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Fine-sampled Photographic Quantitation of Dermal Wound Healing Senescence in Aged BALB/cByJ Mice and Therapeutic Intervention with FGF-1
Title
Fine-sampled Photographic Quantitation of Dermal Wound Healing Senescence in Aged BALB/cByJ Mice and Therapeutic Intervention with FGF-1: Novel photographic quantitation of dermal healing.
Creator
Mellers, Alana, Tenorio, Connie, Lacatusu, Diana, Powell, Brett, Patel, Bhavi, Harper, Kathleen, Blaber, Michael
Abstract/Description
Objective: Determine quantitative parameters of dermal wound healing senescence in aged BALB/cByJ mice (an important animal model of aging) and evaluate the potential for therapeutic intervention by fibroblast growth factor-1 (FGF-1). Approach: Utilize a novel, non-invasive, fine-sampled photographic methodology to quantify wound healing parameters for healing phases from wounding through to wound closure. Results: Parameters associated with key healing phases were quantified and compared for...
Show moreObjective: Determine quantitative parameters of dermal wound healing senescence in aged BALB/cByJ mice (an important animal model of aging) and evaluate the potential for therapeutic intervention by fibroblast growth factor-1 (FGF-1). Approach: Utilize a novel, non-invasive, fine-sampled photographic methodology to quantify wound healing parameters for healing phases from wounding through to wound closure. Results: Parameters associated with key healing phases were quantified and compared for non-aged and aged cohorts of both sexes. The results identify a sexual dimorphism in dermal wound healing, with non-aged females exhibiting a greater overall healing efficiency compared to males. This enhanced healing in females, however, senesces with age such that healing parameters for aged males and females are statistically indistinguishable. Topical application of FGF-1 was identified as an effective therapeutic intervention to treat dermal healing senescence in aged females. Innovation: The FGF intervention is being analyzed using a new, recently published model. This approach significantly increases the amount of pre-clinical animal data obtainable in wound healing studies, minimizes cohort number compared to (lethal) histological studies, and permits a direct statistical comparison between different healing studies. Conclusion: Quantitative parameters of dermal wound healing, obtained from non-invasive fine-sampled photographic data, identify topical FGF-1 as an effective therapeutic to treat the senescence of dermal healing present in aged female BALB/cByJ mice. 
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Date Issued
2018-06-25
Identifier
FSU_libsubv1_scholarship_submission_1529889363_21ee7933
Format
Citation
Macros to Conduct Tests of Multimodality in SAS
Title
Macros to Conduct Tests of Multimodality in SAS.
Creator
Neville, Zacharia, Brownstein, Naomi
Abstract/Description
The Dip Test of Unimodality and Silverman's Critical Bandwidth Test are two popular tests to determine if an unknown density contains more than one mode. While the tests can be easily run in R, they are not included in SAS software. We provide implementations of the Dip Test and Silverman Test as macros in the SAS software, capitalizing on the capability of SAS to execute R code internally. Descriptions of the macro parameters, installation steps, and sample macro calls are provided, along...
Show moreThe Dip Test of Unimodality and Silverman's Critical Bandwidth Test are two popular tests to determine if an unknown density contains more than one mode. While the tests can be easily run in R, they are not included in SAS software. We provide implementations of the Dip Test and Silverman Test as macros in the SAS software, capitalizing on the capability of SAS to execute R code internally. Descriptions of the macro parameters, installation steps, and sample macro calls are provided, along with an appendix for troubleshooting. We illustrate the use of the macros on data simulated from one or more Gaussian distributions as well as on the famous iris dataset.
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Date Issued
2018
Identifier
FSU_libsubv1_scholarship_submission_1536176489_9919aa26, 10.1080/00949655.2018.1509979
Format
Citation
Investigating the Dynamics and Polyanion Binding Sites of Fibroblast Growth Factor-1 Using Hydrogen-Deuterium Exchange Mass Spectrometry
Title
Investigating the Dynamics and Polyanion Binding Sites of Fibroblast Growth Factor-1 Using Hydrogen-Deuterium Exchange Mass Spectrometry.
