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(1 - 6 of 6)
- Title
- Personality, Metabolic Rate and Aerobic Capacity.
- Creator
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Terracciano, Antonio, Schrack, Jennifer, Sutin, Angelina, Chan, Wayne, Simonsick, Eleanor M., Ferrucci, Luigi
- Abstract/Description
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Personality traits and cardiorespiratory fitness in older adults are reliable predictors of health and longevity. We examined the association between personality traits and energy expenditure at rest (basal metabolic rate) and during normal and maximal sustained walking. Personality traits and oxygen (VO(2)) consumption were assessed in 642 participants from the Baltimore Longitudinal Study of Aging. Results indicate that personality traits were mostly unrelated to resting metabolic rate and...
Show morePersonality traits and cardiorespiratory fitness in older adults are reliable predictors of health and longevity. We examined the association between personality traits and energy expenditure at rest (basal metabolic rate) and during normal and maximal sustained walking. Personality traits and oxygen (VO(2)) consumption were assessed in 642 participants from the Baltimore Longitudinal Study of Aging. Results indicate that personality traits were mostly unrelated to resting metabolic rate and energy expenditure at normal walking pace. However, those who scored lower on neuroticism (r = -0.12) and higher on extraversion (r = 0.11), openness (r = 0.13), and conscientiousness (r = 0.09) had significantly higher energy expenditure at peak walking pace. In addition to greater aerobic capacity, individuals with a more resilient personality profile walked faster and were more efficient in that they required less energy per meter walked. The associations between personality and energy expenditure were not moderated by age or sex, but were in part explained by the proportion of fat mass. In conclusion, differences in personality may matter the most during more challenging activities that require cardiorespiratory fitness. These findings suggest potential pathways that link personality to health outcomes, such as obesity and longevity.
Show less - Date Issued
- 2013
- Identifier
- FSU_migr_mhs-0011, 10.1371/journal.pone.0054746
- Format
- Citation
- Title
- Activation Profiles of Human Kallikrein-Related Peptidases by Matrix Metalloproteinases.
- Creator
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Yoon, Hyesook, Blaber, Sachiko, Li, Wu, Scarisbrick, Isobel, Blaber, Michael
- Abstract/Description
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Abstract The 15 human kallikrein-related peptidases (KLKs) are clinically important biomarkers and therapeutic targets of interest in inflammation, cancer, and neurodegenerative disease. KLKs are secreted as inactive pro-forms (pro-KLKs) that are activated extracellularly by specific proteolytic release of their amino-terminal pro-peptide, and this is a key step in their functional regulation. Physiologically relevant KLK regulatory cascades of activation have been described in skin...
Show moreAbstract The 15 human kallikrein-related peptidases (KLKs) are clinically important biomarkers and therapeutic targets of interest in inflammation, cancer, and neurodegenerative disease. KLKs are secreted as inactive pro-forms (pro-KLKs) that are activated extracellularly by specific proteolytic release of their amino-terminal pro-peptide, and this is a key step in their functional regulation. Physiologically relevant KLK regulatory cascades of activation have been described in skin desquamation and semen liquefaction, and work by a large number of investigators has elucidated pairwise and autolytic activation relationships among the KLKs with the potential for more extensive activation cascades. More recent work has asked whether functional intersection of KLKs with other types of regulatory proteases exists. Such studies show a capacity for members of the thrombostasis axis to act as broad activators of pro-KLKs. In the present report, we ask whether such functional intersection is possible between the KLKs and the members of the matrix metalloproteinase (MMP) family by evaluating the ability of the MMPs to activate pro-KLKs. The results identify MMP-20 as a broad activator of pro-KLKs, suggesting the potential for intersection of the KLK and MMP axes under pathological dysregulation of MMP-20 expression.
Show less - Date Issued
- 2013
- Identifier
- FSU_migr_biomed_faculty_publications-0042, 10.1515/hsz-2012-0249, PMC3709557
- Format
- Citation
- Title
- Depressive Symptoms Are Associated with Weight Gain Among Women.
- Creator
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Sutin, Angelina, Zonderman, Alan
- Abstract/Description
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BACKGROUND: Many studies have linked depression and obesity; few have more than two assessments of depressive symptoms and adiposity to address the potential bidirectional relationship between adiposity and depressive symptoms from young adulthood through old age. We tested whether baseline depressive symptoms are associated with changes in weight, whether baseline adiposity is associated with changes in depressive symptoms, and whether these associations vary by sex.MethodParticipants (n...
