have not been examined. The purpose of this study was to investigate the acute and timing effects of oral HMB supplementation on serum creatine kinase (CK), lactate dehydrogenase (LDH), muscle soreness, and maximal voluntary contraction (MVC). Sixteen non-resistance trained men (22 ± 2 yrs) were assigned to HMB-Pre or HMB-Post groups. In a crossover design...
Show moreWhile chronic β-Hydroxy β-Methylbutyrate (HMB) supplementation (≥ 2 wk) lowers exercise induced muscle damage, its acute or timing effects have not been examined. The purpose of this study was to investigate the acute and timing effects of oral HMB supplementation on serum creatine kinase (CK), lactate dehydrogenase (LDH), muscle soreness, and maximal voluntary contraction (MVC). Sixteen non-resistance trained men (22 ± 2 yrs) were assigned to HMB-Pre or HMB-Post groups. In a crossover design, all subjects performed 55 maximal eccentric knee extension/flexion contractions on 2 occasions on either the right or left leg. HMB-Pre (N = 8) randomly received 3 grams of either a placebo or HMB before and a placebo after exercise. HMB-Post (N = 8) received a placebo before and either 3 grams of HMB or a placebo after exercise. Muscle damage tests were recorded before, at 8, 24, 48, and 72 hrs post exercise. There was a reduction in MVC and an increase in soreness in the quadriceps and hamstrings following exercise (p < 0.001). Although HMB-Pre approached significance in attenuating soreness for the quadriceps (p = 0.07), there was no time x group effect. Serum indices of damage increased, peaking at 48 hrs for CK (773%) (p < 0.001) and 72 hrs for LDH (180%) (p < 0.001). While there were no time x group effects of HMB on CK and LDH, post hoc analysis revealed that only HMB-Pre showed no significant increase in LDH levels following exercise. Our findings suggest no clear acute or timing effects of HMB supplementation. However, consuming HMB before exercise appeared to prevent increases in LDH.
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Date Issued: 2009-02-04
Identifier: FSU_pmch_19193206, 10.1186/1743-7075-6-6, PMC2642830, 19193206, 19193206, 1743-7075-6-6
Format: Citation

Title: Acute BDNF treatment upregulates GluR1-SAP97 and GluR2-GRIP1 interactions: implications for sustained AMPA receptor expression..
Creator: Jourdi, Hussam, Kabbaj, Mohamed
Abstract/Description: Brain-derived neurotrophic factor (BDNF) plays several prominent roles in synaptic plasticity and in learning and memory formation. Reduced BDNF levels and altered BDNF signaling have been reported in several brain diseases and behavioral disorders, which also exhibit reduced levels of AMPAr subunits. BDNF treatment acutely regulates AMPA receptor expression and function, including synaptic AMPAr subunit trafficking, and implicates several well defined signaling molecules that are required to...
Show moreBrain-derived neurotrophic factor (BDNF) plays several prominent roles in synaptic plasticity and in learning and memory formation. Reduced BDNF levels and altered BDNF signaling have been reported in several brain diseases and behavioral disorders, which also exhibit reduced levels of AMPAr subunits. BDNF treatment acutely regulates AMPA receptor expression and function, including synaptic AMPAr subunit trafficking, and implicates several well defined signaling molecules that are required to elicit long term potentiation and depression (LTP and LTD, respectively). Long term encoding of synaptic events, as in long term memory formation, requires AMPAr stabilization and maintenance. However, factors regulating AMPAr stabilization in neuronal cell membranes and synaptic sites are not well characterized. In this study, we examine the effects of acute BDNF treatment on levels of AMPAr-associated scaffolding proteins and on AMPAr subunit-scaffolding protein interactions. We also examine the effects of BDNF-dependent enhanced interactions between AMPAr subunits with their specific scaffolding proteins on the accumulation of both types of proteins. Our results show that acute BDNF treatment upregulates the interactions between AMPAr subunits (GluR1 and GluR2) with their scaffold proteins SAP97 and GRIP1, respectively, leading to prolonged increased accumulation of both categories of proteins, albeit with distinct mechanisms for GluR1 and GluR2. Our findings reveal a new role for BDNF in the long term maintenance of AMPA receptor subunits and associated scaffolding proteins at synapses and further support the role of BDNF as a key regulator of synaptic consolidation. These results have potential implications for recent findings implicating BDNF and AMPAr subunits in various brain diseases and behavioral disorders.
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Date Issued: 2013-01-01
Identifier: FSU_pmch_23460828, 10.1371/journal.pone.0057124, PMC3584105, 23460828, 23460828, PONE-D-12-38051
Format: Citation

