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Method of applying high temperature compatible insulation to superconductors
Title
Method of applying high temperature compatible insulation to superconductors.
Creator
Hascicek, Yusuf S., Celik, Erdal, Mutlu, Ibrahim
Abstract/Description
There is described a method of applying insulative coating on high temperature superconductors and low temperature superconductors from sol-gel solutions prepared from Zr, or Zr with one of Mg, Y, Ce, In and Sn based precursor materials. The solution is prepared with isopropanol as a solvent and acetyl acetone as a catalyst. The conductors are dipped into the solution and thereafter dried at a temperature effective to evaporate the solvent. Thereafter, heat treatment in the presence of oxygen...
Show moreThere is described a method of applying insulative coating on high temperature superconductors and low temperature superconductors from sol-gel solutions prepared from Zr, or Zr with one of Mg, Y, Ce, In and Sn based precursor materials. The solution is prepared with isopropanol as a solvent and acetyl acetone as a catalyst. The conductors are dipped into the solution and thereafter dried at a temperature effective to evaporate the solvent. Thereafter, heat treatment in the presence of oxygen is applied at a temperature sufficient to oxidize the precursors to result in a ceramic insulative coating on the conductor.
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Date Issued
2002-05-14
Identifier
FSU_uspto_6387852, 6387852, 985992, 09/973374, 600b83161da1122888348587dc18798c
Format
Citation
Method of detecting compromised computers in a network
Title
Method of detecting compromised computers in a network.
Creator
Chen, Peng Sheng, Duan, Zhenhai
Abstract/Description
A method of detecting a compromised machine on a network. The method receives an email message from a machine on the network and classifies it as either spam or non-spam. A probability ratio is then updated, according to whether the message was spam or non-spam, by applying a sequential probability ratio test. If the probability ratio is greater than or equal to a first threshold, then the machine is compromised. If the probability ratio is less than or equal to a second threshold, then the...
Show moreA method of detecting a compromised machine on a network. The method receives an email message from a machine on the network and classifies it as either spam or non-spam. A probability ratio is then updated, according to whether the message was spam or non-spam, by applying a sequential probability ratio test. If the probability ratio is greater than or equal to a first threshold, then the machine is compromised. If the probability ratio is less than or equal to a second threshold, then the machine is normal. The operations of receiving a message, classifying the message, updating the probability ratio, and indicating the machine is normal or compromised until the probability ratio is greater than or equal to the first threshold are repeated for a plurality of messages. Such repeated operations are performed on each of the messages one at a time, as each of the messages is received.
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Date Issued
2013-10-15
Identifier
FSU_uspto_8560624, 8560624, 1922309, 13/591866, 6c9256d97d167832cbab694dc904bd27
Format
Citation
Low self-absorbing, intrinsically scintillating polymers
Title
Low self-absorbing, intrinsically scintillating polymers.
Creator
Schlenoff, Joseph B., Dharia, Jayesh, Johnson, Kurtis F.
Abstract/Description
Polymers containing covalently-bonded, low self-absorbing, scintillating chromophores, polymerizable chromophores of the formula: ##STR1## wherein R.sub.1 is vinyl, .alpha.-methyl vinyl, vinyl phenyl, or vinyl benzyl, and R.sub.2 and R.sub.3 are independently hydrogen, alkyl, aryl, cyano, nitro, halo, or ether, and a process for the preparation of polymers containing low self-absorbing, scintillating chromophores.
Date Issued
1993-11-02
Identifier
FSU_uspto_5258478, 5258478, 915739, 07/874748, 600b83161da1122888348587dc18798c
Format
Citation
Magnetic shimming configuration with optimized turn geometry and electrical circuitry
Title
Magnetic shimming configuration with optimized turn geometry and electrical circuitry.
Creator
Bird, Mark D., Painter, Thomas A., Bole, Scott T.
Abstract/Description
A magnetic shimming configuration for a high-field magnet having optimized turn geometry and electrical circuitry. The present invention accomplishes this by combining the corrective functionalities of the standard X and ZX shims into two single, simplified electrical circuits and conductors, optimized for field strength as a function of turn location. The standard Y and ZY shims were also replaced with two single, simplified circuits and conductor that is corrective of the Y and ZY fields....
Show moreA magnetic shimming configuration for a high-field magnet having optimized turn geometry and electrical circuitry. The present invention accomplishes this by combining the corrective functionalities of the standard X and ZX shims into two single, simplified electrical circuits and conductors, optimized for field strength as a function of turn location. The standard Y and ZY shims were also replaced with two single, simplified circuits and conductor that is corrective of the Y and ZY fields. The new configuration also eliminates the need of additional “second, outboard turns” of the traditional X, ZX, Y, and ZY shims, located further away from the mid-plane.
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Date Issued
2008-09-23
Identifier
FSU_uspto_7427908, 7427908, 1855543, 12/004993, 6c9256d97d167832cbab694dc904bd27
Format
Citation
Lipid multilayer microarrays and their use for cell culture screening
Title
Lipid multilayer microarrays and their use for cell culture screening.
Creator
Lenhert, Steven, Kusi-Appiah, Aubrey
Abstract/Description
Provided is a device having one or more lipid multilayer arrays of lipid multilayer structures on a substrate. Each lipid multilayer structure encapsulates an encapsulated material that may be delivered to a cell that is in contact with the lipid multilayer structure to determine the cellular response of the cell to the encapsulated material.
Date Issued
2016-09-20
Identifier
FSU_uspto_9447446, 9447446, 2611948, 13/534772, 6c9256d97d167832cbab694dc904bd27
Format
Citation
Magnetic particle composition for therapeutic hyperthermia
Title
Magnetic particle composition for therapeutic hyperthermia.
Creator
Chen, Ching-Jen, Haik, Yousef
Abstract/Description
Magnetic nanoparticle compositions are provided which provide an inherent temperature regulator for use in magnetic heating, particularly for use in magnetic hyperthermia medical treatments. The composition includes magnetic nanoparticles having a Curie temperature of between 40 and 46° C., preferably about 42° C., and may further include a polymeric material and optionally a drug or radiosensitizing agent. Methods of hyperthermia treatment of a patient in need thereof are provided...
Show moreMagnetic nanoparticle compositions are provided which provide an inherent temperature regulator for use in magnetic heating, particularly for use in magnetic hyperthermia medical treatments. The composition includes magnetic nanoparticles having a Curie temperature of between 40 and 46° C., preferably about 42° C., and may further include a polymeric material and optionally a drug or radiosensitizing agent. Methods of hyperthermia treatment of a patient in need thereof are provided which include the steps of administering to the patient a composition comprising magnetic nanoparticles having a Curie temperature of between 40 and 46° C.; and exposing the magnetic nanoparticles in the patient to an alternating magnetic field effective to generate hysteresis heat in the nanoparticles.
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Date Issued
2010-11-30
Identifier
FSU_uspto_7842281, 7842281, 1462906, 11/125488, 6c9256d97d167832cbab694dc904bd27
Format
Citation
Method of indefinite culture of hepatitis C virus
Title
Method of indefinite culture of hepatitis C virus.
