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- Title
- Method of applying high temperature compatible insulation to superconductors.
- Creator
-
Hascicek, Yusuf S., Celik, Erdal, Mutlu, Ibrahim
- Abstract/Description
-
There is described a method of applying insulative coating on high temperature superconductors and low temperature superconductors from sol-gel solutions prepared from Zr, or Zr with one of Mg, Y, Ce, In and Sn based precursor materials. The solution is prepared with isopropanol as a solvent and acetyl acetone as a catalyst. The conductors are dipped into the solution and thereafter dried at a temperature effective to evaporate the solvent. Thereafter, heat treatment in the presence of oxygen...
Show moreThere is described a method of applying insulative coating on high temperature superconductors and low temperature superconductors from sol-gel solutions prepared from Zr, or Zr with one of Mg, Y, Ce, In and Sn based precursor materials. The solution is prepared with isopropanol as a solvent and acetyl acetone as a catalyst. The conductors are dipped into the solution and thereafter dried at a temperature effective to evaporate the solvent. Thereafter, heat treatment in the presence of oxygen is applied at a temperature sufficient to oxidize the precursors to result in a ceramic insulative coating on the conductor.
Show less - Date Issued
- 2002-05-14
- Identifier
- FSU_uspto_6387852, 6387852, 985992, 09/973374, 600b83161da1122888348587dc18798c
- Format
- Citation
- Title
- Method of detecting compromised computers in a network.
- Creator
-
Chen, Peng Sheng, Duan, Zhenhai
- Abstract/Description
-
A method of detecting a compromised machine on a network. The method receives an email message from a machine on the network and classifies it as either spam or non-spam. A probability ratio is then updated, according to whether the message was spam or non-spam, by applying a sequential probability ratio test. If the probability ratio is greater than or equal to a first threshold, then the machine is compromised. If the probability ratio is less than or equal to a second threshold, then the...
Show moreA method of detecting a compromised machine on a network. The method receives an email message from a machine on the network and classifies it as either spam or non-spam. A probability ratio is then updated, according to whether the message was spam or non-spam, by applying a sequential probability ratio test. If the probability ratio is greater than or equal to a first threshold, then the machine is compromised. If the probability ratio is less than or equal to a second threshold, then the machine is normal. The operations of receiving a message, classifying the message, updating the probability ratio, and indicating the machine is normal or compromised until the probability ratio is greater than or equal to the first threshold are repeated for a plurality of messages. Such repeated operations are performed on each of the messages one at a time, as each of the messages is received.
Show less - Date Issued
- 2013-10-15
- Identifier
- FSU_uspto_8560624, 8560624, 1922309, 13/591866, 6c9256d97d167832cbab694dc904bd27
- Format
- Citation
- Title
- Low self-absorbing, intrinsically scintillating polymers.
- Creator
-
Schlenoff, Joseph B., Dharia, Jayesh, Johnson, Kurtis F.
- Abstract/Description
-
Polymers containing covalently-bonded, low self-absorbing, scintillating chromophores, polymerizable chromophores of the formula: ##STR1## wherein R.sub.1 is vinyl, .alpha.-methyl vinyl, vinyl phenyl, or vinyl benzyl, and R.sub.2 and R.sub.3 are independently hydrogen, alkyl, aryl, cyano, nitro, halo, or ether, and a process for the preparation of polymers containing low self-absorbing, scintillating chromophores.
- Date Issued
- 1993-11-02
- Identifier
- FSU_uspto_5258478, 5258478, 915739, 07/874748, 600b83161da1122888348587dc18798c
- Format
- Citation
- Title
- Magnetic shimming configuration with optimized turn geometry and electrical circuitry.
- Creator
-
Bird, Mark D., Painter, Thomas A., Bole, Scott T.
- Abstract/Description
-
A magnetic shimming configuration for a high-field magnet having optimized turn geometry and electrical circuitry. The present invention accomplishes this by combining the corrective functionalities of the standard X and ZX shims into two single, simplified electrical circuits and conductors, optimized for field strength as a function of turn location. The standard Y and ZY shims were also replaced with two single, simplified circuits and conductor that is corrective of the Y and ZY fields....
Show moreA magnetic shimming configuration for a high-field magnet having optimized turn geometry and electrical circuitry. The present invention accomplishes this by combining the corrective functionalities of the standard X and ZX shims into two single, simplified electrical circuits and conductors, optimized for field strength as a function of turn location. The standard Y and ZY shims were also replaced with two single, simplified circuits and conductor that is corrective of the Y and ZY fields. The new configuration also eliminates the need of additional “second, outboard turns” of the traditional X, ZX, Y, and ZY shims, located further away from the mid-plane.
Show less - Date Issued
- 2008-09-23
- Identifier
- FSU_uspto_7427908, 7427908, 1855543, 12/004993, 6c9256d97d167832cbab694dc904bd27
- Format
- Citation
- Title
- Lipid multilayer microarrays and their use for cell culture screening.
- Creator
-
Lenhert, Steven, Kusi-Appiah, Aubrey
- Abstract/Description
-
Provided is a device having one or more lipid multilayer arrays of lipid multilayer structures on a substrate. Each lipid multilayer structure encapsulates an encapsulated material that may be delivered to a cell that is in contact with the lipid multilayer structure to determine the cellular response of the cell to the encapsulated material.
- Date Issued
- 2016-09-20
- Identifier
- FSU_uspto_9447446, 9447446, 2611948, 13/534772, 6c9256d97d167832cbab694dc904bd27
- Format
- Citation
- Title
- Magnetic particle composition for therapeutic hyperthermia.
- Creator
-
Chen, Ching-Jen, Haik, Yousef
- Abstract/Description
-
Magnetic nanoparticle compositions are provided which provide an inherent temperature regulator for use in magnetic heating, particularly for use in magnetic hyperthermia medical treatments. The composition includes magnetic nanoparticles having a Curie temperature of between 40 and 46° C., preferably about 42° C., and may further include a polymeric material and optionally a drug or radiosensitizing agent. Methods of hyperthermia treatment of a patient in need thereof are provided...
Show moreMagnetic nanoparticle compositions are provided which provide an inherent temperature regulator for use in magnetic heating, particularly for use in magnetic hyperthermia medical treatments. The composition includes magnetic nanoparticles having a Curie temperature of between 40 and 46° C., preferably about 42° C., and may further include a polymeric material and optionally a drug or radiosensitizing agent. Methods of hyperthermia treatment of a patient in need thereof are provided which include the steps of administering to the patient a composition comprising magnetic nanoparticles having a Curie temperature of between 40 and 46° C.; and exposing the magnetic nanoparticles in the patient to an alternating magnetic field effective to generate hysteresis heat in the nanoparticles.
Show less - Date Issued
- 2010-11-30
- Identifier
- FSU_uspto_7842281, 7842281, 1462906, 11/125488, 6c9256d97d167832cbab694dc904bd27
- Format
- Citation
- Title
- Method of indefinite culture of hepatitis C virus.