Title: Acute exercise with whole-body vibration decreases wave reflection and leg arterial stiffness.
Creator: Figueroa, Arturo, Vicil, Florence, Sanchez-Gonzalez, Marcos A
Abstract/Description: Whole-body vibration exercise (WBV) acutely decreases brachial-ankle pulse wave velocity (baPWV), an index of systemic arterial stiffness. However, the effect of WBV on segmental PWV and aortic hemodynamics is unknown. We examined the acute effects of WBV on arterial function. Fifteen young men performed ten 1-min sets of static squat with WBV (40 Hz, 1 mm, 5.37 G) and without WBV (no-WBV). Brachial and aortic blood pressure (BP), heart rate (HR), augmentation index (AIx), baPWV, carotid...
Show moreWhole-body vibration exercise (WBV) acutely decreases brachial-ankle pulse wave velocity (baPWV), an index of systemic arterial stiffness. However, the effect of WBV on segmental PWV and aortic hemodynamics is unknown. We examined the acute effects of WBV on arterial function. Fifteen young men performed ten 1-min sets of static squat with WBV (40 Hz, 1 mm, 5.37 G) and without WBV (no-WBV). Brachial and aortic blood pressure (BP), heart rate (HR), augmentation index (AIx), baPWV, carotid-femoral PWV (cfPWV), and femoral-ankle (faPWV), were recorded before and 5, 15, and 30 min after both trials. Brachial and aortic SBP (P < 0.01), and HR (P < 0.01) were increased only at 5 min after both exercise trials. AIx was elevated through the recovery after no-WBV while decreased at 15 and 30 min after WBV exercise. FaPWV was decreased (P < 0.01) at 5 min after both trials, but returned to baseline at 15 min after no-WBV exercise and was maintained decreased at 15 and 30 min after WBV exercise. There were no significant changes in brachial and aortic diastolic BP, cfPWV and baPWV after both trials. Our findings indicate that regardless of WBV, static squat causes a small transient increase in hemodynamic responses during early recovery. WBV counteracts the increase in AIx induced by static squat and reduces wave reflection magnitude through a local effect on arterial stiffness.
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Date Issued: 2011-01-01
Identifier: FSU_pmch_22254186, PMC3253511, 22254186, 22254186
Format: Citation

Title: Acute Sleep Deprivation Blocks Short- and Long-Term Operant Memory in .
Creator: Krishnan, Harini C, Gandour, Catherine E, Ramos, Joshua L, Wrinkle, Mariah C, Sanchez-Pacheco, Joseph J, Lyons, Lisa C
Abstract/Description: Insufficient sleep in individuals appears increasingly common due to the demands of modern work schedules and technology use. Consequently, there is a growing need to understand the interactions between sleep deprivation and memory. The current study determined the effects of acute sleep deprivation on short and long-term associative memory using the marine mollusk , a relatively simple model system well known for studies of learning and memory. were sleep deprived for 9 hours using context...
Show moreInsufficient sleep in individuals appears increasingly common due to the demands of modern work schedules and technology use. Consequently, there is a growing need to understand the interactions between sleep deprivation and memory. The current study determined the effects of acute sleep deprivation on short and long-term associative memory using the marine mollusk , a relatively simple model system well known for studies of learning and memory. were sleep deprived for 9 hours using context changes and tactile stimulation either prior to or after training for the operant learning paradigm, learning that food is inedible (LFI). The effects of sleep deprivation on short-term (STM) and long-term memory (LTM) were assessed. Acute sleep deprivation prior to LFI training impaired the induction of STM and LTM with persistent effects lasting at least 24 h. Sleep deprivation immediately after training blocked the consolidation of LTM. However, sleep deprivation following the period of molecular consolidation did not affect memory recall. Memory impairments were independent of handling-induced stress, as daytime handled control animals demonstrated no memory deficits. Additional training immediately after sleep deprivation failed to rescue the induction of memory, but additional training alleviated the persistent impairment in memory induction when training occurred 24 h following sleep deprivation. Acute sleep deprivation inhibited the induction and consolidation, but not the recall of memory. These behavioral studies establish as an effective model system for studying the interactions between sleep and memory formation.
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Date Issued: 2016-12-01
Identifier: FSU_pmch_27748243, 10.5665/sleep.6320, PMC5103805, 27748243, 27748243, sp-00313-16
Format: Citation