Creator
Tang, Hengli
Abstract/Description
The invention discloses a method of maintaining hepatitis C virus (HCV) growing indefinitely in cell culture. The method includes providing a culture of cells susceptible to infection by HCV; introducing to the cell culture an inoculum containing an infective dose of HCV; contacting the inoculated cell culture with a growth medium containing an excess of uridine and cytidine; and changing spent growth medium with fresh growth medium containing the excess of uridine and cytidine on a...
Show moreThe invention discloses a method of maintaining hepatitis C virus (HCV) growing indefinitely in cell culture. The method includes providing a culture of cells susceptible to infection by HCV; introducing to the cell culture an inoculum containing an infective dose of HCV; contacting the inoculated cell culture with a growth medium containing an excess of uridine and cytidine; and changing spent growth medium with fresh growth medium containing the excess of uridine and cytidine on a predetermined schedule.
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Date Issued
2010-07-20
Identifier
FSU_uspto_7759087, 7759087, 2400173, 11/536324, 6c9256d97d167832cbab694dc904bd27
Format
Citation
Method of locating a fault in a power distribution system comprising at least one DC voltage distributed resource having a controllable voltage source converter
Title
Method of locating a fault in a power distribution system comprising at least one DC voltage distributed resource having a controllable voltage source converter.
Creator
Li, Hui, Tatcho, Passinam, Steurer, Mischa
Abstract/Description
The present invention provides a method to ensure that distributed resources of a power distribution system remain connected to the circuitry of the power distribution system when a fault occurs at a distributed resource node to assist in identifying the location of the fault by continuing to inject current from the distributed resources into the distribution system, wherein at least one of the distributed resources is a DC voltage distributed resource comprising a controllable voltage source...
Show moreThe present invention provides a method to ensure that distributed resources of a power distribution system remain connected to the circuitry of the power distribution system when a fault occurs at a distributed resource node to assist in identifying the location of the fault by continuing to inject current from the distributed resources into the distribution system, wherein at least one of the distributed resources is a DC voltage distributed resource comprising a controllable voltage source converter.
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Date Issued
2016-08-09
Identifier
FSU_uspto_9411005, 9411005, 1616461, 14/962522, 6c9256d97d167832cbab694dc904bd27
Format
Citation
Method of locating a fault in a power distribution system comprising at least one wind turbine distributed resource
Title
Method of locating a fault in a power distribution system comprising at least one wind turbine distributed resource.
Creator
Li, Hui, Tatcho, Passinam, Steurer, Mischa
Abstract/Description
The present invention provides a method to ensure that distributed resources of a power distribution system remain connected to the circuitry of the power distribution system when a fault occurs at a distributed resource node to assist in identifying the location of the fault by continuing to inject current from the distributed resources into the distribution system, wherein at least one of the distributed resources is a wind turbine.
Date Issued
2016-08-16
Identifier
FSU_uspto_9417277, 9417277, 1616461, 14/962367, 6c9256d97d167832cbab694dc904bd27
Format
Citation
Method of locating a fault in a power distribution system using a direct current signal of a distributed resource modulated by an alternating current signal
Title
Method of locating a fault in a power distribution system using a direct current signal of a distributed resource modulated by an alternating current signal.
Creator
Li, Hui, Tatcho, Passinam, Steurer, Mischa
Abstract/Description
The present invention provides a method to ensure that distributed resources of a power distribution system remain connected to the circuitry of the power distribution system when a fault occurs at a distributed resource node to assist in identifying the location of the fault by continuing to inject a direct current (DC) signal from the controllable voltage source converter of at least one DC voltage distributed resource into the distribution system and modulating an alternating current (AC)...
Show moreThe present invention provides a method to ensure that distributed resources of a power distribution system remain connected to the circuitry of the power distribution system when a fault occurs at a distributed resource node to assist in identifying the location of the fault by continuing to inject a direct current (DC) signal from the controllable voltage source converter of at least one DC voltage distributed resource into the distribution system and modulating an alternating current (AC) signal on top of the direct current (DC) signal.
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Date Issued
2016-09-13
Identifier
FSU_uspto_9442153, 9442153, 1616461, 14/962583, 6c9256d97d167832cbab694dc904bd27
Format
Citation
Method of locating a fault in a power distribution system comprising at least one distributed resource having a controllable voltage source converter
Title
Method of locating a fault in a power distribution system comprising at least one distributed resource having a controllable voltage source converter.
Creator
Li, Hui, Tatcho, Passinam, Steurer, Mischa
Abstract/Description
The present invention provides a method to ensure that distributed resources of a power distribution system remain connected to the circuitry of the power distribution system when a fault occurs at a distributed resource node to assist in identifying the location of the fault by continuing to inject current from the distributed resources into the distribution system, wherein at least one of the distributed resource comprises a controllable voltage source converter.
Date Issued
2016-07-12
Identifier
FSU_uspto_9389270, 9389270, 1616461, 14/962820, 6c9256d97d167832cbab694dc904bd27
Format
Citation
Method of locating a fault in a power distribution system comprising at least one solar panel distributed resource
Title
Method of locating a fault in a power distribution system comprising at least one solar panel distributed resource.
Creator
Li, Hui, Tatcho, Passinam, Steurer, Mischa
Abstract/Description
The present invention provides a method to ensure that distributed resources of a power distribution system remain connected to the circuitry of the power distribution system when a fault occurs at a distributed resource node to assist in identifying the location of the fault by continuing to inject current from the distributed resources into the distribution system, wherein at least one of the distributed resources is a solar panel.
Date Issued
2016-08-23
Identifier
FSU_uspto_9423445, 9423445, 1616461, 14/962465, 6c9256d97d167832cbab694dc904bd27
Format
Citation
Method of detecting compromised computers in a network
Title
Method of detecting compromised computers in a network.
Creator
Duan, Zhenhai
Abstract/Description
A method of detecting a compromised machine on a network. The method receives an email message from a machine on the network and classifies it as either spam or non-spam. A probability ratio is then updated, according to whether the message was spam or non-spam, by applying a sequential probability ratio test. If the probability ratio is greater than or equal to a first threshold, then the machine is compromised. If the probability ratio is less than or equal to a second threshold, then the...
Show moreA method of detecting a compromised machine on a network. The method receives an email message from a machine on the network and classifies it as either spam or non-spam. A probability ratio is then updated, according to whether the message was spam or non-spam, by applying a sequential probability ratio test. If the probability ratio is greater than or equal to a first threshold, then the machine is compromised. If the probability ratio is less than or equal to a second threshold, then the machine is normal. The operations of receiving a message, classifying the message, updating the probability ratio, and indicating the machine is normal or compromised until the probability ratio is greater than or equal to the first threshold are repeated for a plurality of messages. Such repeated operations are performed on each of the messages one at a time, as each of the messages is received.
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Date Issued
2012-10-02
Identifier
FSU_uspto_8280968, 8280968, 2145251, 12/762714, 6c9256d97d167832cbab694dc904bd27
Format
Citation
Method of detecting compromised computers in a network
Title
Method of detecting compromised computers in a network.
Creator
Chen, Peng Sheng, Duan, Zhenhai
Abstract/Description
A method of detecting a compromised machine on a network. The method receives an email message from a machine on the network and classifies it as either spam or non-spam. A probability ratio is then updated, according to whether the message was spam or non-spam, by applying a sequential probability ratio test. If the probability ratio is greater than or equal to a first threshold, then the machine is compromised. If the probability ratio is less than or equal to a second threshold, then the...