- Creator
-
Tang, Hengli
- Abstract/Description
-
The invention discloses a method of maintaining hepatitis C virus (HCV) growing indefinitely in cell culture. The method includes providing a culture of cells susceptible to infection by HCV; introducing to the cell culture an inoculum containing an infective dose of HCV; contacting the inoculated cell culture with a growth medium containing an excess of uridine and cytidine; and changing spent growth medium with fresh growth medium containing the excess of uridine and cytidine on a...
Show moreThe invention discloses a method of maintaining hepatitis C virus (HCV) growing indefinitely in cell culture. The method includes providing a culture of cells susceptible to infection by HCV; introducing to the cell culture an inoculum containing an infective dose of HCV; contacting the inoculated cell culture with a growth medium containing an excess of uridine and cytidine; and changing spent growth medium with fresh growth medium containing the excess of uridine and cytidine on a predetermined schedule.
Show less - Date Issued
- 2010-07-20
- Identifier
- FSU_uspto_7759087, 7759087, 2400173, 11/536324, 6c9256d97d167832cbab694dc904bd27
- Format
- Citation
- Title
- Method of locating a fault in a power distribution system comprising at least one DC voltage distributed resource having a controllable voltage source converter.
- Creator
-
Li, Hui, Tatcho, Passinam, Steurer, Mischa
- Abstract/Description
-
The present invention provides a method to ensure that distributed resources of a power distribution system remain connected to the circuitry of the power distribution system when a fault occurs at a distributed resource node to assist in identifying the location of the fault by continuing to inject current from the distributed resources into the distribution system, wherein at least one of the distributed resources is a DC voltage distributed resource comprising a controllable voltage source...
Show moreThe present invention provides a method to ensure that distributed resources of a power distribution system remain connected to the circuitry of the power distribution system when a fault occurs at a distributed resource node to assist in identifying the location of the fault by continuing to inject current from the distributed resources into the distribution system, wherein at least one of the distributed resources is a DC voltage distributed resource comprising a controllable voltage source converter.
Show less - Date Issued
- 2016-08-09
- Identifier
- FSU_uspto_9411005, 9411005, 1616461, 14/962522, 6c9256d97d167832cbab694dc904bd27
- Format
- Citation
- Title
- Method of locating a fault in a power distribution system comprising at least one wind turbine distributed resource.
- Creator
-
Li, Hui, Tatcho, Passinam, Steurer, Mischa
- Abstract/Description
-
The present invention provides a method to ensure that distributed resources of a power distribution system remain connected to the circuitry of the power distribution system when a fault occurs at a distributed resource node to assist in identifying the location of the fault by continuing to inject current from the distributed resources into the distribution system, wherein at least one of the distributed resources is a wind turbine.
- Date Issued
- 2016-08-16
- Identifier
- FSU_uspto_9417277, 9417277, 1616461, 14/962367, 6c9256d97d167832cbab694dc904bd27
- Format
- Citation
- Title
- Method of locating a fault in a power distribution system using a direct current signal of a distributed resource modulated by an alternating current signal.
- Creator
-
Li, Hui, Tatcho, Passinam, Steurer, Mischa
- Abstract/Description
-
The present invention provides a method to ensure that distributed resources of a power distribution system remain connected to the circuitry of the power distribution system when a fault occurs at a distributed resource node to assist in identifying the location of the fault by continuing to inject a direct current (DC) signal from the controllable voltage source converter of at least one DC voltage distributed resource into the distribution system and modulating an alternating current (AC)...
Show moreThe present invention provides a method to ensure that distributed resources of a power distribution system remain connected to the circuitry of the power distribution system when a fault occurs at a distributed resource node to assist in identifying the location of the fault by continuing to inject a direct current (DC) signal from the controllable voltage source converter of at least one DC voltage distributed resource into the distribution system and modulating an alternating current (AC) signal on top of the direct current (DC) signal.
Show less - Date Issued
- 2016-09-13
- Identifier
- FSU_uspto_9442153, 9442153, 1616461, 14/962583, 6c9256d97d167832cbab694dc904bd27
- Format
- Citation
- Title
- Method of locating a fault in a power distribution system comprising at least one distributed resource having a controllable voltage source converter.
- Creator
-
Li, Hui, Tatcho, Passinam, Steurer, Mischa
- Abstract/Description
-
The present invention provides a method to ensure that distributed resources of a power distribution system remain connected to the circuitry of the power distribution system when a fault occurs at a distributed resource node to assist in identifying the location of the fault by continuing to inject current from the distributed resources into the distribution system, wherein at least one of the distributed resource comprises a controllable voltage source converter.
- Date Issued
- 2016-07-12
- Identifier
- FSU_uspto_9389270, 9389270, 1616461, 14/962820, 6c9256d97d167832cbab694dc904bd27
- Format
- Citation
- Title
- Method of locating a fault in a power distribution system comprising at least one solar panel distributed resource.
- Creator
-
Li, Hui, Tatcho, Passinam, Steurer, Mischa
- Abstract/Description
-
The present invention provides a method to ensure that distributed resources of a power distribution system remain connected to the circuitry of the power distribution system when a fault occurs at a distributed resource node to assist in identifying the location of the fault by continuing to inject current from the distributed resources into the distribution system, wherein at least one of the distributed resources is a solar panel.
- Date Issued
- 2016-08-23
- Identifier
- FSU_uspto_9423445, 9423445, 1616461, 14/962465, 6c9256d97d167832cbab694dc904bd27
- Format
- Citation
- Title
- Method of detecting compromised computers in a network.
- Creator
-
Duan, Zhenhai
- Abstract/Description
-
A method of detecting a compromised machine on a network. The method receives an email message from a machine on the network and classifies it as either spam or non-spam. A probability ratio is then updated, according to whether the message was spam or non-spam, by applying a sequential probability ratio test. If the probability ratio is greater than or equal to a first threshold, then the machine is compromised. If the probability ratio is less than or equal to a second threshold, then the...
Show moreA method of detecting a compromised machine on a network. The method receives an email message from a machine on the network and classifies it as either spam or non-spam. A probability ratio is then updated, according to whether the message was spam or non-spam, by applying a sequential probability ratio test. If the probability ratio is greater than or equal to a first threshold, then the machine is compromised. If the probability ratio is less than or equal to a second threshold, then the machine is normal. The operations of receiving a message, classifying the message, updating the probability ratio, and indicating the machine is normal or compromised until the probability ratio is greater than or equal to the first threshold are repeated for a plurality of messages. Such repeated operations are performed on each of the messages one at a time, as each of the messages is received.
Show less - Date Issued
- 2012-10-02
- Identifier
- FSU_uspto_8280968, 8280968, 2145251, 12/762714, 6c9256d97d167832cbab694dc904bd27
- Format
- Citation
- Title
- Method of detecting compromised computers in a network.
- Creator
-
Chen, Peng Sheng, Duan, Zhenhai
- Abstract/Description
-
A method of detecting a compromised machine on a network. The method receives an email message from a machine on the network and classifies it as either spam or non-spam. A probability ratio is then updated, according to whether the message was spam or non-spam, by applying a sequential probability ratio test. If the probability ratio is greater than or equal to a first threshold, then the machine is compromised. If the probability ratio is less than or equal to a second threshold, then the...