Title: ADAM19: A Novel Target for Metabolic Syndrome in Humans and Mice..
Creator: Weerasekera, Lakshini, Rudnicka, Caroline, Sang, Qing-Xiang, Curran, Joanne E, Johnson, Matthew P, Moses, Eric K, Göring, Harald H H, Blangero, John, Hricova, Jana, Schlaich,...
Show moreWeerasekera, Lakshini, Rudnicka, Caroline, Sang, Qing-Xiang, Curran, Joanne E, Johnson, Matthew P, Moses, Eric K, Göring, Harald H H, Blangero, John, Hricova, Jana, Schlaich, Markus, Matthews, Vance B
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Abstract/Description: Obesity is one of the most prevalent metabolic diseases in the Western world and correlates directly with insulin resistance, which may ultimately culminate in type 2 diabetes (T2D). We sought to ascertain whether the human metalloproteinase A Disintegrin and Metalloproteinase 19 (ADAM19) correlates with parameters of the metabolic syndrome in humans and mice. To determine the potential novel role of ADAM19 in the metabolic syndrome, we first conducted microarray studies on peripheral blood...
Show moreObesity is one of the most prevalent metabolic diseases in the Western world and correlates directly with insulin resistance, which may ultimately culminate in type 2 diabetes (T2D). We sought to ascertain whether the human metalloproteinase A Disintegrin and Metalloproteinase 19 (ADAM19) correlates with parameters of the metabolic syndrome in humans and mice. To determine the potential novel role of ADAM19 in the metabolic syndrome, we first conducted microarray studies on peripheral blood mononuclear cells from a well-characterised human cohort. Secondly, we examined the expression of ADAM19 in liver and gonadal white adipose tissue using an in vivo diet induced obesity mouse model. Finally, we investigated the effect of neutralising ADAM19 on diet induced weight gain, insulin resistance in vivo, and liver TNF- levels. Significantly, we show that, in humans, ADAM19 strongly correlates with parameters of the metabolic syndrome, particularly BMI, relative fat, HOMA-IR, and triglycerides. Furthermore, we identified that ADAM19 expression was markedly increased in the liver and gonadal white adipose tissue of obese and T2D mice. Excitingly, we demonstrate in our diet induced obesity mouse model that neutralising ADAM19 therapy results in weight loss, improves insulin sensitivity, and reduces liver TNF- levels. Our novel data suggest that ADAM19 is pro-obesogenic and enhances insulin resistance. Therefore, neutralisation of ADAM19 may be a potential therapeutic approach to treat obesity and T2D.
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Date Issued: 2017-01-01
Identifier: FSU_pmch_28265178, 10.1155/2017/7281986, PMC5318628, 28265178, 28265178
Format: Citation