Show moreA method of detecting a compromised machine on a network. The method receives an email message from a machine on the network and classifies it as either spam or non-spam. A probability ratio is then updated, according to whether the message was spam or non-spam, by applying a sequential probability ratio test. If the probability ratio is greater than or equal to a first threshold, then the machine is compromised. If the probability ratio is less than or equal to a second threshold, then the machine is normal. The operations of receiving a message, classifying the message, updating the probability ratio, and indicating the machine is normal or compromised until the probability ratio is greater than or equal to the first threshold are repeated for a plurality of messages. Such repeated operations are performed on each of the messages one at a time, as each of the messages is received.
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Date Issued
2013-10-29
Identifier
FSU_uspto_8572197, 8572197, 1922309, 13/632384, 6c9256d97d167832cbab694dc904bd27
Format
Citation
Method of locating a fault in a power distribution system comprising at least one microturbine distributed resource
Title
Method of locating a fault in a power distribution system comprising at least one microturbine distributed resource.
Creator
Li, Hui, Tatcho, Passinam, Steurer, Mischa
Abstract/Description
The present invention provides a method to ensure that distributed resources of a power distribution system remain connected to the circuitry of the power distribution system when a fault occurs at a distributed resource node to assist in identifying the location of the fault by continuing to inject current from the distributed resources into the distribution system, wherein at least one of the distributed resources is a microturbine.
Date Issued
2016-08-09
Identifier
FSU_uspto_9411006, 9411006, 1616461, 14/962434, 6c9256d97d167832cbab694dc904bd27
Format
Citation
Method of locating a fault in a power distribution system comprising at least one cogeneration distributed resource
Title
Method of locating a fault in a power distribution system comprising at least one cogeneration distributed resource.
Creator
Li, Hui, Tatcho, Passinam, Steurer, Mischa
Abstract/Description
The present invention provides a method to ensure that distributed resources of a power distribution system remain connected to the circuitry of the power distribution system when a fault occurs at a distributed resource node to assist in identifying the location of the fault by continuing to inject current from the distributed resources into the distribution system, wherein at least one of the distributed resources is a cogeneration resource.
Date Issued
2016-08-16
Identifier
FSU_uspto_9417276, 9417276, 1616461, 14/962496, 6c9256d97d167832cbab694dc904bd27
Format
Citation
Intermediates for tricyclic or tetracyclic taxanes
Title
Intermediates for tricyclic or tetracyclic taxanes.
Creator
Holton, Robert A., Somoza, Carmen, Shindo, Mitsuru, Biediger, Ronald J., Boatman, P. Douglas, Smith, Chase C., Liang, Feng, Murthi, Krishna K., Kim, Hyeong Baik
Abstract/Description
The synthesis of taxol and other tricyclic and tetracyclic taxanes.
Date Issued
2001-08-21
Identifier
FSU_uspto_6278026, 6278026, 711524, 09/333382, 600b83161da1122888348587dc18798c
Format
Citation
Purified linear epitopes from cashew nuts, nucleic acids encoding therefor, and associated methods
Title
Purified linear epitopes from cashew nuts, nucleic acids encoding therefor, and associated methods.
Creator
Roux, Kenneth H., Sathe, Shridhar K., Teuber, Suzanne S.
Abstract/Description
Disclosed are major allergenic proteins in cashew nut, which are legumin-like proteins and 2S albumins. Also disclosed is a polypeptide allergen in the 7S superfamily, which includes vicilin-like and sucrose binding proteins. Several linear epitopes of the cashew nut are identified and characterized. The invention further discloses the sequence of cDNA encoding the allergenic polypeptide, the allergen being designated Ana o 1, and also describes the characterization of the expressed...
Show moreDisclosed are major allergenic proteins in cashew nut, which are legumin-like proteins and 2S albumins. Also disclosed is a polypeptide allergen in the 7S superfamily, which includes vicilin-like and sucrose binding proteins. Several linear epitopes of the cashew nut are identified and characterized. The invention further discloses the sequence of cDNA encoding the allergenic polypeptide, the allergen being designated Ana o 1, and also describes the characterization of the expressed recombinant polypeptide and associated methods employing the polypeptide.
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Date Issued
2016-03-29
Identifier
FSU_uspto_9296798, 9296798, 1946887, 13/851192, 0a4642a77d52197c97f5d592966b68d7
Format
Citation
Protein separation from a protein mixture
Title
Protein separation from a protein mixture.
Creator
Sang, Qing-Xiang (Amy), Sahab, Ziad Joseph
Abstract/Description
A process for separating a protein from a sample containing a mixture of proteins is disclosed. The process comprises forming an aqueous combination comprising the sample and an ion exchange material at a pH which is less than the pI of a first fraction of the proteins in the aqueous dispersion but greater than the pI of a second fraction of the proteins in the aqueous dispersion. The aqueous dispersion may then be intensely mixed, causing a fraction of the proteins in the combination to bind...
Show moreA process for separating a protein from a sample containing a mixture of proteins is disclosed. The process comprises forming an aqueous combination comprising the sample and an ion exchange material at a pH which is less than the pI of a first fraction of the proteins in the aqueous dispersion but greater than the pI of a second fraction of the proteins in the aqueous dispersion. The aqueous dispersion may then be intensely mixed, causing a fraction of the proteins in the combination to bind to the ion exchange material, and, optionally, centrifuged, causing the combination to stratify into a concentrated solids fraction and a supernatant, the supernatant containing the fraction of the proteins that did not bind to the ion exchange material. This process, including the steps of intense mixing and centrifugation, requires no expensive, specialized instrumentation, can be quickly performed, and is carried out in non-denaturing conditions, allowing for the separated proteins to be further studied.
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Date Issued
2009-09-08
Identifier
FSU_uspto_7585955, 7585955, 2248480, 11/366124, 6c9256d97d167832cbab694dc904bd27
Format
Citation
Proton-transfer, low self-absorbing chromophores for use in scintillators
Title
Proton-transfer, low self-absorbing chromophores for use in scintillators.
Creator
Schlenoff, Joseph B., Gao, Feng (Frank), Dharia, Jayesh, Johnson, Kurtis F.
Abstract/Description
Proton-transfer, low self-absorbing chromophores of the formula: ##STR1## wherein R.sub.2 and R.sub.3 are independently hydrogen, alkyl, aryl, cyano, nitro, halo or an ether group, R.sub.4 is O or N--H, and R.sub.5 is thienyl, naphthyl, furanyl, pyrrolyl, phenyl vinyl, diphenyl vinyl, phenyl ethynyl, hydroxy chromonyl phenyl, didecyloxy hydroxy chromonyl phenyl, phenyl or ##STR2## wherein R.sub.1 is vinyl, vinyl phenyl, vinyl benzyl, alkyl ethenyl, or alkyl phenyl ethenyl, provided that when...