Show moreA method of detecting a compromised machine on a network. The method receives an email message from a machine on the network and classifies it as either spam or non-spam. A probability ratio is then updated, according to whether the message was spam or non-spam, by applying a sequential probability ratio test. If the probability ratio is greater than or equal to a first threshold, then the machine is compromised. If the probability ratio is less than or equal to a second threshold, then the machine is normal. The operations of receiving a message, classifying the message, updating the probability ratio, and indicating the machine is normal or compromised until the probability ratio is greater than or equal to the first threshold are repeated for a plurality of messages. Such repeated operations are performed on each of the messages one at a time, as each of the messages is received.
Show less - Date Issued
- 2013-10-29
- Identifier
- FSU_uspto_8572197, 8572197, 1922309, 13/632384, 6c9256d97d167832cbab694dc904bd27
- Format
- Citation
- Title
- Method of locating a fault in a power distribution system comprising at least one microturbine distributed resource.
- Creator
-
Li, Hui, Tatcho, Passinam, Steurer, Mischa
- Abstract/Description
-
The present invention provides a method to ensure that distributed resources of a power distribution system remain connected to the circuitry of the power distribution system when a fault occurs at a distributed resource node to assist in identifying the location of the fault by continuing to inject current from the distributed resources into the distribution system, wherein at least one of the distributed resources is a microturbine.
- Date Issued
- 2016-08-09
- Identifier
- FSU_uspto_9411006, 9411006, 1616461, 14/962434, 6c9256d97d167832cbab694dc904bd27
- Format
- Citation
- Title
- Method of locating a fault in a power distribution system comprising at least one cogeneration distributed resource.
- Creator
-
Li, Hui, Tatcho, Passinam, Steurer, Mischa
- Abstract/Description
-
The present invention provides a method to ensure that distributed resources of a power distribution system remain connected to the circuitry of the power distribution system when a fault occurs at a distributed resource node to assist in identifying the location of the fault by continuing to inject current from the distributed resources into the distribution system, wherein at least one of the distributed resources is a cogeneration resource.
- Date Issued
- 2016-08-16
- Identifier
- FSU_uspto_9417276, 9417276, 1616461, 14/962496, 6c9256d97d167832cbab694dc904bd27
- Format
- Citation
- Title
- Intermediates for tricyclic or tetracyclic taxanes.
- Creator
-
Holton, Robert A., Somoza, Carmen, Shindo, Mitsuru, Biediger, Ronald J., Boatman, P. Douglas, Smith, Chase C., Liang, Feng, Murthi, Krishna K., Kim, Hyeong Baik
- Abstract/Description
-
The synthesis of taxol and other tricyclic and tetracyclic taxanes.
- Date Issued
- 2001-08-21
- Identifier
- FSU_uspto_6278026, 6278026, 711524, 09/333382, 600b83161da1122888348587dc18798c
- Format
- Citation
- Title
- Purified linear epitopes from cashew nuts, nucleic acids encoding therefor, and associated methods.
- Creator
-
Roux, Kenneth H., Sathe, Shridhar K., Teuber, Suzanne S.
- Abstract/Description
-
Disclosed are major allergenic proteins in cashew nut, which are legumin-like proteins and 2S albumins. Also disclosed is a polypeptide allergen in the 7S superfamily, which includes vicilin-like and sucrose binding proteins. Several linear epitopes of the cashew nut are identified and characterized. The invention further discloses the sequence of cDNA encoding the allergenic polypeptide, the allergen being designated Ana o 1, and also describes the characterization of the expressed...
Show moreDisclosed are major allergenic proteins in cashew nut, which are legumin-like proteins and 2S albumins. Also disclosed is a polypeptide allergen in the 7S superfamily, which includes vicilin-like and sucrose binding proteins. Several linear epitopes of the cashew nut are identified and characterized. The invention further discloses the sequence of cDNA encoding the allergenic polypeptide, the allergen being designated Ana o 1, and also describes the characterization of the expressed recombinant polypeptide and associated methods employing the polypeptide.
Show less - Date Issued
- 2016-03-29
- Identifier
- FSU_uspto_9296798, 9296798, 1946887, 13/851192, 0a4642a77d52197c97f5d592966b68d7
- Format
- Citation
- Title
- Protein separation from a protein mixture.
- Creator
-
Sang, Qing-Xiang (Amy), Sahab, Ziad Joseph
- Abstract/Description
-
A process for separating a protein from a sample containing a mixture of proteins is disclosed. The process comprises forming an aqueous combination comprising the sample and an ion exchange material at a pH which is less than the pI of a first fraction of the proteins in the aqueous dispersion but greater than the pI of a second fraction of the proteins in the aqueous dispersion. The aqueous dispersion may then be intensely mixed, causing a fraction of the proteins in the combination to bind...
Show moreA process for separating a protein from a sample containing a mixture of proteins is disclosed. The process comprises forming an aqueous combination comprising the sample and an ion exchange material at a pH which is less than the pI of a first fraction of the proteins in the aqueous dispersion but greater than the pI of a second fraction of the proteins in the aqueous dispersion. The aqueous dispersion may then be intensely mixed, causing a fraction of the proteins in the combination to bind to the ion exchange material, and, optionally, centrifuged, causing the combination to stratify into a concentrated solids fraction and a supernatant, the supernatant containing the fraction of the proteins that did not bind to the ion exchange material. This process, including the steps of intense mixing and centrifugation, requires no expensive, specialized instrumentation, can be quickly performed, and is carried out in non-denaturing conditions, allowing for the separated proteins to be further studied.
Show less - Date Issued
- 2009-09-08
- Identifier
- FSU_uspto_7585955, 7585955, 2248480, 11/366124, 6c9256d97d167832cbab694dc904bd27
- Format
- Citation
- Title
- Proton-transfer, low self-absorbing chromophores for use in scintillators.
- Creator
-
Schlenoff, Joseph B., Gao, Feng (Frank), Dharia, Jayesh, Johnson, Kurtis F.
- Abstract/Description
-
Proton-transfer, low self-absorbing chromophores of the formula: ##STR1## wherein R.sub.2 and R.sub.3 are independently hydrogen, alkyl, aryl, cyano, nitro, halo or an ether group, R.sub.4 is O or N--H, and R.sub.5 is thienyl, naphthyl, furanyl, pyrrolyl, phenyl vinyl, diphenyl vinyl, phenyl ethynyl, hydroxy chromonyl phenyl, didecyloxy hydroxy chromonyl phenyl, phenyl or ##STR2## wherein R.sub.1 is vinyl, vinyl phenyl, vinyl benzyl, alkyl ethenyl, or alkyl phenyl ethenyl, provided that when...
Show moreProton-transfer, low self-absorbing chromophores of the formula: ##STR1## wherein R.sub.2 and R.sub.3 are independently hydrogen, alkyl, aryl, cyano, nitro, halo or an ether group, R.sub.4 is O or N--H, and R.sub.5 is thienyl, naphthyl, furanyl, pyrrolyl, phenyl vinyl, diphenyl vinyl, phenyl ethynyl, hydroxy chromonyl phenyl, didecyloxy hydroxy chromonyl phenyl, phenyl or ##STR2## wherein R.sub.1 is vinyl, vinyl phenyl, vinyl benzyl, alkyl ethenyl, or alkyl phenyl ethenyl, provided that when R.sub.5 is phenyl and R.sub.2 and R.sub.3 are hydrogen, R.sub.4 is N--H.