Title: Adapting a Parenting Intervention for Parents Aging Out of the Child Welfare System: A Systematic Approach to Expand the Reach of an Evidence-Based Intervention.
Creator: Holtrop, Kendal, Canto, Angela I., Schelbe, Lisa, McWey, Lenore M., Radey, Melissa, Montgomery, Jordan E.
Abstract/Description: Parents aging out of the child welfare system face a constellation of unique risk factors that threaten the well-being of themselves and their children. Although parenting interventions are an important resource for providing much-needed services to parents aging out, there is currently a lack of evidence-based parenting interventions that address the unique needs of this population. The purpose of this project was to systematically adapt an evidence-based parenting intervention for parents...
Show moreParents aging out of the child welfare system face a constellation of unique risk factors that threaten the well-being of themselves and their children. Although parenting interventions are an important resource for providing much-needed services to parents aging out, there is currently a lack of evidence-based parenting interventions that address the unique needs of this population. The purpose of this project was to systematically adapt an evidence-based parenting intervention for parents aging out. An established adaptation framework was used to guide this process, and acceptability and feasibility outcomes were evaluated as part of a pilot study of the adapted intervention. Preliminary intervention adaptations included modifications to program delivery and program content. Study findings indicated a high level of parent satisfaction with the adapted intervention but challenges to feasibility because of inconsistent attendance and the substantial effort required for intervention delivery. This study constitutes a critical first step toward increasing the reach of evidence-based parenting interventions among parents aging out of the child welfare system and underscores the need for continued efforts to develop sustainable and effective parenting services for this at-risk population.
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Date Issued: 2018-01-18
Identifier: FSU_libsubv1_scholarship_submission_1505825967_759341a9, 10.1037/ort0000308
Format: Citation

Title: Adapting open-source drone autopilots for real-time iceberg observations.
Creator: Carlson, Daniel F, Rysgaard, Søren
Abstract/Description: Drone autopilots are naturally suited for real-time iceberg tracking as they measure position and orientation (pitch, roll, and heading) and they transmit these data to a ground station. We powered an ArduPilot Mega (APM) 2.6 with a 5V 11 Ah lithium ion battery (a smartphone power bank), placed the APM and battery in a waterproof sportsman's box, and tossed the box and its contents by hand onto an 80 m-long iceberg from an 8 m boat. The data stream could be viewed on a laptop, which greatly...
Show moreDrone autopilots are naturally suited for real-time iceberg tracking as they measure position and orientation (pitch, roll, and heading) and they transmit these data to a ground station. We powered an ArduPilot Mega (APM) 2.6 with a 5V 11 Ah lithium ion battery (a smartphone power bank), placed the APM and battery in a waterproof sportsman's box, and tossed the box and its contents by hand onto an 80 m-long iceberg from an 8 m boat. The data stream could be viewed on a laptop, which greatly enhanced safety while collecting conductivity/temperature/depth (CTD) profiles from the small boat in the iceberg's vicinity. The 10 s position data allowed us to compute the distance of each CTD profile to the iceberg, which is necessary to determine if a given CTD profile was collected within the iceberg's meltwater plume. The APM position data greatly reduced position uncertainty when compared to 5 min position data obtained from a Spot Trace unit. The APM functioned for over 10 h without depleting the battery. We describe the specific hardware used and the software settings necessary to use the APM as a real-time iceberg tracker. Furthermore, the methods described here apply to all Ardupilot-compatible autopilots. Given the low cost ($90) and ease of use, drone autopilots like the APM should be included as another tool for studying iceberg motion and for enhancing safety of marine operations. •Commercial off-the-shelf iceberg trackers are typically configured to record positions over relatively long intervals (months to years) and are not well-suited for short-term (hours to few days), high-frequency monitoring•Drone autopilots are cheap and provide high-frequency (>1 Hz) and real-time information about iceberg drift and orientation•Drone autopilots and ground control software can be easily adapted to studies of iceberg-ocean interactions and operational iceberg management.
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Date Issued: 2018-09-06
Identifier: FSU_pmch_30225206, 10.1016/j.mex.2018.09.003, PMC6139390, 30225206, 30225206, S2215-0161(18)30145-6
Format: Citation