Show moreProton-transfer, low self-absorbing chromophores of the formula: ##STR1## wherein R.sub.2 and R.sub.3 are independently hydrogen, alkyl, aryl, cyano, nitro, halo or an ether group, R.sub.4 is O or N--H, and R.sub.5 is thienyl, naphthyl, furanyl, pyrrolyl, phenyl vinyl, diphenyl vinyl, phenyl ethynyl, hydroxy chromonyl phenyl, didecyloxy hydroxy chromonyl phenyl, phenyl or ##STR2## wherein R.sub.1 is vinyl, vinyl phenyl, vinyl benzyl, alkyl ethenyl, or alkyl phenyl ethenyl, provided that when R.sub.5 is phenyl and R.sub.2 and R.sub.3 are hydrogen, R.sub.4 is N--H.
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Date Issued
1996-09-03
Identifier
FSU_uspto_5552551, 5552551, 915739, 08/096956, 600b83161da1122888348587dc18798c
Format
Citation
Self insulating substrate tape
Title
Self insulating substrate tape.
Creator
Hascicek, Yusuf S., Mutlu, Ibrahim, Belenli, Ibrahim
Abstract/Description
A process for manufacturing superconducting magnets is described. Two conducting tapes are assembled with an insulating ceramic layer deposited between facing sides of the tapes. The tapes and the insulative refractory material are bonded together by, for example, rolling to result in a self insulating substrate tape to which superconducting composition precursors are applied for later annealing. In one aspect, the composite tape is then wound to result in a pancake coil which is exposed to...
Show moreA process for manufacturing superconducting magnets is described. Two conducting tapes are assembled with an insulating ceramic layer deposited between facing sides of the tapes. The tapes and the insulative refractory material are bonded together by, for example, rolling to result in a self insulating substrate tape to which superconducting composition precursors are applied for later annealing. In one aspect, the composite tape is then wound to result in a pancake coil which is exposed to high temperatures in an oxidizing environment to convert the superconducting precursors to superconducting materials. The resultant high temperature superconducting composition coil can then be used as a high temperature superconducting magnet with appropriate conducting connectors applied thereto.
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Date Issued
2002-05-14
Identifier
FSU_uspto_6387525, 6387525, 985992, 09/560787, 600b83161da1122888348587dc18798c
Format
Citation
Route to synthetic analogues of Rocaglamide and Aglafoline using cascade transformations initiated by oxy-cope rearrangement of bis-alkynes
Title
Route to synthetic analogues of Rocaglamide and Aglafoline using cascade transformations initiated by oxy-cope rearrangement of bis-alkynes.
Creator
Alabugin, Igor V., Pal, Runa
Abstract/Description
A method for preparing a cyclobutene compound or a cyclopentenone is provided. The method comprises contacting an α,β-diketone with a metal acetylide at a temperature below 0° C. to thereby form a reaction mixture comprising a bis-alkyne precursor. The bis-alkyne precursor rearranges into a bis-allenic intermediate, which undergoes further rearrangement into the cyclobutene compound or the cyclopentenone compound as the temperature of the reaction mixture increases from below...
Show moreA method for preparing a cyclobutene compound or a cyclopentenone is provided. The method comprises contacting an α,β-diketone with a metal acetylide at a temperature below 0° C. to thereby form a reaction mixture comprising a bis-alkyne precursor. The bis-alkyne precursor rearranges into a bis-allenic intermediate, which undergoes further rearrangement into the cyclobutene compound or the cyclopentenone compound as the temperature of the reaction mixture increases from below 0° C. to above 0° C.
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Date Issued
2015-12-08
Identifier
FSU_uspto_9206100, 9206100, 2368265, 13/820176, 6c9256d97d167832cbab694dc904bd27
Format
Citation
Polymer mechanical damping composites and methods of production
Title
Polymer mechanical damping composites and methods of production.
Creator
Schlenoff, Joseph B.
Abstract/Description
An article comprising a polyelectrolyte complex, the polyelectrolyte complex comprising an intermolecular blend of a predominantly positively-charged polyelectrolyte and a predominantly negatively charged polyelectrolyte and being free of salt crystals having a size greater than about 1 micrometer and free of voids having a size greater than about 100 nm, the article having no transverse dimension less than about 10,000 nm.
Date Issued
2012-06-26
Identifier
FSU_uspto_8206816, 8206816, 915739, 12/439647, 6c9256d97d167832cbab694dc904bd27
Format
Citation
Polymer mechanical damping composites and methods of production
Title
Polymer mechanical damping composites and methods of production.
Creator
Schlenoff, Joseph B.
Abstract/Description
A method of reshaping an article comprising a polyelectrolyte complex, the polyelectrolyte complex comprising an intermolecular blend of a predominantly positively-charged polyelectrolyte and a predominantly negatively charged polyelectrolyte by controlling the salt doping level.
Date Issued
2012-06-26
Identifier
FSU_uspto_8206822, 8206822, 915739, 12/399690, 6c9256d97d167832cbab694dc904bd27
Format
Citation
Polymer foam-based piezoelectric materials and method of manufacture
Title
Polymer foam-based piezoelectric materials and method of manufacture.
Creator
Li, Yan Li, Zeng, Changchun
Abstract/Description
Thermally stable piezoelectric polymer foams (ferroelectrets) with high piezoelectric activity for sensing and actuation. The invention further includes a method of fabricating such foams in an environmentally friendly manner.
Date Issued
2016-11-08
Identifier
FSU_uspto_9490420, 9490420, 1340410, 14/827596, 6c9256d97d167832cbab694dc904bd27
Format
Citation
Scalable liposome microarray screening
Title
Scalable liposome microarray screening.
Creator
Lenhert, Steven, Kusi-Appiah, Aubrey, Lowry, Troy W.
Abstract/Description
A method comprising the following steps: (a) contacting a topographically structured stamp to an array of spots comprising lipid ink on a palette to force the lipid ink of each of the spots into recesses of the topographically structured stamp, (b) removing the palette from the topographically structured stamp so that at least some the lipid ink from each of the spots is retained in the recesses of the topographically structured stamp, and (c) printing the lipid ink in each of the recesses on...
Show moreA method comprising the following steps: (a) contacting a topographically structured stamp to an array of spots comprising lipid ink on a palette to force the lipid ink of each of the spots into recesses of the topographically structured stamp, (b) removing the palette from the topographically structured stamp so that at least some the lipid ink from each of the spots is retained in the recesses of the topographically structured stamp, and (c) printing the lipid ink in each of the recesses on a substrate as an array of stamped spots using the topographically structured stamp to thereby form a patterned substrate, wherein the recesses have one or more recess patterns, wherein each stamped spot of the array of stamped spots comprises lipid multilayer structure, and wherein the patterned array is based on the one or more recess patterns.
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Date Issued
2016-12-06
Identifier
FSU_uspto_9513222, 9513222, 2611948, 14/413319, 6c9256d97d167832cbab694dc904bd27
Format
Citation
Sanitary pads for men
Title
Sanitary pads for men.
Creator
Lipner, Harry
Abstract/Description
Sanitary pads for men are disposable in a storage mode in which they are flat and non-overlapping for easy carrying in pockets. The sanitary pads may be folded in order to form generally semi-cylindrical portions which envelop the wearer's penis and prevent embarrassment to incontinent men. In the storage or carrying mode, the pad may alternately be T-shaped or constructed in a generally rectangular shape. Adhesive means, such as double sided tape, or fabric loop and hook fasteners may be...