Show less - Date Issued
- 1996-09-03
- Identifier
- FSU_uspto_5552551, 5552551, 915739, 08/096956, 600b83161da1122888348587dc18798c
- Format
- Citation
- Title
- Self insulating substrate tape.
- Creator
-
Hascicek, Yusuf S., Mutlu, Ibrahim, Belenli, Ibrahim
- Abstract/Description
-
A process for manufacturing superconducting magnets is described. Two conducting tapes are assembled with an insulating ceramic layer deposited between facing sides of the tapes. The tapes and the insulative refractory material are bonded together by, for example, rolling to result in a self insulating substrate tape to which superconducting composition precursors are applied for later annealing. In one aspect, the composite tape is then wound to result in a pancake coil which is exposed to...
Show moreA process for manufacturing superconducting magnets is described. Two conducting tapes are assembled with an insulating ceramic layer deposited between facing sides of the tapes. The tapes and the insulative refractory material are bonded together by, for example, rolling to result in a self insulating substrate tape to which superconducting composition precursors are applied for later annealing. In one aspect, the composite tape is then wound to result in a pancake coil which is exposed to high temperatures in an oxidizing environment to convert the superconducting precursors to superconducting materials. The resultant high temperature superconducting composition coil can then be used as a high temperature superconducting magnet with appropriate conducting connectors applied thereto.
Show less - Date Issued
- 2002-05-14
- Identifier
- FSU_uspto_6387525, 6387525, 985992, 09/560787, 600b83161da1122888348587dc18798c
- Format
- Citation
- Title
- Route to synthetic analogues of Rocaglamide and Aglafoline using cascade transformations initiated by oxy-cope rearrangement of bis-alkynes.
- Creator
-
Alabugin, Igor V., Pal, Runa
- Abstract/Description
-
A method for preparing a cyclobutene compound or a cyclopentenone is provided. The method comprises contacting an α,β-diketone with a metal acetylide at a temperature below 0° C. to thereby form a reaction mixture comprising a bis-alkyne precursor. The bis-alkyne precursor rearranges into a bis-allenic intermediate, which undergoes further rearrangement into the cyclobutene compound or the cyclopentenone compound as the temperature of the reaction mixture increases from below...
Show moreA method for preparing a cyclobutene compound or a cyclopentenone is provided. The method comprises contacting an α,β-diketone with a metal acetylide at a temperature below 0° C. to thereby form a reaction mixture comprising a bis-alkyne precursor. The bis-alkyne precursor rearranges into a bis-allenic intermediate, which undergoes further rearrangement into the cyclobutene compound or the cyclopentenone compound as the temperature of the reaction mixture increases from below 0° C. to above 0° C.
Show less - Date Issued
- 2015-12-08
- Identifier
- FSU_uspto_9206100, 9206100, 2368265, 13/820176, 6c9256d97d167832cbab694dc904bd27
- Format
- Citation
- Title
- Polymer mechanical damping composites and methods of production.
- Creator
-
Schlenoff, Joseph B.
- Abstract/Description
-
An article comprising a polyelectrolyte complex, the polyelectrolyte complex comprising an intermolecular blend of a predominantly positively-charged polyelectrolyte and a predominantly negatively charged polyelectrolyte and being free of salt crystals having a size greater than about 1 micrometer and free of voids having a size greater than about 100 nm, the article having no transverse dimension less than about 10,000 nm.
- Date Issued
- 2012-06-26
- Identifier
- FSU_uspto_8206816, 8206816, 915739, 12/439647, 6c9256d97d167832cbab694dc904bd27
- Format
- Citation
- Title
- Polymer mechanical damping composites and methods of production.
- Creator
-
Schlenoff, Joseph B.
- Abstract/Description
-
A method of reshaping an article comprising a polyelectrolyte complex, the polyelectrolyte complex comprising an intermolecular blend of a predominantly positively-charged polyelectrolyte and a predominantly negatively charged polyelectrolyte by controlling the salt doping level.
- Date Issued
- 2012-06-26
- Identifier
- FSU_uspto_8206822, 8206822, 915739, 12/399690, 6c9256d97d167832cbab694dc904bd27
- Format
- Citation
- Title
- Polymer foam-based piezoelectric materials and method of manufacture.
- Creator
-
Li, Yan Li, Zeng, Changchun
- Abstract/Description
-
Thermally stable piezoelectric polymer foams (ferroelectrets) with high piezoelectric activity for sensing and actuation. The invention further includes a method of fabricating such foams in an environmentally friendly manner.
- Date Issued
- 2016-11-08
- Identifier
- FSU_uspto_9490420, 9490420, 1340410, 14/827596, 6c9256d97d167832cbab694dc904bd27
- Format
- Citation
- Title
- Scalable liposome microarray screening.
- Creator
-
Lenhert, Steven, Kusi-Appiah, Aubrey, Lowry, Troy W.
- Abstract/Description
-
A method comprising the following steps: (a) contacting a topographically structured stamp to an array of spots comprising lipid ink on a palette to force the lipid ink of each of the spots into recesses of the topographically structured stamp, (b) removing the palette from the topographically structured stamp so that at least some the lipid ink from each of the spots is retained in the recesses of the topographically structured stamp, and (c) printing the lipid ink in each of the recesses on...
Show moreA method comprising the following steps: (a) contacting a topographically structured stamp to an array of spots comprising lipid ink on a palette to force the lipid ink of each of the spots into recesses of the topographically structured stamp, (b) removing the palette from the topographically structured stamp so that at least some the lipid ink from each of the spots is retained in the recesses of the topographically structured stamp, and (c) printing the lipid ink in each of the recesses on a substrate as an array of stamped spots using the topographically structured stamp to thereby form a patterned substrate, wherein the recesses have one or more recess patterns, wherein each stamped spot of the array of stamped spots comprises lipid multilayer structure, and wherein the patterned array is based on the one or more recess patterns.
Show less - Date Issued
- 2016-12-06
- Identifier
- FSU_uspto_9513222, 9513222, 2611948, 14/413319, 6c9256d97d167832cbab694dc904bd27
- Format
- Citation
- Title
- Sanitary pads for men.
- Creator
-
Lipner, Harry
- Abstract/Description
-
Sanitary pads for men are disposable in a storage mode in which they are flat and non-overlapping for easy carrying in pockets. The sanitary pads may be folded in order to form generally semi-cylindrical portions which envelop the wearer's penis and prevent embarrassment to incontinent men. In the storage or carrying mode, the pad may alternately be T-shaped or constructed in a generally rectangular shape. Adhesive means, such as double sided tape, or fabric loop and hook fasteners may be...