Title: Adapting the Ideas of Translational Science for Translational Family Science.
Creator: Grzywacz, Joseph G, Allen, Jeffrey W
Abstract/Description: Family science has been doing translational science since before it came into vogue. Nevertheless, the field has been subjected to the same forces in the broader academy that have created a widening chasm between discovery and practice. Thus, the primary objective of this article is to translate the principles, concepts, and models of translational science to solidify an identity for family science and help the field move forward in broader academic, care delivery, and policy arenas....
Show moreFamily science has been doing translational science since before it came into vogue. Nevertheless, the field has been subjected to the same forces in the broader academy that have created a widening chasm between discovery and practice. Thus, the primary objective of this article is to translate the principles, concepts, and models of translational science to solidify an identity for family science and help the field move forward in broader academic, care delivery, and policy arenas. Alternative models of translational science, primarily from biomedicine but also from other disciplines, are reviewed and critically analyzed, and core concepts and principles are isolated, elaborated, and applied to family science. Family science's long-standing commitment to the doctrine of evidence-based practice, and its ongoing endorsement of the principles of scientific duality and multidisciplinary utility, places it in a preeminent position for using the zeitgeist of translational science to move forward. Nonetheless, the field has important epistemological, practical, professional, and curricular steps to complete to better position itself as a distinct and valued body of scientists. Ultimately, we argue that embracing the principles, concepts, and models of translational science should be leveraged by family science to help brand itself as a unique and essential social science field for enhancing the human condition.
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Date Issued: 2017-10-01
Identifier: FSU_pmch_29422702, 10.1111/fare.12284, PMC5798476, 29422702, 29422702
Format: Citation

Title: Addiction, cigarette smoking, and voluntary control of action: Do cigarette smokers lose their free will?.
Creator: Baumeister, Roy F
Abstract/Description: Opinions differ widely as to whether addicts lose the ability to control their behavior and employ free will. This article reviews empirical findings regarding multiple questions relevant to the issue of free will among addicted smokers: Is smoking voluntary behavior? Can people quit smoking? Why don't people quit smoking? Why do smokers relapse when they try to quit? Do addicted smokers suffer from irresistible cravings? Are there some people who cannot quit? Are there conditions that make...
Show moreOpinions differ widely as to whether addicts lose the ability to control their behavior and employ free will. This article reviews empirical findings regarding multiple questions relevant to the issue of free will among addicted smokers: Is smoking voluntary behavior? Can people quit smoking? Why don't people quit smoking? Why do smokers relapse when they try to quit? Do addicted smokers suffer from irresistible cravings? Are there some people who cannot quit? Are there conditions that make resistance impossible? Why would they smoke knowing it can kill them? The evidence reviewed here seems most consistent with the view that smokers retain control over their actions but cannot easily stop having frequent desires to smoke.
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Date Issued: 2017-01-24
Identifier: FSU_pmch_29450229, 10.1016/j.abrep.2017.01.003, PMC5800589, 29450229, 29450229, S2352-8532(17)30005-6
Format: Citation