Show moreSanitary pads for men are disposable in a storage mode in which they are flat and non-overlapping for easy carrying in pockets. The sanitary pads may be folded in order to form generally semi-cylindrical portions which envelop the wearer's penis and prevent embarrassment to incontinent men. In the storage or carrying mode, the pad may alternately be T-shaped or constructed in a generally rectangular shape. Adhesive means, such as double sided tape, or fabric loop and hook fasteners may be used to secure the pads in proper position. The pads are a layered structure including an inner relatively thick layer of absorbent material, a water barrier layer made of plastic, and an outer relatively thin absorbent layer.
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Date Issued
1986-03-18
Identifier
FSU_uspto_4576599, 4576599, 505970, 06/609651, 600b83161da1122888348587dc18798c
Format
Citation
Robust deconvolution of complex mixtures by covariance spectroscopy
Title
Robust deconvolution of complex mixtures by covariance spectroscopy.
Creator
Bruschweiler, Rafael, Zhang, Fengli
Abstract/Description
Methods and systems are provided for the deconvolution of the NMR spectrum of a mixture into individual components and spin systems by combining covariance total correlation spectroscopy (TOCSY) spectra with covariance NMR. The method may include obtaining a 2D TOCSY spectra of a chemical mixture and then performing a series of analytical steps to identify the individual components of the mixture.
Date Issued
2010-11-16
Identifier
FSU_uspto_7835872, 7835872, 2438672, 12/032903, 6c9256d97d167832cbab694dc904bd27
Format
Citation
Self-balanced modulation and magnetic rebalancing method for parallel multilevel inverters
Title
Self-balanced modulation and magnetic rebalancing method for parallel multilevel inverters.
Creator
Li, Hui, Shi, Yanjun
Abstract/Description
A self-balanced modulation method and a closed-loop magnetic flux rebalancing control method for parallel multilevel inverters. The combination of the two methods provides for balancing of the magnetic flux of the inter-cell transformers (ICTs) of the parallel multilevel inverters without deteriorating the quality of the output voltage. In various embodiments a parallel multi-level inverter modulator is provide including a multi-channel comparator to generate a multiplexed digitized ideal...
Show moreA self-balanced modulation method and a closed-loop magnetic flux rebalancing control method for parallel multilevel inverters. The combination of the two methods provides for balancing of the magnetic flux of the inter-cell transformers (ICTs) of the parallel multilevel inverters without deteriorating the quality of the output voltage. In various embodiments a parallel multi-level inverter modulator is provide including a multi-channel comparator to generate a multiplexed digitized ideal waveform for a parallel multi-level inverter and a finite state machine (FSM) module coupled to the parallel multi-channel comparator, the FSM module to receive the multiplexed digitized ideal waveform and to generate a pulse width modulated gate-drive signal for each switching device of the parallel multi-level inverter. The system and method provides for optimization of the output voltage spectrum without influence the magnetic balancing.
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Date Issued
2017-11-28
Identifier
FSU_uspto_9831800, 9831800, 1616461, 15/297828, 6c9256d97d167832cbab694dc904bd27
Format
Citation
Purified linear epitopes from cashew nuts, nucleic acids encoding therefor and associated methods
Title
Purified linear epitopes from cashew nuts, nucleic acids encoding therefor and associated methods.
Creator
Roux, Kenneth H., Sathe, Shridhar K., Teuber, Suzanne S.
Abstract/Description
Disclosed are major allergenic proteins in cashew nut, which are legumin-like proteins and 2S albumins. Also disclosed is a polypeptide allergen in the 7S superfamily, which includes vicilin-like and sucrose binding proteins. Several linear epitopes of the cashew nut are identified and characterized. The invention further discloses the sequence of cDNA encoding the allergenic polypeptide, the allergen being designated Ana o 1, and also describes the characterization of the expressed...
Show moreDisclosed are major allergenic proteins in cashew nut, which are legumin-like proteins and 2S albumins. Also disclosed is a polypeptide allergen in the 7S superfamily, which includes vicilin-like and sucrose binding proteins. Several linear epitopes of the cashew nut are identified and characterized. The invention further discloses the sequence of cDNA encoding the allergenic polypeptide, the allergen being designated Ana o 1, and also describes the characterization of the expressed recombinant polypeptide and associated methods employing the polypeptide.
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Date Issued
2012-09-25
Identifier
FSU_uspto_8273856, 8273856, 1946887, 12/466565, 6c9256d97d167832cbab694dc904bd27
Format
Citation
Processes for the production of polycyclic fused ring compounds
Title
Processes for the production of polycyclic fused ring compounds.
Creator
Holton, Robert A., Vu, Phong H.
Abstract/Description
The present invention provides processes for the production of polycyclic fused ring compounds. The polycyclic fused ring compounds are produced by protecting a polycyclic fused ring polyol with a bridging silicon-based protecting group and attaching a suitable side chain. Polycyclic fused ring compounds and intermediate compounds are also described.
Date Issued
2010-02-23
Identifier
FSU_uspto_7667055, 7667055, 711524, 11/449535, 6c9256d97d167832cbab694dc904bd27
Format
Citation
Prosthetic socket apparatus and systems
Title
Prosthetic socket apparatus and systems.
Creator
Wang, Ben, Zhang, Chun Hua, Zeng, Changchun, Kramer, Leslie D., Gillis, Arlene
Abstract/Description
A prosthetic sock for a patient to wear over a residual limb is provided. The prosthetic sock includes an inner layer configured to fit over at least a portion of the residual limb of the patient. A foam layer is disposed on an outer surface of the inner layer. The foam layer compensates for changes in shape or volume of the residual limb within the prosthetic sock by changing shape in a manner effective to maintain a secure fit between the residual limb and a prosthetic socket of a...
Show moreA prosthetic sock for a patient to wear over a residual limb is provided. The prosthetic sock includes an inner layer configured to fit over at least a portion of the residual limb of the patient. A foam layer is disposed on an outer surface of the inner layer. The foam layer compensates for changes in shape or volume of the residual limb within the prosthetic sock by changing shape in a manner effective to maintain a secure fit between the residual limb and a prosthetic socket of a prosthetic limb.
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Date Issued
2016-11-08
Identifier
FSU_uspto_9486333, 9486333, 1240690, 13/864675, 6c9256d97d167832cbab694dc904bd27
Format
Citation
Processes for the preparation of paclitaxel
Title
Processes for the preparation of paclitaxel.
Creator
Holton, Robert A., Vu, Phong H.
Abstract/Description
The present invention provides processes for the production of paclitaxel. Paclitaxel is produced by protecting the C(7) and the C(10) hydroxy groups of 10-DAB with a bridging silicon-based protecting group. The resulting 7,10-protected 10-DAB derivative is then derivatized and deprotected to form paclitaxel.
Date Issued
2008-04-15
Identifier
FSU_uspto_7358378, 7358378, 711524, 11/449075, 6c9256d97d167832cbab694dc904bd27
Format
Citation
Processes for the preparation of docetaxel
Title
Processes for the preparation of docetaxel.
Creator
Holton, Robert A., Vu, Phong H.
Abstract/Description
The present invention provides processes for the production of docetaxel. Docetaxel is produced by protecting the C(7) and the C(10) hydroxy groups of 10-DAB with a bridging silicon-based protecting group. The resulting 7,10-protected 10-DAB derivative is then derivatized and deprotected to form docetaxel.
