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Title: The Search for N* Resonances: Measurement of Differential Cross Sections and Polarization Observables for γp → pω and γp → K0Σ+ Using Circularly-Polarized Photons at CLAS, Jefferson Lab.
Creator: Akbar, Zulkaida, Crede, Volker, Meyer-Bäse, Anke, Piekarewicz, Jorge, Eugenio, Paul Michael, Adams, Todd, Florida State University, College of Arts and Sciences, Department of...
Show moreAkbar, Zulkaida, Crede, Volker, Meyer-Bäse, Anke, Piekarewicz, Jorge, Eugenio, Paul Michael, Adams, Todd, Florida State University, College of Arts and Sciences, Department of Physics
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Abstract/Description: The study of baryon resonances offers a deeper understanding of the strong interaction, since the dynamics and relevant degrees of freedom hidden within them are reflected by the properties of these states. The baryon resonances have been fairly accurately predicted in the low-energy region by constituent quark models and lattice quantum chromodynamics. However, most of the predicted higher-lying excited resonances (center-of-mass energies above 1.7 GeV/c²) and experimental findings do not...
Show moreThe study of baryon resonances offers a deeper understanding of the strong interaction, since the dynamics and relevant degrees of freedom hidden within them are reflected by the properties of these states. The baryon resonances have been fairly accurately predicted in the low-energy region by constituent quark models and lattice quantum chromodynamics. However, most of the predicted higher-lying excited resonances (center-of-mass energies above 1.7 GeV/c²) and experimental findings do not match up. The model calculations predict more baryon resonances than have been experimentally observed. Quark model calculations have suggested that some of the unobserved resonances couple strongly to γp reactions. The higher-lying excited are also generally predicted to have strong couplings to final states involving a heavier meson, e.g. one of the vector mesons, ρ, ω, ϕ. The excited states of the nucleon are usually found as broadly overlapping resonances, which may decay into a multitude of finasl states involving mesons and baryons. Polarization observables make it possible to isolate singleresonance contributions from other interference terms. This works presents measurements of the helicity asymmetry, E, for the reaction γp → pω in the energy range 1.1 GeV < Eγ < 2.3 GeV, differential cross sections, and spin density matrix elements, also for the reaction γp → pω in the energy range 1.5 GeV < Eγ < 5.4 GeV. Photoproduction of nucleon resonances in their decay to strange particles also offers attractive possibilities because the strange quark in the particle generates another degree of freedom and gives additional information not available from the nucleon-nucleon scattering. Thus, we have also extracted the helicity asymmetry, E, for the reaction γp → K⁰Σ⁺ in the energy range 1.1 GeV < Eγ < 2.1 GeV, differential cross sections, and recoil hyperon polarization, P, also for the reaction γp → K⁰Σ⁺ in the energy range 1.15 GeV < Eγ < 3.0 GeV. The data were collected at Jefferson Lab, using the CLAS detector, as part of the g9a and g12 experiments. Both experiments, as part of the N* spectroscopy program at Jefferson Laboratory, accumulated photoproduction data using circularly-polarized photons incident on a longitudinally-polarized butanol target in the g9a experiment and un-polarized liquid hydrogen target for the g12 experiment. A partial-wave analysis to the E data for the reaction γp → pω within the Bonn-Gatchina framework found dominant contributions from the 3/2⁺ near threshold, which is identified with the sub-treshold N(1720)3/2⁺ resonance. Some additional resonances and the t-channel π and pomeron exchange are needed to describe the data.
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Date Issued: 2018
Identifier: 2018_Su_Akbar_fsu_0071E_14714
Format: Thesis

Title: Spin Transport in Silicon Nanowires with an Intrinsic Axial Doping Gradient.
Creator: Kountouriotis, Konstantinos, Xiong, Peng, Lenhert, Steven John, Hill, S., Crede, Volker, Schlottmann, Pedro U., Florida State University, College of Arts and Sciences,...
Show moreKountouriotis, Konstantinos, Xiong, Peng, Lenhert, Steven John, Hill, S., Crede, Volker, Schlottmann, Pedro U., Florida State University, College of Arts and Sciences, Department of Physics
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Abstract/Description: This dissertation is focused on electrical spin injection and detection at the nanoscale dimensions that semiconductor nanowires offer. Semiconductor spintronics is the natural extension of metallic spintronics for applications in semiconductor industry. After the tremendous impact of the giant magnetoresistance effect (GMR) in hard disk read heads, semiconductor spintronics has been thought as the key ingredient for the realization of spin field-effect transistors (Spin-FETs). The advantages...
Show moreThis dissertation is focused on electrical spin injection and detection at the nanoscale dimensions that semiconductor nanowires offer. Semiconductor spintronics is the natural extension of metallic spintronics for applications in semiconductor industry. After the tremendous impact of the giant magnetoresistance effect (GMR) in hard disk read heads, semiconductor spintronics has been thought as the key ingredient for the realization of spin field-effect transistors (Spin-FETs). The advantages of spintronic devices would include non-volatility, enhanced data processing speeds, decreased electric power consumption and facilitation of quantum computation. The primary goal of this research is to study spin dynamics and spin-polarized transport in semiconductor nanowire (NW) channels, specifically in phosphorus (P) doped silicon (Si) nanowires (NWs). The interest in one-dimensional (1D) nanoscopic devices is driven by the rich spin-dependent physics quantum confinement engenders, and the eventual miniaturization of the spintronic devices down to nanoscales. One of the most important aspects to achieve efficient spin injection from a ferromagnet (FM) into a semiconductor (SC) is the interface between the two materials. This study is focused primarily on this effect and how it can be tuned. In this work, we peform systematic spin transport measurements on a unique type of P-doped Si NWs which exhibit an inherent doping gradient along the axial direction. On a single NW, we place a series of FM electrodes, which form contacts that evolve from Ohmic-like to Schottky barriers of increasing heights and widths due to the pronounced doping gradient. This facilitates rigorous investigation of the dependence of the spin signal on the nature of the FM/SC interface. The advantage of using a single NW to study the afformentioned effects is that possible complications during the fabrication process are minimized compared to experiments that use multiple different devices to perform such experiments. 2-terminal (2T), nonlocal 4-terminal (4T) and 3-terminal (3T) spin valve (SV) measurements using different configurations of FM electrodes were performed on the Si NWs. In addition, 3T and nonlocal 4T Hanle measurements were performed. The collected data reveal distinct correlations between the spin signals and the injector and detector interfacial properties. These results were possible due to the unique inhomogeneous doping profile of our Si NWs. This study reveals a distinct correlation between the spin signals and the FM/Si NW injector interfacial properties. Specifically, we observe a decreasing injected current spin polarization due to diminishing contribution of the d-electrons, thus the necessary tunneling contact for efficient spin injection and its properties are being investigated and analyzed. The results demonstrate that there is an optimal window of interface resistance parameters for maximum injected current spin polarization. In addition, they suggest a new approach for maximizing the spin signals by making devices with asymmetric interfaces. To the best of our knowledge, this is the first report of electrical spin injection in SC channels with asymmetric interfaces.
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Date Issued: 2018
Identifier: 2018_Su_Kountouriotis_fsu_0071E_14593
Format: Thesis

Title: Selective Disclosure in Self-Reported Suicide Risk Screening.
Creator: Podlogar, Matthew C., Joiner, Thomas, Taylor, John, Plant, Ashby, Schmidt, Norman B., Sachs-Ericsson, Natalie J., Florida State University, College of Arts and Sciences,...
Show morePodlogar, Matthew C., Joiner, Thomas, Taylor, John, Plant, Ashby, Schmidt, Norman B., Sachs-Ericsson, Natalie J., Florida State University, College of Arts and Sciences, Department of Psychology
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Abstract/Description: Reliance on self-reported screening for suicide risk may be contributing to a lack of progress in suicide prevention, in part, because of limitations related to stigma, ambivalence, and deception in responding. One change to potentially mitigate these issues and improve screening effectiveness is to allow for explicit selective disclosure of information, specifically by including a “prefer not to disclose” option in screening items. This study aimed to achieve the following: (1) investigate...
Show moreReliance on self-reported screening for suicide risk may be contributing to a lack of progress in suicide prevention, in part, because of limitations related to stigma, ambivalence, and deception in responding. One change to potentially mitigate these issues and improve screening effectiveness is to allow for explicit selective disclosure of information, specifically by including a “prefer not to disclose” option in screening items. This study aimed to achieve the following: (1) investigate whether selective disclosure is a valid and reliable construct of suicide risk among high risk populations, (2) identify causal mechanisms and moderators of selective disclosure, and (3) investigate the relationship between selective disclosure and death/suicide implicit association (d/s-IAT). These aims were investigated using online self-report surveys across three independent samples of adults in higher-risk and lower help-seeking populations, and who reported high current distress: Military and veterans (n = 135), men over age 50, (n = 187), and LGBTQ young adults (n = 140). Across groups, results indicated that selective disclosure was highly specific to individuals who reported higher risk for suicide, and was prevalent in approximately one out of four participants who endorsed some level of suicide risk. Above and beyond explicit report of suicide risk, reported inaccuracy of risk disclosure, low help seeking, and hopelessness were the only predictors significantly associated with selective disclosure across all groups. Qualitative results also highlighted the importance of “mistrust,” “misunderstanding,” and “fear of stigmatized consequences” as drivers for selective disclosure. Personality traits and mode of assessment did not appear to affect likelihood for selective disclosure. Implicit association to death/suicide was significantly associated with explicit report of suicide risk across all groups, but was not associated with selective disclosure. These results suggest that adding explicit selective disclosure choices to suicide risk screening items is unlikely to substantially increase screening sensitivity, as nearly all selective disclosers self-reported elevated suicide risk. However, allowing for and evaluating explicit selective disclosure among suicide risk reporters may provide useful information for risk assessment and follow-up, and preemptively addressing drivers for selective disclosure before or during suicide risk screening may increase screening effectiveness.
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Date Issued: 2018
Identifier: 2018_Su_Podlogar_fsu_0071E_14699
Format: Thesis

Title: Social Legacy of the Olympic Games from a Social Innovation Perspective.
Creator: Kim, Sanghoon, Kim, Amy C. H., Newman, Joshua I., Xue, Hanhan, Florida State University, College of Education, Department of Sport Management
Abstract/Description: Recently, cities that bid for hosting the Olympic Games have withdrawn due to public referendums and lack of political support. Although the International Olympic Committee’s (IOC) efforts to underline the importance of the Olympic legacy at a series of symposiums such as “The legacy of the Olympic Games 1984-2000” and the “Olympic Agenda of 2020”, numerous media platforms and studies have presented the negative consequences of hosting the Olympics. Compared to other legacies, the social...
Show moreRecently, cities that bid for hosting the Olympic Games have withdrawn due to public referendums and lack of political support. Although the International Olympic Committee’s (IOC) efforts to underline the importance of the Olympic legacy at a series of symposiums such as “The legacy of the Olympic Games 1984-2000” and the “Olympic Agenda of 2020”, numerous media platforms and studies have presented the negative consequences of hosting the Olympics. Compared to other legacies, the social legacy of the Olympics was relatively overlooked until recently. Although the IOC has set objectives to uphold the positive aspects of its social legacy, the development of practical strategies to address the socially-driven issues caused by hosting the Olympics still remains as a challenge to overcome. In efforts to fill this gap, the purpose of this study is to analyze the current process and evaluation system for the Olympic social legacy based on the frame of newspaper coverage, as well as discussing the strategies on how to achieve social innovation through the Olympic Games based on the SIOG model. I employed the media framing as the theoretical framework and conduct a content analysis of newspaper coverage in the U.S, The New York Times, USA Today, Los Angeles Times, and The Washington Post published between 1990 and 2016. The frame found in newspaper articles about the Olympic social legacy in the present study enabled me to investigate how the residents of the host city have experienced the social legacy of the Olympic Games and the problems behind the current process (Entman, 1993; Misener, 2012). In addition, the result of the analysis provided implications of how the Olympic social legacy needs to be planned and managed based on the SIOG model (Entman, 1993; Misener, 2012). The frames identified from the newspaper coverage revealed that there was a gap between the resident’s needs and actual provisions provided by hosting the Olympic Games. Overall, the social legacies planned by the organizers and committees did not work effectively before, during, and after the Olympic Games. In addition, By applying the social innovation framework to the social legacy of the Olympic Games, hosting the Olympic Games will provide solutions for problems focusing on needs that are unmet, which can resolve these various problems and make the integrated society sustainable.
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Date Issued: 2018
Identifier: 2018_Su_Kim_fsu_0071N_14655
Format: Thesis

