Search results

Title: Cystic Fibrosis Kidney Disease: 10 Tips For Clinicians.
Creator: Nowakowski, Alexandra C. H.
Abstract/Description: Increased longevity in people with cystic fibrosis (CF) means that more people are surviving long enough to develop kidney complications. Nephrologists and their colleagues now face a steep learning curve as many of them encounter patients with CF related kidney disease (CFKD) for the first time. This article presents perspectives from a medical sociologist with CF on what renal health professionals should know about people with CFKD. It outlines challenges that people with CFKD as they age,...
Show moreIncreased longevity in people with cystic fibrosis (CF) means that more people are surviving long enough to develop kidney complications. Nephrologists and their colleagues now face a steep learning curve as many of them encounter patients with CF related kidney disease (CFKD) for the first time. This article presents perspectives from a medical sociologist with CF on what renal health professionals should know about people with CFKD. It outlines challenges that people with CFKD as they age, framing these struggles as opportunities for clinicians to help these unique patients achieve and maintain their best possible quality of life.
Show less
Date Issued: 2018-08-28
Identifier: FSU_libsubv1_wos_000442990600001, 10.3389/fmed.2018.00242
Format: Citation

Title: Psychological well-being and risk of dementia.
Creator: Sutin, Angelina R, Stephan, Yannick, Terracciano, Antonio
Abstract/Description: Well-being is a psychological resource that buffers against age-related disease. We test whether this protective effect extends to dementia and whether it is independent of distress. Participants (N = 10,099) were from the Health and Retirement Study. Five aspects of positive psychological functioning (life satisfaction, optimism, mastery, purpose in life, and positive affect) were tested as predictors of incident dementia over 6 to 8 years. Purpose in life was associated with a 30% decreased...
Show moreWell-being is a psychological resource that buffers against age-related disease. We test whether this protective effect extends to dementia and whether it is independent of distress. Participants (N = 10,099) were from the Health and Retirement Study. Five aspects of positive psychological functioning (life satisfaction, optimism, mastery, purpose in life, and positive affect) were tested as predictors of incident dementia over 6 to 8 years. Purpose in life was associated with a 30% decreased risk of dementia, independent of psychological distress, other clinical and behavioral risk factors, income/wealth, and genetic risk. After controlling for distress and other risk factors, the other aspects of well-being were not associated with dementia risk. After considering psychological distress, we found that measures of well-being were generally not protective against risk of dementia. An exception is purpose in life, which suggests that a meaningful and goal-driven life reduces risk of dementia.
Show less
Date Issued: 2018-05-01
Identifier: FSU_pmch_29314273, 10.1002/gps.4849, PMC5882524, 29314273, 29314273
Format: Citation

Title: Subjective age and risk of incident dementia: Evidence from the National Health and Aging Trends survey..
Creator: Stephan, Yannick, Sutin, Angelina R, Luchetti, Martina, Terracciano, Antonio
Abstract/Description: The present study examines the association between subjective age and risk of incident dementia in a large longitudinal sample of older adults. Participants were adults aged 65 years and older from the National Health and Aging Trends Study (NHATS). Subjective age, covariates, and cognitive status were assessed in 2011 and cognitive status was again assessed in 2012, 2013, 2014 and 2015. Incident dementia was determined based on answers from self and proxy respondents. The analyses included...
Show moreThe present study examines the association between subjective age and risk of incident dementia in a large longitudinal sample of older adults. Participants were adults aged 65 years and older from the National Health and Aging Trends Study (NHATS). Subjective age, covariates, and cognitive status were assessed in 2011 and cognitive status was again assessed in 2012, 2013, 2014 and 2015. Incident dementia was determined based on answers from self and proxy respondents. The analyses included 4262 participants without dementia at baseline. Adjusting for demographic factors and baseline cognition, an older subjective age was related to higher likelihood of incident dementia. This association was partly accounted by depressive symptoms. Beyond the effect of chronological age, feeling older is associated with the risk of incident dementia.
Show less
Date Issued: 2018-05-01
Identifier: FSU_pmch_29471080, 10.1016/j.jpsychires.2018.02.008, PMC5866231, 29471080, 29471080, S0022-3956(17)31023-3
Format: Citation

Title: Facets of Conscientiousness and risk of dementia.
Creator: Sutin, A R, Stephan, Y, Terracciano, A
Abstract/Description: Multiple studies have found Conscientiousness to be protective against dementia. The purpose of this study is to identify which specific aspects, or facets, of Conscientiousness are most protective against cognitive impairment and whether these associations are moderated by demographic factors and/or genetic risk. Health and Retirement Study participants were selected for analysis if they completed the facets of Conscientiousness measure, scored in the range of normal cognitive functioning at...
Show moreMultiple studies have found Conscientiousness to be protective against dementia. The purpose of this study is to identify which specific aspects, or facets, of Conscientiousness are most protective against cognitive impairment and whether these associations are moderated by demographic factors and/or genetic risk. Health and Retirement Study participants were selected for analysis if they completed the facets of Conscientiousness measure, scored in the range of normal cognitive functioning at the baseline personality assessment, and had at least one follow-up assessment of cognition over the up to 6-year follow-up (N = 11 181). Cox regression was used to test for risk of incident dementia and risk of incident cognitive impairment not dementia (CIND). Over the follow-up, 278 participants developed dementia and 2186 participants developed CIND. The facet of responsibility had the strongest and most consistent association with dementia risk: every standard deviation increase in this facet was associated with a nearly 35% decreased risk of dementia; self-control and industriousness were also protective. Associations were generally similar when controlling for clinical, behavioral, and genetic risk factors. These three facets were also independent predictors of decreased risk of CIND. The present research indicates that individuals who see themselves as responsible, able to control their behavior, and hard workers are less likely to develop CIND or dementia and that these associations persist after accounting for some common clinical, behavioral, and genetic risk factors.
Show less
Date Issued: 2018-04-01
Identifier: FSU_pmch_28874220, 10.1017/S0033291717002306, PMC5839940, 28874220, 28874220, S0033291717002306
Format: Citation

Title: Cognitive Impairment, Dementia, and Personality Stability Among Older Adults.
Creator: Terracciano, Antonio, Stephan, Yannick, Luchetti, Martina, Sutin, Angelina R
Abstract/Description: There is contrasting evidence on personality stability in advanced age, and limited knowledge on the impact of cognitive impairment and dementia on trait stability. Group- and individual-level longitudinal analyses of the five major dimensions of personality assessed twice over 4 years ( N = 9,935) suggest that rank-order stability was progressively lower with advancing age (from r = 0.68 for age 50 to 60 years to r = 0.58 for age >80 years). Stability was low in the dementia group ( r = 0.43...
Show moreThere is contrasting evidence on personality stability in advanced age, and limited knowledge on the impact of cognitive impairment and dementia on trait stability. Group- and individual-level longitudinal analyses of the five major dimensions of personality assessed twice over 4 years ( N = 9,935) suggest that rank-order stability was progressively lower with advancing age (from r = 0.68 for age 50 to 60 years to r = 0.58 for age >80 years). Stability was low in the dementia group ( r = 0.43), and this was not simply due to lower reliability given that internal consistency remained adequate in the dementia group. Among individuals with no cognitive impairment or dementia, there was no association between stability and age ( r = 0.70 even for age >80 years). These results suggest that the lower personality stability in older adults is not due to age but cognitive impairment and dementia.
Show less
Date Issued: 2018-04-01
Identifier: FSU_pmch_29214858, 10.1177/1073191117691844, PMC5725278, 29214858, 29214858
Format: Citation

Title: Physical Activity and Personality Development over Twenty Years: Evidence from Three Longitudinal Samples..
Creator: Stephan, Yannick, Sutin, Angelina R, Luchetti, Martina, Bosselut, Grégoire, Terracciano, Antonio
Abstract/Description: A physically inactive lifestyle is associated with maladaptive patterns of personality development over relatively short follow-up periods. The present study extends existing research by examining whether this association persists over 20 years. Participants (total = 8,723) were drawn from the Wisconsin Longitudinal Study Graduates and Siblings samples and the Midlife in the United States Study. Controlling for demographic factors and disease burden, baseline physical inactivity was related...
Show moreA physically inactive lifestyle is associated with maladaptive patterns of personality development over relatively short follow-up periods. The present study extends existing research by examining whether this association persists over 20 years. Participants (total = 8,723) were drawn from the Wisconsin Longitudinal Study Graduates and Siblings samples and the Midlife in the United States Study. Controlling for demographic factors and disease burden, baseline physical inactivity was related to steeper declines in conscientiousness in all three samples and a meta-analysis (β=-.06). The meta-analysis further showed that lower physical activity was associated with declines in openness (β=-.05), extraversion (β=-.03), and agreeableness (β=-.03). These findings provide evidence that a physically inactive lifestyle is associated with long-term detrimental personality trajectories.
Show less
Date Issued: 2018-04-01
Identifier: FSU_pmch_29651189, 10.1016/j.jrp.2018.02.005, PMC5892442, 29651189, 29651189
Format: Citation

Title: Personality and sleep quality: Evidence from four prospective studies..
Creator: Stephan, Yannick, Sutin, Angelina R, Bayard, Sophie, Križan, Zlatan, Terracciano, Antonio
Abstract/Description: The present study examined the longitudinal association between personality traits and sleep quality in 4 samples of middle-aged and older adults. Participants (N > 22,000) were adults aged 30 to 107 years old from the Wisconsin Longitudinal Study (WLS), the Midlife in the United States Study (MIDUS), the Health and Retirement Study (HRS), and the Midlife in Japan Study (MIDJA). Personality and sleep quality were assessed at baseline and again 4 to 10 years later. Scoring lower on neuroticism...
Show moreThe present study examined the longitudinal association between personality traits and sleep quality in 4 samples of middle-aged and older adults. Participants (N > 22,000) were adults aged 30 to 107 years old from the Wisconsin Longitudinal Study (WLS), the Midlife in the United States Study (MIDUS), the Health and Retirement Study (HRS), and the Midlife in Japan Study (MIDJA). Personality and sleep quality were assessed at baseline and again 4 to 10 years later. Scoring lower on neuroticism and higher on extraversion was associated with better sleep quality at baseline and over time, with effect sizes larger than those of demographic factors. Low conscientiousness was associated with a worsening of sleep quality over time. Openness and agreeableness were unrelated to sleep quality. Poor sleep quality at baseline was associated with steeper declines in extraversion, agreeableness, and conscientiousness and a smaller decrease in neuroticism over time. Replicable findings across samples support longitudinal associations between personality and sleep quality. This study identified specific personality traits that are associated with poor and worsening sleep quality, and substantiated previous findings that poor sleep quality is associated with detrimental personality trajectories. (PsycINFO Database Record
Show less
Date Issued: 2018-03-01
Identifier: FSU_pmch_29172602, 10.1037/hea0000577, PMC5837948, 29172602, 29172602, 2017-52631-001
Format: Citation

Title: What Exactly Is An "snf-ist?".
Creator: Gillespie, Suzanne M., Levy, Cari R., Katz, Paul R.
Date Issued: 2018-01
Identifier: FSU_libsubv1_wos_000419113300040, 10.1001/jamainternmed.2017.7212
Format: Citation

Title: Parental perception of child weight and inflammation: Perceived overweight is associated with higher child c-reactive protein..
Creator: Sutin, Angelina R, Rust, George, Robinson, Eric, Daly, Michael, Terracciano, Antonio
Abstract/Description: Self-perceived overweight and weight discrimination are associated with inflammation in adulthood. We test whether there is an intergenerational association of parent perception of child overweight on higher levels of child c-reactive protein (CRP), a marker of inflammation implicated in stress. Data were from the National Health and Nutrition Examination Survey 2005-2014 (N=4988). Parents reported their perception of their child's weight; CRP was assayed from children's blood samples....
Show moreSelf-perceived overweight and weight discrimination are associated with inflammation in adulthood. We test whether there is an intergenerational association of parent perception of child overweight on higher levels of child c-reactive protein (CRP), a marker of inflammation implicated in stress. Data were from the National Health and Nutrition Examination Survey 2005-2014 (N=4988). Parents reported their perception of their child's weight; CRP was assayed from children's blood samples. Children whose parents perceived them as overweight had higher CRP levels than children who were perceived about the right weight; perceived underweight was also associated with higher CRP (F(2,4977)=9.23, p<.001). These associations were independent of the child's objective weight status and waist circumference and held when the sample was limited to children with objective overweight and obesity. These results suggest an intergenerational transfer of the psychological perception of body weight from parents to the inflammatory health of their child.
Show less
Date Issued: 2017-12-01
Identifier: FSU_pmch_29054818, 10.1016/j.biopsycho.2017.10.004, PMC5703214, 29054818, 29054818, S0301-0511(17)30288-0
Format: Citation

Title: Childhood Socioeconomic Status and Stress in Late Adulthood: A Longitudinal Approach to Measuring Allostatic Load..
Creator: Graves, Katelyn Y, Nowakowski, Alexandra C H
Abstract/Description: This study examines how the effects of childhood socioeconomic status (SES) may carry on into late adulthood. We examine how childhood SES affects both perceived stress and allostatic load, which is a cumulative measure of the body's biologic response to chronic stress. We use the National Social Life, Health, and Aging Project, Waves 1 and 2, and suggest a novel method of incorporating a longitudinal allostatic load measure. Individuals who grew up in low SES households have higher...
Show moreThis study examines how the effects of childhood socioeconomic status (SES) may carry on into late adulthood. We examine how childhood SES affects both perceived stress and allostatic load, which is a cumulative measure of the body's biologic response to chronic stress. We use the National Social Life, Health, and Aging Project, Waves 1 and 2, and suggest a novel method of incorporating a longitudinal allostatic load measure. Individuals who grew up in low SES households have higher allostatic load scores in late adulthood, and this association is mediated mostly by educational attainment. The longitudinal allostatic load measure shows similar results to the singular measures and allows us to include 2 time points into one outcome measure. Incorporating 2 separate time points into one measure is important because allostatic load is a measure of cumulative physiological dysregulation, and longitudinal data provide a more comprehensive measure.
Show less
Date Issued: 2017-11-29
Identifier: FSU_pmch_29226194, 10.1177/2333794X17744950, PMC5714076, 29226194, 29226194, 10.1177_2333794X17744950
Format: Citation