Creator
Angalakurthi, Siva K, Tenorio, Connie A, Blaber, Michael, Middaugh, Russell
Abstract/Description
In this study, we examined the local dynamics of acidic fibroblast growth factor (FGF-1) as well as the binding sites of various polyanions including poly-sulfates (heparin and low MW heparin) and poly-phosphates (phytic acid and ATP) using hydrogen-deuterium exchange mass spectrometry (HX-MS). For local dynamics, results are analyzed at the peptide level as well as in terms of buried amides employing crystallographic B-factors and compared with a residue level heat map generated from HX-MS...
Show moreIn this study, we examined the local dynamics of acidic fibroblast growth factor (FGF-1) as well as the binding sites of various polyanions including poly-sulfates (heparin and low MW heparin) and poly-phosphates (phytic acid and ATP) using hydrogen-deuterium exchange mass spectrometry (HX-MS). For local dynamics, results are analyzed at the peptide level as well as in terms of buried amides employing crystallographic B-factors and compared with a residue level heat map generated from HX-MS results. Results show that strand 4 and 5 and the turn between them to be the most flexible regions as was previously seen by NMR. On the other hand, the C-terminal strands 8, 9 and 10 appear to be more rigid which is also consistent with crystallographic B-factors as well as local dynamics studies conducted by NMR. Crystal structures of FGF-1 in complex with heparin have shown that heparin binds to N-terminal Asn18 and to C-terminal Lys105, Tryp107, Lys112, Lys113, Arg119, Pro121, Arg122, Gln127 and Lys128 indicating electrostatic forces as dominant interactions. Heparin binding as determined by HX-MS is consistent with crystallography data. Previous studies have also shown that other polyanions including low MW heparin, phytic acid and ATP dramatically increase the thermal stability of FGF-1. Using HX-MS, we find other poly anions tested bind in a similar manner to heparin, primarily targeting the turns in the lysine rich C-terminal region of FGF-1 along with two distinct N-terminal regions that contains lysines and arginines/ histidines. This confirms the interactions between FGF-1 and polyanions are primary directed by electrostatics.
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Date Issued
2018-04-05
Identifier
FSU_libsubv1_scholarship_submission_1523040928_8f170751
Format
Citation
Silence is Golden
Title
Silence is Golden: Team Problem Solving and Communication Costs.
Creator
Charness, Gary, Cooper, David, Grossman, Zachary
Abstract/Description
Numerous experimental studies have found that teams outperform individuals on intellective problems by a large degree. This result is intuitively appealing, as teams can benefit from sharing insights. However, much of this literature considers a task that involves a single clear insight. We instead analyze experiments comparing the performance of individuals and teams of four subjects at solving a series of challenging logic puzzles, where the solution involves a series of incremental steps....
Show moreNumerous experimental studies have found that teams outperform individuals on intellective problems by a large degree. This result is intuitively appealing, as teams can benefit from sharing insights. However, much of this literature considers a task that involves a single clear insight. We instead analyze experiments comparing the performance of individuals and teams of four subjects at solving a series of challenging logic puzzles, where the solution involves a series of incremental steps. Contrary to the existing literature, team performance is statistically indistinguishable from that of individuals when there is no cost to sending a message. Frictions resulting from both congestion and incorrect suggestions substantially derail the solution process for teams. If we impose a very small cost of communication on teams, the performance of teams improves. Underlying these results is a robust negative relationship between frequency of communication and team performance. Using a straightforward prediction exercise, we show that performance would have improved dramatically if the best member of each team had been asked to solve the puzzles alone rather than forming a team.
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Date Issued
2018-01-26
Identifier
FSU_libsubv1_scholarship_submission_1516997564_26bd399d
Format
Citation
Dirac Cone in two dimensional bilayer graphene by intercalation with V, Nb, and Ta transition metals
Title
Dirac Cone in two dimensional bilayer graphene by intercalation with V, Nb, and Ta transition metals.