Title: Sensor Systems and Signal Processing Algorithms for Wireless Applications.
Creator: Mukherjee, Avishek, Zhang, Zhenghao, Yu, Ming, Kumar, Piyush, Liu, Xiuwen, Florida State University, College of Arts and Sciences, Department of Computer Science
Abstract/Description: The demand for high performance wireless networks and systems have become increasingly high over the last decade. This dissertation addresses three systems that were designed to improving the efficiency, reliability and security of wireless systems. To improve the efficiency and reliability of wireless systems, we propose two algorithms, namely CSIFit and CSIApx, to compress the Channel State Information (CSI) of Wi-Fi networks with Orthogonal Frequency Division Multiplexing (OFDM) and...
Show moreThe demand for high performance wireless networks and systems have become increasingly high over the last decade. This dissertation addresses three systems that were designed to improving the efficiency, reliability and security of wireless systems. To improve the efficiency and reliability of wireless systems, we propose two algorithms, namely CSIFit and CSIApx, to compress the Channel State Information (CSI) of Wi-Fi networks with Orthogonal Frequency Division Multiplexing (OFDM) and Multiple Input Multiple Output (MIMO). We evaluated these systems with both experimental and synthesized CSI data. Our work on CSIApx confirmed that we can achieve very good compression ratios with very little loss accuracy, at a fraction of the complexity needed in current state-of-the-art compression methods. The second system is sensor based application to reliably detect falls inside homes. A automatic fall detection system has tremendous value to the well-being of seniors living alone. We design and implement MultiSense, a novel fall detection system, which has the following desirable features. First, it does not require the human to wear any device, therefore is convenient to seniors. Second, it has been tested in typical settings including living rooms and bathrooms, and has shown very good accuracy. Third, it is built with inexpensive components, with expected hardware cost around $150 to cover a typical room. MultiSense does not require any training data and is comparatively non-invasive than similar systems. Our evaluation showed that MultiSense achieved no False Negatives, i.e., was able to detect falls accurately each time, while producing no False Positives in a daily use test. Therefore, we believe MultiSense can be used to accurately detect human falls and can be extremely helpful to seniors living alone. Lastly, TBAS is a spoof detection method designed to improve the security of wireless networks. TBAS is based on two facts: 1) different transmitting locations likely result in different wireless channels, and 2) the drift in channel state information within a short time interval should be bounded. We proposed and implemented TBAS on Microsoft's SORA platform as well as commodity wireless cards and tested it's performance in typical Wi-Fi environments with different levels of channel mobility. Our results show that TBAS can be very accurate when running on 3 by 2 systems and above, i.e., TBAS on MIMO has a very low false positive error ratio, where a false positive event occurs when two packets from the same user are misclassified as from different users, while also maintaining a very low false negative ratio of 0.1%, where a false negative event occurs when two packets from different users are misclassified as from the same user. We believe our experimental findings can be used as a guideline for future systems that will deploy TBAS.
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Date Issued: 2018
Identifier: 2018_Su_Mukherjee_fsu_0071E_14750
Format: Thesis

Title: The Social Identity of Partisanship: Measuring the "Identity" in Party Identification.
Creator: Langley, Dennis Franklin, Gomez, Brad T., Plant, Ashby, Pietryka, Matthew T., Jackson, Robert A., Florida State University, College of Social Sciences and Public Policy,...
Show moreLangley, Dennis Franklin, Gomez, Brad T., Plant, Ashby, Pietryka, Matthew T., Jackson, Robert A., Florida State University, College of Social Sciences and Public Policy, Department of Political Science
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Abstract/Description: Party identification is perhaps the central concept in political science. It has appeared in countless theories and empirical analyses across the political science literature. Party identification was originally conceived as a psychological attachment to the political parties but recent evidence shows that the standard measure for party identification, the NES measure, confounds group identity and group attitude. I show that party social identity, a direct measure of group identity, explains...
Show moreParty identification is perhaps the central concept in political science. It has appeared in countless theories and empirical analyses across the political science literature. Party identification was originally conceived as a psychological attachment to the political parties but recent evidence shows that the standard measure for party identification, the NES measure, confounds group identity and group attitude. I show that party social identity, a direct measure of group identity, explains variation in candidate preferences in political primaries where the standard measure of party identification cannot. I also show that machine learning can be used to predict party social identity in surveys that did not directly measure it, and that these predictions can be used to revisit empirical analyses and reevaluate inferences related to party identification. Finally, I show that changes in the NES measure of party identification may be due to changes in either the group attitude or the group identity component and that retrospective evaluations, commonly used to explain changes in party identification, are only associated with changes in the group attitude component of the NES measure.
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Date Issued: 2018
Identifier: 2018_Su_Langley_fsu_0071E_14761
Format: Thesis

Title: The Role of Oxytocin: Social Exclusion and Suicidal Behavior.
Creator: Chu, Carol, Joiner, Thomas, Kirby, David, Hammock, Elizabeth Anne Dunn, Li, Wen, Cougle, Jesse R., Florida State University, College of Arts and Sciences, Department of Psychology
Abstract/Description: Background: Social exclusion is a robust correlate of suicidal ideation and behavior. However, there is little research examining the biological factors contributing to the link between social exclusion and suicide risk. Prior research has indicated that oxytocin, an important modulating neuropeptide in the regulation of social interactions, protects against the negative effects of social exclusion by motivating social behavior in excluded individuals. In non-psychiatric controls, oxytocin...
Show moreBackground: Social exclusion is a robust correlate of suicidal ideation and behavior. However, there is little research examining the biological factors contributing to the link between social exclusion and suicide risk. Prior research has indicated that oxytocin, an important modulating neuropeptide in the regulation of social interactions, protects against the negative effects of social exclusion by motivating social behavior in excluded individuals. In non-psychiatric controls, oxytocin levels and desires to affiliate with others increase in response to feelings of loneliness and social exclusion; however, in individuals with psychiatric disorders that are associated with serious suicide-related symptoms, oxytocin levels decrease in response to social exclusion. This suggests that dysregulated oxytocin functioning may be a correlate of suicidal behavior among socially excluded, at-risk individuals. However, crucially, no studies have examined this potential association. Aims: This study examined whether individuals with and without a history of suicide attempts differ in their oxytocin levels and desires to affiliate with others at baseline and following social exclusion. Methods: Young adults (N = 100) with and without prior attempts completed Cyberball, a computerized, social exclusion paradigm. Prior to and approximately 10 minutes after Cyberball, blood samples and levels of self-reported desires to affiliate with others, thwarted belongingness and perceived burdensomeness were obtained. Data were analyzed using one-way MANOVAs and two-way mixed design ANCOVAs. Results: No group differences emerged at baseline. Although no main effects emerged, a significant group by time interaction effect emerged such that among suicide attempters, desires to affiliate and oxytocin levels significantly decreased following social exclusion. Among depressed and healthy controls, desires to affiliate and oxytocin levels increased following exclusion. There were no significant changes in thwarted belongingness and perceived burdensomeness across groups following exclusion. Conclusions: Overall, our findings suggest that dysregulated oxytocin levels in response to social exclusion may be a correlate of suicide risk.
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Date Issued: 2017
Identifier: 2018_Su_Chu_fsu_0071E_13706
Format: Thesis

Title: Sensor Fault Detection and Isolation in Power Systems.
Creator: Yang, Huawei, Edrington, Christopher S., Ordóñez, Juan Carlos, Moss, Pedro L., Foo, Simon Y., Florida State University, College of Engineering, Department of Electrical and...
Show moreYang, Huawei, Edrington, Christopher S., Ordóñez, Juan Carlos, Moss, Pedro L., Foo, Simon Y., Florida State University, College of Engineering, Department of Electrical and Computer Engineering
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Abstract/Description: In large-scale power systems, the integration of intelligent monitoring system increases the system resiliency and the control robustness. For example, sensor monitoring allows to automatically supervise the health of sensors and detect sensor failures without relying on hardware redundancy, and hence, it will further reduce the cost of monitoring systems in power systems. Sensor failure is critical in smart grids, where controllers rely on healthy measurements from different sensors to...
Show moreIn large-scale power systems, the integration of intelligent monitoring system increases the system resiliency and the control robustness. For example, sensor monitoring allows to automatically supervise the health of sensors and detect sensor failures without relying on hardware redundancy, and hence, it will further reduce the cost of monitoring systems in power systems. Sensor failure is critical in smart grids, where controllers rely on healthy measurements from different sensors to determine all kinds of operations. Current literature review shows that most of the researchers focus on control and management side of smart grids, assuming the information control centers or agencies get from sensors is accurate. However, when sensor failure happens, missing data and/or bad data can flow into control and management systems, which may lead to potential malfunction or even power system failures. This brings the need for Sensor Fault Detection and Isolation (SFDI), to eliminate this potential threat. The integration of the SFDI into monitoring systems will allow avoiding the contingencies due to fault data, and therefore increases the system resiliency and the control robustness. Hardware redundancy is the common solution for SFDI. By placing multiple sensors in the same position, the control center can then rely on redundant sensors when one is broken or inaccurate. Apparently, this method will increase the cost significantly when applying to large power systems. Analytical redundancy, on the contrary, a quantitative method built from power system models, is a more promising solution. It does not necessarily require hardware redundancy and hence can lower the cost. With an appropriate number of sensors placed in strategic locations, the algorithm can then automatically detect sensor failures without the need of extra redundant sensors. Furthermore, SFDI together with intelligent sensor optimization and placement will also facilitate the transfer of conventional central grid control to distributed decision making agencies with minimum computation and communication burden for each branch, and thus, it will enhance the system performance and resiliency. In this dissertation, a comprehensive review over the state-of-the-art FDI methodologies is given at first, then a proposed algorithm to determine the optimal location of computation agents is introduced, which serves as a guide for the SFDI algorithm implementation explained right after. The results of the algorithms indicated promising application in power system monitoring.
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Date Issued: 2018
Identifier: 2018_Su_Yang_fsu_0071E_14730
Format: Thesis