Title: Adding Stable Carbon Isotopes Improves Model Representation Of The Role Of Microbial Communities In Peatland Methane Cycling.
Creator: Deng, Jia, McCalley, Carmody K., Frolking, Steve, Chanton, Jeff, Crill, Patrick, Varner, Ruth, Tyson, Gene, Rich, Virginia, Hines, Mark, Saleska, Scott R., Li, Changsheng
Abstract/Description: Climate change is expected to have significant and uncertain impacts on methane (CH4) emissions from northern peatlands. Biogeochemical models can extrapolate site-specificCH(4) measurements to larger scales and predict responses of CH4 emissions to environmental changes. However, these models include considerable uncertainties and limitations in representing CH4 production, consumption, and transport processes. To improve predictions of CH4 transformations, we incorporated acetate and stable...
Show moreClimate change is expected to have significant and uncertain impacts on methane (CH4) emissions from northern peatlands. Biogeochemical models can extrapolate site-specificCH(4) measurements to larger scales and predict responses of CH4 emissions to environmental changes. However, these models include considerable uncertainties and limitations in representing CH4 production, consumption, and transport processes. To improve predictions of CH4 transformations, we incorporated acetate and stable carbon (C) isotopic dynamics associated with CH4 cycling into a biogeochemistry model, DNDC. By including these new features, DNDC explicitly simulates acetate dynamics and the relative contribution of acetotrophic and hydro-genotrophic methanogenesis (AM and HM) to CH4 production, and predicts the C isotopic signature (delta C-13) in soil C pools and emitted gases. When tested against biogeochemical and microbial community observations at two sites in a zone of thawing permafrost in a subarctic peatland in Sweden, the new formulation substantially improved agreement with CH4 production pathways and delta C-13 in emitted CH4 (delta C-13-CH4), a measure of the integrated effects of microbial production and consumption, and of physical transport. We also investigated the sensitivity of simulated delta C-13-CH4 to C isotopic composition of substrates and, to fractionation factors for CH4 production (alpha(AM) and alpha(HM)), CH4 oxidation (alpha(MO)), and plant-mediated CH4 transport (alpha(TP)). The sensitivity analysis indicated that the delta C-13-CH4 is highly sensitive to the factors associated with microbial metabolism (alpha(AM), alpha(HM), and alpha(MO)). The model framework simulating stable C isotopic dynamics provides a robust basis for better constraining and testing microbial mechanisms in predicting CH4 cycling in peatlands.
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Date Issued: 2017-06
Identifier: FSU_libsubv1_wos_000406239300036, 10.1002/2016MS000817
Format: Citation

Title: Adhd, Depression, And Motor Vehicle Crashes: A Prospective Cohort Study Of Continuously-monitored, Real-world Driving.
Creator: Aduen, Paula A., Kofler, Michael J., Sarver, Dustin E., Wells, Erica L., Soto, Elia F., Cox, Daniel J.
Abstract/Description: ADHD is associated with automobile crashes, traffic fatalities, and serious road trauma, but it is unclear whether this risk is (a) driven by ADHD symptoms specifically, and (b) unique to ADHD or transdiagnostic across psychiatric disabilities, such as depression, that also have concentration problems as core symptoms. The current study provides the first prospective, continuously-monitored evaluation of crash risk related to ADHD symptoms, including the first on-road comparison of ADHD with...
Show moreADHD is associated with automobile crashes, traffic fatalities, and serious road trauma, but it is unclear whether this risk is (a) driven by ADHD symptoms specifically, and (b) unique to ADHD or transdiagnostic across psychiatric disabilities, such as depression, that also have concentration problems as core symptoms. The current study provides the first prospective, continuously-monitored evaluation of crash risk related to ADHD symptoms, including the first on-road comparison of ADHD with another high-prevalence psychiatric disability (depression). A probability-based sample of 3226 drivers from six U.S. sites, including subsamples with self-reported ADHD (n = 274) and depression (n = 251), consented to have their vehicles outfitted with sophisticated data acquisition technologies to continuously monitor real-world, day-to-day driving from 'engine-on to engine-of for 1-2 years (Mean = 440 consecutive days/driver, Mean = 9528 miles/driver). Crashes and near-crashes were objectively identified via software-based algorithms and double-coded manual validation (blinded to clinical status). Miles driven, days monitored, age, gender, education, and marital status were controlled. ADHD symptoms portended 5% increased crash risk per increase in symptom severity score (IRR = 1.05). This risk corresponded to approximately 1 biennial crash and 1 annual near-crash per driver with ADHD; crash risk doubled for drivers reporting ADHD symptom severity near the sample's maximum. Analyses based on self-reported clinical status indicated similarly elevated rates for ADHD (IRR = 1.46) and depression (IRR = 1.34) that may be related, in part, to both groups' inattention/concentration symptoms. Risk was not attenuated by ADHD usual treatment, but varied according to antidepressant medication status. Previous studies have significantly underestimated the risk for traffic crashes conveyed by ADHD and depression.
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Date Issued: 2018-06-01
Identifier: FSU_libsubv1_wos_000430521400007, 10.1016/j.jpsychires.2018.02.026
Format: Citation