Creator
Pakhira, Srimanta, Lucht, Kevin P., Mendoza-Cortes, Jose L.
Abstract/Description
Bilayer graphene (BLG) is semiconductor whose band gap and properties can be tuned by various methods such as doping or applying gate voltage. Here, we show how to tune electronic properties of BLG by intercalation of transition metal (TM) atoms between two monolayer graphene (MLG) using a novel dispersion-corrected first-principle density functional theory approach. We intercalated V, Nb, and Ta atoms between two MLG. We found that the symmetry, the spin, and the concentration of TM atoms in...
Show moreBilayer graphene (BLG) is semiconductor whose band gap and properties can be tuned by various methods such as doping or applying gate voltage. Here, we show how to tune electronic properties of BLG by intercalation of transition metal (TM) atoms between two monolayer graphene (MLG) using a novel dispersion-corrected first-principle density functional theory approach. We intercalated V, Nb, and Ta atoms between two MLG. We found that the symmetry, the spin, and the concentration of TM atoms in BLG-intercalated materials are the important parameters to control and to obtain a Dirac Cone in their band structures. Our study reveals that the BLG intercalated with one Vanadium (V) atom, BLG-1V, has a Dirac Cone at the K-point. In all the cases, the present DFT calculations show that the 2pz sub-shells of C atoms in graphene and the 3dyz sub-shells of the TM atoms provide the electron density near the Fermi level EF which controls the material properties. Thus, we show that out-of-plane atoms can influence in-plane electronic densities in BLG, and enumerate the conditions necessary to control the Dirac point. This study presents a new strategy for controlling the material properties of BLG so that they exhibit various behaviors, including: metal, semi-metal, and semiconductor by varying the concentration and spin arrangement of the TM atoms in BLG while offering insight into the physical properties of 2D BLG-intercalated materials.
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Date Issued
2017-09-16
Identifier
FSU_libsubv1_scholarship_submission_1519056039_9000b4fa
Format
Citation
Assessment and Screening of Depression in Heart Failure Patients
Title
Assessment and Screening of Depression in Heart Failure Patients: Nurses' Knowledge and Barriers.
Creator
Nguyen, Jimmy, Graven, Lucinda
Abstract/Description
Purpose: Heart failure (HF) is a devastating, progressive disease. Many HF patients have undiagnosed depression, increasing mortality and hospital visits. Nurses and providers often fail to recognize depression in this population. Therefore, this project aimed to explore current nurse knowledge base regarding depression; identify barriers to depression screening in HF patients; and introduce two depression screening tools, the Center for Epidemiologic Studies Depression Scale (CES-D-3) and...
Show morePurpose: Heart failure (HF) is a devastating, progressive disease. Many HF patients have undiagnosed depression, increasing mortality and hospital visits. Nurses and providers often fail to recognize depression in this population. Therefore, this project aimed to explore current nurse knowledge base regarding depression; identify barriers to depression screening in HF patients; and introduce two depression screening tools, the Center for Epidemiologic Studies Depression Scale (CES-D-3) and the Patient Health Questionnaire (PHQ-2). Methods: Using a quasi-experimental, pre/post design, an educational intervention was performed at a 300+ bed hospital, including a 15-minute educational intervention on depression and depression screening tools. Registered nurses completed a survey before (n = 51) and one month after (n = 31). Results: The sample was predominantly female (77%), 25-35 years old (67%), and cared for HF patients at least once a month (96%). The three largest barriers to depression screening reported included lack of time (100%), comfort level with patient (65%), and unsure how to assess (61%). Post-intervention, both nurses and patients responded better to the PHQ-2 versus the CES-D (77% versus 23%), with 74% of nurses using the tools at least once. This project observed a significant increase of comfort level and familiarity with depression (Z = -3.14, p < 0.04). Discussion: Although an improvement in comfort and familiarity with depression was noted, depression screens were not routinely used afterwards (74% used at least once). The intervention and/or the project duration may have been too short to notice a culture change. Conclusions: This project suggests that depression education can increase familiarity, comfort level, and knowledge of depression in nurses working with HF patients in acute care settings. The PHQ-2 may be a viable option to screening, given it was preferred over the CES-3, by both patient and nurses.