Title: Exploring the Role of the Directed Motivational Currents on the Persian Heritage Language Learners' Success.
Creator: Mansouri, Soheil, Cappuccio, Brenda L., Southerland, Sherry A., Jakubowski, Elizabeth M., Florida State University, College of Education, School of Teacher Education
Abstract/Description: The phenomenon of Directed Motivational Currents (DMCs) (Dörnyei et al., 2014) is described as a period of intense motivational drive in pursuit of a highly-desired personal goal and vision. A DMC is thoroughly different from other motivational behaviors or ideal forms of engagements that already are recognized in the literature; and “being in the zone” (Dörnyei et al., 2014) is easily visible to individuals around the person experiencing a DMC. Focusing on periods of different motives and...
Show moreThe phenomenon of Directed Motivational Currents (DMCs) (Dörnyei et al., 2014) is described as a period of intense motivational drive in pursuit of a highly-desired personal goal and vision. A DMC is thoroughly different from other motivational behaviors or ideal forms of engagements that already are recognized in the literature; and “being in the zone” (Dörnyei et al., 2014) is easily visible to individuals around the person experiencing a DMC. Focusing on periods of different motives and motivational orientations experienced by heritage language learners of Persian in Startalk summer programs in 2014 and 2015, the current study investigates a) how the components of the DMCs (Dörnyei et al., 2016) are presented into the curricula and lesson/learning plans of Startalk Persian programs, and b) whether these components can explain the success of Persian heritage language learners at this program. The results revealed that the curricula and lesson/learning plans of the Startalk 2014 and 2015 summer programs consisted of the explicit and implicit five components of Group DMCs (Dörnyei et al., 2016). In addition, none of the participants in the program thoroughly experienced the five components of the DMC. However, the existence of extrinsic and intrinsic motivation (Deci & Ryan, 1985), integrative and instrumental orientations (Gardner & Lambert,1972), and positive progress feedback (Dörnyei et al., 2016) from parents and relatives at home and in the community have led to proficiency in Persian language. The results indicate that the framework of DMCs (Dörnyei et al., 2014) might fail to fit in the context of Persian heritage language learners in this study because all the learners relied on their extrinsic and intrinsic motivations, along with integrative and instrumental orientations in pursuit of their heritage language, and did so without experiencing any DMCs. The results and implications will be discussed with reference to the literature.
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Date Issued: 2018
Identifier: 2018_Su_Mansouri_fsu_0071E_14676
Format: Thesis

Title: Expressions of Integrity: Baroque Flute Players Reflect on Early Music.
Creator: Clapper, Laura M., Amsler, Eva, Clary, Richard, Ohlsson, Eric Paul, Keesecker, Jeff, Eyerly, Sarah, Florida State University, College of Music, College of Music
Abstract/Description: The purpose of this treatise is to reframe the concept of "being authentic" as "expressing integrity," both in the context of early music performance and as a way to discuss the personal expression of the self. The culture of the early music movement in the twentieth century provides an interesting case study for understanding how a modern notion of authenticity impacted the beliefs, value system, and identity of early music's invested groups and individuals. "Expressing integrity" is a new...
Show moreThe purpose of this treatise is to reframe the concept of "being authentic" as "expressing integrity," both in the context of early music performance and as a way to discuss the personal expression of the self. The culture of the early music movement in the twentieth century provides an interesting case study for understanding how a modern notion of authenticity impacted the beliefs, value system, and identity of early music's invested groups and individuals. "Expressing integrity" is a new semantic model that better represents the process of musical performance as well as the unique experience of the individual. While authenticity in early music implies an extra-personal and extra-musical set of standards that limits personal expression in the music-making process, "expressing integrity" values each unique interpretation and performance as only one facet of an individual's personal experience. In this way, "expressing integrity" as a concept is not limited to early music but is also applicable to other areas of performance and creative expression. This treatise strives to define authenticity, identify its limitations, and re-cite authenticity to the individual as an expression of integrity. More specifically, this project aims to highlight the experiences of Baroque flute players from different generations of the early music movement and to create empathy for the processes of becoming an early music specialist. Three Baroque flute players contributed to this project: Stephen Preston, Jed Wentz, and Sarah Paysnick. Each of these flutists began his/her career at different times, and their early music training took place in three different countries. The first half of this treatise defines the philosophical concepts of sincerity and authenticity in the context of twentieth-century modernist thought. This also includes unpacking the language and mindset regarding authenticity within the context of the early music movement, discussing the moral implications of the "Authenticity Debate," and describing the "authentic" performance-practice principles central to the early music revival. Expressing integrity emerges from an understanding of the objective and subjective dimensions in early music performance and aims to re-cite authenticity to the individual. The second half of this treatise presents the three interviews with the Baroque flutists as discrete chapters. The interviews represent individual expressions of integrity and are reflections of these Baroque flute players' experiences as early music professionals. Through the interview process, Preston, Wentz, and Paysnick share their insight and wisdom on topics relevant to the practice of early music while contemplating its future trajectory.
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Date Issued: 2018
Identifier: 2018_Su_Clapper_fsu_0071E_14607
Format: Thesis

Title: Essays on Asymmetric Information and Insurance Policy.
Creator: Bedsworth, Fredrick Travis, Holcombe, Randall G., Born, Patricia, Isaac, R. Mark, Kitchens, Carl T., Florida State University, College of Social Sciences and Public Policy,...
Show moreBedsworth, Fredrick Travis, Holcombe, Randall G., Born, Patricia, Isaac, R. Mark, Kitchens, Carl T., Florida State University, College of Social Sciences and Public Policy, Department of Economics
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Abstract/Description: Due to the rollout of provisions from the Affordable Care Act beginning in 2010 there has been significant interest in the effects of health insurance, and more broadly, the effects of health insurance policy on individuals and firms. Using empirical and experimental methods, I investigate the impact of insurance and insurance policy on individuals and firms. More specifically, I am interested in the behavioral impacts of health insurance and of the impacts of insurance in general on...
Show moreDue to the rollout of provisions from the Affordable Care Act beginning in 2010 there has been significant interest in the effects of health insurance, and more broadly, the effects of health insurance policy on individuals and firms. Using empirical and experimental methods, I investigate the impact of insurance and insurance policy on individuals and firms. More specifically, I am interested in the behavioral impacts of health insurance and of the impacts of insurance in general on individuals. Further, I am interested in studying the impact of insurance mandates on businesses. To study these issues I use health data from the Behavioral Risk Factor Surveillance System, experimental data generated from an experiment my co-authors and I conducted at Florida State University, and employment data from the Current Population Survey
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Date Issued: 2018
Identifier: 2018_Su_Bedsworth_fsu_0071E_14771
Format: Thesis

Title: Essays on Entry Regulation and the Non-Profit Sector.
Creator: Duff, Joseph A., Isaac, R. Mark, Großer, Jens W., Fournier, Gary M., Pevnitskaya, Svetlana A, Semykina, Anastasia, Florida State University, College of Social Sciences and...
Show moreDuff, Joseph A., Isaac, R. Mark, Großer, Jens W., Fournier, Gary M., Pevnitskaya, Svetlana A, Semykina, Anastasia, Florida State University, College of Social Sciences and Public Policy, Department of Economics
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Abstract/Description: In first two chapters of this dissertation, I examine the effects of Certificate-of-Need (CON) regulation on technological investment and prices, and also examine decisions about service provision in hospitals and other non-profit services. CON regulation provides state authority to restrict major capital investments as a way of reducing costs. CON regulation was initially implemented at the federal level in 1972, and while falling out of favor in 1981, 34 states including Florida have a...
Show moreIn first two chapters of this dissertation, I examine the effects of Certificate-of-Need (CON) regulation on technological investment and prices, and also examine decisions about service provision in hospitals and other non-profit services. CON regulation provides state authority to restrict major capital investments as a way of reducing costs. CON regulation was initially implemented at the federal level in 1972, and while falling out of favor in 1981, 34 states including Florida have a state-wide CON program in place as of 2017. The purpose of CON regulation is to address this surplus of equipment by requiring that new purchases of equipment and providing new services be subject to prior approval from CON authorities, automatically for some key types of operations and for others if the costs exceed the capital threshold. Hospitals must demonstrate to the CON board that the equipment serves a community need or unmet demand; if successful, they may be granted a Certificate of Need to purchase the new equipment. It is reasonable to believe that services that are subject to CON regulation are offered less often than unregulated services. I examine how this process affects the supply of technology in the first chapter. One major argument against CON laws is that they restrict competition and keep prices high. In the second chapter, I examine whether the technology restrictions of CON regulation result in higher prices and market power. In the third chapter of the dissertation, I look at another issue affecting non-profit firms; the issue of overhead expenses. Overhead expenses are defined as any expense that does not count as directly contributing to the program. There is evidence that many potential donors dislike paying for overhead costs, even though they are vital to the operational abilities of a nonprofit. I empirically test how overhead expenses affect a nonprofit's financial success as well as its survival rate. For the first chapter of the dissertation, the chapter is co-authored with Gary Fournier. Our collaboration involved a great deal of joint effort at every phase of research. Gary Fournier supervised in the design of the project, discussing sampling issues, identifying data sources and limitations, and helped suggest empirical strategies. My contribution was to carry out the empirical analysis and the full written report. For the third chapter of the dissertation, the chapter is co-authored with Joseph Stinn. His contributions to the project are the motivation, the literature review, the idea to analyze survival rates of nonprofits, and the idea to use liabilities as an instrument. My main contributions are the theoretical model, and the empirical strategies. We jointly carried out the data collection, empirical analysis and the written report.
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Date Issued: 2018
Identifier: 2018_Su_Duff_fsu_0071E_14752
Format: Thesis

Title: Essays on Mergers and Acquisitions.
Creator: Rosenblum, Aaron, Cheng, Yingmei, Fendler, Rachel Loveitt, Zuehlke, Thomas W., Autore, Donald M., Liu, Baixiao, Florida State University, College of Business, Department of Finance
Abstract/Description: We use increases and decreases in the ranking scores of Fortune’s Most Admired Companies to test the proposition that media shocks can increase (decrease) the value of a manager’s reputational capital and, thus, enhance (diminish) his power to extract corporate resources for private benefit at the expense of shareholders. Consistent with the proposition increases (decreases) in scores are associated with stock price decreases (increases). And, CEOs whose firms experience increases (reductions...
Show moreWe use increases and decreases in the ranking scores of Fortune’s Most Admired Companies to test the proposition that media shocks can increase (decrease) the value of a manager’s reputational capital and, thus, enhance (diminish) his power to extract corporate resources for private benefit at the expense of shareholders. Consistent with the proposition increases (decreases) in scores are associated with stock price decreases (increases). And, CEOs whose firms experience increases (reductions) in scores experience increases (reductions) in compensation and in job tenure, and their firms undertake more (fewer) acquisitions and the acquisitions are less (more) value increasing. Prior Literature has emphasized the costs financial distress imposes on a firm. In this study, I examine a potential benefit financial distress can provide a firm, aligning the interests of managers and shareholders. I find that financially distressed firms see a 3.5% higher market reaction to the announcement of acquisitions than non-distressed firms. This effect is stronger for poorly governed firms, consistent with the hypothesis that the large reputational cost of failure incentivizes managers to act in the best interest of their firm.
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Date Issued: 2018
Identifier: 2018_Su_Rosenblum_fsu_0071E_14409
Format: Thesis

Title: An Evaluation of the Psychometric Properties of the Academic Behaviors and Skills of College Students (ABS-C) Scale.
Creator: Diers, Sarah E., Prevatt, Frances F., Lewis, Sandra, Krach, S. Kathleen, Becker, Martin Swanbrow, Florida State University, College of Education, Department of Educational...
Show moreDiers, Sarah E., Prevatt, Frances F., Lewis, Sandra, Krach, S. Kathleen, Becker, Martin Swanbrow, Florida State University, College of Education, Department of Educational Psychology and Learning Systems
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Abstract/Description: The Academic Behaviors and Skills of College Students (ABS-C) Scale is a measure that assesses in- and out-of-classroom behaviors and skills that may be affecting current academic standing. The measure inquires for self-perceptions of why college students may be having difficulty in courses. The ABS-C Scale demonstrates promising utility as a single instrument that encompasses a variety of specific academic behaviors and skills. The 42-item scale includes six subscales that measure academic...
Show moreThe Academic Behaviors and Skills of College Students (ABS-C) Scale is a measure that assesses in- and out-of-classroom behaviors and skills that may be affecting current academic standing. The measure inquires for self-perceptions of why college students may be having difficulty in courses. The ABS-C Scale demonstrates promising utility as a single instrument that encompasses a variety of specific academic behaviors and skills. The 42-item scale includes six subscales that measure academic preparedness, time management, study skills, academic outcomes, assistance seeking, and classroom engagement. The ABS-C Scale can be easily and quickly administered via an online-based survey. The present study evaluated and provided further evidence for the psychometric properties of the ABS-C Scale. The findings provided evidence of reliability and validity by means of internal consistency, factorial validity (confirmatory factor analysis), and discriminant validity (group differences among those with ADHD, SLD, or no diagnosis). The ABS-C Scale has the potential to inform preventive measures and interventions that could increase achievement and be targeted to identify the academic needs of those with learning difficulties. This scale could be used to evaluate the effectiveness of programs designed to teach or remediate the use of effective academic competencies, as well as the efficacy of research efforts investigating these factors. In working with students with disabilities, this measure could also be useful in allowing practitioners to identify specific academic behaviors and skills that need remediation.
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Date Issued: 2017
Identifier: 2018_Su_Diers_fsu_0071E_13793
Format: Thesis