Title: Aging Partners Managing Chronic Illness Together: Introducing the Content Collection..
Creator: Nowakowski, Alexandra C H, Sumerau, J E
Abstract/Description: Prior literature on illness management within intimate relationships demonstrates a variety of benefits from supportive partnership. Indeed, much of the earliest research in this field engaged older adults with and without chronic conditions. However, this pioneering literature gave little consideration to relationships in which multiple partners were coping with chronic illness. By contrast, the majority of published manuscripts presented a "sick partner/well partner" model in which...
Show morePrior literature on illness management within intimate relationships demonstrates a variety of benefits from supportive partnership. Indeed, much of the earliest research in this field engaged older adults with and without chronic conditions. However, this pioneering literature gave little consideration to relationships in which multiple partners were coping with chronic illness. By contrast, the majority of published manuscripts presented a "sick partner/well partner" model in which caregiving flowed only in one direction. Yet this idea makes little sense in the context of contemporaneous data on population aging and health as a majority of older adults now live with at least one chronic condition. Scholars still have not delved explicitly into the experiences of the vast population of older relationship partners who are managing chronic conditions simultaneously. We thus welcome readers to this special content collection on .
Show less
Date Issued: 2017-11-01
Identifier: FSU_pmch_29119129, 10.1177/2333721417737679, PMC5669316, 29119129, 29119129, 10.1177_2333721417737679
Format: Citation

Title: Feeling Older and the Development of Cognitive Impairment and Dementia.
Creator: Stephan, Yannick, Sutin, Angelina R, Luchetti, Martina, Terracciano, Antonio
Abstract/Description: Subjective age is a biopsychosocial marker of aging associated with a range of outcomes in old age. In the domain of cognition, feeling older than one's chronological age is related to lower cognitive performance and steeper cognitive decline among older adults. The present study examines whether an older subjective age is associated with the risk of incident cognitive impairment and dementia. Participants were 5,748 individuals aged 65 years and older drawn from the Health and Retirement...
Show moreSubjective age is a biopsychosocial marker of aging associated with a range of outcomes in old age. In the domain of cognition, feeling older than one's chronological age is related to lower cognitive performance and steeper cognitive decline among older adults. The present study examines whether an older subjective age is associated with the risk of incident cognitive impairment and dementia. Participants were 5,748 individuals aged 65 years and older drawn from the Health and Retirement Study. Measures of subjective age, cognition, and covariates were obtained at baseline, and follow-up cognition was assessed over a 2- to 4-year period. Only participants without cognitive impairment were included at baseline. At follow-up, participants were classified into one of the three categories: normal functioning, cognitive impairment without dementia (CIND), and dementia. An older subjective age at baseline was associated with higher likelihood of CIND (odds ratio [OR] = 1.18; 1.09-1.28) and dementia (OR = 1.29; 1.02-1.63) at follow-up, controlling for chronological age, other demographic factors, and baseline cognition. Physical inactivity and depressive symptoms partly accounted for these associations. An older subjective age is a marker of individuals' risk of subsequent cognitive impairment and dementia.
Show less
Date Issued: 2017-10-01
Identifier: FSU_pmch_27436103, 10.1093/geronb/gbw085, PMC5927095, 27436103, 27436103, gbw085
Format: Citation

Title: Personality and Lung Function in Older Adults.
Creator: Terracciano, Antonio, Stephan, Yannick, Luchetti, Martina, Gonzalez-Rothi, Ricardo, Sutin, Angelina R
Abstract/Description: Lung disease is a leading cause of disability and death among older adults. We examine whether personality traits are associated with lung function and shortness of breath (dyspnea) in a national cohort with and without chronic obstructive pulmonary disease (COPD). Participants (N = 12,670) from the Health and Retirement Study were tested for peak expiratory flow (PEF) and completed measures of personality, health behaviors, and a medical history. High neuroticism and low extraversion,...
Show moreLung disease is a leading cause of disability and death among older adults. We examine whether personality traits are associated with lung function and shortness of breath (dyspnea) in a national cohort with and without chronic obstructive pulmonary disease (COPD). Participants (N = 12,670) from the Health and Retirement Study were tested for peak expiratory flow (PEF) and completed measures of personality, health behaviors, and a medical history. High neuroticism and low extraversion, openness, agreeableness, and conscientiousness were associated with lower PEF, and higher likelihood of COPD and dyspnea. Conscientiousness had the strongest and most consistent associations, including lower risk of PEF less than 80% of the predicted value (OR = 0.67; 0.62-0.73) and dyspnea (OR = 0.52; 0.47-0.57). Although attenuated, the associations remained significant when accounting for smoking, physical activity, and chronic diseases including cardiovascular and psychiatric disorders. The associations between personality and PEF or dyspnea were similar among those with or without COPD, suggesting that psychological links to lung function are not disease dependent. In longitudinal analyses, high neuroticism (β = -0.019) and low conscientiousness (β = 0.027) predicted steeper declines in PEF. A vulnerable personality profile is common among individuals with limited lung function and COPD, predicts shortness of breath and worsening lung function.
Show less
Date Issued: 2017-10-01
Identifier: FSU_pmch_26786321, 10.1093/geronb/gbv161, PMC5926981, 26786321, 26786321, gbv161
Format: Citation

Title: Impacts of Initial Transformation to a Patient-Centered Medical Home on Diabetes Outcomes in Federally Qualified Health Centers in Florida.
Creator: Kinsell, Heidi S, Hall, Allyson G, Harman, Jeffrey S, Tewary, Sweta, Brickman, Andrew
Abstract/Description: Federally qualified health centers (FQHCs) in Florida see large numbers of vulnerable patients with diabetes. Patient-centered medical home (PCMH) models can lead to improvements in health for patients with chronic conditions and cost savings for providers. Therefore, FQHCs are increasingly moving to PCMH models of care. The study objective was to examine the effects of initial transformation to a level 3 National Committee for Quality Assurance (NCQA) certified PCMH in 2011, on clinical...
Show moreFederally qualified health centers (FQHCs) in Florida see large numbers of vulnerable patients with diabetes. Patient-centered medical home (PCMH) models can lead to improvements in health for patients with chronic conditions and cost savings for providers. Therefore, FQHCs are increasingly moving to PCMH models of care. The study objective was to examine the effects of initial transformation to a level 3 National Committee for Quality Assurance (NCQA) certified PCMH in 2011, on clinical diabetes outcomes among 27 clinic sites from a network of FQHCs in Florida. We used de-identified, longitudinal electronic health record (EHR) data from 2010-2012 and multivariate logistic regression to analyze the effects of initial transformation on the odds of having well-controlled HbA1c, body mass index (BMI), and blood pressure (BP) among vulnerable patients with diabetes. Models controlled for clustering by year, patient, and organizational characteristics. Overall, transformation to a PCMH was associated with 19% greater odds of having well-controlled HbA1c values with no statistically significant impact on BMI or BP. Subanalyses showed transformation had less of an effect on BP for African American patients and HbA1c control for Medicare enrollees but a greater effect on weight control for patients older than 35 years. Transformation to a PCMH in FQHCs appears to improve the health of vulnerable patients with diabetes, with less improvement for subsets of patients. Future research should seek to understand the heterogeneous effects of patient-centered transformation on various subgroups.
Show less
Date Issued: 2017-10-01
Identifier: FSU_pmch_29161972, 10.1177/2150131917742300, PMC5932745, 29161972, 29161972
Format: Citation

Title: Maternal cigarette smoking during pregnancy and the trajectory of externalizing and internalizing symptoms across childhood: Similarities and differences across parent, teacher, and self reports..
Creator: Sutin, Angelina R, Flynn, Heather A, Terracciano, Antonio
Abstract/Description: Maternal smoking during pregnancy (MSDP) has been associated with symptoms of externalizing (e.g., hyperactivity) and internalizing (e.g., emotional) disorders in childhood. The present research addresses two new questions about the nature of this relation: (1) Do the associations between MSDP and externalizing and internalizing symptoms vary by who reports the symptoms? and (2) Is MSDP associated with changes in symptomatology across childhood? We address these questions with two cohorts...
Show moreMaternal smoking during pregnancy (MSDP) has been associated with symptoms of externalizing (e.g., hyperactivity) and internalizing (e.g., emotional) disorders in childhood. The present research addresses two new questions about the nature of this relation: (1) Do the associations between MSDP and externalizing and internalizing symptoms vary by who reports the symptoms? and (2) Is MSDP associated with changes in symptomatology across childhood? We address these questions with two cohorts from the Longitudinal Study of Australian Children (LSAC). Parents and teachers completed the Strengths and Difficulties Questionnaire up to six times every two years between child ages 4 and 14 in the older cohort (N = 3841) and up to four times between child ages 4 and 10 in the younger cohort (N = 3714); the study children also completed the same questionnaire up to three times starting at age 10. Across the two cohorts, MSDP was associated with more externalizing symptoms as reported by parents, teachers, and self. MSDP was also associated with increases in externalizing symptoms across childhood when teachers assessed the symptoms but not when parents assessed them. Finally, MSDP was not consistently associated with the average level of internalizing symptoms, but it was associated with increases in these symptoms across childhood. The present research indicates a robust association between MSDP and the average level of externalizing symptoms in childhood regardless of who reports the symptoms. It also indicates that whether MSDP is associated with the trajectory of externalizing symptomatology depends on who reports on the symptoms.
Show less
Date Issued: 2017-08-01
Identifier: FSU_pmch_28359941, 10.1016/j.jpsychires.2017.03.003, PMC5647462, 28359941, 28359941, S0022-3956(16)30806-8
Format: Citation

Title: Temperament and body weight from ages 4 to 15 years.
Creator: Sutin, A R, Kerr, J A, Terracciano, A
Abstract/Description: In adulthood, conscientiousness and neuroticism are correlates of body weight and weight gain. The present research examines whether the childhood antecedents of these traits, persistence and negative reactivity, respectively, are associated with weight gain across childhood. We likewise examine sociability as a predictor of childhood weight gain and whether these three traits are associated with weight concerns and weight-management strategies in adolescence. Participants (N=4153) were drawn...
Show moreIn adulthood, conscientiousness and neuroticism are correlates of body weight and weight gain. The present research examines whether the childhood antecedents of these traits, persistence and negative reactivity, respectively, are associated with weight gain across childhood. We likewise examine sociability as a predictor of childhood weight gain and whether these three traits are associated with weight concerns and weight-management strategies in adolescence. Participants (N=4153) were drawn from the Longitudinal Study of Australian Children, an ongoing, population-based study of child and family health and well-being. At the baseline assessment, caregivers reported on their child's temperament. At every assessment from ages 4-5 to 14-15 years, study children were weighed and measured by trained staff; there were up to six biennial assessments of body mass index and waist circumference. At ages 14-15 years, study children (n=2975) also self-reported on their weight concerns and weight-management strategies. Study children rated lower in persistence or higher in negative reactivity in early childhood gained more weight between the ages of 4 and 15 years. Sociability was associated with weight gain among girls but not among boys. Lower persistence and higher negative reactivity at ages 4-5 years were also associated with greater weight concerns, restrained eating and use of unhealthy weight-management strategies at ages 14-15 years. Childhood traits related to conscientiousness and neuroticism are associated with objective weight gain across childhood and with concerns and strategies to manage weight in adolescence. These results are consistent with a lifespan perspective that indicates that trait psychological functioning contributes to health-related markers from childhood through old age.
Show less
Date Issued: 2017-07-01
Identifier: FSU_pmch_28280272, 10.1038/ijo.2017.62, PMC5496782, 28280272, 28280272, ijo201762
Format: Citation

Title: Parental educational attainment and adult offspring personality: An intergenerational life span approach to the origin of adult personality traits..
Creator: Sutin, Angelina R, Luchetti, Martina, Stephan, Yannick, Robins, Richard W, Terracciano, Antonio
Abstract/Description: Why do some individuals have more self-control or are more vulnerable to stress than others? Where do these basic personality traits come from? Although a fundamental question in personality, more is known about how traits are related to important life outcomes than their developmental origins. The present research took an intergenerational life span approach to address whether a significant aspect of the childhood environment-parental educational attainment-was associated with offspring...
Show moreWhy do some individuals have more self-control or are more vulnerable to stress than others? Where do these basic personality traits come from? Although a fundamental question in personality, more is known about how traits are related to important life outcomes than their developmental origins. The present research took an intergenerational life span approach to address whether a significant aspect of the childhood environment-parental educational attainment-was associated with offspring personality traits in adulthood. We tested the association between parents' educational levels and adult offspring personality traits in 7 samples (overall age range 14-95) and meta-analytically combined the results (total N > 60,000). Parents with more years of education had children who were more open, extraverted, and emotionally stable as adults. These associations were small but consistent, of similar modest magnitude to the association between life events and change in personality in adulthood, and were also supported by longitudinal analyses. Contrary to expectations, parental educational attainment was unrelated to offspring Conscientiousness, except for a surprisingly negative association in the younger cohorts. The results were similar in a subsample of participants who were adopted, which suggested that environmental mechanisms were as relevant as shared genetic variants. Participant levels of education were associated with greater conscientiousness, emotional stability, extraversion, and openness and partially mediated the relation between parent education and personality. Child IQ and family income were also partial mediators. The results of this research suggest that parental educational attainment is 1 intergenerational factor associated with offspring personality development in adulthood. (PsycINFO Database Record
Show less
Date Issued: 2017-07-01
Identifier: FSU_pmch_28287753, 10.1037/pspp0000137, PMC5472504, 28287753, 28287753, 2017-11240-001
Format: Citation