Title: Adiabatic Sweep Cross-polarization Magic-angle-spinning Nmr Of Half-integer Quadrupolar Spins.
Creator: Wi, Sungsool, Kim, Chul, Schurko, Robert, Frydman, Lucio
Abstract/Description: The use of frequency-swept radiofrequency (rf) pulses for enhancing signals in the magic-angle spinning (MAS) spectra of half-integer quadrupolar nuclides was explored. The broadband adiabatic inversion cross-polarization magic-angle spinning (BRAIN-CPMAS) method, involving an adiabatic inversion pulse on the S-channel and a simultaneous rectangular spin-lock pulse on the I-channel (H-1), was applied to I (1/2) -> S(3/2) systems. Optimal BRAIN-CPMAS matching conditions were found to involve...
Show moreThe use of frequency-swept radiofrequency (rf) pulses for enhancing signals in the magic-angle spinning (MAS) spectra of half-integer quadrupolar nuclides was explored. The broadband adiabatic inversion cross-polarization magic-angle spinning (BRAIN-CPMAS) method, involving an adiabatic inversion pulse on the S-channel and a simultaneous rectangular spin-lock pulse on the I-channel (H-1), was applied to I (1/2) -> S(3/2) systems. Optimal BRAIN-CPMAS matching conditions were found to involve low rf pulse strengths for both the I- and S-spin channels. At these low and easily attainable rf field strengths, level-crossing events among the energy levels |3/2 >, |1/2 >, | -1/2 >, | - 3/2 > that are known to complicate the CPMAS of quadrupolar nuclei, are mostly avoided. Zero- and double-quantum polarization transfer modes, akin to those we have observed for 1(1/2) -> S(1/2) polarization transfers, were evidenced by these analyses even in the presence of the quadrupolar interaction. H-1-Na-23 and H-1-B-11 BRAIN-CPMAS conditions were experimentally explored on model compounds by optimizing the width of the adiabatic sweep, as well as the rf pulse powers of the H-1 and Na-23/B-11 channels, for different MAS rates. The experimental data obtained on model compounds containing spin-3/2 nuclides, matched well predictions from numerical simulations and from an average Hamiltonian theory model. Extensions to half-integer spin nuclides with higher spins and potential applications of this BRAIN-CPMAS approach are discussed. (C) 2017 Elsevier Inc. All rights reserved.
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Date Issued: 2017-04
Identifier: FSU_libsubv1_wos_000399861500017, 10.1016/j.jmr.2017.02.021
Format: Citation

Title: Advanced Molecular Techniques Provide New Rigorous Tools For Characterizing Organic Matter Quality In Complex Systems.
Creator: Wilson, Rachel M., Tfaily, Malak M.
Abstract/Description: Carbon flux rates are widely understood to be substrate controlled; however, characterizing substrate quality continues to be a challenge. We suggest that, while optical measurements have their place, they are not the only, or the best, tool for characterizing organic matter quality. Nominal oxidation state of the carbon provides a thermodynamically relevant measure, which could be used as a metric of organic matter quality. Calculating nominal oxidation state of the carbon requires a suite...
Show moreCarbon flux rates are widely understood to be substrate controlled; however, characterizing substrate quality continues to be a challenge. We suggest that, while optical measurements have their place, they are not the only, or the best, tool for characterizing organic matter quality. Nominal oxidation state of the carbon provides a thermodynamically relevant measure, which could be used as a metric of organic matter quality. Calculating nominal oxidation state of the carbon requires a suite of advanced complementary analysis but is then trivial to calculate from the resulting data sets.
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Date Issued: 2018-06-01
Identifier: FSU_libsubv1_wos_000438667200001, 10.1029/2018JG004525
Format: Citation

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