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Date Issued
2018-04-26
Identifier
FSU_libsubv1_scholarship_submission_1524801870_41be20a3
Format
Citation
Long Acting Reversible Contraceptives
Title
Long Acting Reversible Contraceptives: An Educational Tool to Improve Awareness.
Creator
Adams, Tracy, Greenhalgh, Jolynn
Abstract/Description
Purpose: The aim of this study was to increase awareness of contraceptive methods and measure the likelihood that participants request a more effective method, including long-acting reversible contraceptives (LARCs), than they are currently using. Methods: This project was a quazi-experimental, cross-sectional designed study. The intervention consisted of one-on-one time with an experienced family planning nurse using the Centers for Disease Control and Prevention (CDC) “Effectiveness of...
Show morePurpose: The aim of this study was to increase awareness of contraceptive methods and measure the likelihood that participants request a more effective method, including long-acting reversible contraceptives (LARCs), than they are currently using. Methods: This project was a quazi-experimental, cross-sectional designed study. The intervention consisted of one-on-one time with an experienced family planning nurse using the Centers for Disease Control and Prevention (CDC) “Effectiveness of Family Planning Methods” handout as a teaching tool (CDC, 2017). A post-survey measured how likely women were to ask about more effective contraceptives including LARC. Results: Data was collected over a four day period, resulting in 17 participants. Six women (35.3%) were using no method. Post intervention, three (50%) stated they would talk with their practitioner about a more or most effective method of birth control. Three women were using a less effective method. One hundred percent of these women were likely to ask about most effective methods. Five participants (29.4%) were using a moderately effective method. Three of these five (60%) were interested in a most effective method. Three participants (17.6%) were already using a most effective method. Discussion: Nine of the 17 participants (52.9%) were likely to ask their practitioner about LARC. This demonstrates a positive correlation between contraceptive education and increased interest in LARC. Conclusion: LARC family planning methods, although proven safe and effective methods of birth control, are underutilized in the United States. When provided education on all available methods, women are better equipped to choose a method that not only fits their lifestyle, but also offers a high level of efficacy. More research with larger numbers of study participants is needed to determine best practices for improving LARC usage in the United States.
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Date Issued
2018-04-06
Identifier
FSU_libsubv1_scholarship_submission_1524061692_aea16f4e
Format
Citation
Evaluating Appearance-Based Education on Sunscreen Knowledge and Use in Young Adults
Title
Evaluating Appearance-Based Education on Sunscreen Knowledge and Use in Young Adults.
Creator
Otis, Mishya, Greenhalgh, Jolynn
Date Issued
2019-03-23
Identifier
FSU_libsubv1_scholarship_submission_1553360219_4af178d0
Format
Citation
Older Adults’ Perceptions of Differences in Levels of Services Provided by Emergency Rooms
Title
Older Adults’ Perceptions of Differences in Levels of Services Provided by Emergency Rooms.
Creator
Morgan López, Leilani, Porterfield, Susan
Abstract/Description
This quality improvement project is designed to increase knowledge in the older adult population of the differences between Emergency Rooms and Urgent Care Facilities and the services they provide so that they can make informed decisions regarding which facility is best suited for their healthcare needs. As the numbers of ERs increase, educating older adults on these differences and reducing inappropriate ER use will help minimize overcrowding in ERs and reduce costs associated with wasted...
Show moreThis quality improvement project is designed to increase knowledge in the older adult population of the differences between Emergency Rooms and Urgent Care Facilities and the services they provide so that they can make informed decisions regarding which facility is best suited for their healthcare needs. As the numbers of ERs increase, educating older adults on these differences and reducing inappropriate ER use will help minimize overcrowding in ERs and reduce costs associated with wasted resources, improve patient satisfaction and improve outcomes.