Title: Personality traits and risk of cognitive impairment and dementia.
Creator: Terracciano, Antonio, Stephan, Yannick, Luchetti, Martina, Albanese, Emiliano, Sutin, Angelina R
Abstract/Description: We investigated the association between five factor model personality traits (neuroticism, extraversion, openness, agreeableness, and conscientiousness) and risk of dementia, cognitive impairment not dementia (CIND), and conversion from CIND to dementia in a large national cohort. Participants from the Health and Retirement Study (N > 10,000) completed a personality scale in 2006-2008 and their cognitive status was tracked for up to 8 years using the modified Telephone Interview for Cognitive...
Show moreWe investigated the association between five factor model personality traits (neuroticism, extraversion, openness, agreeableness, and conscientiousness) and risk of dementia, cognitive impairment not dementia (CIND), and conversion from CIND to dementia in a large national cohort. Participants from the Health and Retirement Study (N > 10,000) completed a personality scale in 2006-2008 and their cognitive status was tracked for up to 8 years using the modified Telephone Interview for Cognitive Status (TICSm). Adjusting for age, sex, education, race, and ethnicity, lower conscientiousness and agreeableness and higher neuroticism were independently associated with increased risk of dementia. These associations remained significant after adjusting for other risk factors for dementia, including income, wealth, smoking, physical inactivity, obesity, diabetes, hypertension, and blood biomarkers. These associations were not modified by age, sex, race, ethnicity, and education, suggesting that the associations of personality with risk of dementia were similar across demographic groups. Neuroticism and conscientiousness were also associated with risk of CIND. Low conscientiousness predicted conversion from CIND to dementia. Using brief assessments of personality and cognition, we found robust evidence that personality is associated with risk of cognitive impairment and dementia in a large national sample.
Show less
Date Issued: 2017-06-01
Identifier: FSU_pmch_28153642, 10.1016/j.jpsychires.2017.01.011, PMC5374012, 28153642, 28153642, S0022-3956(16)30635-5
Format: Citation

Title: Surface-based morphometry reveals the neuroanatomical basis of the five-factor model of personality.
Creator: Riccelli, Roberta, Toschi, Nicola, Nigro, Salvatore, Terracciano, Antonio, Passamonti, Luca
Abstract/Description: The five-factor model (FFM) is a widely used taxonomy of human personality; yet its neuro anatomical basis remains unclear. This is partly because past associations between gray-matter volume and FFM were driven by different surface-based morphometry (SBM) indices (i.e. cortical thickness, surface area, cortical folding or any combination of them). To overcome this limitation, we used Free-Surfer to study how variability in SBM measures was related to the FFM in n = 507 participants from the...
Show moreThe five-factor model (FFM) is a widely used taxonomy of human personality; yet its neuro anatomical basis remains unclear. This is partly because past associations between gray-matter volume and FFM were driven by different surface-based morphometry (SBM) indices (i.e. cortical thickness, surface area, cortical folding or any combination of them). To overcome this limitation, we used Free-Surfer to study how variability in SBM measures was related to the FFM in n = 507 participants from the Human Connectome Project.Neuroticism was associated with thicker cortex and smaller area and folding in prefrontal-temporal regions. Extraversion was linked to thicker pre-cuneus and smaller superior temporal cortex area. Openness was linked to thinner cortex and greater area and folding in prefrontal-parietal regions. Agreeableness was correlated to thinner prefrontal cortex and smaller fusiform gyrus area. Conscientiousness was associated with thicker cortex and smaller area and folding in prefrontal regions. These findings demonstrate that anatomical variability in prefrontal cortices is linked to individual differences in the socio-cognitive dispositions described by the FFM. Cortical thickness and surface area/folding were inversely related each others as a function of different FFM traits (neuroticism, extraversion and consciousness vs openness), which may reflect brain maturational effects that predispose or protect against psychiatric disorders.
Show less
Date Issued: 2017-04-01
Identifier: FSU_pmch_28122961, 10.1093/scan/nsw175, PMC5390726, 28122961, 28122961, nsw175
Format: Citation

Title: Surface-based Morphometry Reveals The Neuroanatomical Basis Of The Five-factor Model Of Personality.
Creator: Riccelli, Roberta, Toschi, Nicola, Nigro, Salvatore, Terracciano, Antonio, Passamonti, Luca
Abstract/Description: The five-factor model (FFM) is a widely used taxonomy of human personality; yet its neuro anatomical basis remains unclear. This is partly because past associations between gray-matter volume and FFM were driven by different surface-based morphometry (SBM) indices (i.e. cortical thickness, surface area, cortical folding or any combination of them). To overcome this limitation, we used Free-Surfer to study how variability in SBM measures was related to the FFM in n = 507 participants from the...
Show moreThe five-factor model (FFM) is a widely used taxonomy of human personality; yet its neuro anatomical basis remains unclear. This is partly because past associations between gray-matter volume and FFM were driven by different surface-based morphometry (SBM) indices (i.e. cortical thickness, surface area, cortical folding or any combination of them). To overcome this limitation, we used Free-Surfer to study how variability in SBM measures was related to the FFM in n = 507 participants from the Human Connectome Project. Neuroticismwas associated with thicker cortex and smaller area and folding in prefrontal-temporal regions. Extraversion was linked to thicker pre-cuneus and smaller superior temporal cortex area. Openness was linked to thinner cortex and greater area and folding in prefrontal-parietal regions. Agreeableness was correlated to thinner prefrontal cortex and smaller fusiform gyrus area. Conscientiousness was associated with thicker cortex and smaller area and folding in prefrontal regions. These findings demonstrate that anatomical variability in prefrontal cortices is linked to individual differences in the socio-cognitive dispositions described by the FFM. Cortical thickness and surface area/folding were inversely related each others as a function of different FFM traits (neuroticism, extraversion and consciousness vs openness), which may reflect brain maturational effects that predispose or protect against psychiatric disorders.
Show less
Date Issued: 2017-04
Identifier: FSU_libsubv1_wos_000404548900015, 10.1093/scan/nsw175
Format: Citation

Title: Sensory functioning and personality development among older adults.
Creator: Stephan, Yannick, Sutin, Angelina R, Bosselut, Grégoire, Terracciano, Antonio
Abstract/Description: Deficits in sensory functioning, such as poor vision and hearing, take a significant toll on quality of life. Little is known, however, about their relation with personality development across adulthood. This study examined whether baseline and change in vision and hearing were associated with personality change over a 4-year period. Participants (N = 7,471; Mage = 66.89; 59% women) were drawn from the Health and Retirement Study. They provided data on vision, hearing, and personality both at...
Show moreDeficits in sensory functioning, such as poor vision and hearing, take a significant toll on quality of life. Little is known, however, about their relation with personality development across adulthood. This study examined whether baseline and change in vision and hearing were associated with personality change over a 4-year period. Participants (N = 7,471; Mage = 66.89; 59% women) were drawn from the Health and Retirement Study. They provided data on vision, hearing, and personality both at baseline and 4 years later. Poor vision and hearing at baseline and declines in vision and hearing over time were independently related to steeper declines in extraversion, agreeableness, openness, and conscientiousness, and less decline in neuroticism, controlling for demographic factors, disease burden, and depressive symptoms. Sensory functioning was generally a stronger predictor of personality change than disease burden or depressive symptoms. Consistent with evidence that poor and worsening sensory functions compromise individuals' interactions with the social and physical environment, this study found deficits in hearing and vision were also associated with maladaptive personality trajectories in older adults. (PsycINFO Database Record
Show less
Date Issued: 2017-03-01
Identifier: FSU_pmch_28287784, 10.1037/pag0000159, PMC5481780, 28287784, 28287784, 2017-10607-004
Format: Citation

Title: Personality and actigraphy-measured physical activity in older adults.
Creator: Artese, Ashley, Ehley, Desirae, Sutin, Angelina R, Terracciano, Antonio
Abstract/Description: Most studies on personality and physical activity have relied on self-report measures. This study examined the relation between Five Factor Model personality traits and objective physical activity in older adults. Sixty-nine participants (Mage = 80.2 years; SD = 7.1) wore the ActiGraph monitor for 7 days and completed the NEO Personality Inventory-3 First Half. Extraversion, Agreeableness, and Conscientiousness were associated with more moderate physical activity and more steps per day...
Show moreMost studies on personality and physical activity have relied on self-report measures. This study examined the relation between Five Factor Model personality traits and objective physical activity in older adults. Sixty-nine participants (Mage = 80.2 years; SD = 7.1) wore the ActiGraph monitor for 7 days and completed the NEO Personality Inventory-3 First Half. Extraversion, Agreeableness, and Conscientiousness were associated with more moderate physical activity and more steps per day whereas Neuroticism was inversely related to these physical activity measures (βs > .20). The associations for Neuroticism and Conscientiousness were attenuated by approximately 20-40% when accounting for disease burden and body mass index but were essentially unchanged for Extraversion and Agreeableness. These findings confirm self-report evidence that personality traits are associated with physical activity levels in older adults. (PsycINFO Database Record
Show less
Date Issued: 2017-03-01
Identifier: FSU_pmch_28287783, 10.1037/pag0000158, PMC5369413, 28287783, 28287783, 2017-10607-003
Format: Citation

Title: Subjective Age and Dementia.
Creator: Jaconelli, Alban, Terracciano, Antonio, Sutin, Angelina R, Sarrazin, Philippe, Raffard, Stéphane, Stephan, Yannick
Abstract/Description: Existing evidence indicates that a younger subjective age is a marker of successful aging, including better health and cognition. Building upon this evidence, it is likely that individuals with dementia might feel older. However, subjective evaluation of age might not be affected by dementia because these individuals tend to be anosognosic and report positive health-related quality of life. Data from two cross-sectional samples from France and the United States were used to compare the...
Show moreExisting evidence indicates that a younger subjective age is a marker of successful aging, including better health and cognition. Building upon this evidence, it is likely that individuals with dementia might feel older. However, subjective evaluation of age might not be affected by dementia because these individuals tend to be anosognosic and report positive health-related quality of life. Data from two cross-sectional samples from France and the United States were used to compare the subjective age ratings of individuals with and without dementia. Results from both samples revealed that individuals with dementia felt younger than their age but did not differ from the controls, even after controlling for sex, chronological age, education, and self-rated health. The present study suggests that there are no large differences in the subjective experience of age between healthy individuals and those with dementia.
Show less
Date Issued: 2017-03-01
Identifier: FSU_pmch_28452675, 10.1080/07317115.2016.1187695, PMC5412589, 28452675, 28452675
Format: Citation

Title: Sources of Weight Discrimination and Health.
Creator: Sutin, Angelina R, Terracciano, Antonio
Abstract/Description: Individuals who perceive weight discrimination tend to be less healthy. The correlates of weight discrimination, however, may vary by source of the discrimination (e.g., from a healthcare provider, stranger, family member, etc.). The present research used a large national sample (=4,990) to examine the prevalence and demographic predictors of sources of weight discrimination and whether subjective health and depressive symptoms associated with discrimination varied by source. Approximately 13...
Show moreIndividuals who perceive weight discrimination tend to be less healthy. The correlates of weight discrimination, however, may vary by source of the discrimination (e.g., from a healthcare provider, stranger, family member, etc.). The present research used a large national sample (=4,990) to examine the prevalence and demographic predictors of sources of weight discrimination and whether subjective health and depressive symptoms associated with discrimination varied by source. Approximately 13% of the respondents reported experiencing discrimination based on their body weight. Of these participants, the prevalence across sources ranged from 4% from educators to 52% from strangers. Women and younger participants were more likely to experience bias from their families; participants with higher BMIs were more likely to experience discrimination from a service industry professional or a stranger. Participants had lower subjective health when the source of weight discrimination came from either a stranger or a family member, whereas depressive symptoms were higher across all sources of discrimination except for from a service professional or a stranger. These results support previous research that indicates weight discrimination is common and comes from many sources and further suggests that the health correlates may differ depending on who is the source of the unfair treatment.
Show less
Date Issued: 2017-02-01
Identifier: FSU_pmch_28289702, 10.1037/sah0000037, PMC5345569, 28289702, 28289702
Format: Citation

Title: Personality and Frailty: Evidence From Four Samples..
Creator: Stephan, Yannick, Sutin, Angelina R, Canada, Brice, Terracciano, Antonio
Abstract/Description: Frailty is a prevalent geriatric syndrome. Little is known about the psychological factors associated with this syndrome. Based on four large samples of older adults aged from 65 to 104 years old, the present study examined whether personality traits are related to frailty. High neuroticism, low conscientiousness, low extraversion, low openness and low agreeableness were related to higher frailty across samples. Longitudinal analysis conducted in one sample revealed that high neuroticism was...
Show moreFrailty is a prevalent geriatric syndrome. Little is known about the psychological factors associated with this syndrome. Based on four large samples of older adults aged from 65 to 104 years old, the present study examined whether personality traits are related to frailty. High neuroticism, low conscientiousness, low extraversion, low openness and low agreeableness were related to higher frailty across samples. Longitudinal analysis conducted in one sample revealed that high neuroticism was associated with worsening frailty over an 8-year period. Higher frailty at baseline and over time was related to maladaptive personality changes. This study extends existing knowledge on the link between personality and health in older adults, by identifying the personality traits associated with frailty, a complex geriatric syndrome.
Show less
Date Issued: 2017-02-01
Identifier: FSU_pmch_28649150, 10.1016/j.jrp.2016.12.006, PMC5482292, 28649150, 28649150
Format: Citation