Show moreSanitary pads for men are disposable in a storage mode in which they are flat and non-overlapping for easy carrying in pockets. The sanitary pads may be folded in order to form generally semi-cylindrical portions which envelop the wearer's penis and prevent embarrassment to incontinent men. In the storage or carrying mode, the pad may alternately be T-shaped or constructed in a generally rectangular shape. Adhesive means, such as double sided tape, or fabric loop and hook fasteners may be used to secure the pads in proper position. The pads are a layered structure including an inner relatively thick layer of absorbent material, a water barrier layer made of plastic, and an outer relatively thin absorbent layer.
Show less - Date Issued
- 1986-03-18
- Identifier
- FSU_uspto_4576599, 4576599, 505970, 06/609651, 600b83161da1122888348587dc18798c
- Format
- Citation
- Title
- Robust deconvolution of complex mixtures by covariance spectroscopy.
- Creator
-
Bruschweiler, Rafael, Zhang, Fengli
- Abstract/Description
-
Methods and systems are provided for the deconvolution of the NMR spectrum of a mixture into individual components and spin systems by combining covariance total correlation spectroscopy (TOCSY) spectra with covariance NMR. The method may include obtaining a 2D TOCSY spectra of a chemical mixture and then performing a series of analytical steps to identify the individual components of the mixture.
- Date Issued
- 2010-11-16
- Identifier
- FSU_uspto_7835872, 7835872, 2438672, 12/032903, 6c9256d97d167832cbab694dc904bd27
- Format
- Citation
- Title
- Self-balanced modulation and magnetic rebalancing method for parallel multilevel inverters.
- Creator
-
Li, Hui, Shi, Yanjun
- Abstract/Description
-
A self-balanced modulation method and a closed-loop magnetic flux rebalancing control method for parallel multilevel inverters. The combination of the two methods provides for balancing of the magnetic flux of the inter-cell transformers (ICTs) of the parallel multilevel inverters without deteriorating the quality of the output voltage. In various embodiments a parallel multi-level inverter modulator is provide including a multi-channel comparator to generate a multiplexed digitized ideal...
Show moreA self-balanced modulation method and a closed-loop magnetic flux rebalancing control method for parallel multilevel inverters. The combination of the two methods provides for balancing of the magnetic flux of the inter-cell transformers (ICTs) of the parallel multilevel inverters without deteriorating the quality of the output voltage. In various embodiments a parallel multi-level inverter modulator is provide including a multi-channel comparator to generate a multiplexed digitized ideal waveform for a parallel multi-level inverter and a finite state machine (FSM) module coupled to the parallel multi-channel comparator, the FSM module to receive the multiplexed digitized ideal waveform and to generate a pulse width modulated gate-drive signal for each switching device of the parallel multi-level inverter. The system and method provides for optimization of the output voltage spectrum without influence the magnetic balancing.
Show less - Date Issued
- 2017-11-28
- Identifier
- FSU_uspto_9831800, 9831800, 1616461, 15/297828, 6c9256d97d167832cbab694dc904bd27
- Format
- Citation
- Title
- Purified linear epitopes from cashew nuts, nucleic acids encoding therefor and associated methods.
- Creator
-
Roux, Kenneth H., Sathe, Shridhar K., Teuber, Suzanne S.
- Abstract/Description
-
Disclosed are major allergenic proteins in cashew nut, which are legumin-like proteins and 2S albumins. Also disclosed is a polypeptide allergen in the 7S superfamily, which includes vicilin-like and sucrose binding proteins. Several linear epitopes of the cashew nut are identified and characterized. The invention further discloses the sequence of cDNA encoding the allergenic polypeptide, the allergen being designated Ana o 1, and also describes the characterization of the expressed...
Show moreDisclosed are major allergenic proteins in cashew nut, which are legumin-like proteins and 2S albumins. Also disclosed is a polypeptide allergen in the 7S superfamily, which includes vicilin-like and sucrose binding proteins. Several linear epitopes of the cashew nut are identified and characterized. The invention further discloses the sequence of cDNA encoding the allergenic polypeptide, the allergen being designated Ana o 1, and also describes the characterization of the expressed recombinant polypeptide and associated methods employing the polypeptide.
Show less - Date Issued
- 2012-09-25
- Identifier
- FSU_uspto_8273856, 8273856, 1946887, 12/466565, 6c9256d97d167832cbab694dc904bd27
- Format
- Citation
- Title
- Processes for the production of polycyclic fused ring compounds.
- Creator
-
Holton, Robert A., Vu, Phong H.
- Abstract/Description
-
The present invention provides processes for the production of polycyclic fused ring compounds. The polycyclic fused ring compounds are produced by protecting a polycyclic fused ring polyol with a bridging silicon-based protecting group and attaching a suitable side chain. Polycyclic fused ring compounds and intermediate compounds are also described.
- Date Issued
- 2010-02-23
- Identifier
- FSU_uspto_7667055, 7667055, 711524, 11/449535, 6c9256d97d167832cbab694dc904bd27
- Format
- Citation
- Title
- Prosthetic socket apparatus and systems.
- Creator
-
Wang, Ben, Zhang, Chun Hua, Zeng, Changchun, Kramer, Leslie D., Gillis, Arlene
- Abstract/Description
-
A prosthetic sock for a patient to wear over a residual limb is provided. The prosthetic sock includes an inner layer configured to fit over at least a portion of the residual limb of the patient. A foam layer is disposed on an outer surface of the inner layer. The foam layer compensates for changes in shape or volume of the residual limb within the prosthetic sock by changing shape in a manner effective to maintain a secure fit between the residual limb and a prosthetic socket of a...
Show moreA prosthetic sock for a patient to wear over a residual limb is provided. The prosthetic sock includes an inner layer configured to fit over at least a portion of the residual limb of the patient. A foam layer is disposed on an outer surface of the inner layer. The foam layer compensates for changes in shape or volume of the residual limb within the prosthetic sock by changing shape in a manner effective to maintain a secure fit between the residual limb and a prosthetic socket of a prosthetic limb.
Show less - Date Issued
- 2016-11-08
- Identifier
- FSU_uspto_9486333, 9486333, 1240690, 13/864675, 6c9256d97d167832cbab694dc904bd27
- Format
- Citation
- Title
- Processes for the preparation of paclitaxel.
- Creator
-
Holton, Robert A., Vu, Phong H.
- Abstract/Description
-
The present invention provides processes for the production of paclitaxel. Paclitaxel is produced by protecting the C(7) and the C(10) hydroxy groups of 10-DAB with a bridging silicon-based protecting group. The resulting 7,10-protected 10-DAB derivative is then derivatized and deprotected to form paclitaxel.
- Date Issued
- 2008-04-15
- Identifier
- FSU_uspto_7358378, 7358378, 711524, 11/449075, 6c9256d97d167832cbab694dc904bd27
- Format
- Citation
- Title
- Processes for the preparation of docetaxel.
- Creator
-
Holton, Robert A., Vu, Phong H.
- Abstract/Description
-
The present invention provides processes for the production of docetaxel. Docetaxel is produced by protecting the C(7) and the C(10) hydroxy groups of 10-DAB with a bridging silicon-based protecting group. The resulting 7,10-protected 10-DAB derivative is then derivatized and deprotected to form docetaxel.
- Date Issued
- 2009-06-23
- Identifier
- FSU_uspto_7550608, 7550608, 711524, 11/449048, 6c9256d97d167832cbab694dc904bd27
- Format
- Citation
- Title
- Semi-synthetic quorum sensors.