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Date Issued
2020-04-21
Identifier
FSU_libsubv1_scholarship_submission_1587068674_1079d9fc
Format
Citation
Evaluating Barriers to Learning and Performing Cardiopulmonary Resuscitation in a Rural Community with a High Prevalence of Out of Hospital Cardiac Arrests
Title
Evaluating Barriers to Learning and Performing Cardiopulmonary Resuscitation in a Rural Community with a High Prevalence of Out of Hospital Cardiac Arrests: Evaluating Barriers to Learning and Performing CPR.
Creator
Turnage, Megan Lynn
Abstract/Description
Purpose Identify and reduce barriers to learning and performing bystander cardiopulmonary resuscitation (CPR) in Newberry, Florida to improve bystander CPR initiation and performance and decrease mortality related to out of hospital cardiac arrests (OHCA). Methodology This quality improvement project took place from October 2019 to January 2020. A CPR education course was provided to a convenience sample within Newberry. Three surveys (pre-, immediate post-, and three-months post-education)...
Show morePurpose Identify and reduce barriers to learning and performing bystander cardiopulmonary resuscitation (CPR) in Newberry, Florida to improve bystander CPR initiation and performance and decrease mortality related to out of hospital cardiac arrests (OHCA). Methodology This quality improvement project took place from October 2019 to January 2020. A CPR education course was provided to a convenience sample within Newberry. Three surveys (pre-, immediate post-, and three-months post-education) collected data on participant demographics, perceived barriers to CPR education, bystander CPR initiation, and bystander CPR performance. Results The initial survey revealed the greatest learning barrier of bystander CPR was lack of information, while the greatest bystander CPR performance barrier was lack of confidence. The two post-education survey results indicated the threat of contracting a disease was the greatest concern in performing bystander CPR. ConclusionResults from this intervention support the need for timely and consistent CPR training in remote, rural, areas of the United States. This quality improvement project identified and reduced perceived bystander CPR learning and performing barriers when comparing median scores before, immediately after, and three months after the CPR education intervention.
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Date Issued
2020-04-02
Identifier
FSU_libsubv1_scholarship_submission_1585862877_2c5139b2
Format
Citation
Silence is Golden
Title
Silence is Golden: Team Problem Solving and Communication Costs.
Creator
Charness, Gary, Cooper, David, Grossman, Zachary
Abstract/Description
We conduct experiments comparing the performance of individuals and teams of four subjects in solving two rather different tasks. The first involves nonograms (numerical logic puzzle). Here the solution requires a series of incremental steps. The second task uses CRT-type questions, which require a single, specific insight. Contrary to the existing literature, team performance in both tasks is statistically indistinguishable from that of individuals when there is no cost to sending a message....
Show moreWe conduct experiments comparing the performance of individuals and teams of four subjects in solving two rather different tasks. The first involves nonograms (numerical logic puzzle). Here the solution requires a series of incremental steps. The second task uses CRT-type questions, which require a single, specific insight. Contrary to the existing literature, team performance in both tasks is statistically indistinguishable from that of individuals when there is no cost to sending a message. If a tiny message cost is imposed, team performance improves and becomes statistically better than that of individuals, although still worse than previous research on teams would have suggested. Message costs reduce the quantity of messages but increase the quality, specifically the mix of good and bad suggestions. The improved quality of communication with message costs allows teams to outperform individuals.
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Date Issued
2019-05-09
Identifier
FSU_libsubv1_scholarship_submission_1558020369_a400f80d
Format
Citation
Tariffs and their Impact on Global Trade and Local Economies
Title
Tariffs and their Impact on Global Trade and Local Economies.
Creator
Flores, Aldair S.