Date Issued
2009-06-23
Identifier
FSU_uspto_7550608, 7550608, 711524, 11/449048, 6c9256d97d167832cbab694dc904bd27
Format
Citation
Semi-synthetic quorum sensors
Title
Semi-synthetic quorum sensors.
Creator
Lenhert, Steven
Abstract/Description
Described is a device comprising a substrate, and a quorum sensor array on the substrate. The quorum sensor array comprises quorum sensors that release signal molecules in response to one or more environmental signals being sense by the quorum sensors to thereby amplify the one or more environmental signals by causing a signal chain reaction in neighboring quorum sensors of the quorum sensor array. Each of the quorum sensors comprises a lipid multilayer structure. Also described is a method...
Show moreDescribed is a device comprising a substrate, and a quorum sensor array on the substrate. The quorum sensor array comprises quorum sensors that release signal molecules in response to one or more environmental signals being sense by the quorum sensors to thereby amplify the one or more environmental signals by causing a signal chain reaction in neighboring quorum sensors of the quorum sensor array. Each of the quorum sensors comprises a lipid multilayer structure. Also described is a method comprising providing data for changes in optical properties of at least part of the quorum sensor array in response to exposing the quorum sensor array to one or more environmental signals, and determining the presence of the one or more environmental signals based on the data.
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Date Issued
2015-08-11
Identifier
FSU_uspto_9102974, 9102974, 2611948, 13/248250, 6c9256d97d167832cbab694dc904bd27
Format
Citation
Protein controlling synthesis of collagen and associated methods
Title
Protein controlling synthesis of collagen and associated methods.
Creator
Stefanovic, Branko
Abstract/Description
A method of screening an agent for ability to interfere with collagen synthesis includes the steps of reacting a polypeptide having an amino acid sequence comprising SEQ ID NO: 1 with collagen mRNAs in the presence of the agent and detecting if the agent has interfered with binding of the polypeptide to the mRNAs. Another method includes the steps of reacting the polypeptide with nonmuscle myosin filaments in the presence of the agent and detecting if the agent has interfered with binding of...
Show moreA method of screening an agent for ability to interfere with collagen synthesis includes the steps of reacting a polypeptide having an amino acid sequence comprising SEQ ID NO: 1 with collagen mRNAs in the presence of the agent and detecting if the agent has interfered with binding of the polypeptide to the mRNAs. Another method includes the steps of reacting the polypeptide with nonmuscle myosin filaments in the presence of the agent and detecting if the agent has interfered with binding of the polypeptide to the nonmuscle myosin filaments.
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Date Issued
2014-04-15
Identifier
FSU_uspto_8697385, 8697385, 2858218, 13/706747, 6c9256d97d167832cbab694dc904bd27
Format
Citation
RNAi therapeutic for treatment of hepatitis C infection
Title
RNAi therapeutic for treatment of hepatitis C infection.
Creator
Tang, Hengli
Abstract/Description
Small interfering RNAs (siRNAs) or small hairpin RNA (shRNAs) and compositions comprising same are provided that target human cyclophilin A (CyPA) to inhibit Hepatitis C (HCV) infection. Such siRNA and shRNAs may have a length of from about 19 to about 29 contiguous nucleotides corresponding to a specific region of human cyclophilin A (CyPA) cDNA of from about nucleotide 155 to about nucleotide 183 having particular potency against CyPA and HCV. Such siRNA and shRNAs may be formulated as...
Show moreSmall interfering RNAs (siRNAs) or small hairpin RNA (shRNAs) and compositions comprising same are provided that target human cyclophilin A (CyPA) to inhibit Hepatitis C (HCV) infection. Such siRNA and shRNAs may have a length of from about 19 to about 29 contiguous nucleotides corresponding to a specific region of human cyclophilin A (CyPA) cDNA of from about nucleotide 155 to about nucleotide 183 having particular potency against CyPA and HCV. Such siRNA and shRNAs may be formulated as naked compositions or pharmaceutical compositions. DNA polynucleotides, plasmids, and viral or non-viral vectors are provided that encode siRNA or shRNA molecules, which may be delivered directly to cells or in combination with delivery agents, such as lipids, polymers, encapsulated lipid particles, such as liposomes. Methods for treating, managing inhibiting, preventing, etc., HCV infection using such siRNA and shRNAs and compositions comprising same are also provided.
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Date Issued
2013-10-22
Identifier
FSU_uspto_8563529, 8563529, 2400173, 13/558428, 6c9256d97d167832cbab694dc904bd27
Format
Citation
Radiosensitizing diamines and their pharmaceutical preparations
Title
Radiosensitizing diamines and their pharmaceutical preparations.
Creator
Hofer, Kurt G., Yang, Li-Xi
Abstract/Description
A compound comprising a diamine containing from 2-4 electron-affinic radiosensitizing functional groups or a salt thereof is provided. In a preferred embodiment the compound has the formula ##STR1## wherein A comprises a carbon chain having from about 2-10 carbons in the chain, R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are H, or T, T is ##STR2## wherein A' comprises a carbon chain having from about 1-8 carbons in the chain, R.sup.5 is H, lower alkyl, or halo, and R.sup.6 is H, lower alkyl, halo...
Show moreA compound comprising a diamine containing from 2-4 electron-affinic radiosensitizing functional groups or a salt thereof is provided. In a preferred embodiment the compound has the formula ##STR1## wherein A comprises a carbon chain having from about 2-10 carbons in the chain, R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are H, or T, T is ##STR2## wherein A' comprises a carbon chain having from about 1-8 carbons in the chain, R.sup.5 is H, lower alkyl, or halo, and R.sup.6 is H, lower alkyl, halo or nitro, provided that at least one of R.sup.1 and R.sup.2, and at least one of R.sup.3 and R.sup.4 is T. Intermediates for, pharmaceutical compositions containing, methods for making and methods for using such compounds to radiosensitize and kill hypoxic tumor cells are also provided.
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Date Issued
1997-12-23
Identifier
FSU_uspto_5700825, 5700825, 7999, 08/414272, 600b83161da1122888348587dc18798c
Format
Citation
Reagent for synthesis of para-methoxbenzyl (PMB) ethers and associated methods
Title
Reagent for synthesis of para-methoxbenzyl (PMB) ethers and associated methods.
Creator
Dudley, Gregory B.
Abstract/Description
A newly synthesized compound designated lepidine ether 2-(4-Methoxybenzyloxy)-4-methylquinoline reacts with methyl triflate in the presence of alcohols to generate a neutral organic salt that transfers the para-methoxybenzyl (PMB) protecting group onto alcohols in high yield and under mild conditions.
Date Issued
2011-06-14
Identifier
FSU_uspto_7960553, 7960553, 2398067, 11/865952, 6c9256d97d167832cbab694dc904bd27
Format
Citation
Radiosensitizing taxanes and their pharmaceutical preparations
Title
Radiosensitizing taxanes and their pharmaceutical preparations.
Creator
Holton, Robert A., Nadizadeh, Hossain, Yang, Li-Xi
Abstract/Description
Taxanes containing electron-affinic radiosensitizing functional groups, their pharmaceutical preparations, and methods of making and using this new class of highly potent radiosensitizers of tumor cells.