Title: Personality and Body Weight: Mechanisms, Longitudinal Associations and Context..
Creator: Sutin, Angelina R, Terracciano, Antonio
Abstract/Description: Models of personality and health have grown in complexity as more is discovered about how traits are related to health-related behaviors, morbidity, and mortality. The present article applies a model of personality and health that incorporates longitudinal relations, behavioral and physiological mechanisms, and context to the relation between Five-Factor Model personality traits and body mass index (BMI) and obesity (BMI≥30). Conscientiousness is associated consistently with lower body weight...
Show moreModels of personality and health have grown in complexity as more is discovered about how traits are related to health-related behaviors, morbidity, and mortality. The present article applies a model of personality and health that incorporates longitudinal relations, behavioral and physiological mechanisms, and context to the relation between Five-Factor Model personality traits and body mass index (BMI) and obesity (BMI≥30). Conscientiousness is associated consistently with lower body weight; the relation between the other traits and BMI is more complex. Conscientiousness is also associated with risk of obesity over time, and specific aspects of Conscientiousness and Neuroticism are associated with greater weight gain and are also sensitive to changes in weight over time. Behavioral (e.g., physical activity) and physiological (e.g., inflammation) factors explain part of the association between personality and BMI. Finally, the broader social environment shapes the expression of personality in relation to body weight. This review highlights replicable associations between personality and BMI and potential mechanisms of this association. Future research needs to better address how specific aspects of the social and family environment moderate the relation between personality and BMI and take a lifespan perspective to better incorporate how traits contribute to weight starting in childhood.
Show less
Date Issued: 2017-01-01
Identifier: FSU_pmch_29249895, 10.2132/personality.26.1.1, PMC5730066, 29249895, 29249895
Format: Citation

Title: Breastfeeding and Adult Personality.
Creator: Sutin, Angelina R, Stephan, Yannick, Terracciano, Antonio
Abstract/Description: Five Factor Model (FFM) personality traits are implicated in long-term health-risk behaviors and outcomes. Less research has addressed how early-life experiences are associated with individual differences in these traits in adulthood. We examine whether having been breastfed is associated with adult personality and well-being in the National Longitudinal Study of Adolescent to Adult Health. At Wave 1, caregivers reported whether the target child had been breastfed. At Wave 4, participants (...
Show moreFive Factor Model (FFM) personality traits are implicated in long-term health-risk behaviors and outcomes. Less research has addressed how early-life experiences are associated with individual differences in these traits in adulthood. We examine whether having been breastfed is associated with adult personality and well-being in the National Longitudinal Study of Adolescent to Adult Health. At Wave 1, caregivers reported whether the target child had been breastfed. At Wave 4, participants (=13,113; 53% female; =28.98) completed measures of psychological functioning. We tested for mean-level differences in the traits by breastfeeding status (yes/no) and by the duration of breastfeeding, controlling for basic demographic factors and early-life factors that could confound the breastfeeding-personality association (e.g., mother education). Participants who had been breastfed scored lower in neuroticism, anxiety, and hostility and higher in openness and optimism than those not breastfed. A curvilinear relation suggested that neuroticism was lowest for those breastfed for 9-12 months and highest for those either breastfed for >24 months or exclusively bottle-fed. Breastfeeding was unrelated to conscientiousness or state psychological functioning. This research suggests long-term psychological benefits to breastfeeding and indicates that early life experiences are associated with traits that are consequential for adult health.
Show less
Date Issued: 2016-09-01
Identifier: FSU_pmch_28966441, 10.1002/per.2030, PMC5614468, 28966441, 28966441
Format: Citation

Title: Gender specific profiles of white coat and masked hypertension impacts on arterial structure and function in the SardiNIA study.
Creator: Scuteri, Angelo, Morrell, Christopher H, Orru', Marco, AlGhatrif, Majid, Saba, Pier Sergio, Terracciano, Antonio, Ferreli, Liana Anna Pina, Loi, Francesco, Marongiu, Michele,...
Show moreScuteri, Angelo, Morrell, Christopher H, Orru', Marco, AlGhatrif, Majid, Saba, Pier Sergio, Terracciano, Antonio, Ferreli, Liana Anna Pina, Loi, Francesco, Marongiu, Michele, Pilia, Maria Grazia, Delitala, Alessandro, Tarasov, Kirill V, Schlessinger, David, Ganau, Antonello, Cucca, Francesco, Lakatta, Edward G
Show less
Date Issued: 2016-08-15
Identifier: FSU_pmch_27179214, 10.1016/j.ijcard.2016.04.172, PMC5206901, 27179214, 27179214, S0167-5273(16)30875-0
Format: Citation

Title: The Five-Factor Model of Personality and Physical Inactivity: A Meta-Analysis of 16 Samples..
Creator: Sutin, Angelina R, Stephan, Yannick, Luchetti, Martina, Artese, Ashley, Oshio, Atsushi, Terracciano, Antonio
Abstract/Description: A sedentary lifestyle is harmful for health; personality traits may contribute to physical (in)activity. With participant-level data from 16 samples (>125,000), we examined the personality correlates of physical inactivity, frequency of physical activity, and sedentary behavior (in a subset of samples). Lower Neuroticism and higher Conscientiousness were associated with more physical activity and less inactivity and sedentary behavior. Extraversion and Openness were also associated with more...
Show moreA sedentary lifestyle is harmful for health; personality traits may contribute to physical (in)activity. With participant-level data from 16 samples (>125,000), we examined the personality correlates of physical inactivity, frequency of physical activity, and sedentary behavior (in a subset of samples). Lower Neuroticism and higher Conscientiousness were associated with more physical activity and less inactivity and sedentary behavior. Extraversion and Openness were also associated with more physical activity and less inactivity, but these traits were mostly unrelated to specific sedentary behaviors (e.g., TV watching). The results generally did not vary by age or sex. The findings support the notion that the interest, motivational, emotional, and interpersonal processes assessed by five-factor model traits partly shape the individual's engagement in physical activity.
Show less
Date Issued: 2016-08-01
Identifier: FSU_pmch_29056783, 10.1016/j.jrp.2016.05.001, PMC5650243, 29056783, 29056783
Format: Citation

Title: Personality and Cognitive Decline in Older Adults: Data From a Longitudinal Sample and Meta-Analysis..
Creator: Luchetti, Martina, Terracciano, Antonio, Stephan, Yannick, Sutin, Angelina R
Abstract/Description: Personality traits are associated with risk of dementia; less is known about their association with the trajectory of cognitive functioning. This research examines the association between the 5 major dimensions of personality and cognitive function and decline in older adulthood and includes a meta-analysis of published studies. Personality traits, objective and subjective memory, and cognitive status were collected in a large national sample (N = 13,987) with a 4-year follow-up period. For...
Show morePersonality traits are associated with risk of dementia; less is known about their association with the trajectory of cognitive functioning. This research examines the association between the 5 major dimensions of personality and cognitive function and decline in older adulthood and includes a meta-analysis of published studies. Personality traits, objective and subjective memory, and cognitive status were collected in a large national sample (N = 13,987) with a 4-year follow-up period. For each trait, the meta-analysis pooled results from up to 5 prospective studies to examine personality and change in global cognition. Higher Neuroticism was associated with worse performance on all cognitive measures and greater decline in memory, whereas higher Conscientiousness and Openness were associated with better memory performance concurrently and less decline over time. All traits were associated with subjective memory. Higher Conscientiousness and lower Extraversion were associated with better cognitive status and less decline. Although modest, these associations were generally larger than that of hypertension, diabetes, history of psychological treatment, obesity, smoking, and physical inactivity. The meta-analysis supported the association between Neuroticism and Conscientiousness and cognitive decline. Personality is associated with cognitive decline in older adults, with effects comparable to established clinical and lifestyle risk factors.
Show less
Date Issued: 2016-07-01
Identifier: FSU_pmch_25583598, 10.1093/geronb/gbu184, PMC4903032, 25583598, 25583598, gbu184
Format: Citation

Title: Genome-wide association study identifies 74 loci associated with educational attainment.
Creator: Okbay, Aysu, Beauchamp, Jonathan P, Fontana, Mark Alan, Lee, James J, Pers, Tune H, Rietveld, Cornelius A, Turley, Patrick, Chen, Guo-Bo, Emilsson, Valur, Meddens, S Fleur W,...
Show moreOkbay, Aysu, Beauchamp, Jonathan P, Fontana, Mark Alan, Lee, James J, Pers, Tune H, Rietveld, Cornelius A, Turley, Patrick, Chen, Guo-Bo, Emilsson, Valur, Meddens, S Fleur W, Oskarsson, Sven, Pickrell, Joseph K, Thom, Kevin, Timshel, Pascal, de Vlaming, Ronald, Abdellaoui, Abdel, Ahluwalia, Tarunveer S, Bacelis, Jonas, Baumbach, Clemens, Bjornsdottir, Gyda, Brandsma, Johannes H, Pina Concas, Maria, Derringer, Jaime, Furlotte, Nicholas A, Galesloot, Tessel E, Girotto, Giorgia, Gupta, Richa, Hall, Leanne M, Harris, Sarah E, Hofer, Edith, Horikoshi, Momoko, Huffman, Jennifer E, Kaasik, Kadri, Kalafati, Ioanna P, Karlsson, Robert, Kong, Augustine, Lahti, Jari, van der Lee, Sven J, deLeeuw, Christiaan, Lind, Penelope A, Lindgren, Karl-Oskar, Liu, Tian, Mangino, Massimo, Marten, Jonathan, Mihailov, Evelin, Miller, Michael B, van der Most, Peter J, Oldmeadow, Christopher, Payton, Antony, Pervjakova, Natalia, Peyrot, Wouter J, Qian, Yong, Raitakari, Olli, Rueedi, Rico, Salvi, Erika, Schmidt, Börge, Schraut, Katharina E, Shi, Jianxin, Smith, Albert V, Poot, Raymond A, St Pourcain, Beate, Teumer, Alexander, Thorleifsson, Gudmar, Verweij, Niek, Vuckovic, Dragana, Wellmann, Juergen, Westra, Harm-Jan, Yang, Jingyun, Zhao, Wei, Zhu, Zhihong, Alizadeh, Behrooz Z, Amin, Najaf, Bakshi, Andrew, Baumeister, Sebastian E, Biino, Ginevra, Bønnelykke, Klaus, Boyle, Patricia A, Campbell, Harry, Cappuccio, Francesco P, Davies, Gail, De Neve, Jan-Emmanuel, Deloukas, Panos, Demuth, Ilja, Ding, Jun, Eibich, Peter, Eisele, Lewin, Eklund, Niina, Evans, David M, Faul, Jessica D, Feitosa, Mary F, Forstner, Andreas J, Gandin, Ilaria, Gunnarsson, Bjarni, Halldórsson, Bjarni V, Harris, Tamara B, Heath, Andrew C, Hocking, Lynne J, Holliday, Elizabeth G, Homuth, Georg, Horan, Michael A, Hottenga, Jouke-Jan, de Jager, Philip L, Joshi, Peter K, Jugessur, Astanand, Kaakinen, Marika A, Kähönen, Mika, Kanoni, Stavroula, Keltigangas-Järvinen, Liisa, Kiemeney, Lambertus A L M, Kolcic, Ivana, Koskinen, Seppo, Kraja, Aldi T, Kroh, Martin, Kutalik, Zoltan, Latvala, Antti, Launer, Lenore J, Lebreton, Maël P, Levinson, Douglas F, Lichtenstein, Paul, Lichtner, Peter, Liewald, David C M, Loukola, Anu, Madden, Pamela A, Mägi, Reedik, Mäki-Opas, Tomi, Marioni, Riccardo E, Marques-Vidal, Pedro, Meddens, Gerardus A, McMahon, George, Meisinger, Christa, Meitinger, Thomas, Milaneschi, Yusplitri, Milani, Lili, Montgomery, Grant W, Myhre, Ronny, Nelson, Christopher P, Nyholt, Dale R, Ollier, William E R, Palotie, Aarno, Paternoster, Lavinia, Pedersen, Nancy L, Petrovic, Katja E, Porteous, David J, Räikkönen, Katri, Ring, Susan M, Robino, Antonietta, Rostapshova, Olga, Rudan, Igor, Rustichini, Aldo, Salomaa, Veikko, Sanders, Alan R, Sarin, Antti-Pekka, Schmidt, Helena, Scott, Rodney J, Smith, Blair H, Smith, Jennifer A, Staessen, Jan A, Steinhagen-Thiessen, Elisabeth, Strauch, Konstantin, Terracciano, Antonio, Tobin, Martin D, Ulivi, Sheila, Vaccargiu, Simona, Quaye, Lydia, van Rooij, Frank J A, Venturini, Cristina, Vinkhuyzen, Anna A E, Völker, Uwe, Völzke, Henry, Vonk, Judith M, Vozzi, Diego, Waage, Johannes, Ware, Erin B, Willemsen, Gonneke, Attia, John R, Bennett, David A, Berger, Klaus, Bertram, Lars, Bisgaard, Hans, Boomsma, Dorret I, Borecki, Ingrid B, Bültmann, Ute, Chabris, Christopher F, Cucca, Francesco, Cusi, Daniele, Deary, Ian J, Dedoussis, George V, van Duijn, Cornelia M, Eriksson, Johan G, Franke, Barbara, Franke, Lude, Gasparini, Paolo, Gejman, Pablo V, Gieger, Christian, Grabe, Hans-Jörgen, Gratten, Jacob, Groenen, Patrick J F, Gudnason, Vilmundur, van der Harst, Pim, Hayward, Caroline, Hinds, David A, Hoffmann, Wolfgang, Hyppönen, Elina, Iacono, William G, Jacobsson, Bo, Järvelin, Marjo-Riitta, Jöckel, Karl-Heinz, Kaprio, Jaakko, Kardia, Sharon L R, Lehtimäki, Terho, Lehrer, Steven F, Magnusson, Patrik K E, Martin, Nicholas G, McGue, Matt, Metspalu, Andres, Pendleton, Neil, Penninx, Brenda W J H, Perola, Markus, Pirastu, Nicola, Pirastu, Mario, Polasek, Ozren, Posthuma, Danielle, Power, Christine, Province, Michael A, Samani, Nilesh J, Schlessinger, David, Schmidt, Reinhold, Sørensen, Thorkild I A, Spector, Tim D, Stefansson, Kari, Thorsteinsdottir, Unnur, Thurik, A Roy, Timpson, Nicholas J, Tiemeier, Henning, Tung, Joyce Y, Uitterlinden, André G, Vitart, Veronique, Vollenweider, Peter, Weir, David R, Wilson, James F, Wright, Alan F, Conley, Dalton C, Krueger, Robert F, Davey Smith, George, Hofman, Albert, Laibson, David I, Medland, Sarah E, Meyer, Michelle N, Yang, Jian, Johannesson, Magnus, Visscher, Peter M, Esko, Tõnu, Koellinger, Philipp D, Cesarini, David, Benjamin, Daniel J
Show less
Abstract/Description: Educational attainment is strongly influenced by social and other environmental factors, but genetic factors are estimated to account for at least 20% of the variation across individuals. Here we report the results of a genome-wide association study (GWAS) for educational attainment that extends our earlier discovery sample of 101,069 individuals to 293,723 individuals, and a replication study in an independent sample of 111,349 individuals from the UK Biobank. We identify 74 genome-wide...
Show moreEducational attainment is strongly influenced by social and other environmental factors, but genetic factors are estimated to account for at least 20% of the variation across individuals. Here we report the results of a genome-wide association study (GWAS) for educational attainment that extends our earlier discovery sample of 101,069 individuals to 293,723 individuals, and a replication study in an independent sample of 111,349 individuals from the UK Biobank. We identify 74 genome-wide significant loci associated with the number of years of schooling completed. Single-nucleotide polymorphisms associated with educational attainment are disproportionately found in genomic regions regulating gene expression in the fetal brain. Candidate genes are preferentially expressed in neural tissue, especially during the prenatal period, and enriched for biological pathways involved in neural development. Our findings demonstrate that, even for a behavioural phenotype that is mostly environmentally determined, a well-powered GWAS identifies replicable associated genetic variants that suggest biologically relevant pathways. Because educational attainment is measured in large numbers of individuals, it will continue to be useful as a proxy phenotype in efforts to characterize the genetic influences of related phenotypes, including cognition and neuropsychiatric diseases.
Show less
Date Issued: 2016-05-26
Identifier: FSU_pmch_27225129, 10.1038/nature17671, PMC4883595, 27225129, 27225129, nature17671
Format: Citation