Abstract/Description
In order to create sustainable societies, countries follow the well-known principles of supply and demand of goods that are involved in international trade. Due to the current importance of this trade, some important regulations have been implemented to maintain order in this flow that takes place beyond national borders. These regulations can be exemplified by the different tariffs that regulate the global market. According to Merriam-Webster dictionary, a tariff is “a schedule of duties...
Show moreIn order to create sustainable societies, countries follow the well-known principles of supply and demand of goods that are involved in international trade. Due to the current importance of this trade, some important regulations have been implemented to maintain order in this flow that takes place beyond national borders. These regulations can be exemplified by the different tariffs that regulate the global market. According to Merriam-Webster dictionary, a tariff is “a schedule of duties imposed by a government on imported or in some countries exported goods.” Nowadays, tariffs are an important concept in International Business, for it involves other topics as the difference in cultures, economic trends, and international politics.
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Date Issued
2015-06-11
Identifier
FSU_libsubv1_scholarship_submission_1561571095_8ceea4c0
Format
Citation
Is Immigration Sustainable in the Republic of Panama?
Title
Is Immigration Sustainable in the Republic of Panama?.
Creator
Flores, Aldair S.
Abstract/Description
The recent economic and social trends in most countries around the world have kept the migratory flows far from stopping. The 2000 and 2008 financial crises were a motivation for many people to leave their country. Regarding Latin Americans, a great number of people felt attracted to other countries, rather than to the traditional destinations such as the United States and the European Union exclusively. Plus, factors as the cultural change and a stricter migratory regulation caused these...
Show moreThe recent economic and social trends in most countries around the world have kept the migratory flows far from stopping. The 2000 and 2008 financial crises were a motivation for many people to leave their country. Regarding Latin Americans, a great number of people felt attracted to other countries, rather than to the traditional destinations such as the United States and the European Union exclusively. Plus, factors as the cultural change and a stricter migratory regulation caused these citizens to focus on other countries inside Latin America.
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Date Issued
2017-04-21
Identifier
FSU_libsubv1_scholarship_submission_1561570756_2b818a7f
Format
Citation
Teachers' Learning of Teaching With Multiple Strategies
Title
Teachers' Learning of Teaching With Multiple Strategies: Understanding Challenges to the Mathematics Florida Standards during a Lesson Study Cycle.
Creator
Farfan, Guillermo, Murata, Aki, Roehrig, Alysia
Abstract/Description
Viewing teachers as learners of policy reform, this exploratory study examines a group of elementary mathematics teachers as they discussed teaching with multiple strategies as found in the new Mathematics Florida Standards during a lesson study cycle. In particular, it describes how teachers: (1) advance different explanations for teaching with multiple strategies in the new standards, and (2) anticipate or recognize major obstacles to the implementation of these new standards....
Show moreViewing teachers as learners of policy reform, this exploratory study examines a group of elementary mathematics teachers as they discussed teaching with multiple strategies as found in the new Mathematics Florida Standards during a lesson study cycle. In particular, it describes how teachers: (1) advance different explanations for teaching with multiple strategies in the new standards, and (2) anticipate or recognize major obstacles to the implementation of these new standards. Considerations of this study’s results to further research on teacher professional development and educational reform are also briefly discussed.
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Date Issued
2019-08-07
Identifier
FSU_libsubv1_scholarship_submission_1565210126_3e3fe1a2
Format
Citation
Withdrawal Confounding in Studies of The Pharmacological Management of Substance Use Disorders
Title
Withdrawal Confounding in Studies of The Pharmacological Management of Substance Use Disorders.
Creator
Dunleavy, Daniel J.
Abstract/Description
Nanopublication on Substance Abuse Clinical Trial Design
Date Issued
2020-04-27
Identifier
FSU_libsubv1_scholarship_submission_1596333966_aecc8325, 10.5281/zenodo.3767449
Format
Citation
Fast Science, Slow Science
Title
Fast Science, Slow Science: Finding Balance in the Time of COVID-19 and the Age of Misinformation.