Show moreBACKGROUND: Many studies have linked depression and obesity; few have more than two assessments of depressive symptoms and adiposity to address the potential bidirectional relationship between adiposity and depressive symptoms from young adulthood through old age. We tested whether baseline depressive symptoms are associated with changes in weight, whether baseline adiposity is associated with changes in depressive symptoms, and whether these associations vary by sex.MethodParticipants (n=2251; 47% female) were from the Baltimore Longitudinal Study of Aging (BLSA). Using hierarchical linear modeling (HLM) on 30 years of data, the trajectory of adiposity and depressive symptoms over adulthood was estimated from >10 000 observations (mean=4.5 assessments per participant) of body mass index (BMI; kg/m2), waist circumference and hip circumference and >10 000 observations (mean=4.5 assessments per participant) of the Center for Epidemiological Studies Depression Scale (CES-D). Baseline depressive symptoms and adiposity were then tested as predictors of the trajectory of adiposity and depressive symptoms respectively. Additional analyses tested for sex-specific associations. RESULTS: Sex moderated the association between depressive symptoms and weight gain such that women who experienced depressed affect had greater increases in BMI (binteraction=0.12, s.e.=0.04), waist (binteraction=0.22, s.e.=0.10) and hip circumference (binteraction=0.20, s.e.=0.07) across the adult lifespan, controlling for relevant demographic and behavioral covariates. Baseline adiposity was unrelated to the trajectory of depressive symptoms (median b=0.00) for both sexes. CONCLUSIONS: Women who experience symptoms of depression tend to gain more weight across adulthood than men who experience such symptoms. Whether an individual was normal weight or overweight was unrelated to changes in depressive symptoms across adulthood.
Show less - Date Issued
- 2012
- Identifier
- FSU_migr_mhs-0012, 10.1017/S0033291712000566
- Format
- Citation
- Title
- Human Coronary Artery Smooth Muscle Cell Responses to Bioactive Polyelectrolyte Multilayer Interfaces.
- Creator
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Newcomer, Robert, Moussallem, Maroun, Keller, Thomas C. S., Schlenoff, Joseph B., Sang, Qing-Xiang
- Abstract/Description
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Under normal physiological conditions, mature human coronary artery smooth muscle cells (hCASMCs) exhibit a "contractile" phenotype marked by low rates of proliferation and protein synthesis, but these cells possess the remarkable ability to dedifferentiate into a "synthetic" phenotype when stimulated by conditions of pathologic stress. A variety of polyelectrolyte multilayer (PEMU) films are shown here to exhibit bioactive properties that induce distinct responses from cultured hCASMCs....
Show moreUnder normal physiological conditions, mature human coronary artery smooth muscle cells (hCASMCs) exhibit a "contractile" phenotype marked by low rates of proliferation and protein synthesis, but these cells possess the remarkable ability to dedifferentiate into a "synthetic" phenotype when stimulated by conditions of pathologic stress. A variety of polyelectrolyte multilayer (PEMU) films are shown here to exhibit bioactive properties that induce distinct responses from cultured hCASMCs. Surfaces terminated with Nafion or poly(styrenesulfonic acid) (PSS) induce changes in the expression and organization of intracellular proteins, while a hydrophilic, zwitterionic copolymer of acrylic acid and 3-[2-(acrylamido)-ethyl dimethylammonio] propane sulfonate (PAA-co-PAEDAPS) is resistant to cell attachment and suppresses the formation of key cytoskeletal components. Differential expression of heat shock protein 90 and actin is observed, in terms of both their magnitude and cellular localization, and distinct cytoplasmic patterns of vimentin are seen. The ionophore A23187 induces contraction in confluent hCASMC cultures on Nafion-terminated surfaces. These results demonstrate that PEMU coatings exert direct effects on the cytoskeletal organization of attaching hCASMCs, impeding growth in some cases, inducing changes consistent with phenotypic modulation in others, and suggesting potential utility for PEMU surfaces as a coating for coronary artery stents and other implantable medical devices.
Show less - Date Issued
- 2011
- Identifier
- FSU_migr_chm_faculty_publications-0011, 10.4061/2011/854068
- Format
- Citation
- Title
- Personality and Metabolic Syndrome.