- Creator
-
Lenhert, Steven
- Abstract/Description
-
Described is a device comprising a substrate, and a quorum sensor array on the substrate. The quorum sensor array comprises quorum sensors that release signal molecules in response to one or more environmental signals being sense by the quorum sensors to thereby amplify the one or more environmental signals by causing a signal chain reaction in neighboring quorum sensors of the quorum sensor array. Each of the quorum sensors comprises a lipid multilayer structure. Also described is a method...
Show moreDescribed is a device comprising a substrate, and a quorum sensor array on the substrate. The quorum sensor array comprises quorum sensors that release signal molecules in response to one or more environmental signals being sense by the quorum sensors to thereby amplify the one or more environmental signals by causing a signal chain reaction in neighboring quorum sensors of the quorum sensor array. Each of the quorum sensors comprises a lipid multilayer structure. Also described is a method comprising providing data for changes in optical properties of at least part of the quorum sensor array in response to exposing the quorum sensor array to one or more environmental signals, and determining the presence of the one or more environmental signals based on the data.
Show less - Date Issued
- 2015-08-11
- Identifier
- FSU_uspto_9102974, 9102974, 2611948, 13/248250, 6c9256d97d167832cbab694dc904bd27
- Format
- Citation
- Title
- Protein controlling synthesis of collagen and associated methods.
- Creator
-
Stefanovic, Branko
- Abstract/Description
-
A method of screening an agent for ability to interfere with collagen synthesis includes the steps of reacting a polypeptide having an amino acid sequence comprising SEQ ID NO: 1 with collagen mRNAs in the presence of the agent and detecting if the agent has interfered with binding of the polypeptide to the mRNAs. Another method includes the steps of reacting the polypeptide with nonmuscle myosin filaments in the presence of the agent and detecting if the agent has interfered with binding of...
Show moreA method of screening an agent for ability to interfere with collagen synthesis includes the steps of reacting a polypeptide having an amino acid sequence comprising SEQ ID NO: 1 with collagen mRNAs in the presence of the agent and detecting if the agent has interfered with binding of the polypeptide to the mRNAs. Another method includes the steps of reacting the polypeptide with nonmuscle myosin filaments in the presence of the agent and detecting if the agent has interfered with binding of the polypeptide to the nonmuscle myosin filaments.
Show less - Date Issued
- 2014-04-15
- Identifier
- FSU_uspto_8697385, 8697385, 2858218, 13/706747, 6c9256d97d167832cbab694dc904bd27
- Format
- Citation
- Title
- RNAi therapeutic for treatment of hepatitis C infection.
- Creator
-
Tang, Hengli
- Abstract/Description
-
Small interfering RNAs (siRNAs) or small hairpin RNA (shRNAs) and compositions comprising same are provided that target human cyclophilin A (CyPA) to inhibit Hepatitis C (HCV) infection. Such siRNA and shRNAs may have a length of from about 19 to about 29 contiguous nucleotides corresponding to a specific region of human cyclophilin A (CyPA) cDNA of from about nucleotide 155 to about nucleotide 183 having particular potency against CyPA and HCV. Such siRNA and shRNAs may be formulated as...
Show moreSmall interfering RNAs (siRNAs) or small hairpin RNA (shRNAs) and compositions comprising same are provided that target human cyclophilin A (CyPA) to inhibit Hepatitis C (HCV) infection. Such siRNA and shRNAs may have a length of from about 19 to about 29 contiguous nucleotides corresponding to a specific region of human cyclophilin A (CyPA) cDNA of from about nucleotide 155 to about nucleotide 183 having particular potency against CyPA and HCV. Such siRNA and shRNAs may be formulated as naked compositions or pharmaceutical compositions. DNA polynucleotides, plasmids, and viral or non-viral vectors are provided that encode siRNA or shRNA molecules, which may be delivered directly to cells or in combination with delivery agents, such as lipids, polymers, encapsulated lipid particles, such as liposomes. Methods for treating, managing inhibiting, preventing, etc., HCV infection using such siRNA and shRNAs and compositions comprising same are also provided.
Show less - Date Issued
- 2013-10-22
- Identifier
- FSU_uspto_8563529, 8563529, 2400173, 13/558428, 6c9256d97d167832cbab694dc904bd27
- Format
- Citation
- Title
- Radiosensitizing diamines and their pharmaceutical preparations.
- Creator
-
Hofer, Kurt G., Yang, Li-Xi
- Abstract/Description
-
A compound comprising a diamine containing from 2-4 electron-affinic radiosensitizing functional groups or a salt thereof is provided. In a preferred embodiment the compound has the formula ##STR1## wherein A comprises a carbon chain having from about 2-10 carbons in the chain, R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are H, or T, T is ##STR2## wherein A' comprises a carbon chain having from about 1-8 carbons in the chain, R.sup.5 is H, lower alkyl, or halo, and R.sup.6 is H, lower alkyl, halo...
Show moreA compound comprising a diamine containing from 2-4 electron-affinic radiosensitizing functional groups or a salt thereof is provided. In a preferred embodiment the compound has the formula ##STR1## wherein A comprises a carbon chain having from about 2-10 carbons in the chain, R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are H, or T, T is ##STR2## wherein A' comprises a carbon chain having from about 1-8 carbons in the chain, R.sup.5 is H, lower alkyl, or halo, and R.sup.6 is H, lower alkyl, halo or nitro, provided that at least one of R.sup.1 and R.sup.2, and at least one of R.sup.3 and R.sup.4 is T. Intermediates for, pharmaceutical compositions containing, methods for making and methods for using such compounds to radiosensitize and kill hypoxic tumor cells are also provided.
Show less - Date Issued
- 1997-12-23
- Identifier
- FSU_uspto_5700825, 5700825, 7999, 08/414272, 600b83161da1122888348587dc18798c
- Format
- Citation
- Title
- Reagent for synthesis of para-methoxbenzyl (PMB) ethers and associated methods.
- Creator
-
Dudley, Gregory B.
- Abstract/Description
-
A newly synthesized compound designated lepidine ether 2-(4-Methoxybenzyloxy)-4-methylquinoline reacts with methyl triflate in the presence of alcohols to generate a neutral organic salt that transfers the para-methoxybenzyl (PMB) protecting group onto alcohols in high yield and under mild conditions.
- Date Issued
- 2011-06-14
- Identifier
- FSU_uspto_7960553, 7960553, 2398067, 11/865952, 6c9256d97d167832cbab694dc904bd27
- Format
- Citation
- Title
- Radiosensitizing taxanes and their pharmaceutical preparations.
- Creator
-
Holton, Robert A., Nadizadeh, Hossain, Yang, Li-Xi
- Abstract/Description
-
Taxanes containing electron-affinic radiosensitizing functional groups, their pharmaceutical preparations, and methods of making and using this new class of highly potent radiosensitizers of tumor cells.
- Date Issued
- 2006-06-27
- Identifier
- FSU_uspto_7067552, 7067552, 711524, 09/978436, 600b83161da1122888348587dc18798c
- Format
- Citation
- Title
- Solid-state NMR method for screening cell membrane protein binding drug candidates.