Creator
Dunleavy, Daniel J., Hendricks, Vincent F.
Abstract/Description
The COVID-19 pandemic has placed politicians, community leaders, and everyday citizens in a difficult position. Decisions need to be made, but are typically done so with incomplete information, and often with a sense of anxiety and urgency. We discuss how the pandemic has changed science, for better and for worse, how this change affects decision-making, and how it interrelates with broader social phenomenon, such as the hyperconnectivity of the information age and consequent spread of...
Show moreThe COVID-19 pandemic has placed politicians, community leaders, and everyday citizens in a difficult position. Decisions need to be made, but are typically done so with incomplete information, and often with a sense of anxiety and urgency. We discuss how the pandemic has changed science, for better and for worse, how this change affects decision-making, and how it interrelates with broader social phenomenon, such as the hyperconnectivity of the information age and consequent spread of misinformation. Taken together, these issues place us at high risk for implementing poor policies and making dangerous decisions about personal safety. We end by considering some ways that science can be made more rigorous, in order to inform policies related to the pandemic and other social problems, how scientists may play a more active role in policy-decisions, and how citizens and community leaders can make better informed decisions themselves.
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Date Issued
2020/09/28
Identifier
FSU_libsubv1_scholarship_submission_1601320901_aa2b6ce7, 10.5281/zenodo.4056908
Format
Citation
Descriptive Study to Examine the Relationship between Preoperative Gabapentin Dose, Postoperative Pain, and its Effect on Sedation
Title
A Descriptive Study to Examine the Relationship between Preoperative Gabapentin Dose, Postoperative Pain, and its Effect on Sedation.
Creator
Kim, Eudeum Lee
Abstract/Description
AbstractTitle: A Descriptive Study to Examine the Relationship between Preoperative Gabapentin Dose, Postoperative Pain, and its Effect on SedationPrimary Investigator (PI): Eudeum Lee Kim, BSN, RN-BC Purpose: The purpose of this project is to describe the relationship between different doses of preoperative gabapentin on postoperative pain and sedation. Additionally, this project will explore how the patient’s length of stay in the recovery varies across demographic factors. This project may...
Show moreAbstractTitle: A Descriptive Study to Examine the Relationship between Preoperative Gabapentin Dose, Postoperative Pain, and its Effect on SedationPrimary Investigator (PI): Eudeum Lee Kim, BSN, RN-BC Purpose: The purpose of this project is to describe the relationship between different doses of preoperative gabapentin on postoperative pain and sedation. Additionally, this project will explore how the patient’s length of stay in the recovery varies across demographic factors. This project may be beneficial since the goal of the surgery center is to provide patients minimum sedation to facilitate the procedure effectively and promote successful discharge to home with the shortest recovery stay.Methods: This study is a descriptive and cross-sectional retrospective chart review performed at the Emerald Coast Surgery Center in Fort Walton Beach, Florida. 232 patient charts were selected based on the inclusion criteria: 15 years and older and received gabapentin preoperatively from January 2018 to April 2020. The association of preoperative gabapentin on postoperative pain relief, level of sedation, and length of stay in the recovery room across patients’ demographic factors examined.Results: There is no clinically significant difference among gabapentin dosages and postoperative pain scores, sedation level, but the mean length of stay increases with the higher dosages of gabapentin. Among other demographic factors, the age of 66 and older for all three gabapentin dosages reported the longest mean length of stay in the recovery room.Discussion: Findings from this project may support the prolonged sedating effect of gabapentin, which delays discharge from the recovery room. Conclusions: Preoperative use of gabapentin may decrease the pain. However, there were no dose-related effects on better relief. Higher doses of gabapentin increase the length of stay in the recovery, which indicates future studies related to possible factors that may lead to a longer stay in the recovery room. Major Professor: Susan Porterfield, Ph.D., FNP-C
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Date Issued
2021-02-04
Identifier
FSU_libsubv1_scholarship_submission_1612452098_08b80b85
Format
Citation