- Creator
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Sutin, Angelina, Costa, Paul, Uda, Manuela, Ferrucci, Luigi, Schlessinger, David, Terracciano, Antonio
- Abstract/Description
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The prevalence of metabolic syndrome has paralleled the sharp increase in obesity. Given its tremendous physical, emotional, and financial burden, it is of critical importance to identify who is most at risk and the potential points of intervention. Psychological traits, in addition to physiological and social risk factors, may contribute to metabolic syndrome. The objective of the present research is to test whether personality traits are associated with metabolic syndrome in a large...
Show moreThe prevalence of metabolic syndrome has paralleled the sharp increase in obesity. Given its tremendous physical, emotional, and financial burden, it is of critical importance to identify who is most at risk and the potential points of intervention. Psychological traits, in addition to physiological and social risk factors, may contribute to metabolic syndrome. The objective of the present research is to test whether personality traits are associated with metabolic syndrome in a large community sample. Participants (N = 5,662) from Sardinia, Italy, completed a comprehensive personality questionnaire, the NEO-PI-R, and were assessed on all components of metabolic syndrome (waist circumference, triglycerides, high-density lipoprotein cholesterol, blood pressure, and fasting glucose). Logistic regressions were used to predict metabolic syndrome from personality traits, controlling for age, sex, education, and current smoking status. Among adults over age 45 (n = 2,419), Neuroticism and low Agreeableness were associated with metabolic syndrome, whereas high Conscientiousness was protective. Individuals who scored in the top 10% on Conscientiousness were approximately 40% less likely to have metabolic syndrome (OR = 0.61, 95% CI = 0.41-0.92), whereas those who scored in the lowest 10% on Agreeableness were 50% more likely to have it (OR = 1.53, 95% CI = 1.09-2.16). At the facet level, traits related to impulsivity and hostility were the most strongly associated with metabolic syndrome. The present research indicates that those with fewer psychological resources are more vulnerable to metabolic syndrome and suggests a psychological component to other established risk factors.
Show less - Date Issued
- 2010
- Identifier
- FSU_migr_mhs-0020, 10.1007/s11357-010-9153-9
- Format
- Citation
- Title
- Mobile Health Unit for Obesity Education: Attitudes and Perceptions Among Local Homeless Residents.
- Creator
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Soberon, Angelica, Brown, L., RodrÃguez, Jose
- Abstract/Description
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Objective: Poverty is a risk factor for obesity. Using homelessness as a marker for poverty, we examined the prevalence of obesity in Leon County, Florida's homeless population to determine their attitudes and perceptions towards the disease. Methods: Our medical team equipped a mobile health unit with educational material before visiting homeless shelters, health fairs and shopping areas in Northwest Florida. Participants at these sites completed a short survey and our staff calculated Body...
Show moreObjective: Poverty is a risk factor for obesity. Using homelessness as a marker for poverty, we examined the prevalence of obesity in Leon County, Florida's homeless population to determine their attitudes and perceptions towards the disease. Methods: Our medical team equipped a mobile health unit with educational material before visiting homeless shelters, health fairs and shopping areas in Northwest Florida. Participants at these sites completed a short survey and our staff calculated Body Mass Index (BMI). The team also distributed lifestyle modification and obesity patient education. BMI and survey responses were compared and analyzed using statistical software. Results: Subjects were assigned to one of two groups: the homeless group or the "all others" group. The homeless group's responses and BMIs were compared to the "all others" group. Weight status in the homeless group was distributed as follows: normal weight (48.3%), overweight (39.7%) and obese (12.1%). The distribution among all other participants was: normal weight (34.8%), overweight (25.8%), and obese (39.3%). Homeless participants overestimated their BMI category as often as all others, were less likely to participate in weight loss interventions, and less likely to recognize overweight and obesity as a problem. Conclusion: Medical practitioners need to recognize the role of patients' attitudes about weight loss and clarify definitions of exercise. Obesity is less prevalent among the homeless; however, the same obesity trends exist. In addition, we learned that the homeless are eager to learn about obesity and healthy lifestyles, but may not be as willing to attempt interventions that have worked in other populations. Mobile health units can be used to reach out to them.
Show less - Date Issued
- 2009
- Identifier
- FSU_migr_fmr-0035
- Format
- Citation