Title: New insight into fat, muscle and bone relationship in women: determining the threshold at which body fat assumes negative relationship with bone mineral density..
Creator: Liu, Pei-Yang, Ilich, Jasminka Z, Brummel-Smith, Ken, Ghosh, Sunita
Abstract/Description: The aim was to investigate the relationships among lean mass (LM), fat mass (FM), and bone mineral density (BMD) in women stratified by body mass index (BMI) (BMI - normal-weight, overweight, obese) and to determine threshold at which body fat assumes negative relationship with BMD. This was a cross-sectional study in 471 healthy Caucasian women, aged 18-67 years. BMD, LM, and FM were measured using dual-energy X-ray absorptiometry. Analysis of variance with Bonferroni corrections was used to...
Show moreThe aim was to investigate the relationships among lean mass (LM), fat mass (FM), and bone mineral density (BMD) in women stratified by body mass index (BMI) (BMI - normal-weight, overweight, obese) and to determine threshold at which body fat assumes negative relationship with BMD. This was a cross-sectional study in 471 healthy Caucasian women, aged 18-67 years. BMD, LM, and FM were measured using dual-energy X-ray absorptiometry. Analysis of variance with Bonferroni corrections was used to test the BMI group differences. Linear regression was used to examine independent contributions of LM and FM on BMD of various skeletal sites (controlling for age and height). In overweight/obese women PROC LOESS plots were used to determine the inflection points at which either LM or FM relationship with BMD changes direction. Separate analyses in pre- and post-menopausal women were conducted as well. Spine and femoral neck BMD were not different among three BMI groups while total body, femur and radius BMD were statistically different (the highest in the obese group). Linear regression revealed that LM had significant positive association with BMD of various skeletal sites in all groups. FM showed a negative association with BMD of femoral neck and femur in normal-weight and spine in overweight women, but a positive association with radius in obese women. Inflection points showed that body fat between 33% and 38% assumed negative relationship with BMD for most skeletal sites in overweight and obese women. Although LM has strong positive relationship with BMD, FM above 33% in overweight/obese women is negatively related to BMD of most skeletal sites. Therefore, overweight/obesity after certain amount of FM, may not be a protective factor against osteoporosis in females. For clinical practice in women, it is important to maintain LM and keep FM accrual below ~30% body fat to maintain good skeletal health.
Show less
Date Issued: 2014-11-01
Identifier: FSU_pmch_25538842, PMC4274553, 25538842, 25538842
Format: Citation

Title: GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment.
Creator: Rietveld, Cornelius, Medland, Sarah, Derringer, Jaime, Yang, Jian, Esko, Tönu, Martin, Nicolas, Westra, Harm-Jan, Shakhbazov, Konstantin, Abdellaoui, Abdel, Agrawal, Arpana,...
Show moreRietveld, Cornelius, Medland, Sarah, Derringer, Jaime, Yang, Jian, Esko, Tönu, Martin, Nicolas, Westra, Harm-Jan, Shakhbazov, Konstantin, Abdellaoui, Abdel, Agrawal, Arpana, Albrecht, Eva, Alizadeh, Behrooz, Amin, Najaf, Barnard, John, Baumeister, Sebastian, Benke, Kelly, Bielak, Lawrence, Boatman, Jeffrey A., Boyle, Patricia, Davies, Gail, de Leeuw, Christiaan, Eklund, Niina, Evans, Daniel, Ferhmann, Rudolf, Fischer, Krista, Gieger, Christian, Gjessing, Håkon K, Hägg, Sara, Harris, Jennifer, Hayward, Caroline, Holzapfel, Christina, Ibrahim-Verbaas, Carla, Ingelsson, Erik, Jacobsson, Bo, Joshi, Peter, Jugessur, Astanand, Kaakinen, Marika, Kanoni, Stavroula, Karjalainen, Juha, Kolcic, Ivana, Kristiansson, Kati, Kutalik, Zoltán, Lahti, Jari, Lee, Sang, Lin, Peng, Lind, Penelope, Liu, Yongmei, Lohman, Kurt, Loitfelder, Marisa, McMahon, George, Vidal, Pedro, Meirelles, Osorio, Milani, Lili, Myhre, Ronny, Nuotio, Marja-Liisa, Oldmeadow, Christopher, Petrovic, Katja, Peyrot, Wouter, Polasek, Ozren, Quaye, Lydia, Reinmaa, Eva, Rice, John, Rizzi, Thais, Schmidt, Helena, Schmidt, Reinhold, Smith, Albert, Smith, Jennifer, Tanaka, Toshiko, Terracciano, Antonio, van der Loos, Matthijs, Vitart, Veronique, Völzke, Henry, Wellmann, Jürgen, Yu, Lei, Zhao, Wei, Allik, Jüri, Attia, John, Bandinelli, Stefania, Bastardot, François, Beauchamp, Jonathan, Bennett, David, Berger, Klaus, Bierut, Laura, Boomsma, Dorret, Bültmann, Ute, Campbell, Harry, Chabris, Christopher, Cherkas, Lynn, Chung, Mina, Cucca, Francesco, de Andrade, Mariza, De Jager, Philip, De Neve, Jan-Emmanuel, Deary, Ian J., Dedoussis, George, Deloukas, Panos, Dimitriou, Maria, Eiríksdóttir, Guðny, Elderson, Martin, Eriksson, Johan, Evans, David, Faul, Jessica, Ferrucci, Luigi, Garcia, Melissa, Grönberg, Henrik, Guðnason, Vilmundur, Hall, Per, Harris, Juliette, Harris, Tamara, Hastie, Nicholas, Heath, Andrew, Hernandez, Dena, Hoffmann, Wolfgang, Hofman, Adriaan, Holle, Rolf, Holliday, Elizabeth, Hottenga, Jouke-Jan, Iacono, William, Illig, Thomas, Järvelin, Marjo-Riitta, Kähönen, Mika, Kaprio, Jaakko, Kirkpatrick, Robert, Kowgier, Matthew, Latvala, Antti, Launer, Lenore, Lawlor, Debbie, Lehtimäki, Terho, Li, Jingmei, Lichtenstein, Paul, Lichtner, Peter, Liewald, David, Madden, Pamela, Magnusson, Patrik, Mäkinen, Tomi, Masala, Marco, McGue, Matthew, Metspalu, Andres, Mielck, Andreas, Miller, Michael, Montgomery, Grant, Mukherjee, Sutapa, Nyholt, Dale, Oostra, Ben A., Palmer, Lyle, Palotie, Aarno, Penninx, Brenda, Perola, Markus, Peyser, Patricia, Preisig, Martin, Räikkönen, Katri, Raitakari, Olli, Realo, Anu, Ring, Susan, Ripatti, Samuli, Rivadeneira, Fernando, Rudan, Igor, Rustichini, Aldo, Salomaa, Veikko, Sarin, Antti-Pekka, Schlessinger, David, Scott, Rodney, Snieder, Harold, St Pourcain, Beate, Starr, John M., Sul, Jae, Surakka, Ida, Svento, Rauli, Teumer, Alexander, Tiemeier, Henning, van Rooij, Frank, Van Wagoner, David, Vartiainen, Erkki, Viikari, Jorma, Vollenweider, Peter, Vonk, Judith, Waeber, Gérard, Weir, David, Wichmann, H.-Erich (Heinz-Erich), Widen, Elisabeth, Willemsen, Gonneke, Wilson, James F. (James Flett), Wright, Alan, Conley, Dalton, Smith, George Davey, Franke, Lude, Groenen, Patrick, Hofman, Albert, Johannesson, Magnus, Kardia, Sharon, Krueger, Robert F., Laibson, David, Martin, Nicholas G., Meyer, Michelle, Posthuma, Danielle, Thurik, A. R. (A. Roy), Timpson, Nicholas, Uitterlinden, André G., van Duijn, Cornelia, Visscher, Peter, Benjamin, Daniel, Cesarini, David, Koellinger, Philipp
Show less
Abstract/Description: A genome-wide association study (GWAS) of educational attainment was conducted in a discovery sample of 101,069 individuals and a replication sample of 25,490. Three independent single-nucleotide polymorphisms (SNPs) are genome-wide significant (rs9320913, rs11584700, rs4851266), and all three replicate. Estimated effects sizes are small (coefficient of determination R(2) ≈ 0.02%), approximately 1 month of schooling per allele. A linear polygenic score from all measured SNPs accounts for ≈2%...
Show moreA genome-wide association study (GWAS) of educational attainment was conducted in a discovery sample of 101,069 individuals and a replication sample of 25,490. Three independent single-nucleotide polymorphisms (SNPs) are genome-wide significant (rs9320913, rs11584700, rs4851266), and all three replicate. Estimated effects sizes are small (coefficient of determination R(2) ≈ 0.02%), approximately 1 month of schooling per allele. A linear polygenic score from all measured SNPs accounts for ≈2% of the variance in both educational attainment and cognitive function. Genes in the region of the loci have previously been associated with health, cognitive, and central nervous system phenotypes, and bioinformatics analyses suggest the involvement of the anterior caudate nucleus. These findings provide promising candidate SNPs for follow-up work, and our effect size estimates can anchor power analyses in social-science genetics.
Show less
Date Issued: 2013
Identifier: FSU_migr_geriatrics_faculty_publications-0007, 10.1126/science.1235488
Format: Citation

Title: The Molecular Genetic Architecture of Self-Employment.
Creator: van der Loos, Matthijs, Rietveld, Cornelius, Eklund, Niina, Koellinger, Philipp, Rivadeneira, Fernando, Abecasis, Gonçalo, Ankra-Badu, Georgina, Baumeister, Sebastian, Benjamin,...
Show morevan der Loos, Matthijs, Rietveld, Cornelius, Eklund, Niina, Koellinger, Philipp, Rivadeneira, Fernando, Abecasis, Gonçalo, Ankra-Badu, Georgina, Baumeister, Sebastian, Benjamin, Daniel, Biffar, Reiner, Blankenberg, Stefan, Boomsma, Dorret, Cesarini, David, Cucca, Francesco, de Geus, Eco, Dedoussis, George, Deloukas, Panos, Dimitriou, Maria, Eiriksdottir, Guðny, Eriksson, Johan, Gieger, Christian, Gudnason, Vilmundur, Höhne, Birgit, Holle, Rolf, Hottenga, Jouke-Jan, Isaacs, Aaron, Järvelin, Marjo-Riitta, Johannesson, Magnus, Kaakinen, Marika, Kähönen, Mika, Kanoni, Stavroula, Laaksonen, Maarit, Lahti, Jari, Launer, Lenore, Lehtimäki, Terho, Loitfelder, Marisa, Magnusson, Patrik, Naitza, Silvia, Oostra, Ben A., Perola, Markus, Petrovic, Katja, Quaye, Lydia, Raitakari, Olli, Ripatti, Samuli, Scheet, Paul A. (Paul Anthony), Schlessinger, David, Schmidt, Carsten, Schmidt, Helena, Schmidt, Reinhold, Senft, Andrea, Smith, Albert, Spector, Timothy, Surakka, Ida, Svento, Rauli, Terracciano, Antonio, Tikkanen, Emmi, van Duijn, Cornelia, Viikari, Jorma, Völzke, Henry, Wichmann, H.-Erich (Heinz-Erich), Wild, Philipp, Willems, Sara, Willemsen, Gonneke, van Rooij, Frank, Groenen, Patrick, Uitterlinden, André G., Hofman, Albert, Thurik, A. R. (A. Roy)
Show less
Abstract/Description: Economic variables such as income, education, and occupation are known to affect mortality and morbidity, such as cardiovascular disease, and have also been shown to be partly heritable. However, very little is known about which genes influence economic variables, although these genes may have both a direct and an indirect effect on health. We report results from the first large-scale collaboration that studies the molecular genetic architecture of an economic variable–entrepreneurship–that...
Show moreEconomic variables such as income, education, and occupation are known to affect mortality and morbidity, such as cardiovascular disease, and have also been shown to be partly heritable. However, very little is known about which genes influence economic variables, although these genes may have both a direct and an indirect effect on health. We report results from the first large-scale collaboration that studies the molecular genetic architecture of an economic variable–entrepreneurship–that was operationalized using self-employment, a widely-available proxy. Our results suggest that common SNPs when considered jointly explain about half of the narrow-sense heritability of self-employment estimated in twin data (σg2/σP2 = 25%, h2 = 55%). However, a meta-analysis of genome-wide association studies across sixteen studies comprising 50,627 participants did not identify genome-wide significant SNPs. 58 SNPs with p<10−5 were tested in a replication sample (n = 3,271), but none replicated. Furthermore, a gene-based test shows that none of the genes that were previously suggested in the literature to influence entrepreneurship reveal significant associations. Finally, SNP-based genetic scores that use results from the meta-analysis capture less than 0.2% of the variance in self-employment in an independent sample (p≥0.039). Our results are consistent with a highly polygenic molecular genetic architecture of self-employment, with many genetic variants of small effect. Although self-employment is a multi-faceted, heavily environmentally influenced, and biologically distal trait, our results are similar to those for other genetically complex and biologically more proximate outcomes, such as height, intelligence, personality, and several diseases.
Show less
Date Issued: 2013
Identifier: FSU_migr_geriatrics_faculty_publications-0006, 10.1371/journal.pone.0060542
Format: Citation