Title: The Eight Lhadé Tsowa (Lha Sde Tsho Brgyad): A Historical Examination of an Amdo Tibetan Community and Its Monastery.
Creator: Foltz, Cameron Kyle Bender, Cuevas, Bryan J., Buhrman, Kristina Mairi, Hellweg, Joseph, Florida State University, College of Arts and Sciences, Department of Religion
Abstract/Description: A variety of social groups exist in the cultural area known in Tibetan as Amdo (covering parts of present-day Qinghai, Gansu, and Sichuan provinces in western China; see Map 1). Much investigation remains to be conducted on these terms as other scholars have noted (Hille, Horlemann, and Nietupski 2015:4). Not only are there a multitude of terms in use, but Tibetan communities in different regions use the same term to describe different kinds of social groups. One such term, tsowa, is commonly...
Show moreA variety of social groups exist in the cultural area known in Tibetan as Amdo (covering parts of present-day Qinghai, Gansu, and Sichuan provinces in western China; see Map 1). Much investigation remains to be conducted on these terms as other scholars have noted (Hille, Horlemann, and Nietupski 2015:4). Not only are there a multitude of terms in use, but Tibetan communities in different regions use the same term to describe different kinds of social groups. One such term, tsowa, is commonly used in Amdo. Many scholars have translated tsowa as “tribe” or “clan;” both of which introduce inaccurate connotations. As the meaning of tsowa is not uniform, local case studies in different regions are necessary to document the range of meanings this term contains. This work is but one such case study of a group of tsowa, the Eight Lhadé Tsowa, that coalesced as support communities for a monastery in present-day Trika (Ch. Guide) County, which is in Tsolho Prefecture (Ch. Hainan) of Qinghai Province. It is based on documentary sources, both historical and contemporary, and will hopefully be used as the basis for future fieldwork. The present study surveys the available literature on tsowa, examines the history of one group of tsowa, proposes a working definition, and raises questions for future research.
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Date Issued: 2018
Identifier: 2018_Su_Foltz_fsu_0071N_14590
Format: Thesis

Title: An Empirical Investigation of Social Exclusion, Attachment to Possessions, and Saving Behaviors.
Creator: Mathes, Brittany M., Schmidt, Norman B., Cougle, Jesse R., Ganley, Colleen M., Florida State University, College of Arts and Sciences, Department of Psychology
Abstract/Description: Hoarding disorder (HD) is characterized by an inability to discard possessions that contributes to clutter that interferes with the use of one’s home. One of the core features of HD is an emotional attachment to possessions. Initial theoretical work suggests individuals with HD may become overly attached to possessions in an effort to compensate for poor interpersonal connections, though little empirical work has explored this hypothesis. The current study provided an initial investigation of...
Show moreHoarding disorder (HD) is characterized by an inability to discard possessions that contributes to clutter that interferes with the use of one’s home. One of the core features of HD is an emotional attachment to possessions. Initial theoretical work suggests individuals with HD may become overly attached to possessions in an effort to compensate for poor interpersonal connections, though little empirical work has explored this hypothesis. The current study provided an initial investigation of the association between social disconnectedness, attachment to possessions, and saving behaviors. The sample comprised 117 undergraduate students selected for reporting hoarding symptoms above the non-clinical mean (i.e., 23) on the Saving Inventory-Revised. Participants were randomized to a social inclusion or social exclusion condition using the Cyberball paradigm. Participants completed a series of self-report questionnaires and behavioral tasks at baseline, pre-manipulation, and post-manipulation that assessed social disconnectedness, attachment to possessions, and hoarding behaviors. Contrary to hypotheses, baseline social disconnectedness was not significantly correlated with attachment to possessions nor hoarding behaviors. Individuals who were socially excluded saved significantly more items than did those who were socially included, though this was not due to changes in attachment to possessions. Future studies should further investigate the association between interpersonal processes and hoarding symptoms in a more severe sample and using different methodology. Though initial hypotheses were largely not supported, the current study nonetheless provides an important initial examination of the associations between interpersonal and object relationships in HD.
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Date Issued: 2018
Identifier: 2018_Su_Mathes_fsu_0071N_14791
Format: Thesis

Title: Ensemble Proper Orthogonal Decomposition Algorithms for the Incompressible Navier-Stokes Equations.
Creator: Schneier, Michael, Gunzburger, Max D., Sussman, Mark, Peterson, Janet S., Erlebacher, Gordon, Huang, Chen, Florida State University, College of Arts and Sciences, Department of...
Show moreSchneier, Michael, Gunzburger, Max D., Sussman, Mark, Peterson, Janet S., Erlebacher, Gordon, Huang, Chen, Florida State University, College of Arts and Sciences, Department of Scientific Computing
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Abstract/Description: The definition of partial differential equation (PDE) models usually involves a set of parameters whose values may vary over a wide range. The solution of even a single set of parameter values may be quite expensive. In many cases, e.g., optimization, control, uncertainty quantification, and other settings, solutions are needed for many sets of parameter values. We consider the case of the time-dependent Navier-Stokes equations for which a recently developed ensemble-based method allows for...
Show moreThe definition of partial differential equation (PDE) models usually involves a set of parameters whose values may vary over a wide range. The solution of even a single set of parameter values may be quite expensive. In many cases, e.g., optimization, control, uncertainty quantification, and other settings, solutions are needed for many sets of parameter values. We consider the case of the time-dependent Navier-Stokes equations for which a recently developed ensemble-based method allows for the efficient determination of the multiple solutions corresponding to many parameter sets. The method uses the average of the multiple solutions at any time step to define a linear set of equations that determines the solutions at the next time step. In this work we incorporate a proper orthogonal decomposition (POD) reduced-order model into the ensemble-based method to further reduce the computational cost; in total, three algorithms are developed. Initially a first order accurate in time scheme for low Reynolds number flows is considered. Next a second order algorithm useful for applications that require long-term time integration, such as climate and ocean forecasting is developed. Lastly, in order to extend this approach to convection dominated flows a model incorporating a POD spatial filter is presented. For all these schemes stability and convergence results for the ensemble-based methods are extended to the ensemble-POD schemes. Numerical results are provided to illustrate the theoretical stability and convergence results which have been proven.
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Date Issued: 2018
Identifier: 2018_Su_Schneier_fsu_0071E_14687
Format: Thesis

Title: Control of Legged Robotic Systems: Substantiation of Gait Design, Multi-Modal Behaviors, and Dynamic Scaling Theory in Practice.
Creator: Blackman, Daniel J., Clark, Jonathan E., Oates, William, Moore, Carl A., Florida State University, College of Engineering, Department of Mechanical Engineering
Abstract/Description: Through limb structure and neuromuscular control, animals have demonstrated the ability to navigate obstacles and uneven terrain using a variety of different mechanisms and behaviors. Learning from the capabilities of animals, it is possible to develop robotic platforms that can aid in the study of these motions towards the production of new technologies for military, search and rescue, and medical applications. To produce these systems, it is important to first understand the underlying...
Show moreThrough limb structure and neuromuscular control, animals have demonstrated the ability to navigate obstacles and uneven terrain using a variety of different mechanisms and behaviors. Learning from the capabilities of animals, it is possible to develop robotic platforms that can aid in the study of these motions towards the production of new technologies for military, search and rescue, and medical applications. To produce these systems, it is important to first understand the underlying dynamics and design principles existent in nature that afford creatures such dexterous and agile movements. The creation of robots with legs provide a means for studying different aspects of the dynamics of legged locomotion. This includes investigations of limb coordination for gait controller design, the role of passive compliance in dynamic running, mechanical leg design and configuration for optimal energetic output, and scalability of legged systems in both simulation and through experimentation. This thesis aims to provide insight into the design and implementation of terrestrial robotic platforms with legs.
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Date Issued: 2018
Identifier: 2018_Su_Blackman_fsu_0071N_14797
Format: Thesis

Title: Crystal Structure Prediction via Deep Learning.
Creator: Ryan, Kevin, Shatruk, Mykhailo, Barbu, Adrian G., DePrince, A. Eugene, Latturner, Susan, Florida State University, College of Arts and Sciences, Department of Chemistry and...
Show moreRyan, Kevin, Shatruk, Mykhailo, Barbu, Adrian G., DePrince, A. Eugene, Latturner, Susan, Florida State University, College of Arts and Sciences, Department of Chemistry and Biochemistry
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Abstract/Description: Vast information on existing crystal structures, which is available through the large open-access and commercialized repositories of crystallographic data, provides an excellent starting point for the implementation of deep learning techniques to the discovery of hidden relationships that might be contained in such large datasets. The machine learning algorithm can be thought of as a fitting procedure for a complicated heuristic model using a large amount of data.1-2 This model is later...
Show moreVast information on existing crystal structures, which is available through the large open-access and commercialized repositories of crystallographic data, provides an excellent starting point for the implementation of deep learning techniques to the discovery of hidden relationships that might be contained in such large datasets. The machine learning algorithm can be thought of as a fitting procedure for a complicated heuristic model using a large amount of data.1-2 This model is later tested to estimate its ability to generalize to unknown crystal structures in a holdout set, i.e. its predictive ability. Herein, we describe a neural network model trained to predict the likelihood of chemical elements adopting different topologies of atomic sites in known crystal structures. The neural network is shown examples of topologies from known crystal structures and trained to predict the element that adopted that topology. We apply the trained model to predict possible compositions of unknown compounds that might be pursued by a synthetic chemist. We demonstrate that the deep neural network is capable of automatically “discovering” relevant descriptors from high-dimensional “raw representations” of the crystallographic data. Since the input data contain purely geometrical and topological information, any chemical knowledge residing within the neural network output must have been learned during training, and thus was “discovered”. The neural network’s learned representation of local topology shows evidence of known geometric and chemical trends not explicitly provided to the network during training.
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Date Issued: 2018
Identifier: 2018_Su_Ryan_fsu_0071E_14685
Format: Thesis

Title: Insect Herbivores Increase The Spatial Aggregation Of A Clonal Plant.
Creator: Hakes, Alyssa S., Halpern, Stacey, Underwood, Nora
Abstract/Description: Premise of research.In a plant population, the pattern of spatial dispersion from uniform to strongly aggregated can influence the intensity of ecological interactions, including those between plants and their consumers, such as herbivorous insects. Whether insect herbivores also contribute to the generation of dispersion patterns within plant populations, however, is not well understood. We investigated how insect herbivory and plant density interact to influence the degree of aggregation of...
Show morePremise of research.In a plant population, the pattern of spatial dispersion from uniform to strongly aggregated can influence the intensity of ecological interactions, including those between plants and their consumers, such as herbivorous insects. Whether insect herbivores also contribute to the generation of dispersion patterns within plant populations, however, is not well understood. We investigated how insect herbivory and plant density interact to influence the degree of aggregation of stems in experimental plots of the clonal perennial herb Solanum carolinense, a noxious weed in the southeastern United States and invasive in other parts of the world.Methodology.We planted S. carolinense in 40 experimental plots at five densities and maintained each plot at one of two herbivory levels. Stems in every plot were initially planted in a uniform dispersion pattern. For 3 yr, we quantified the dispersion of clonal recruits in each plot at six spatial scales.Pivotal results.At larger spatial scales, we found significant interactions between plant density and insect herbivory. In plots with herbivores, spatial aggregation increased as plant density decreased, but this relationship was weak or nonexistent in plots where herbivores were excluded (herbivore-excluded plots exhibited random dispersion of stems across all densities). Solanum carolinense in plots exposed to herbivores were on average twice as aggregated as those that had herbivores excluded.Conclusions.These results suggest that insect herbivores can influence clonal growth or ramet survival in ways that increase population-level aggregation of S. carolinense. Our findings also imply that S. carolinense populations in its invasive range may have increased spatial spread and decreased intraspecific competition when herbivory is low. We discuss the potential for specific types of feedbacks between insect damage and plant dispersion, highlighting important targets for future research.
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Date Issued: 2018-04
Identifier: FSU_libsubv1_wos_000426758000005, 10.1086/696685
Format: Citation