- Creator
-
Brey, William W., Cross, Timothy A., Smirnov, Alexej, Chekmenev, Eduard Y.
- Abstract/Description
-
Disclosed is a method for detection of ligand-cell membrane protein binding by solid state NMR spectroscopy. The method starts by forming a lipid bilayer inside nanopores of an anodic aluminum oxide (AAO) substrate, the lipid bilayer containing a membrane protein sample. The AAO substrate is treated with multiple candidate ligands having potential binding affinity for the membrane protein. Solid-state NMR analysis is performed on the treated AAO/lipid preparation so as to generate an NMR...
Show moreDisclosed is a method for detection of ligand-cell membrane protein binding by solid state NMR spectroscopy. The method starts by forming a lipid bilayer inside nanopores of an anodic aluminum oxide (AAO) substrate, the lipid bilayer containing a membrane protein sample. The AAO substrate is treated with multiple candidate ligands having potential binding affinity for the membrane protein. Solid-state NMR analysis is performed on the treated AAO/lipid preparation so as to generate an NMR spectrum for the treated membrane protein. The solid-state NMR spectrum of the treated membrane protein is compared with the spectrum of the same preparation of membrane protein in the absence of the ligands. It is then determined whether the solid-state NMR spectrum of the treated membrane protein has shifted from the NMR spectrum of the untreated membrane protein, a shift being indicative of protein binding by the candidate ligand.
Show less - Date Issued
- 2010-03-16
- Identifier
- FSU_uspto_7678546, 7678546, 1171403, 11/865302, 6c9256d97d167832cbab694dc904bd27
- Format
- Citation
- Title
- Solid state NMR method for screening cell membrane protein binding drug candidates.
- Creator
-
Brey, William W., Cross, Timothy A., Smirnov, Alexej, Chekmenev, Eduard Y.
- Abstract/Description
-
Disclosed is a method for detection of ligand-cell membrane protein binding by solid state NMR spectroscopy. The method starts by forming a lipid bilayer inside nanopores of an anodic aluminum oxide (AAO) substrate, the lipid bilayer containing a membrane protein sample. The AAO substrate is treated with multiple candidate ligands having potential binding affinity for the membrane protein. Solid-state NMR analysis is performed on the treated AAO/lipid preparation so as to generate an NMR...
Show moreDisclosed is a method for detection of ligand-cell membrane protein binding by solid state NMR spectroscopy. The method starts by forming a lipid bilayer inside nanopores of an anodic aluminum oxide (AAO) substrate, the lipid bilayer containing a membrane protein sample. The AAO substrate is treated with multiple candidate ligands having potential binding affinity for the membrane protein. Solid-state NMR analysis is performed on the treated AAO/lipid preparation so as to generate an NMR spectrum for the treated membrane protein. The solid-state NMR spectrum of the treated membrane protein is compared with the spectrum of the same preparation of membrane protein in the absence of the ligands. It is then determined whether the solid-state NMR spectrum of the treated membrane protein has shifted from the NMR spectrum of the untreated membrane protein, a shift being indicative of protein binding by the candidate ligand.
Show less - Date Issued
- 2010-03-09
- Identifier
- FSU_uspto_7674595, 7674595, 1171403, 12/366173, 6c9256d97d167832cbab694dc904bd27
- Format
- Citation
- Title
- RNAi therapeutic for treatment of hepatitis C infection.
- Creator
-
Tang, Hengli
- Abstract/Description
-
Small interfering RNAs (siRNAs) or small hairpin RNA (shRNAs) and compositions comprising same are provided that specifically target human cyclophilin A (CyPA) to effectively inhibit Hepatitis C (HCV) infection in a cell. Such siRNA and shRNAs may have a length of from about 19 to about 29 contiguous nucleotides corresponding to a specific region of human cyclophilin A (CyPA) cDNA of from about nucleotide 155 to about nucleotide 183 having particular potency against CyPA and HCV. Such siRNA...
Show moreSmall interfering RNAs (siRNAs) or small hairpin RNA (shRNAs) and compositions comprising same are provided that specifically target human cyclophilin A (CyPA) to effectively inhibit Hepatitis C (HCV) infection in a cell. Such siRNA and shRNAs may have a length of from about 19 to about 29 contiguous nucleotides corresponding to a specific region of human cyclophilin A (CyPA) cDNA of from about nucleotide 155 to about nucleotide 183 having particular potency against CyPA and HCV. Such siRNA and shRNAs may be formulated as naked compositions or as pharmaceutical compositions. DNA polynucleotides, plasmids, and viral or non-viral vectors are also provided that encode siRNA or shRNA molecules, which may be delivered directly to cells or in combination with known delivery agents, such as lipids, polymers, encapsulated lipid particles, such as liposomes. Methods for treating, managing inhibiting, preventing, etc., HCV infection using such siRNA and shRNAs and compositions comprising same are also provided.
Show less - Date Issued
- 2012-11-27
- Identifier
- FSU_uspto_8318925, 8318925, 2400173, 13/034851, 6c9256d97d167832cbab694dc904bd27
- Format
- Citation
- Title
- RNAi therapeutic for treatment of hepatitis C infection.
- Creator
-
Tang, Hengli
- Abstract/Description
-
Small interfering RNAs (siRNAs) or small hairpin RNA (shRNAs) and compositions comprising same are provided that specifically target human cyclophilin A (CyPA) to effectively inhibit Hepatitis C(HCV) infection in a cell. Such siRNA and shRNAs may have a length of from about 19 to about 29 contiguous nucleotides corresponding to a specific region of human cyclophilin A (CyPA) cDNA of from about nucleotide 155 to about nucleotide 183 having particular potency against CyPA and HCV. Such siRNA...
Show moreSmall interfering RNAs (siRNAs) or small hairpin RNA (shRNAs) and compositions comprising same are provided that specifically target human cyclophilin A (CyPA) to effectively inhibit Hepatitis C(HCV) infection in a cell. Such siRNA and shRNAs may have a length of from about 19 to about 29 contiguous nucleotides corresponding to a specific region of human cyclophilin A (CyPA) cDNA of from about nucleotide 155 to about nucleotide 183 having particular potency against CyPA and HCV. Such siRNA and shRNAs may be formulated as naked compositions or as pharmaceutical compositions. DNA polynucleotides, plasmids, and viral or non-viral vectors are also provided that encode siRNA or shRNA molecules, which may be delivered directly to cells or in combination with known delivery agents, such as lipids, polymers, encapsulated lipid particles, such as liposomes. Methods for treating, managing inhibiting, preventing, etc., HCV infection using such siRNA and shRNAs and compositions comprising same are also provided.
Show less - Date Issued
- 2012-08-28
- Identifier
- FSU_uspto_8252763, 8252763, 2400173, 13/036044, 6c9256d97d167832cbab694dc904bd27
- Format
- Citation
- Title
- RNAi therapeutic for treatment of hepatitis C infection.