Title: Five-Factor Personality Traits and Age Trajectories of Self-Rated Health: The Role of Question Framing.
Creator: Löckenhoff, Corinna, Terracciano, Antonio, Ferrucci, Luigi, Costa, Paul
Abstract/Description: We examined the influence of personality traits on mean levels and age trends in 4 single-item measures of self-rated health: general rating, comparison to age peers, comparison to past health, and expectations for future health. Community-dwelling participants (N = 1,683) completed 7,474 self-rated health assessments over a period of up to 19 years. In hierarchical linear modeling analyses, age-associated declines differed across the 4 health items. Across age groups, high Neuroticism and...
Show moreWe examined the influence of personality traits on mean levels and age trends in 4 single-item measures of self-rated health: general rating, comparison to age peers, comparison to past health, and expectations for future health. Community-dwelling participants (N = 1,683) completed 7,474 self-rated health assessments over a period of up to 19 years. In hierarchical linear modeling analyses, age-associated declines differed across the 4 health items. Across age groups, high Neuroticism and low Conscientiousness, low Extraversion, and low Openness were associated with worse health ratings, with notable differences across the 4 health items. Furthermore, high Neuroticism predicted steeper declines in health ratings involving temporal comparisons. We consider theoretical implications regarding the mechanisms behind associations among personality traits and self-rated health.
Show less
Date Issued: 2012
Identifier: FSU_migr_geriatrics_faculty_publications-0011, 10.1111/j.1467-6494.2011.00724.x
Format: Citation

Title: Longevity Candidate Genes and Their Association with Personality Traits in the Elderly.
Creator: Luciano, Michelle, Lopez, Lorna, de Moor, Marleen, Harris, Sarah, Davies, Gail, Nutile, Teresa, Krueger, Robert F., Esko, Tönu, Schlessinger, David, Toshiko, Tanaka, Derringer,...
Show moreLuciano, Michelle, Lopez, Lorna, de Moor, Marleen, Harris, Sarah, Davies, Gail, Nutile, Teresa, Krueger, Robert F., Esko, Tönu, Schlessinger, David, Toshiko, Tanaka, Derringer, Jaime, Realo, Anu, Hansell, Narelle, Pergadia, Michele, Pesonen, Anu-Katriina, Sanna, Serena, Terracciano, Antonio, Madden, Pamela, Penninx, Brenda, Spinhoven, Philip, Hartman, Catherina, Oostra, Ben A., Janssens, A., Eriksson, Johan, Starr, John M., Cannas, Alessandra, Ferrucci, Luigi, Metspalu, Andres, Wright, Margeret, Heath, Andrew, van Duijn, Cornelia, Bierut, Laura, Raikkonen, Katri, Martin, Nicholas G., Ciullo, Marina, Rujescu, Dan, Boomsma, Dorret, Deary, Ian J.
Show less
Abstract/Description: Human longevity and personality traits are both heritable and are consistently linked at the phenotypic level. We test the hypothesis that candidate genes influencing longevity in lower organisms are associated with variance in the five major dimensions of human personality (measured by the NEO-FFI and IPIP inventories) plus related mood states of anxiety and depression. Seventy single nucleotide polymorphisms (SNPs) in six brain expressed, longevity candidate genes (AFG3L2, FRAP1, MAT1A,...
Show moreHuman longevity and personality traits are both heritable and are consistently linked at the phenotypic level. We test the hypothesis that candidate genes influencing longevity in lower organisms are associated with variance in the five major dimensions of human personality (measured by the NEO-FFI and IPIP inventories) plus related mood states of anxiety and depression. Seventy single nucleotide polymorphisms (SNPs) in six brain expressed, longevity candidate genes (AFG3L2, FRAP1, MAT1A, MAT2A, SYNJ1, and SYNJ2) were typed in over 1,000 70-year old participants from the Lothian Birth Cohort of 1936 (LBC1936). No SNPs were associated with the personality and psychological distress traits at a Bonferroni corrected level of significance (P < 0.0002), but there was an over-representation of nominally significant (P < 0.05) SNPs in the synaptojanin-2 (SYNJ2) gene associated with agreeableness and symptoms of depression. Eight SNPs which showed nominally significant association across personality measurement instruments were tested in an extremely large replication sample of 17,106 participants. SNP rs350292, in SYNJ2, was significant: the minor allele was associated with an average decrease in NEO agreeableness scale scores of 0.25 points, and 0.67 points in the restricted analysis of elderly cohorts (most aged >60 years). Because we selected a specific set of longevity genes based on functional genomics findings, further research on other longevity gene candidates is warranted to discover whether they are relevant candidates for personality and psychological distress traits.
Show less
Date Issued: 2012
Identifier: FSU_migr_geriatrics_faculty_publications-0013, 10.1002/ajmg.b.32013
Format: Citation

Title: Increased Genetic Vulnerability to Smoking at CHRNA5 in Early-Onset Smokers.
Creator: Hartz, Sarah, Short, Susan, Saccone, Nancy, Culverhouse, Robert, Chen, LiShiun, Schwantes-An, Tae-Hwi, Coon, Hilary, Han, Younghun, Stephens, Sarah, Sun, Juzhong, Chen,...
Show moreHartz, Sarah, Short, Susan, Saccone, Nancy, Culverhouse, Robert, Chen, LiShiun, Schwantes-An, Tae-Hwi, Coon, Hilary, Han, Younghun, Stephens, Sarah, Sun, Juzhong, Chen, Xiangning, Ducci, Francesca, Dueker, Nicole, Franceschini, Nora, Frank, Josef, Geller, Frank, Gubjartsson, Daniel, Hansel, Nadia, Jiang, Chenhui, Keskitalo-Vuokko, Kaisu, Liu, Zhen, Lyytikäinen, Leo-Pekka, Michel, Martha, Rawal, Rajesh, Rosenberger, Albert, Scheet, Paul A. (Paul Anthony), Shaffer, John, Teumer, Alexander, Thompson, John, Vink, Jacqueline, Vogelzangs, Nicole, Wenzlaff, Angela, Wheeler, William, Xiao, Xiangjun, Yang, Bao-Zhu, Aggen, Steven, Balmforth, Anthony, Baumeister, Sebastian, Beaty, Terri H., Bennett, Siiri, Bergen, Andrew, Boyd, Heather, Broms, Ulla, Campbell, Harry, Chatterjee, Nilanjan, Chen, Jingchun, Cheng, Yu-Ching, Cichon, Sven, Couper, David, Cucca, Francesco, Dick, Danielle M. (Danielle Marie), Foroud, Tatiana, Furberg, Helena, Giegling, Ina, Gu, Fangyi, Hall, A. S. (Alistair Scott), Hällfors, Jenni, Han, Shizhong, Hartmann, Annette, Hayward, Caroline, Heikkilä, Kauko, Hewitt, John K., Hottenga, Jouke-Jan, Jensen, Majken, Jousilahti, Pekka, Kaakinen, Marika, Kittner, Steven, Konte, Bettina, Korhonen, Tellervo, Landi, Maria-Teresa, Laatikainen, Tiina, Leppert, Mark, Levy, Steven, Mathias, Rasika, McNeil, Daniel, Medland, Sarah, Montgomery, Grant, Muley, Thomas, Murray, Tanda, Nauck, Matthias, North, Kari, Pergadia, Michele, Polasek, Ozren, Ramos, Erin Michele, Ripatti, Samuli, Risch, Angela, Ruczinski, Ingo, Rudan, Igor, Salomaa, Veikko, Schlessinger, David, Styrkársdóttir, Unnur, Terracciano, Antonio, Uda, Manuela, Willemsen, Gonneke, Wu, Xifeng, Abecasis, Gonçalo, Barnes, Kathleen, Bickeböller, Heike, Boerwinkle, Eric, Boomsma, Dorret, Caporaso, Neil, Duan, Jubao, Edenberg, Howard, Francks, Clyde, Gejman, Pablo, Gelernter, Joel, Grabe, Hans, Hops, Hyman, Jarvelin, Marjo-Riitta, Viikari, Jorma, Kähönen, Mika, Kendler, Kenneth S., Lehtimäki, Terho, Levinson, Douglas, Marazita, Mary, Marchini, Jonathan, Melbye, Mads, Mitchell, Braxton, Murray, Jeffrey, Nöthen, Markus, Penninx, Brenda, Raitakari, Olli, Rietschel, Marcella, Rujescu, Dan, Samani, Nilesh J., Sanders, Alan, Schwartz, Ann, Shete, Sanjay, Shi, Jianxin, Spitz, Margaret R., Stefansson, Kari, Swan, Gary, Thorgeirsson, Thorgeir, Völzke, Henry, Wei, Qingyi, Wichmann, H.-Erich (Heinz-Erich), Amos, Christopher I., Breslau, Naomi, Cannon, Dale S., Ehringer, Marissa, Grucza, Richard, Hatsukami, Dorothy, Heath, Andrew, Johnson, Eric, Kaprio, Jaakko, Madden, Pamela, Martin, Nicholas G., Stevens, Victoria, Stitzel, Jerry, Weiss, Robert, Kraft, Peter, Bierut, Laura
Show less
Abstract/Description: CONTEXT: Recent studies have shown an association between cigarettes per day (CPD) and a nonsynonymous single-nucleotide polymorphism in CHRNA5, rs16969968. OBJECTIVE: To determine whether the association between rs16969968 and smoking is modified by age at onset of regular smoking. DATA SOURCES: Primary data. STUDY SELECTION: Available genetic studies containing measures of CPD and the genotype of rs16969968 or its proxy. DATA EXTRACTION: Uniform statistical analysis scripts were run locally...
Show moreCONTEXT: Recent studies have shown an association between cigarettes per day (CPD) and a nonsynonymous single-nucleotide polymorphism in CHRNA5, rs16969968. OBJECTIVE: To determine whether the association between rs16969968 and smoking is modified by age at onset of regular smoking. DATA SOURCES: Primary data. STUDY SELECTION: Available genetic studies containing measures of CPD and the genotype of rs16969968 or its proxy. DATA EXTRACTION: Uniform statistical analysis scripts were run locally. Starting with 94,050 ever-smokers from 43 studies, we extracted the heavy smokers (CPD >20) and light smokers (CPD ≤10) with age-at-onset information, reducing the sample size to 33,348. Each study was stratified into early-onset smokers (age at onset ≤16 years) and late-onset smokers (age at onset >16 years), and a logistic regression of heavy vs light smoking with the rs16969968 genotype was computed for each stratum. Meta-analysis was performed within each age-at-onset stratum. DATA SYNTHESIS: Individuals with 1 risk allele at rs16969968 who were early-onset smokers were significantly more likely to be heavy smokers in adulthood (odds ratio [OR] = 1.45; 95% CI, 1.36-1.55; n = 13,843) than were carriers of the risk allele who were late-onset smokers (OR = 1.27; 95% CI, 1.21-1.33, n = 19,505) (P = .01). CONCLUSION: These results highlight an increased genetic vulnerability to smoking in early-onset smokers.
Show less
Date Issued: 2012
Identifier: FSU_migr_geriatrics_faculty_publications-0040, 10.1001/archgenpsychiatry.2012.124
Format: Citation