Title: Sleep In A Large, Multi-university Sample Of College Students: Sleep Problem Prevalence, Sex Differences, And Mental Health Correlates.
Creator: Becker, Stephen P., Jarrett, Matthew A., Luebbe, Aaron M., Garner, Annie A., Burns, G. Leonard, Kofler, Michael J.
Abstract/Description: Objectives: To (1) describe sleep problems in a large, multi-university sample of college students; (2) evaluate sex differences; and (3) examine the unique associations of mental health symptoms (i.e., anxiety, depression, attention-deficit/hyperactivity disorder inattention [ADHD-IN], ADHD hyperactivity-impulsivity [ADHD-HI]) in relation to sleep problems. Methods: 7,626 students (70% female; 81% White) ages 18-29 years (M = 19.14, SD = 1.42) from six universities completed measures...
Show moreObjectives: To (1) describe sleep problems in a large, multi-university sample of college students; (2) evaluate sex differences; and (3) examine the unique associations of mental health symptoms (i.e., anxiety, depression, attention-deficit/hyperactivity disorder inattention [ADHD-IN], ADHD hyperactivity-impulsivity [ADHD-HI]) in relation to sleep problems. Methods: 7,626 students (70% female; 81% White) ages 18-29 years (M = 19.14, SD = 1.42) from six universities completed measures assessing mental health symptoms and the Pittsburgh Sleep Quality Index (PSQI). Results: A substantial minority of students endorsed sleep problems across specific sleep components. Specifically, 27% described their sleep quality as poor, 36% reported obtaining less than 7 hours of sleep per night, and 43% reported that it takes >30 minutes to fall asleep at least once per week. 62% of participants met cut-off criteria for poor sleep, though rates differed between females (64%) and males (57%). In structural regression models, both anxiety and depression symptoms were uniquely associated with disruptions in most PSQI sleep component domains. However, anxiety (but not depression) symptoms were uniquely associated with more sleep disturbances and sleep medication use, whereas depression (but not anxiety) symptoms were uniquely associated with increased daytime dysfunction. ADHD-IN symptoms were uniquely associatedwith poorer sleep quality and increased daytime dysfunction, whereas ADHD-HI symptoms were uniquely associated with more sleep disturbances and less daytime dysfunction. Lastly, ADHD-IN, anxiety, and depression symptoms were each independently associated with poor sleep status. Conclusions: This study documents a high prevalence of poor sleep among college students, some sex differences, and distinct patterns of mental health symptoms in relation to sleep problems. (c) 2018 National Sleep Foundation. Published by Elsevier Inc. All rights reserved.
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Date Issued: 2018-04
Identifier: FSU_libsubv1_wos_000428027200009, 10.1016/j.sleh.2018.01.001
Format: Citation

Title: Intrinsic disorder within AKAP79 fine-tunes anchored phosphatase activity toward substrates and drug sensitivity.
Creator: Nygren, Patrick J, Mehta, Sohum, Schweppe, Devin K, Langeberg, Lorene K, Whiting, Jennifer L, Weisbrod, Chad R, Bruce, James E, Zhang, Jin, Veesler, David, Scott, John D
Abstract/Description: Scaffolding the calcium/calmodulin-dependent phosphatase 2B (PP2B, calcineurin) focuses and insulates termination of local second messenger responses. Conformational flexibility in regions of intrinsic disorder within A-kinase anchoring protein 79 (AKAP79) delineates PP2B access to phosphoproteins. Structural analysis by negative-stain electron microscopy (EM) reveals an ensemble of dormant AKAP79-PP2B configurations varying in particle length from 160 to 240 Å. A short-linear interaction...
Show moreScaffolding the calcium/calmodulin-dependent phosphatase 2B (PP2B, calcineurin) focuses and insulates termination of local second messenger responses. Conformational flexibility in regions of intrinsic disorder within A-kinase anchoring protein 79 (AKAP79) delineates PP2B access to phosphoproteins. Structural analysis by negative-stain electron microscopy (EM) reveals an ensemble of dormant AKAP79-PP2B configurations varying in particle length from 160 to 240 Å. A short-linear interaction motif between residues 337-343 of AKAP79 is the sole PP2B-anchoring determinant sustaining these diverse topologies. Activation with Ca2/calmodulin engages additional interactive surfaces and condenses these conformational variants into a uniform population with mean length 178 ± 17 Å. This includes a Leu-Lys-Ile-Pro sequence (residues 125-128 of AKAP79) that occupies a binding pocket on PP2B utilized by the immunosuppressive drug cyclosporin. Live-cell imaging with fluorescent activity-sensors infers that this region fine-tunes calcium responsiveness and drug sensitivity of the anchored phosphatase.
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Date Issued: 2017-10-02
Identifier: FSU_pmch_28967377, 10.7554/eLife.30872, PMC5653234, 28967377, 28967377, 30872
Format: Citation

Title: Distinguishing neuronal from astrocytic subcellular microstructures using in vivo Double Diffusion Encoded 1H MRS at 21.1 T.
Creator: Shemesh, Noam, Rosenberg, Jens T, Dumez, Jean-Nicolas, Grant, Samuel C, Frydman, Lucio
Abstract/Description: Measuring cellular microstructures non-invasively and achieving specificity towards a cell-type population within an interrogated in vivo tissue, remains an outstanding challenge in brain research. Magnetic Resonance Spectroscopy (MRS) provides an opportunity to achieve cellular specificity via the spectral resolution of metabolites such as N-Acetylaspartate (NAA) and myo-Inositol (mI), which are considered neuronal and astrocytic markers, respectively. Yet the information typically obtained...
Show moreMeasuring cellular microstructures non-invasively and achieving specificity towards a cell-type population within an interrogated in vivo tissue, remains an outstanding challenge in brain research. Magnetic Resonance Spectroscopy (MRS) provides an opportunity to achieve cellular specificity via the spectral resolution of metabolites such as N-Acetylaspartate (NAA) and myo-Inositol (mI), which are considered neuronal and astrocytic markers, respectively. Yet the information typically obtained with MRS describes metabolic concentrations, diffusion coefficients or relaxation rates rather than microstructures. Understanding how these metabolites are compartmentalized is a challenging but important goal, which so far has been mainly addressed using diffusion models. Here, we present direct in vivo evidence for the confinement of NAA and mI within sub-cellular components, namely, the randomly oriented process of neurons and astrocytes, respectively. Our approach applied Relaxation Enhanced MRS at ultrahigh (21.1 T) field, and used its high 1H sensitivity to measure restricted diffusion correlations for NAA and mI using a Double Diffusion Encoding (DDE) filter. While very low macroscopic anisotropy was revealed by spatially localized Diffusion Tensor Spectroscopy, DDE displayed characteristic amplitude modulations reporting on confinements in otherwise randomly oriented anisotropic microstructures for both metabolites. This implies that for the chosen set of parameters, the DDE measurements had a biased sensitivity towards NAA and mI sited in the more confined environments of neurites and astrocytic branches, than in the cell somata. These measurements thus provide intrinsic diffusivities and compartment diameters, and revealed subcellular neuronal and astrocytic morphologies in normal in vivo rat brains. The relevance of these measurements towards human applications-which could in turn help understand CNS plasticity as well as diagnose brain diseases-is discussed.
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Date Issued: 2017-10-02
Identifier: FSU_pmch_28968410, 10.1371/journal.pone.0185232, PMC5624579, 28968410, 28968410, PONE-D-17-12913
Format: Citation

Title: Cat Family.
Creator: Allen, Brandon, Anderson, Abbie, Brady, Jacqueline, Fintak, Shelby
Abstract/Description: Cat Family Records, a Tallahassee-born record company, navigates the commercially expanding market and independent music scene. Meet the diverse community of artists who form this up-and-coming label. (13 minutes)
Date Issued: 2018-07-12
Identifier: FSU_libsubv1_scholarship_submission_1531421531_e0eda109
Format: Video file

Title: 3'-UTR and microRNA-24 regulate circadian rhythms by repressing PERIOD2 protein accumulation.
Creator: Yoo, Seung-Hee, Kojima, Shihoko, Shimomura, Kazuhiro, Koike, Nobuya, Buhr, Ethan D, Furukawa, Tadashi, Ko, Caroline H, Gloston, Gabrielle, Ayoub, Christopher, Nohara, Kazunari,...
Show moreYoo, Seung-Hee, Kojima, Shihoko, Shimomura, Kazuhiro, Koike, Nobuya, Buhr, Ethan D, Furukawa, Tadashi, Ko, Caroline H, Gloston, Gabrielle, Ayoub, Christopher, Nohara, Kazunari, Reyes, Bryan A, Tsuchiya, Yoshiki, Yoo, Ook-Joon, Yagita, Kazuhiro, Lee, Choogon, Chen, Zheng, Yamazaki, Shin, Green, Carla B, Takahashi, Joseph S
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Abstract/Description: We previously created two PER2::LUCIFERASE (PER2::LUC) circadian reporter knockin mice that differ only in the 3'-UTR region: , which retains the endogenous 3'-UTR and , where the endogenous 3'-UTR was replaced by an SV40 late poly(A) signal. To delineate the in vivo functions of 3'-UTR, we analyzed circadian rhythms of mice. Interestingly, mice displayed more than threefold stronger amplitude in bioluminescence rhythms than mice, and also exhibited lengthened free-running periods (∼24.0 h),...
Show moreWe previously created two PER2::LUCIFERASE (PER2::LUC) circadian reporter knockin mice that differ only in the 3'-UTR region: , which retains the endogenous 3'-UTR and , where the endogenous 3'-UTR was replaced by an SV40 late poly(A) signal. To delineate the in vivo functions of 3'-UTR, we analyzed circadian rhythms of mice. Interestingly, mice displayed more than threefold stronger amplitude in bioluminescence rhythms than mice, and also exhibited lengthened free-running periods (∼24.0 h), greater phase delays following light pulse, and enhanced temperature compensation relative to Analysis of the 3'-UTR sequence revealed that miR-24, and to a lesser degree miR-30, suppressed PER2 protein translation, and the reversal of this inhibition in augmented PER2::LUC protein level and oscillatory amplitude. Interestingly, mRNA and protein oscillatory amplitude as well as CRY1 protein oscillation were increased in mice, suggesting rhythmic overexpression of PER2 enhances expression of and other core clock genes. Together, these studies provide important mechanistic insights into the regulatory roles of 3'-UTR, miR-24, and PER2 in expression and core clock function.
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Date Issued: 2017-10-17
Identifier: FSU_pmch_28973913, 10.1073/pnas.1706611114, PMC5651750, 28973913, 28973913, 1706611114
Format: Citation