Date Issued
2006-06-27
Identifier
FSU_uspto_7067552, 7067552, 711524, 09/978436, 600b83161da1122888348587dc18798c
Format
Citation
Solid-state NMR method for screening cell membrane protein binding drug candidates
Title
Solid-state NMR method for screening cell membrane protein binding drug candidates.
Creator
Brey, William W., Cross, Timothy A., Smirnov, Alexej, Chekmenev, Eduard Y.
Abstract/Description
Disclosed is a method for detection of ligand-cell membrane protein binding by solid state NMR spectroscopy. The method starts by forming a lipid bilayer inside nanopores of an anodic aluminum oxide (AAO) substrate, the lipid bilayer containing a membrane protein sample. The AAO substrate is treated with multiple candidate ligands having potential binding affinity for the membrane protein. Solid-state NMR analysis is performed on the treated AAO/lipid preparation so as to generate an NMR...
Show moreDisclosed is a method for detection of ligand-cell membrane protein binding by solid state NMR spectroscopy. The method starts by forming a lipid bilayer inside nanopores of an anodic aluminum oxide (AAO) substrate, the lipid bilayer containing a membrane protein sample. The AAO substrate is treated with multiple candidate ligands having potential binding affinity for the membrane protein. Solid-state NMR analysis is performed on the treated AAO/lipid preparation so as to generate an NMR spectrum for the treated membrane protein. The solid-state NMR spectrum of the treated membrane protein is compared with the spectrum of the same preparation of membrane protein in the absence of the ligands. It is then determined whether the solid-state NMR spectrum of the treated membrane protein has shifted from the NMR spectrum of the untreated membrane protein, a shift being indicative of protein binding by the candidate ligand.
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Date Issued
2010-03-16
Identifier
FSU_uspto_7678546, 7678546, 1171403, 11/865302, 6c9256d97d167832cbab694dc904bd27
Format
Citation
Solid state NMR method for screening cell membrane protein binding drug candidates
Title
Solid state NMR method for screening cell membrane protein binding drug candidates.
Creator
Brey, William W., Cross, Timothy A., Smirnov, Alexej, Chekmenev, Eduard Y.
Abstract/Description
Disclosed is a method for detection of ligand-cell membrane protein binding by solid state NMR spectroscopy. The method starts by forming a lipid bilayer inside nanopores of an anodic aluminum oxide (AAO) substrate, the lipid bilayer containing a membrane protein sample. The AAO substrate is treated with multiple candidate ligands having potential binding affinity for the membrane protein. Solid-state NMR analysis is performed on the treated AAO/lipid preparation so as to generate an NMR...
Show moreDisclosed is a method for detection of ligand-cell membrane protein binding by solid state NMR spectroscopy. The method starts by forming a lipid bilayer inside nanopores of an anodic aluminum oxide (AAO) substrate, the lipid bilayer containing a membrane protein sample. The AAO substrate is treated with multiple candidate ligands having potential binding affinity for the membrane protein. Solid-state NMR analysis is performed on the treated AAO/lipid preparation so as to generate an NMR spectrum for the treated membrane protein. The solid-state NMR spectrum of the treated membrane protein is compared with the spectrum of the same preparation of membrane protein in the absence of the ligands. It is then determined whether the solid-state NMR spectrum of the treated membrane protein has shifted from the NMR spectrum of the untreated membrane protein, a shift being indicative of protein binding by the candidate ligand.
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Date Issued
2010-03-09
Identifier
FSU_uspto_7674595, 7674595, 1171403, 12/366173, 6c9256d97d167832cbab694dc904bd27
Format
Citation
RNAi therapeutic for treatment of hepatitis C infection
Title
RNAi therapeutic for treatment of hepatitis C infection.
Creator
Tang, Hengli
Abstract/Description
Small interfering RNAs (siRNAs) or small hairpin RNA (shRNAs) and compositions comprising same are provided that specifically target human cyclophilin A (CyPA) to effectively inhibit Hepatitis C (HCV) infection in a cell. Such siRNA and shRNAs may have a length of from about 19 to about 29 contiguous nucleotides corresponding to a specific region of human cyclophilin A (CyPA) cDNA of from about nucleotide 155 to about nucleotide 183 having particular potency against CyPA and HCV. Such siRNA...
Show moreSmall interfering RNAs (siRNAs) or small hairpin RNA (shRNAs) and compositions comprising same are provided that specifically target human cyclophilin A (CyPA) to effectively inhibit Hepatitis C (HCV) infection in a cell. Such siRNA and shRNAs may have a length of from about 19 to about 29 contiguous nucleotides corresponding to a specific region of human cyclophilin A (CyPA) cDNA of from about nucleotide 155 to about nucleotide 183 having particular potency against CyPA and HCV. Such siRNA and shRNAs may be formulated as naked compositions or as pharmaceutical compositions. DNA polynucleotides, plasmids, and viral or non-viral vectors are also provided that encode siRNA or shRNA molecules, which may be delivered directly to cells or in combination with known delivery agents, such as lipids, polymers, encapsulated lipid particles, such as liposomes. Methods for treating, managing inhibiting, preventing, etc., HCV infection using such siRNA and shRNAs and compositions comprising same are also provided.
Show less
Date Issued
2012-11-27
Identifier
FSU_uspto_8318925, 8318925, 2400173, 13/034851, 6c9256d97d167832cbab694dc904bd27
Format
Citation
RNAi therapeutic for treatment of hepatitis C infection
Title
RNAi therapeutic for treatment of hepatitis C infection.
Creator
Tang, Hengli
Abstract/Description
Small interfering RNAs (siRNAs) or small hairpin RNA (shRNAs) and compositions comprising same are provided that specifically target human cyclophilin A (CyPA) to effectively inhibit Hepatitis C(HCV) infection in a cell. Such siRNA and shRNAs may have a length of from about 19 to about 29 contiguous nucleotides corresponding to a specific region of human cyclophilin A (CyPA) cDNA of from about nucleotide 155 to about nucleotide 183 having particular potency against CyPA and HCV. Such siRNA...
Show moreSmall interfering RNAs (siRNAs) or small hairpin RNA (shRNAs) and compositions comprising same are provided that specifically target human cyclophilin A (CyPA) to effectively inhibit Hepatitis C(HCV) infection in a cell. Such siRNA and shRNAs may have a length of from about 19 to about 29 contiguous nucleotides corresponding to a specific region of human cyclophilin A (CyPA) cDNA of from about nucleotide 155 to about nucleotide 183 having particular potency against CyPA and HCV. Such siRNA and shRNAs may be formulated as naked compositions or as pharmaceutical compositions. DNA polynucleotides, plasmids, and viral or non-viral vectors are also provided that encode siRNA or shRNA molecules, which may be delivered directly to cells or in combination with known delivery agents, such as lipids, polymers, encapsulated lipid particles, such as liposomes. Methods for treating, managing inhibiting, preventing, etc., HCV infection using such siRNA and shRNAs and compositions comprising same are also provided.
Show less
Date Issued
2012-08-28
Identifier
FSU_uspto_8252763, 8252763, 2400173, 13/036044, 6c9256d97d167832cbab694dc904bd27
Format
Citation
RNAi therapeutic for treatment of hepatitis C infection
Title
RNAi therapeutic for treatment of hepatitis C infection.