- Creator
-
Tang, Hengli
- Abstract/Description
-
Small interfering RNAs (siRNAs) or small hairpin RNA (shRNAs) and compositions comprising same are provided that specifically target human cyclophilin A (CyPA) to effectively inhibit Hepatitis C (HCV) infection in a cell. Such siRNA and shRNAs may have a length of from about 19 to about 29 contiguous nucleotides corresponding to a specific region of human cyclophilin A (CyPA) cDNA of from about nucleotide 155 to about nucleotide 183 having particular potency against CyPA and HCV. Such siRNA...
Show moreSmall interfering RNAs (siRNAs) or small hairpin RNA (shRNAs) and compositions comprising same are provided that specifically target human cyclophilin A (CyPA) to effectively inhibit Hepatitis C (HCV) infection in a cell. Such siRNA and shRNAs may have a length of from about 19 to about 29 contiguous nucleotides corresponding to a specific region of human cyclophilin A (CyPA) cDNA of from about nucleotide 155 to about nucleotide 183 having particular potency against CyPA and HCV. Such siRNA and shRNAs may be formulated as naked compositions or as pharmaceutical compositions. DNA polynucleotides, plasmids, and viral or non-viral vectors are also provided that encode siRNA or shRNA molecules, which may be delivered directly to cells or in combination with known delivery agents, such as lipids, polymers, encapsulated lipid particles, such as liposomes. Methods for treating, managing inhibiting, preventing, etc., HCV infection using such siRNA and shRNAs and compositions comprising same are also provided.
Show less - Date Issued
- 2011-03-22
- Identifier
- FSU_uspto_7910722, 7910722, 2400173, 12/167402, 6c9256d97d167832cbab694dc904bd27
- Format
- Citation
- Title
- Process for the preparation of 10-desacetoxybaccatin III.
- Creator
-
Holton, Robert A., Somoza, Carmen
- Abstract/Description
-
A process for abstracting a C10 hydroxy, acyloxy or sulfonyloxy substituent from a taxane in which the C10 hydroxy, acyloxy or sulfonyloxy substituted taxane is reacted with samarium diiodide.
- Date Issued
- 1997-08-05
- Identifier
- FSU_uspto_5654447, 5654447, 711524, 08/500868, 600b83161da1122888348587dc18798c
- Format
- Citation
- Title
- Replication timing profiles for leukemia and other cancers.
- Creator
-
Gilbert, David, Ryba, Tyrone
- Abstract/Description
-
Described is a method for determining that a population of cells are a specific type of leukemic cell based on the replication timing fingerprint for the population of cells.
- Date Issued
- 2014-05-13
- Identifier
- FSU_uspto_8725423, 8725423, 1706182, 13/726803, 6c9256d97d167832cbab694dc904bd27
- Format
- Citation
- Title
- Real-time small-signal stability assessment of power electronic-based components in contemporary power systems.
- Creator
-
Salmani, Mohamadamin, Edrington, Chris S.
- Abstract/Description
-
A novel method for real-time small-signal stability analysis for power electronic-based components in a power system. The method is based on impedance measurement techniques and Generalized Nyquist Criterion. The method is capable of real-time application. The method may be used to monitor a system in real-time by perturbing the system persistently and utilizing the system's responses to calculate source/load impedance in time-domain and based on d-q impedance measurement theory. Time-domain...
Show moreA novel method for real-time small-signal stability analysis for power electronic-based components in a power system. The method is based on impedance measurement techniques and Generalized Nyquist Criterion. The method is capable of real-time application. The method may be used to monitor a system in real-time by perturbing the system persistently and utilizing the system's responses to calculate source/load impedance in time-domain and based on d-q impedance measurement theory. Time-domain results may be transferred to frequency-domain results by taking advantage of a fast Fourier transform algorithm (or optionally discrete Fourier transformer for discrete systems) and monitoring the system's stability by obtaining a Nyquist contour and employing Generalized Nyquist Criterion or unit circle criterion.
Show less - Date Issued
- 2016-04-19
- Identifier
- FSU_uspto_9316701, 9316701, 3159080, 14/702063, 6c9256d97d167832cbab694dc904bd27
- Format
- Citation
- Title
- Solid state NMR method for screening cell membrane protein binding drug candidates.
- Creator
-
Brey, William W., Cross, Timothy A., Smirnov, Alexej, Chekmenev, Eduard Y.
- Abstract/Description
-
Disclosed is a method for detection of ligand-cell membrane protein binding by solid state NMR spectroscopy. The method starts by forming a lipid bilayer inside nanopores of an anodic aluminum oxide (AAO) substrate, the lipid bilayer containing a membrane protein sample. The AAO substrate is treated with multiple candidate ligands having potential binding affinity for the membrane protein. Solid-state NMR analysis is performed on the treated AAO/lipid preparation so as to generate an NMR...
Show moreDisclosed is a method for detection of ligand-cell membrane protein binding by solid state NMR spectroscopy. The method starts by forming a lipid bilayer inside nanopores of an anodic aluminum oxide (AAO) substrate, the lipid bilayer containing a membrane protein sample. The AAO substrate is treated with multiple candidate ligands having potential binding affinity for the membrane protein. Solid-state NMR analysis is performed on the treated AAO/lipid preparation so as to generate an NMR spectrum for the treated membrane protein. The solid-state NMR spectrum of the treated membrane protein is compared with the spectrum of the same preparation of membrane protein in the absence of the ligands. It is then determined whether the solid-state NMR spectrum of the treated membrane protein has shifted from the NMR spectrum of the untreated membrane protein, a shift being indicative of protein binding by the candidate ligand.
Show less - Date Issued
- 2010-07-13
- Identifier
- FSU_uspto_7754438, 7754438, 1171403, 12/366190, 6c9256d97d167832cbab694dc904bd27
- Format
- Citation
- Title
- Six-membered.
- Creator
-
McQuade, D. Tyler, Park, Jin Kyoon, Rexford, Matthew D., Lackey, Hershel H.
- Abstract/Description
-
The present invention provides a catalyst complex or ligand, and compositions thereof, for use in a variety of organic reactions having high reactivity and enantioselectivity. The catalyst is a N-heterocyclic carbene having three fused rings with first and second rings being six-membered rings and the third being a five-membered ring. The first ring is fused to the second and has four substituents. The second ring has two nitrogens flanking a carbene atom with one nitrogen bound to a...
Show moreThe present invention provides a catalyst complex or ligand, and compositions thereof, for use in a variety of organic reactions having high reactivity and enantioselectivity. The catalyst is a N-heterocyclic carbene having three fused rings with first and second rings being six-membered rings and the third being a five-membered ring. The first ring is fused to the second and has four substituents. The second ring has two nitrogens flanking a carbene atom with one nitrogen bound to a substituent. The carbene atom may optionally be bonded to a metal. The third ring is fused to the second ring and contains two nitrogens. The third ring of the catalyst has a double bond and two substituents on adjacent non-fused carbons. A non-fused nitrogen of the third ring is partially bonded to another substituent. Methods for the synthesis and use of the catalyst embodiments of the present invention are also provided.
Show less - Date Issued
- 2012-07-17
- Identifier
- FSU_uspto_8222265, 8222265, 1542467, 12/870901, 6c9256d97d167832cbab694dc904bd27
- Format
- Citation