Title: Post-translationally modified muscle-specific ubiquitin ligases as circulating biomarkers in experimental cancer cachexia.
Creator: Mota, Roberto, Rodríguez, Jessica E, Bonetto, Andrea, O'Connell, Thomas M, Asher, Scott A, Parry, Traci L, Lockyer, Pamela, McCudden, Christopher R, Couch, Marion E, Willis,...
Show moreMota, Roberto, Rodríguez, Jessica E, Bonetto, Andrea, O'Connell, Thomas M, Asher, Scott A, Parry, Traci L, Lockyer, Pamela, McCudden, Christopher R, Couch, Marion E, Willis, Monte S
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Abstract/Description: Cancer cachexia is a severe wasting syndrome characterized by the progressive loss of lean body mass and systemic inflammation. Up to 80% of cancer patients experience cachexia, with 20-30% of cancer-related deaths directly linked to cachexia. Despite efforts to identify early cachexia and cancer relapse, clinically useful markers are lacking. Recently, we identified the role of muscle-specific ubiquitin ligases Atrogin-1 (MAFbx, FBXO32) and Muscle Ring Finger-1 in the pathogenesis of cardiac...
Show moreCancer cachexia is a severe wasting syndrome characterized by the progressive loss of lean body mass and systemic inflammation. Up to 80% of cancer patients experience cachexia, with 20-30% of cancer-related deaths directly linked to cachexia. Despite efforts to identify early cachexia and cancer relapse, clinically useful markers are lacking. Recently, we identified the role of muscle-specific ubiquitin ligases Atrogin-1 (MAFbx, FBXO32) and Muscle Ring Finger-1 in the pathogenesis of cardiac atrophy and hypertrophy. We hypothesized that during cachexia, the Atrogin-1 and MuRF1 ubiquitin ligases are released from muscle and migrate to the circulation where they could be detected and serve as a cachexia biomarker. To test this, we induced cachexia in mice using the C26 adenocarcinoma cells or vehicle (control). Body weight, tumor volume, and food consumption were measured from inoculation until ~day 14 to document cachexia. Western blot analysis of serum identified the presence of Atrogin-1 and MuRF1 with unique post-translational modifications consistent with mono- and poly- ubiquitination of Atrogin-1 and MuRF1 found only in cachectic serum. These findings suggest that both increased Atrogin-1 and the presence of unique post-translational modifications may serve as a surrogate marker specific for cachexia.
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Date Issued: 2017-09-01
Identifier: FSU_pmch_28979816, PMC5622228, 28979816, 28979816
Format: Citation

Title: Thirst Increases Chorda Tympani Responses to Sodium Chloride.
Creator: Mast, Thomas G, Breza, Joseph M, Contreras, Robert J
Abstract/Description: In nature, water is present as a low-salt solution, thus we hypothesized that thirst would increase taste responses to low-salt solutions. We investigated the effect of thirst on the 2 different salt detection mechanisms present in the rat chorda tympani (CT) nerve. The first mechanism is dependent upon the epithelial sodium channel (ENaC), is blocked by benzamil, and is specific to the cation sodium. The second mechanism, while undefined, is independent of ENaC, and detects multiple cations....
Show moreIn nature, water is present as a low-salt solution, thus we hypothesized that thirst would increase taste responses to low-salt solutions. We investigated the effect of thirst on the 2 different salt detection mechanisms present in the rat chorda tympani (CT) nerve. The first mechanism is dependent upon the epithelial sodium channel (ENaC), is blocked by benzamil, and is specific to the cation sodium. The second mechanism, while undefined, is independent of ENaC, and detects multiple cations. We expected thirst to increase benzamil-sensitive sodium responses due to mechanistically increasing the benzamil-sensitive ENaC. We recorded CT whole-nerve electrophysiological responses to lingual application of NaCl, KCl (30, 75, 150, 300, 500, and 600 mM), and imitation rainwater in both control and 24-h water-restricted male rats. NaCl solutions were presented in artificial saliva before and after lingual application of 5µM benzamil. Water restriction significantly increased the integrated CT responses to NaCl but not to KCl or imitation rainwater. Consistent with our hypothesis, only the benzamil-sensitive, and not the benzamil-insensitive, CT sodium response significantly increased. Additionally, CT responses to salt were recorded following induction of either osmotic or volemic thirst. Both thirsts significantly enhanced the integrated CT responses to NaCl and KCl, but not imitation rainwater. Interestingly, osmotic and volemic thirsts increased CT responses by increasing both the benzamil-sensitive and benzamil-insensitive CT sodium responses. We propose that thirst increases the sensitivity of the CT nerve to sodium.
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Date Issued: 2017-10-01
Identifier: FSU_pmch_28981824, 10.1093/chemse/bjx052, PMC5863560, 28981824, 28981824, 4083245
Format: Citation

Title: Deployment, Mental Health Problems, Suicidality, and Use of Mental Health Services Among Military Personnel.
Creator: Chu, Carol, Stanley, Ian H, Hom, Melanie A, Lim, Ingrid C, Joiner, Thomas E
Abstract/Description: Following deployment, soldiers may struggle to cope with the after-effects of combat service and experience increased suicidality. Therefore, connection to mental health services is vital. Research regarding the relationship between deployment, suicidality, and mental health connections has been equivocal, with some studies finding a link between deployment history and mental health outcomes, and others not. The purpose of this study was to examine the effects of military deployment on mental...
Show moreFollowing deployment, soldiers may struggle to cope with the after-effects of combat service and experience increased suicidality. Therefore, connection to mental health services is vital. Research regarding the relationship between deployment, suicidality, and mental health connections has been equivocal, with some studies finding a link between deployment history and mental health outcomes, and others not. The purpose of this study was to examine the effects of military deployment on mental health and service utilization outcomes using a longitudinal design. Deployment history, mental health visits, symptoms of suicidality, and various mental health outcomes were assessed in a sample of 1,566 Army recruiters at study entry and 18-months follow-up. Deployment history was positively associated with mental health visits, number of major depressive episodes, and acquired capability for suicide at baseline; however, no significant relationship between deployment, mental health visits, and any other suicide or mental health-related outcomes emerged at baseline or follow-up. Findings suggest a disconnection from mental health services among military personnel. Implications for treatment and suicide prevention efforts among military personnel are discussed.
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Date Issued: 2016-01-01
Identifier: FSU_pmch_28959502, 10.1080/21635781.2016.1153533, PMC5613946, 28959502, 28959502
Format: Citation

Title: Breastfeeding and Adult Personality.
Creator: Sutin, Angelina R, Stephan, Yannick, Terracciano, Antonio
Abstract/Description: Five Factor Model (FFM) personality traits are implicated in long-term health-risk behaviors and outcomes. Less research has addressed how early-life experiences are associated with individual differences in these traits in adulthood. We examine whether having been breastfed is associated with adult personality and well-being in the National Longitudinal Study of Adolescent to Adult Health. At Wave 1, caregivers reported whether the target child had been breastfed. At Wave 4, participants (...
Show moreFive Factor Model (FFM) personality traits are implicated in long-term health-risk behaviors and outcomes. Less research has addressed how early-life experiences are associated with individual differences in these traits in adulthood. We examine whether having been breastfed is associated with adult personality and well-being in the National Longitudinal Study of Adolescent to Adult Health. At Wave 1, caregivers reported whether the target child had been breastfed. At Wave 4, participants (=13,113; 53% female; =28.98) completed measures of psychological functioning. We tested for mean-level differences in the traits by breastfeeding status (yes/no) and by the duration of breastfeeding, controlling for basic demographic factors and early-life factors that could confound the breastfeeding-personality association (e.g., mother education). Participants who had been breastfed scored lower in neuroticism, anxiety, and hostility and higher in openness and optimism than those not breastfed. A curvilinear relation suggested that neuroticism was lowest for those breastfed for 9-12 months and highest for those either breastfed for >24 months or exclusively bottle-fed. Breastfeeding was unrelated to conscientiousness or state psychological functioning. This research suggests long-term psychological benefits to breastfeeding and indicates that early life experiences are associated with traits that are consequential for adult health.
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Date Issued: 2016-09-01
Identifier: FSU_pmch_28966441, 10.1002/per.2030, PMC5614468, 28966441, 28966441
Format: Citation

Title: Coupling between myosin head conformation and the thick filament backbone structure.
Creator: Hu, Zhongjun, Taylor, Dianne W, Edwards, Robert J, Taylor, Kenneth A
Abstract/Description: The recent high-resolution structure of the thick filament from Lethocerus asynchronous flight muscle shows aspects of thick filament structure never before revealed that may shed some light on how striated muscles function. The phenomenon of stretch activation underlies the function of asynchronous flight muscle. It is most highly developed in flight muscle, but is also observed in other striated muscles such as cardiac muscle. Although stretch activation is likely to be complex, involving...
Show moreThe recent high-resolution structure of the thick filament from Lethocerus asynchronous flight muscle shows aspects of thick filament structure never before revealed that may shed some light on how striated muscles function. The phenomenon of stretch activation underlies the function of asynchronous flight muscle. It is most highly developed in flight muscle, but is also observed in other striated muscles such as cardiac muscle. Although stretch activation is likely to be complex, involving more than a single structural aspect of striated muscle, the thick filament itself, would be a prime site for regulatory function because it must bear all of the tension produced by both its associated myosin motors and any externally applied force. Here we show the first structural evidence that the arrangement of myosin heads within the interacting heads motif is coupled to the structure of the thick filament backbone. We find that a change in helical angle of 0.16° disorders the blocked head preferentially within the Lethocerus interacting heads motif. This observation suggests a mechanism for how tension affects the dynamics of the myosin heads leading to a detailed hypothesis for stretch activation and shortening deactivation, in which the blocked head preferentially binds the thin filament followed by the free head when force production occurs.
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Date Issued: 2017-12-01
Identifier: FSU_pmch_28964844, 10.1016/j.jsb.2017.09.009, PMC5733691, 28964844, 28964844, S1047-8477(17)30160-0
Format: Citation

Title: A persistent-mode 0.5 T solid-nitrogen-cooled MgB2 magnet for MRI.
Creator: Ling, Jiayin, Voccio, John P, Hahn, Seungyong, Qu, Timing, Bascuñán, Juan, Iwasa, Yukikazu
Abstract/Description: This paper presents construction details and test results of a persistent-mode 0.5-T MgB magnet developed at the Francis Bitter Magnet Lab, MIT. The magnet, of 276-mm inner diameter and 290-mm outer diameter, consisted of a stack of 8 solenoidal coils with a total height of 460 mm. Each coil was wound with monofilament MgB wire, equipped with a persistent-current switch and terminated with a superconducting joint, forming an individual superconducting loop. Resistive solder joints connected...
Show moreThis paper presents construction details and test results of a persistent-mode 0.5-T MgB magnet developed at the Francis Bitter Magnet Lab, MIT. The magnet, of 276-mm inner diameter and 290-mm outer diameter, consisted of a stack of 8 solenoidal coils with a total height of 460 mm. Each coil was wound with monofilament MgB wire, equipped with a persistent-current switch and terminated with a superconducting joint, forming an individual superconducting loop. Resistive solder joints connected the 8 coils in series. The magnet, after being integrated into a testing system, immersed in solid nitrogen, was operated in a temperature range of 10-13 K. A two-stage cryocooler was deployed to cool a radiation shield and the cold mass that included mainly ~60 kg of solid nitrogen and the magnet. The solid nitrogen was capable of providing a uniform and stable cryogenic environment to the magnet. The magnet sustained a 0.47-T magnetic field at its center persistently in a range of 10-13 K. The current in each coil was inversely calculated from the measured field profile to determine the performance of each coil in persistent-mode operation. Persistent-current switches were successfully operated in solid nitrogen for ramping the magnet. They were also designed to absorb magnetic energy in a protection mechanism; its effectiveness was evaluated in an induced quench.
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Date Issued: 2017-02-01
Identifier: FSU_pmch_28966476, 10.1088/1361-6668/30/2/024011, PMC5613760, 28966476, 28966476
Format: Citation