Title: Meta-Analysis of Genome-Wide Association Studies for Personality.
Creator: de Moor, Marleen, Costa, Paul, Terracciano, Antonio, Krueger, Robert F., de Geus, Eco, Toshiko, Tanaka, Penninx, Brenda, Esko, Tönu, Madden, P., Derringer, Jaime, Amin, Najaf,...
Show morede Moor, Marleen, Costa, Paul, Terracciano, Antonio, Krueger, Robert F., de Geus, Eco, Toshiko, Tanaka, Penninx, Brenda, Esko, Tönu, Madden, P., Derringer, Jaime, Amin, Najaf, Willemsen, Gonneke, Hottenga, Jouke-Jan, Distel, M., Uda, Manuela, Sanna, Serena, Spinhoven, Philip, Hartman, Catherina, Sullivan, P., Realo, Anu, Allik, Jüri, Heath, Andrew, Pergadia, M., Agrawal, Arpana, Lin, P., Grucza, Richard, Nutile, Teresa, Ciullo, Marina, Rujescu, Dan, Giegling, Ina, Konte, Bettina, Widen, Elisabeth, Cousminer, D., Eriksson, Johan, Palotie, Aarno, Peltonen, L., Luciano, Michelle, Tenesa, A., Davies, Gail, Lopez, Lorna, Hansell, Narelle, Medland, Sarah, Ferrucci, Luigi, Schlessinger, David, Montgomery, G., Wright, Margeret, Aulchenko, Y., Janssens, A., Oostra, Ben A., Metspalu, Andres, Abecasis, Gonçalo, Deary, Ian J., Räikkönen, K., Bierut, Laura, Martin, Nicholas G., van Duijn, Cornelia, Boomsma, Dorret
Show less
Abstract/Description: Personality can be thought of as a set of characteristics that influence people's thoughts, feelings and behavior across a variety of settings. Variation in personality is predictive of many outcomes in life, including mental health. Here we report on a meta-analysis of genome-wide association (GWA) data for personality in 10 discovery samples (17,375 adults) and five in silico replication samples (3294 adults). All participants were of European ancestry. Personality scores for Neuroticism,...
Show morePersonality can be thought of as a set of characteristics that influence people's thoughts, feelings and behavior across a variety of settings. Variation in personality is predictive of many outcomes in life, including mental health. Here we report on a meta-analysis of genome-wide association (GWA) data for personality in 10 discovery samples (17,375 adults) and five in silico replication samples (3294 adults). All participants were of European ancestry. Personality scores for Neuroticism, Extraversion, Openness to Experience, Agreeableness and Conscientiousness were based on the NEO Five-Factor Inventory. Genotype data of ≈ 2.4M single-nucleotide polymorphisms (SNPs; directly typed and imputed using HapMap data) were available. In the discovery samples, classical association analyses were performed under an additive model followed by meta-analysis using the weighted inverse variance method. Results showed genome-wide significance for Openness to Experience near the RASA1 gene on 5q14.3 (rs1477268 and rs2032794, P=2.8 × 10(-8) and 3.1 × 10(-8)) and for Conscientiousness in the brain-expressed KATNAL2 gene on 18q21.1 (rs2576037, P=4.9 × 10(-8)). We further conducted a gene-based test that confirmed the association of KATNAL2 to Conscientiousness. In silico replication did not, however, show significant associations of the top SNPs with Openness and Conscientiousness, although the direction of effect of the KATNAL2 SNP on Conscientiousness was consistent in all replication samples. Larger scale GWA studies and alternative approaches are required for confirmation of KATNAL2 as a novel gene affecting Conscientiousness.
Show less
Date Issued: 2012
Identifier: FSU_migr_geriatrics_faculty_publications-0010, 10.1038/mp.2010.128
Format: Citation

Title: Personality Typology in Relation to Muscle Strength.
Creator: Tolea, Magdalena, Terracciano, Antonio, Milaneschi, Yuri, Metter, E. Jeffrey, Ferrucci, Luigi
Abstract/Description: BACKGROUND: Physical inactivity plays a central role in the age-related decline in muscle strength, an important component in the process leading to disability. Personality, a significant determinant of health behaviors including physical activity, could therefore impact muscle strength throughout adulthood and affect the rate of muscle strength decline with aging. Personality typologies combining "high neuroticism" (N ≥ 55), "low extraversion" (E
Show moreBACKGROUND: Physical inactivity plays a central role in the age-related decline in muscle strength, an important component in the process leading to disability. Personality, a significant determinant of health behaviors including physical activity, could therefore impact muscle strength throughout adulthood and affect the rate of muscle strength decline with aging. Personality typologies combining "high neuroticism" (N ≥ 55), "low extraversion" (E < 45), and "low conscientiousness" (C < 45) have been associated with multiple risky health behaviors but have not been investigated with regards to muscle strength. PURPOSE: The purpose of this study is to investigate associations between individual and combined typologies consisting of high N, low E, and low C and muscle strength, and whether physical activity and body mass index act as mediators. METHOD: This cross-sectional study includes 1,220 participants from the Baltimore Longitudinal Study of Aging. RESULTS: High N was found among 18%, low E among 31%, and low C among 26% of the sample. High levels of N, particularly when combined with either low E or low C, were associated with lower muscle strength compared with having only one or none of these personality types. Facet analyses suggest an important role for the N components of depression and hostility. Physical activity level appears to partly explain some of these associations. CONCLUSION: Findings provide support for the notion that the typological approach to personality may be useful in identifying specific personality types at risk of low muscle strength and offer the possibility for more targeted prevention and intervention programs.
Show less
Date Issued: 2012
Identifier: FSU_migr_geriatrics_faculty_publications-0008, 10.1007/s12529-011-9166-5
Format: Citation

Title: Associations Between Personality Traits, Physical Activity Level, and Muscle Strength.
Creator: Tolea, Magdalena, Terracciano, Antonio, Simonsick, Eleanor M., Metter, E. Jeffrey, Costa, Paul, Ferrucci, Luigi
Abstract/Description: Associations among personality as measured by the Five Factor Model, physical activity, and muscle strength were assessed using data from the Baltimore Longitudinal Study of Aging (N = 1220, age: mean = 58, SD = 16). General linear modeling with adjustment for age, sex, race, and body mass index, and bootstrapping for mediation were used. We found neuroticism and most of its facets to negatively correlate with strength. The extraversion domain and its facets of warmth, activity, and positive...
Show moreAssociations among personality as measured by the Five Factor Model, physical activity, and muscle strength were assessed using data from the Baltimore Longitudinal Study of Aging (N = 1220, age: mean = 58, SD = 16). General linear modeling with adjustment for age, sex, race, and body mass index, and bootstrapping for mediation were used. We found neuroticism and most of its facets to negatively correlate with strength. The extraversion domain and its facets of warmth, activity, and positive-emotions were positively correlated with strength, independent of covariates. Mediation analysis results suggest that these associations are partly explained by physical activity level. Findings extend the evidence of an association between personality and physical function to its strength component and indicate health behavior as an important pathway.
Show less
Date Issued: 2012
Identifier: FSU_migr_geriatrics_faculty_publications-0009, 10.1016/j.jrp.2012.02.002
Format: Citation

Title: Aerobic Exercise and Whole-Body Vibration in Offsetting Bone Loss in Older Adults.
Creator: Liu, Pei-Yang, Brummel-Smith, Kenneth, Ilich, Jasminka
Abstract/Description: Osteoporosis and its associated fractures are common complications of aging and most strategies to prevent and/or treat bone loss focused on antiresorptive medications. However, aerobic exercise (AEX) and/or whole-body vibration (WBV) might have beneficial effect on bone mass and provide an alternative approach to increase or maintain bone mineral density (BMD) and reduce the risk of fractures. The purpose of this paper was to investigate the potential benefits of AEX and WBV on BMD in older...
Show moreOsteoporosis and its associated fractures are common complications of aging and most strategies to prevent and/or treat bone loss focused on antiresorptive medications. However, aerobic exercise (AEX) and/or whole-body vibration (WBV) might have beneficial effect on bone mass and provide an alternative approach to increase or maintain bone mineral density (BMD) and reduce the risk of fractures. The purpose of this paper was to investigate the potential benefits of AEX and WBV on BMD in older population and discuss the possible mechanisms of action. Several online databases were utilized and based on the available literature the consensus is that both AEX and WBV may increase spine and femoral BMD in older adults. Therefore, AEX and WBV could serve as nonpharmacological and complementary approaches to increasing/maintaining BMD. However, it is uncertain if noted effects could be permanent and further studies are needed to investigate sustainability of either type of the exercise.
Show less
Date Issued: 2011
Identifier: FSU_migr_geriatrics_faculty_publications-0042, 10.4061/2011/379674
Format: Citation

Title: Rater Wealth Predicts Perceptions of Outgroup Competence.
Creator: Chan, Wayne, McCrae, Robert R., Rogers, Darrin, Weimer, Amy, Greenberg, David, Terracciano, Antonio
Abstract/Description: National income has a pervasive influence on the perception of ingroup stereotypes, with high status and wealthy targets perceived as more competent. In two studies we investigated the degree to which economic wealth of raters related to perceptions of outgroup competence. Raters' economic wealth predicted trait ratings when 1) raters in 48 other cultures rated Americans' competence and 2) Mexican Americans rated Anglo Americans' competence. Rater wealth also predicted ratings of...
Show moreNational income has a pervasive influence on the perception of ingroup stereotypes, with high status and wealthy targets perceived as more competent. In two studies we investigated the degree to which economic wealth of raters related to perceptions of outgroup competence. Raters' economic wealth predicted trait ratings when 1) raters in 48 other cultures rated Americans' competence and 2) Mexican Americans rated Anglo Americans' competence. Rater wealth also predicted ratings of interpersonal warmth on the culture level. In conclusion, raters' economic wealth, either nationally or individually, is significantly associated with perception of outgroup members, supporting the notion that ingroup conditions or stereotypes function as frames of reference in evaluating outgroup traits.
Show less
Date Issued: 2011
Identifier: FSU_migr_geriatrics_faculty_publications-0012, 10.1016/j.jrp.2011.08.001
Format: Citation

Title: Comparative Effects of Dried Plum and Dried Apple On Bone In Postmenopausal Women.
Creator: Hooshmand, Shirin, Chai, Sheau Ching, Saadat, Raz, Payton, Mark, Brummel-Smith, Kenneth, Arjmandi, Bahram
Abstract/Description: Aside from existing drug therapies, certain lifestyle and nutritional factors are known to reduce the risk of osteoporosis. Among the nutritional factors, dried plum or prunes (Prunus domestica L.) is the most effective fruit in both preventing and reversing bone loss. The objective of the present study was to examine the extent to which dried plum reverses bone loss in osteopenic postmenopausal women. We recruited 236 women, 1-10 years postmenopausal, not on hormone replacement therapy or...
Show moreAside from existing drug therapies, certain lifestyle and nutritional factors are known to reduce the risk of osteoporosis. Among the nutritional factors, dried plum or prunes (Prunus domestica L.) is the most effective fruit in both preventing and reversing bone loss. The objective of the present study was to examine the extent to which dried plum reverses bone loss in osteopenic postmenopausal women. We recruited 236 women, 1-10 years postmenopausal, not on hormone replacement therapy or any other prescribed medication known to influence bone metabolism. Qualified participants (n 160) were randomly assigned to one of the two treatment groups: dried plum (100 g/d) or dried apple (comparative control). Participants received 500 mg Ca plus 400 IU (10 μg) vitamin D daily. Bone mineral density (BMD) of lumbar spine, forearm, hip and whole body was assessed at baseline and at the end of the study using dual-energy X-ray absorptiometry. Blood samples were collected at baseline, 3, 6 and 12 months to assess bone biomarkers. Physical activity recall and 1-week FFQ were obtained at baseline, 3, 6 and 12 months to examine physical activity and dietary confounders as potential covariates. Dried plum significantly increased BMD of ulna and spine in comparison with dried apple. In comparison with corresponding baseline values, only dried plum significantly decreased serum levels of bone turnover markers including bone-specific alkaline phosphatase and tartrate-resistant acid phosphatase-5b. The findings of the present study confirmed the ability of dried plum in improving BMD in postmenopausal women in part due to suppressing the rate of bone turnover.
Show less
Date Issued: 2011
Identifier: FSU_migr_geriatrics_faculty_publications-0043, 10.1017/S000711451100119X
Format: Citation

Title: Rater Wealth Predicts Perceptions of Outgroup Competence.
Creator: Chan, Wayne, McCrae, Robert R., Rogers, Darrin, Weimer, Amy, Greenberg, David, Terracciano, Antonio
Abstract/Description: National income has a pervasive influence on the perception of ingroup stereotypes, with high status and wealthy targets perceived as more competent. In two studies we investigated the degree to which economic wealth of raters related to perceptions of outgroup competence. Raters' economic wealth predicted trait ratings when 1) raters in 48 other cultures rated Americans' competence and 2) Mexican Americans rated Anglo Americans' competence. Rater wealth also predicted ratings of...
Show moreNational income has a pervasive influence on the perception of ingroup stereotypes, with high status and wealthy targets perceived as more competent. In two studies we investigated the degree to which economic wealth of raters related to perceptions of outgroup competence. Raters' economic wealth predicted trait ratings when 1) raters in 48 other cultures rated Americans' competence and 2) Mexican Americans rated Anglo Americans' competence. Rater wealth also predicted ratings of interpersonal warmth on the culture level. In conclusion, raters' economic wealth, either nationally or individually, is significantly associated with perception of outgroup members, supporting the notion that ingroup conditions or stereotypes function as frames of reference in evaluating outgroup traits.
Show less
Date Issued: 2011
Identifier: FSU_migr_geriatrics_faculty_publications-0012, 10.1016/j.jrp.2011.08.001
Format: Citation

Title: An Alternative to the Search for Single Polymorphisms: Toward Molecular Personality Scales for the Five-Factor Model.
Creator: McCrae, Robert R., Scally, Matthew, Terracciano, Antonio, Abecasis, Gonçalo, Costa, Paul
Abstract/Description: There is growing evidence that personality traits are affected by many genes, all of which have very small effects. As an alternative to the largely unsuccessful search for individual polymorphisms associated with personality traits, the authors identified large sets of potentially related single nucleotide polymorphisms (SNPs) and summed them to form molecular personality scales (MPSs) with from 4 to 2,497 SNPs. Scales were derived from two thirds of a large (N = 3,972) sample of individuals...
Show moreThere is growing evidence that personality traits are affected by many genes, all of which have very small effects. As an alternative to the largely unsuccessful search for individual polymorphisms associated with personality traits, the authors identified large sets of potentially related single nucleotide polymorphisms (SNPs) and summed them to form molecular personality scales (MPSs) with from 4 to 2,497 SNPs. Scales were derived from two thirds of a large (N = 3,972) sample of individuals from Sardinia who completed the Revised NEO Personality Inventory (P. T. Costa, Jr., & R. R. McCrae, 1992) and were assessed in a genomewide association scan. When MPSs were correlated with the phenotype in the remaining one third of the sample, very small but significant associations were found for 4 of the 5e personality factors when the longest scales were examined. These data suggest that MPSs for Neuroticism, Openness to Experience, Agreeableness, and Conscientiousness (but not Extraversion) contain genetic information that can be refined in future studies, and the procedures described here should be applicable to other quantitative traits.
Show less
Date Issued: 2010
Identifier: FSU_migr_geriatrics_faculty_publications-0015, 10.1037/a0020964
Format: Citation