Creator
Tang, Hengli
Abstract/Description
Small interfering RNAs (siRNAs) or small hairpin RNA (shRNAs) and compositions comprising same are provided that specifically target human cyclophilin A (CyPA) to effectively inhibit Hepatitis C (HCV) infection in a cell. Such siRNA and shRNAs may have a length of from about 19 to about 29 contiguous nucleotides corresponding to a specific region of human cyclophilin A (CyPA) cDNA of from about nucleotide 155 to about nucleotide 183 having particular potency against CyPA and HCV. Such siRNA...
Show moreSmall interfering RNAs (siRNAs) or small hairpin RNA (shRNAs) and compositions comprising same are provided that specifically target human cyclophilin A (CyPA) to effectively inhibit Hepatitis C (HCV) infection in a cell. Such siRNA and shRNAs may have a length of from about 19 to about 29 contiguous nucleotides corresponding to a specific region of human cyclophilin A (CyPA) cDNA of from about nucleotide 155 to about nucleotide 183 having particular potency against CyPA and HCV. Such siRNA and shRNAs may be formulated as naked compositions or as pharmaceutical compositions. DNA polynucleotides, plasmids, and viral or non-viral vectors are also provided that encode siRNA or shRNA molecules, which may be delivered directly to cells or in combination with known delivery agents, such as lipids, polymers, encapsulated lipid particles, such as liposomes. Methods for treating, managing inhibiting, preventing, etc., HCV infection using such siRNA and shRNAs and compositions comprising same are also provided.
Show less
Date Issued
2011-03-22
Identifier
FSU_uspto_7910722, 7910722, 2400173, 12/167402, 6c9256d97d167832cbab694dc904bd27
Format
Citation
Process for the preparation of 10-desacetoxybaccatin III
Title
Process for the preparation of 10-desacetoxybaccatin III.
Creator
Holton, Robert A., Somoza, Carmen
Abstract/Description
A process for abstracting a C10 hydroxy, acyloxy or sulfonyloxy substituent from a taxane in which the C10 hydroxy, acyloxy or sulfonyloxy substituted taxane is reacted with samarium diiodide.
Date Issued
1997-08-05
Identifier
FSU_uspto_5654447, 5654447, 711524, 08/500868, 600b83161da1122888348587dc18798c
Format
Citation
Replication timing profiles for leukemia and other cancers
Title
Replication timing profiles for leukemia and other cancers.
Creator
Gilbert, David, Ryba, Tyrone
Abstract/Description
Described is a method for determining that a population of cells are a specific type of leukemic cell based on the replication timing fingerprint for the population of cells.
Date Issued
2014-05-13
Identifier
FSU_uspto_8725423, 8725423, 1706182, 13/726803, 6c9256d97d167832cbab694dc904bd27
Format
Citation
Real-time small-signal stability assessment of power electronic-based components in contemporary power systems
Title
Real-time small-signal stability assessment of power electronic-based components in contemporary power systems.
Creator
Salmani, Mohamadamin, Edrington, Chris S.
Abstract/Description
A novel method for real-time small-signal stability analysis for power electronic-based components in a power system. The method is based on impedance measurement techniques and Generalized Nyquist Criterion. The method is capable of real-time application. The method may be used to monitor a system in real-time by perturbing the system persistently and utilizing the system's responses to calculate source/load impedance in time-domain and based on d-q impedance measurement theory. Time-domain...
Show moreA novel method for real-time small-signal stability analysis for power electronic-based components in a power system. The method is based on impedance measurement techniques and Generalized Nyquist Criterion. The method is capable of real-time application. The method may be used to monitor a system in real-time by perturbing the system persistently and utilizing the system's responses to calculate source/load impedance in time-domain and based on d-q impedance measurement theory. Time-domain results may be transferred to frequency-domain results by taking advantage of a fast Fourier transform algorithm (or optionally discrete Fourier transformer for discrete systems) and monitoring the system's stability by obtaining a Nyquist contour and employing Generalized Nyquist Criterion or unit circle criterion.
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Date Issued
2016-04-19
Identifier
FSU_uspto_9316701, 9316701, 3159080, 14/702063, 6c9256d97d167832cbab694dc904bd27
Format
Citation
Solid state NMR method for screening cell membrane protein binding drug candidates
Title
Solid state NMR method for screening cell membrane protein binding drug candidates.
Creator
Brey, William W., Cross, Timothy A., Smirnov, Alexej, Chekmenev, Eduard Y.
Abstract/Description
Disclosed is a method for detection of ligand-cell membrane protein binding by solid state NMR spectroscopy. The method starts by forming a lipid bilayer inside nanopores of an anodic aluminum oxide (AAO) substrate, the lipid bilayer containing a membrane protein sample. The AAO substrate is treated with multiple candidate ligands having potential binding affinity for the membrane protein. Solid-state NMR analysis is performed on the treated AAO/lipid preparation so as to generate an NMR...
Show moreDisclosed is a method for detection of ligand-cell membrane protein binding by solid state NMR spectroscopy. The method starts by forming a lipid bilayer inside nanopores of an anodic aluminum oxide (AAO) substrate, the lipid bilayer containing a membrane protein sample. The AAO substrate is treated with multiple candidate ligands having potential binding affinity for the membrane protein. Solid-state NMR analysis is performed on the treated AAO/lipid preparation so as to generate an NMR spectrum for the treated membrane protein. The solid-state NMR spectrum of the treated membrane protein is compared with the spectrum of the same preparation of membrane protein in the absence of the ligands. It is then determined whether the solid-state NMR spectrum of the treated membrane protein has shifted from the NMR spectrum of the untreated membrane protein, a shift being indicative of protein binding by the candidate ligand.
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Date Issued
2010-07-13
Identifier
FSU_uspto_7754438, 7754438, 1171403, 12/366190, 6c9256d97d167832cbab694dc904bd27
Format
Citation
Six-membered
Title
Six-membered.
Creator
McQuade, D. Tyler, Park, Jin Kyoon, Rexford, Matthew D., Lackey, Hershel H.
Abstract/Description
The present invention provides a catalyst complex or ligand, and compositions thereof, for use in a variety of organic reactions having high reactivity and enantioselectivity. The catalyst is a N-heterocyclic carbene having three fused rings with first and second rings being six-membered rings and the third being a five-membered ring. The first ring is fused to the second and has four substituents. The second ring has two nitrogens flanking a carbene atom with one nitrogen bound to a...
Show moreThe present invention provides a catalyst complex or ligand, and compositions thereof, for use in a variety of organic reactions having high reactivity and enantioselectivity. The catalyst is a N-heterocyclic carbene having three fused rings with first and second rings being six-membered rings and the third being a five-membered ring. The first ring is fused to the second and has four substituents. The second ring has two nitrogens flanking a carbene atom with one nitrogen bound to a substituent. The carbene atom may optionally be bonded to a metal. The third ring is fused to the second ring and contains two nitrogens. The third ring of the catalyst has a double bond and two substituents on adjacent non-fused carbons. A non-fused nitrogen of the third ring is partially bonded to another substituent. Methods for the synthesis and use of the catalyst embodiments of the present invention are also provided.
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Date Issued
2012-07-17
Identifier
FSU_uspto_8222265, 8222265, 1542467, 12/870901, 6c9256d97d167832cbab694dc904bd27
Format
Citation

Pages