Title: Controversies on lung cancers manifesting as part-solid nodules.
Creator: Yip, Rowena, Li, Kunwei, Liu, Li, Xu, Dongming, Tam, Kathleen, Yankelevitz, David F, Taioli, Emanuela, Becker, Betsy, Henschke, Claudia I
Abstract/Description: Summarise survival of patients with resected lung cancers manifesting as part-solid nodules (PSNs). PubMed/MEDLINE and EMBASE databases were searched for all studies/clinical trials on CT-detected lung cancer in English before 21 December 2015 to identify surgically resected lung cancers manifesting as PSNs. Outcome measures were lung cancer-specific survival (LCS), overall survival (OS), or disease-free survival (DFS). All PSNs were classified by the percentage of solid component to the...
Show moreSummarise survival of patients with resected lung cancers manifesting as part-solid nodules (PSNs). PubMed/MEDLINE and EMBASE databases were searched for all studies/clinical trials on CT-detected lung cancer in English before 21 December 2015 to identify surgically resected lung cancers manifesting as PSNs. Outcome measures were lung cancer-specific survival (LCS), overall survival (OS), or disease-free survival (DFS). All PSNs were classified by the percentage of solid component to the entire nodule diameter into category PSNs <80% or category PSNs ≥80%. Twenty studies reported on PSNs <80%: 7 reported DFS and 2 OS of 100%, 6 DFS 96.3-98.7%, and 11 OS 94.7-98.9% (median DFS 100% and OS 97.5%). Twenty-seven studies reported on PSNs ≥80%: 1 DFS and 2 OS of 100%, 19 DFS 48.0%-98.0% (median 82.6%), and 16 reported OS 43.0%-98.0% (median DFS 82.6%, OS 85.5%). Both DFS and OS were always higher for PSNs <80%. A clear definition of the upper limit of solid component of a PSN is needed to avoid misclassification because cell-types and outcomes are different for PSN and solid nodules. The workup should be based on the size of the solid component. • Lung cancers manifesting as PSNs are slow growing with high cure rates. • Upper limits of the solid component are important for correct interpretation. • Consensus definition is important for the management of PSNs. • Median disease-free-survival (DFS) increased with decreasing size of the nodule.
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Date Issued: 2018-02-01
Identifier: FSU_pmch_28835992, 10.1007/s00330-017-4975-9, PMC5996385, 28835992, 28835992, 10.1007/s00330-017-4975-9
Format: Citation

Title: Analyzing State Autism Private Insurance Mandates for Allied Health Services: A Pilot Study..
Creator: Douglas, Megan D, Benevides, Teal W, Carretta, Henry
Abstract/Description: Due to the prevalence, severity, and costs associated with autism spectrum disorders (ASDs), it has become a public health issue. In response, state governments have adopted ASD-specific private insurance mandates requiring coverage of ASD screening, diagnosis, and treatment. Despite rapid uptake of these laws, differences exist in the type and levels of coverage, especially for allied health services including occupational therapy. We piloted a structured legal research methodology to code...
Show moreDue to the prevalence, severity, and costs associated with autism spectrum disorders (ASDs), it has become a public health issue. In response, state governments have adopted ASD-specific private insurance mandates requiring coverage of ASD screening, diagnosis, and treatment. Despite rapid uptake of these laws, differences exist in the type and levels of coverage, especially for allied health services including occupational therapy. We piloted a structured legal research methodology to code ASD insurance mandates that impact allied health service provisions. State private insurance mandates were obtained from WestlawNext. A coding methodology was piloted on 14 states and included variables for age and service limits, treatments covered, and medical necessity. Coding methods were feasible and highly reliable among raters. Ten of 12 states had a coverage mandate, many with specific provisions for allied health providers. A full analysis of all 50 states is warranted to identify provisions affecting allied health providers serving individuals with ASD.
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Date Issued: 2017-10-01
Identifier: FSU_pmch_28874097, 10.1177/1539449217730355, PMC5772933, 28874097, 28874097
Format: Citation

Title: When in doubt, go to the library: The effect of a library-intensive freshman research and writing seminar on academic success.
Creator: Hill, Leslie B., Maier-Katkin, Dan, Ladny, Roshni T., Kinsley, Kirsten Michele
Abstract/Description: The paper is an extension of a previous study, which examined student perceptions of a unique freshman seminar offered to Criminology and Criminal Justice students at Florida State University. The seminar is characterized by a heavy focus on interactive library sessions in which students learn how to conduct research and write a scholarly paper. The previous article reported on student perceptions of research and writing skills developed in the seminar. This report, using Multivariate...
Show moreThe paper is an extension of a previous study, which examined student perceptions of a unique freshman seminar offered to Criminology and Criminal Justice students at Florida State University. The seminar is characterized by a heavy focus on interactive library sessions in which students learn how to conduct research and write a scholarly paper. The previous article reported on student perceptions of research and writing skills developed in the seminar. This report, using Multivariate Regression and Propensity Score Matching reveals that compared to a carefully constructed comparison group, first time in college students enrolled in the seminar have statistically significantly higher cumulative grade point averages and percentages of graduation within four years. The seminar’s emphasis on the library as a research tool is thought to have contributed to the differences seen on academic outcomes between students who took the seminar and a matched comparison group.
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Date Issued: 2017-09-21
Identifier: FSU_libsubv1_scholarship_submission_1552566510_6c23f37e, 10.1080/10511253.2017.1372498
Format: Citation

Title: S-Doped MoP Nanoporous Layer Towards High-Efficiency Hydrogen Evolution in pH-Universal Electrolyte.
Creator: Pakhira, Srimanta, Nijamudheen, A., Aguirre-Velez, Carlos I., Mendoza-Cortes, Jose L.
Abstract/Description: In this study, we report a nonprecious metal catalyst for high-efficiency hydrogen evolution reaction (HER). A self-organized S-doped MoP nanoporous layer (S-MoP NPL) is achieved through a facile electrochemical anodic process and a two-step chemical vapor deposition treatment, which was directly used as a binder-free catalyst for HER in pH-universal electrolytes. SMoP NPL exhibits HER behavior with a low overpotential of 86 mV at 10 mA cm−1 and low Tafel slope of 34 mV dec−1 in acidic...
Show moreIn this study, we report a nonprecious metal catalyst for high-efficiency hydrogen evolution reaction (HER). A self-organized S-doped MoP nanoporous layer (S-MoP NPL) is achieved through a facile electrochemical anodic process and a two-step chemical vapor deposition treatment, which was directly used as a binder-free catalyst for HER in pH-universal electrolytes. SMoP NPL exhibits HER behavior with a low overpotential of 86 mV at 10 mA cm−1 and low Tafel slope of 34 mV dec−1 in acidic solution. Moreover, S-MoP NPL also shows high HER activity in basic and neutral electrolytes. Density functional theory (DFT) computations were carried out to support our experiment. The calculations show that the H2 formation (via Volmer−Heyrovsky mechanism) from the reaction of a metal (Mo) absorbed hydride with a solvated proton is favored over S-MoP than MoS2. Both experimental and computational studies demonstrate that the extraordinary HER activity and stability performance displayed by a MoP catalyst can be enhanced by S-doping, opening up a promising paradigm for the conscious design of high-performance nonprecious metal catalyst for hydrogen generation.
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Date Issued: 2018-12-18
Identifier: FSU_libsubv1_scholarship_submission_1551725486_98e8698a, 10.1021/acscatal.8b04291
Format: Citation

Title: The Hox proteins Ubx and AbdA collaborate with the transcription pausing factor M1BP to regulate gene transcription.
Creator: Zouaz, Amel, Auradkar, Ankush, Delfini, Marie Claire, Macchi, Meiggie, Barthez, Marine, Ela Akoa, Serge, Bastianelli, Leila, Xie, Gengqiang, Deng, Wu-Min, Levine, Stuart S,...
Show moreZouaz, Amel, Auradkar, Ankush, Delfini, Marie Claire, Macchi, Meiggie, Barthez, Marine, Ela Akoa, Serge, Bastianelli, Leila, Xie, Gengqiang, Deng, Wu-Min, Levine, Stuart S, Graba, Yacine, Saurin, Andrew J
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Abstract/Description: In metazoans, the pausing of RNA polymerase II at the promoter (paused Pol II) has emerged as a widespread and conserved mechanism in the regulation of gene transcription. While critical in recruiting Pol II to the promoter, the role transcription factors play in transitioning paused Pol II into productive Pol II is, however, little known. By studying how Hox transcription factors control transcription, we uncovered a molecular mechanism that increases productive transcription. We found that...
Show moreIn metazoans, the pausing of RNA polymerase II at the promoter (paused Pol II) has emerged as a widespread and conserved mechanism in the regulation of gene transcription. While critical in recruiting Pol II to the promoter, the role transcription factors play in transitioning paused Pol II into productive Pol II is, however, little known. By studying how Hox transcription factors control transcription, we uncovered a molecular mechanism that increases productive transcription. We found that the Hox proteins AbdA and Ubx target gene promoters previously bound by the transcription pausing factor M1BP, containing paused Pol II and enriched with promoter-proximal Polycomb Group (PcG) proteins, yet lacking the classical H3K27me3 PcG signature. We found that AbdA binding to M1BP-regulated genes results in reduction in PcG binding, the release of paused Pol II, increases in promoter H3K4me3 histone marks and increased gene transcription. Linking transcription factors, PcG proteins and paused Pol II states, these data identify a two-step mechanism of Hox-driven transcription, with M1BP binding leading to Pol II recruitment followed by AbdA targeting, which results in a change in the chromatin landscape and enhanced transcription.
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Date Issued: 2017-10-02
Identifier: FSU_pmch_28871058, 10.15252/embj.201695751, PMC5623858, 28871058, 28871058, embj.201695751
Format: Citation

Title: Facets of Conscientiousness and risk of dementia.
Creator: Sutin, A R, Stephan, Y, Terracciano, A
Abstract/Description: Multiple studies have found Conscientiousness to be protective against dementia. The purpose of this study is to identify which specific aspects, or facets, of Conscientiousness are most protective against cognitive impairment and whether these associations are moderated by demographic factors and/or genetic risk. Health and Retirement Study participants were selected for analysis if they completed the facets of Conscientiousness measure, scored in the range of normal cognitive functioning at...
Show moreMultiple studies have found Conscientiousness to be protective against dementia. The purpose of this study is to identify which specific aspects, or facets, of Conscientiousness are most protective against cognitive impairment and whether these associations are moderated by demographic factors and/or genetic risk. Health and Retirement Study participants were selected for analysis if they completed the facets of Conscientiousness measure, scored in the range of normal cognitive functioning at the baseline personality assessment, and had at least one follow-up assessment of cognition over the up to 6-year follow-up (N = 11 181). Cox regression was used to test for risk of incident dementia and risk of incident cognitive impairment not dementia (CIND). Over the follow-up, 278 participants developed dementia and 2186 participants developed CIND. The facet of responsibility had the strongest and most consistent association with dementia risk: every standard deviation increase in this facet was associated with a nearly 35% decreased risk of dementia; self-control and industriousness were also protective. Associations were generally similar when controlling for clinical, behavioral, and genetic risk factors. These three facets were also independent predictors of decreased risk of CIND. The present research indicates that individuals who see themselves as responsible, able to control their behavior, and hard workers are less likely to develop CIND or dementia and that these associations persist after accounting for some common clinical, behavioral, and genetic risk factors.
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Date Issued: 2018-04-01
Identifier: FSU_pmch_28874220, 10.1017/S0033291717002306, PMC5839940, 28874220, 28874220, S0033291717002306
Format: Citation