Title: Intra-Individual Change in Personality Stability and Age.
Creator: Terracciano, Antonio, McCrae, Robert R., Costa, Paul
Abstract/Description: The stability of individual differences in personality traits is typically examined at the group level with test-retest correlations across two assessments. For 684 subjects (age range 17-76) we computed individual coefficients from three sequential assessments to evaluate intra-individual (i.e., within-person) change in stability over time. For both trait and profile (ipsative) stability, results indicate that intra-individual stability increases up to age 30 and then plateaus. Neither...
Show moreThe stability of individual differences in personality traits is typically examined at the group level with test-retest correlations across two assessments. For 684 subjects (age range 17-76) we computed individual coefficients from three sequential assessments to evaluate intra-individual (i.e., within-person) change in stability over time. For both trait and profile (ipsative) stability, results indicate that intra-individual stability increases up to age 30 and then plateaus. Neither demographic variables (sex, ethnicity, education, and secular trends), nor the standing on the five major dimensions of personality, were predictors of change in trait stability. Contrary to results from studies of adolescents, personality "maturity" was unrelated to personality stability in adulthood. These findings support the notion that personality stability plateaus early in adulthood.
Show less
Date Issued: 2010
Identifier: FSU_migr_geriatrics_faculty_publications-0019, 10.1016/j.jrp.2009.09.006
Format: Citation

Title: Health Literacy as a Tool to Improve the Public Understanding of Alzheimer's Disease.
Creator: Kobylarz, Fred, Pomidor, Alice, Pleasant, Andrew F.
Abstract/Description: The ultimate goal of health literacy is to improve care by enhancing the patient's quality of life, maximizing clinical outcomes, and reducing inequities in health. Successful restructuring of the healthcare system to make it more effective, efficient, and equitable demands that health literacy be integrated as a key source of theoretical and empirical data regarding patients' needs and wishes. This applies across the life course, but it is especially true for the increasing numbers of older...
Show moreThe ultimate goal of health literacy is to improve care by enhancing the patient's quality of life, maximizing clinical outcomes, and reducing inequities in health. Successful restructuring of the healthcare system to make it more effective, efficient, and equitable demands that health literacy be integrated as a key source of theoretical and empirical data regarding patients' needs and wishes. This applies across the life course, but it is especially true for the increasing numbers of older adults who must deal with the medical care system the most, yet often comprehend medical information the least. Nearly nine out of ten people in the United States do not have the level of proficiency in health literacy skills necessary to successfully navigate the healthcare system. According to the National Assessment of Adult Literacy (NAAL), populations overrepresented at the lowest levels of health literacy (below basic level) in the United States include people over age 65, those who did not graduate from high school, persons who did not speak English before starting school, people who have poor health status, those who are of racial and ethnic minority groups, and individuals without medical insurance. An increasing number of efforts are ongoing across the United States and internationally to address health literacy. Significant national initiatives include Healthy People 2010, the Joint Commission's report "Improving Health Literacy to Protect Patient Safety," and the U.S. Department of Heath and Human Services Office of the Surgeon General's "Workshop on Improving Health Literacy." Other organizations attempting to address health literacy include the American Medical Association and the Partnership for Clear Health Communication. Many organizations are launching successful health literacy–based interventions such as the Canyon Ranch Institute's Life Enhancement Program, an integrated approach to prevention and wellness. Additionally, there are a growing number of curricula addressing health literacy being developed by a wide range of organizations and individuals. Equally significant efforts are ongoing in a number of countries around the world, particularly Canada, Australia, and Switzerland. The purposes of this article are to familiarize readers with the concept of health literacy; demonstrate how health literacy can serve as a tool to improve the public's understanding of Alzheimer's disease (AD), the seventh leading cause of death; and suggest generally applicable strategies for clinicians.
Show less
Date Issued: 2010
Identifier: FSU_migr_geriatrics_faculty_publications-0041
Format: Citation

Title: Meta-Analysis and Imputation Refines the Association of 15q25 with Smoking Quantity.
Creator: Liu, Jason, Tozzi, Federica, Waterworth, Dawn, Pillai, Sreekumar, Muglia, Pierandrea, Middleton, Lefkos, Berrettini, Wade, Knouff, Christopher, Yuan, Xin, Waeber, Gérard,...
Show moreLiu, Jason, Tozzi, Federica, Waterworth, Dawn, Pillai, Sreekumar, Muglia, Pierandrea, Middleton, Lefkos, Berrettini, Wade, Knouff, Christopher, Yuan, Xin, Waeber, Gérard, Vollenweider, Peter, Preisig, Martin, Wareham, Nicholas, Zhao, Jing, Loos, Ruth, Barroso, Inês, Khaw, Kay-Tee, Grundy, Scott M., Barter, Philip, Mahley, Robert, Kesaniemi, Antero, McPherson, Ruth, Vincent, John, Strauss, John, Kennedy, James, Farmer, Anne, McGuffin, Peter, Day, Richard, Matthews, Keith, Bakke, Per, Gulsvik, A. (Amund), Lucae, Susanne, Ising, Marcus, Brueckl, Tanja, Horstmann, Sonja, Wichmann, H.-Erich (Heinz-Erich), Rawal, Rajesh, Dahmen, Norbert, Lamina, Claudia, Polasek, Ozren, Zgaga, Lina, Huffman, Jennifer, Campbell, Susan, Kooner, Jaspal, Chambers, John, Burnett, Mary, Devaney, Joseph, Pichard, Augusto, Kent, Kenneth, Satler, Lowell, Lindsay, Joseph, Waksman, Ron, Epstein, Stephen, Wilson, James F. (James Flett), Wild, Sarah, Campbell, Harry, Vitart, Veronique, Reilly, Muredach, Li, Mingyao, Qu, Liming, Wilensky, Robert, Matthai, William, Hakonarson, Hakon, Rader, Daniel, Franke, Andre, Wittig, Michael, Schäfer, Arne, Uda, Manuela, Terracciano, Antonio, Xiao, Xiangjun, Busonero, Fabio, Scheet, Paul A. (Paul Anthony), Schlessinger, David, St Clair, David, Rujescu, Dan, Abecasis, Gonçalo, Grabe, Hans, Teumer, Alexander, Völzke, Henry, Petersmann, Astrid, John, Ulrich, Rudan, Igor, Hayward, Caroline, Wright, Alan, Kolcic, Ivana, Wright, Benjamin, Thompson, John, Balmforth, Anthony, Hall, A. S. (Alistair Scott), Samani, Nilesh J., Anderson, Carl, Ahmad, Tariq, Mathew, Christopher, Parkes, Miles, Satsangi, Jack, Caulfield, Mark, Munroe, Patricia, Farrall, Martin, Dominiczak, A. F., Worthington, Jane, Thomson, Wendy, Eyre, Steve, Barton, Anne, Mooser, Vincent, Francks, Clyde, Marchini, Jonathan
Show less
Abstract/Description: Smoking is a leading global cause of disease and mortality. We established the Oxford-GlaxoSmithKline study (Ox-GSK) to perform a genome-wide meta-analysis of SNP association with smoking-related behavioral traits. Our final data set included 41,150 individuals drawn from 20 disease, population and control cohorts. Our analysis confirmed an effect on smoking quantity at a locus on 15q25 (P = 9.45 x 10(-19)) that includes CHRNA5, CHRNA3 and CHRNB4, three genes encoding neuronal nicotinic...
Show moreSmoking is a leading global cause of disease and mortality. We established the Oxford-GlaxoSmithKline study (Ox-GSK) to perform a genome-wide meta-analysis of SNP association with smoking-related behavioral traits. Our final data set included 41,150 individuals drawn from 20 disease, population and control cohorts. Our analysis confirmed an effect on smoking quantity at a locus on 15q25 (P = 9.45 x 10(-19)) that includes CHRNA5, CHRNA3 and CHRNB4, three genes encoding neuronal nicotinic acetylcholine receptor subunits. We used data from the 1000 Genomes project to investigate the region using imputation, which allowed for analysis of virtually all common SNPs in the region and offered a fivefold increase in marker density over HapMap2 (ref. 2) as an imputation reference panel. Our fine-mapping approach identified a SNP showing the highest significance, rs55853698, located within the promoter region of CHRNA5. Conditional analysis also identified a secondary locus (rs6495308) in CHRNA3.
Show less
Date Issued: 2010
Identifier: FSU_migr_geriatrics_faculty_publications-0018, 10.1038/ng.572
Format: Citation

Title: Plasma BDNF Concentration, Val66Met Genetic Variant and Depression-Related Personality Traits.
Creator: Terracciano, Antonio, Martin, B., Ansari, D., Tanaka, Toshiko, Ferrucci, Luigi, Maudsley, S., Mattson, M., Costa, Paul
Abstract/Description: Brain-derived neurotrophic factor (BDNF) regulates synaptic plasticity and neurogenesis, and BDNF plasma and serum levels have been associated with depression, Alzheimer's disease, and other psychiatric and neurodegenerative disorders. In a relatively large community sample, drawn from the Baltimore Longitudinal Study of Aging (BLSA), we examine whether BDNF plasma concentration is associated with the Val66Met functional polymorphism of the BDNF gene (n = 335) and with depression-related...
Show moreBrain-derived neurotrophic factor (BDNF) regulates synaptic plasticity and neurogenesis, and BDNF plasma and serum levels have been associated with depression, Alzheimer's disease, and other psychiatric and neurodegenerative disorders. In a relatively large community sample, drawn from the Baltimore Longitudinal Study of Aging (BLSA), we examine whether BDNF plasma concentration is associated with the Val66Met functional polymorphism of the BDNF gene (n = 335) and with depression-related personality traits assessed with the NEO-PI-R (n = 391). Plasma concentration of BDNF was not associated with the Val66Met variant in either men or women. However, in men, but not in women, BDNF plasma level was associated with personality traits linked to depression. Contrary to the notion that low BDNF is associated with negative outcomes, we found lower plasma levels in men who score lower on depression and vulnerability to stress (two facets of Neuroticism) and higher on Conscientiousness and Extraversion. These findings challenge the prevailing hypothesis that lower peripheral levels of BDNF are a marker of depression.
Show less
Date Issued: 2010
Identifier: FSU_migr_geriatrics_faculty_publications-0016, 10.1111/j.1601-183X.2010.00579.x
Format: Citation

Title: Sex-Specific Correlates of Walking Speed in a Wide Age-Ranged Population.
Creator: Tolea, Magdalena, Costa, Paul, Terracciano, Antonio, Griswold, Michael, Simonsick, Eleanor M., Najjar, Samer, Scuteri, Angelo, Deiana, Barbara, Orrù, Marco, Masala, Marco, Uda,...
Show moreTolea, Magdalena, Costa, Paul, Terracciano, Antonio, Griswold, Michael, Simonsick, Eleanor M., Najjar, Samer, Scuteri, Angelo, Deiana, Barbara, Orrù, Marco, Masala, Marco, Uda, Manuela, Schlessinger, David, Ferrucci, Luigi
Show less
Abstract/Description: The goals of this cross-sectional study were to explore correlates of walking speed in a large wide age-ranged population and to identify factors affecting lower walking speed at older ages. Participants were 3,872 community-dwelling adults in the first follow-up of the SardiNIA study who completed a 4-m walking test. Sex-specific correlates of walking speed included marital status, height, waist circumference, pulse wave velocity, comorbidity, subjective health, strength, and personality....
Show moreThe goals of this cross-sectional study were to explore correlates of walking speed in a large wide age-ranged population and to identify factors affecting lower walking speed at older ages. Participants were 3,872 community-dwelling adults in the first follow-up of the SardiNIA study who completed a 4-m walking test. Sex-specific correlates of walking speed included marital status, height, waist circumference, pulse wave velocity, comorbidity, subjective health, strength, and personality. Effect modifiers of the age-walking speed association included extraversion (<55 >years, p = .019) and education (<55 >years, p = .021; > or =55 years, p = .012) in women, and openness (<55 >years, p = .005), waist circumference (<55 >years, p = .010), and subjective health (<55 >years, p = .014) in men. The strong impact of personality suggests that certain personality traits may be associated with behaviors that affect physical performance and condition the reduced mobility mostly at younger ages. If these patterns are confirmed in longitudinal studies, personality may be an important target for prevention.
Show less
Date Issued: 2010
Identifier: FSU_migr_geriatrics_faculty_publications-0020, 10.1093/geronb/gbp130
Format: Citation

Department of Behavioral Sciences and Social Medicine (21)	+ -
Department of Nutrition, Food and Exercise Sciences (2)	+ -

Medical sciences (38)	+ -
Personality (31)	+ -
Psychology (31)	+ -
Social aspects (28)	+ -
Psychiatry (27)	+ -

Human behavior (22)	+ -
Social sciences (17)	+ -
Humans (15)	+ -
Female (14)	+ -
Male (14)	+ -
Mental health (12)	+ -
Aged (10)	+ -
Genetics (10)	+ -
Genomics (10)	+ -
Geriatrics (10)	+ -
Behavior (9)	+ -
Longitudinal Studies (9)	+ -
Aged, 80 and over (8)	+ -
Sociology (8)	+ -
Middle Aged (7)	+ -
Social psychiatry (7)	+ -
Adult (6)	+ -
Ethnology (6)	+ -
Adolescent (4)	+ -
Aging/psychology (4)	+ -
Culture (4)	+ -
Diagnosis, Laboratory (4)	+ -
Drug addiction (4)	+ -
Equipment and supplies (4)	+ -
Ethnicity (4)	+ -

text (70)	+ -
journal article (32)	+ -

Terracciano, Antonio (59)	+ -
Costa, Paul (22)	+ -
Sutin, Angelina R (20)	+ -
McCrae, Robert R. (16)	+ -
Stephan, Yannick (15)	+ -

Search In

Pages

Pages

Sort Results By:

Narrow results by:

Collection

Topical Subject

Genre

Type of Resource

Language

Creator

Found In

Owner