Title: Attention bias modification reduces neural correlates of response monitoring.
Creator: Nelson, Brady D, Jackson, Felicia, Amir, Nader, Hajcak, Greg
Abstract/Description: The error-related negativity (ERN) is an electrophysiological response to errors. Individual differences in the ERN have been posited to reflect sensitivity to threat and linked with risk for anxiety disorders. Attention bias modification is a promising computerized intervention that has been shown to decrease threat biases and anxiety symptoms. In the present study, we examined the impact of a single session of attention bias modification, relative to a control task, on the neural correlates...
Show moreThe error-related negativity (ERN) is an electrophysiological response to errors. Individual differences in the ERN have been posited to reflect sensitivity to threat and linked with risk for anxiety disorders. Attention bias modification is a promising computerized intervention that has been shown to decrease threat biases and anxiety symptoms. In the present study, we examined the impact of a single session of attention bias modification, relative to a control task, on the neural correlates of response monitoring, including the ERN, correct response negativity (CRN), and their difference (i.e., the ERN - CRN or ΔERN). The final sample included 60 participants who first completed a flanker task to elicit the ERN and CRN, and were then randomly assigned to attention bias modification (n=30) or a control task (n=30). After completing the attention bias modification or control task, participants completed the same flanker task to again elicit the ERN and CRN. Among participants who completed attention bias modification training, the ERN, CRN, and ΔERN decreased from the pre- to post-training assessment. In contrast, in participants who completed the control task, the CRN, ERN, and ΔERN did not differ between the pre- and post-training assessment. The presents study suggests that a single session of attention bias modification reduces neural correlates of response monitoring, including error-related brain activity. These results also support attention bias modification as a potential mechanistic-based intervention for the prevention and treatment of anxiety pathology.
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Date Issued: 2017-10-01
Identifier: FSU_pmch_28867538, 10.1016/j.biopsycho.2017.08.059, PMC5673533, 28867538, 28867538, S0301-0511(17)30228-4
Format: Citation

Title: Error-Specific Cognitive Control Alterations in Generalized Anxiety Disorder.
Creator: Cavanagh, James F, Meyer, Alexandria, Hajcak, Greg
Abstract/Description: Trait anxiety is reliably associated with enhanced neural responses following errors: meta analyses have described how the electrophysiological response to errors known as the Error-Related Negativity (ERN) is increased in anxious individuals, particularly in relation to worry. The ERN has been related to a broader class of control signals, particularly via a common theta band denominator, but it is unknown whether worry relates to these alternative medial frontal metrics. Moreover, it is...
Show moreTrait anxiety is reliably associated with enhanced neural responses following errors: meta analyses have described how the electrophysiological response to errors known as the Error-Related Negativity (ERN) is increased in anxious individuals, particularly in relation to worry. The ERN has been related to a broader class of control signals, particularly via a common theta band denominator, but it is unknown whether worry relates to these alternative medial frontal metrics. Moreover, it is unclear if increased ERN in anxiety relates to altered cognitive control. In this report we examine EEG activities in Generalized Anxiety Disorder (GAD, N=39) and control (CTL: N=52) participants during an executive control task. We leveraged a previously defined theta-band network to examine if an altered control signal in GAD underlies a differential implementation of cognitive control. GAD and CTL groups were reliably dissociated by both error- and conflict- related neural activity, in both the time and frequency (i.e. theta band) domains. Moreover, we demonstrate that ERN, error-related theta power, and the single trial correlation between theta and response time were unique predictors of GAD status. Overall, we were able to account for nearly 1/4 of the group variance and successfully classify GAD from control participants with 2/3 accuracy. Collectively, these findings suggest that multiple neural metrics of error processing may uniquely distinguish clinical anxiety from healthy individuals, and that mechanisms of control also differ in GAD; finally, these error-related neural measures have the potential to be sensitive and specific bio-signatures of anxiety.
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Date Issued: 2017-07-01
Identifier: FSU_pmch_28871288, 10.1016/j.bpsc.2017.01.004, PMC5580396, 28871288, 28871288
Format: Citation

Title: Phase diagram of URu Fe Si in high magnetic fields.
Creator: Ran, Sheng, Jeon, Inho, Pouse, Naveen, Breindel, Alexander J, Kanchanavatee, Noravee, Huang, Kevin, Gallagher, Andrew, Chen, Kuan-Wen, Graf, David, Baumbach, Ryan E, Singleton,...
Show moreRan, Sheng, Jeon, Inho, Pouse, Naveen, Breindel, Alexander J, Kanchanavatee, Noravee, Huang, Kevin, Gallagher, Andrew, Chen, Kuan-Wen, Graf, David, Baumbach, Ryan E, Singleton, John, Maple, M Brian
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Abstract/Description: Electrical transport measurements were performed on URu Fe Si single-crystal specimens in high magnetic fields up to 45 T (DC fields) and 60 T (pulsed fields). We observed a systematic evolution of the critical fields for both the hidden-order (HO) and large-moment antiferromagnetic (LMAFM) phases and established the 3D phase diagram of In the HO phase, / scales with / and collapses onto a single curve. However, in the LMAFM phase, this single scaling relation is not satisfied. Within a...
Show moreElectrical transport measurements were performed on URu Fe Si single-crystal specimens in high magnetic fields up to 45 T (DC fields) and 60 T (pulsed fields). We observed a systematic evolution of the critical fields for both the hidden-order (HO) and large-moment antiferromagnetic (LMAFM) phases and established the 3D phase diagram of In the HO phase, / scales with / and collapses onto a single curve. However, in the LMAFM phase, this single scaling relation is not satisfied. Within a certain range of values, the HO phase reenters after the LMAFM phase is suppressed by the magnetic field, similar to the behavior observed for URuSi within a certain range of pressures.
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Date Issued: 2017-09-12
Identifier: FSU_pmch_28847927, 10.1073/pnas.1710192114, PMC5604036, 28847927, 28847927, 1710192114
Format: Citation

Title: Language-Independent and Language-Specific Aspects of Early Literacy: An Evaluation of the Common Underlying Proficiency Model..
Creator: Goodrich, J Marc, Lonigan, Christopher J
Abstract/Description: According to the common underlying proficiency model (Cummins, 1981), as children acquire academic knowledge and skills in their first language, they also acquire language-independent information about those skills that can be applied when learning a second language. The purpose of this study was to evaluate the relevance of the common underlying proficiency model for the early literacy skills of Spanish-speaking language-minority children using confirmatory factor analysis. Eight hundred...
Show moreAccording to the common underlying proficiency model (Cummins, 1981), as children acquire academic knowledge and skills in their first language, they also acquire language-independent information about those skills that can be applied when learning a second language. The purpose of this study was to evaluate the relevance of the common underlying proficiency model for the early literacy skills of Spanish-speaking language-minority children using confirmatory factor analysis. Eight hundred fifty-eight Spanish-speaking language-minority preschoolers (mean age = 60.83 months, 50.2% female) participated in this study. Results indicated that bifactor models that consisted of language-independent as well as language-specific early literacy factors provided the best fits to the data for children's phonological awareness and print knowledge skills. Correlated factors models that only included skills specific to Spanish and English provided the best fits to the data for children's oral language skills. Children's language-independent early literacy skills were significantly related across constructs and to language-specific aspects of early literacy. Language-specific aspects of early literacy skills were significantly related within but not across languages. These findings suggest that language-minority preschoolers have a common underlying proficiency for code-related skills but not language-related skills that may allow them to transfer knowledge across languages.
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Date Issued: 2017-08-01
Identifier: FSU_pmch_28848244, 10.1037/edu0000179, PMC5571872, 28848244, 28848244
Format: Citation

Title: Universalizing anonymity anxiety.
Creator: Cahill, Courtney Megan
Date Issued: 2016-10-12
Identifier: FSU_pmch_28852543, 10.1093/jlb/lsw043, PMC5570718, 28852543, 28852543, lsw043
Format: Citation

Title: Origin of the emergence of higher T than bulk in iron chalcogenide thin films.
Creator: Seo, Sehun, Kang, Jong-Hoon, Oh, Myeong Jun, Jeong, Il-Seok, Jiang, Jianyi, Gu, Genda, Lee, Jung-Woo, Lee, Jongmin, Noh, Heesung, Liu, Mengchao, Gao, Peng, Hellstrom, Eric E,...
Show moreSeo, Sehun, Kang, Jong-Hoon, Oh, Myeong Jun, Jeong, Il-Seok, Jiang, Jianyi, Gu, Genda, Lee, Jung-Woo, Lee, Jongmin, Noh, Heesung, Liu, Mengchao, Gao, Peng, Hellstrom, Eric E, Lee, Joo-Hyoung, Jo, Youn Jung, Eom, Chang-Beom, Lee, Sanghan
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Abstract/Description: Fabrication of epitaxial FeSeTe thin films using pulsed laser deposition (PLD) enables improving their superconducting transition temperature (T ) by more than ~40% than their bulk T . Intriguingly, T enhancement in FeSeTe thin films has been observed on various substrates and with different Se content, x. To date, various mechanisms for T enhancement have been reported, but they remain controversial in universally explaining the T improvement in the FeSeTe films. In this report, we...
Show moreFabrication of epitaxial FeSeTe thin films using pulsed laser deposition (PLD) enables improving their superconducting transition temperature (T ) by more than ~40% than their bulk T . Intriguingly, T enhancement in FeSeTe thin films has been observed on various substrates and with different Se content, x. To date, various mechanisms for T enhancement have been reported, but they remain controversial in universally explaining the T improvement in the FeSeTe films. In this report, we demonstrate that the controversies over the mechanism of T enhancement are due to the abnormal changes in the chalcogen ratio (Se:Te) during the film growth and that the previously reported T enhancement in FeSeTe thin films is caused by a remarkable increase of Se content. Although our FeSeTe thin films were fabricated via PLD using a FeSeTe target, the precisely measured composition indicates a Se-rich FeSeTe (0.6 < x < 0.8) as ascertained through accurate compositional analysis by both wavelength dispersive spectroscopy (WDS) and Rutherford backscattering spectrometry (RBS). We suggest that the origin of the abnormal composition change is the difference in the thermodynamic properties of ternary FeSeTe, based on first principle calculations.
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Date Issued: 2017-08-30
Identifier: FSU_pmch_28855591, 10.1038/s41598-017-10383-1, PMC5577040, 28855591, 28855591, 10.1038/s41598-017-10383-1
Format: Citation

Title: Characterization of Dengue Virus Infections Among Febrile Children Clinically Diagnosed With a Non-Dengue Illness, Managua, Nicaragua.
Creator: Waggoner, Jesse J, Gresh, Lionel, Mohamed-Hadley, Alisha, Balmaseda, Angel, Soda, K James, Abeynayake, Janaki, Sahoo, Malaya K, Liu, Yuanyuan, Kuan, Guillermina, Harris, Eva,...
Show moreWaggoner, Jesse J, Gresh, Lionel, Mohamed-Hadley, Alisha, Balmaseda, Angel, Soda, K James, Abeynayake, Janaki, Sahoo, Malaya K, Liu, Yuanyuan, Kuan, Guillermina, Harris, Eva, Pinsky, Benjamin A
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Abstract/Description: We sought to characterize dengue virus (DENV) infections among febrile children enrolled in a pediatric cohort study who were clinically diagnosed with a non-dengue illness ("C cases"). DENV infections were detected and viral load quantitated by real-time reverse transcription-polymerase chain reaction in C cases presenting between January 2007 and January 2013. One hundred forty-one of 2892 C cases (4.88%) tested positive for DENV. Of all febrile cases in the study, DENV-positive C cases...
Show moreWe sought to characterize dengue virus (DENV) infections among febrile children enrolled in a pediatric cohort study who were clinically diagnosed with a non-dengue illness ("C cases"). DENV infections were detected and viral load quantitated by real-time reverse transcription-polymerase chain reaction in C cases presenting between January 2007 and January 2013. One hundred forty-one of 2892 C cases (4.88%) tested positive for DENV. Of all febrile cases in the study, DENV-positive C cases accounted for an estimated 52.0% of patients with DENV viremia at presentation. Compared with previously detected, symptomatic dengue cases, DENV-positive C cases were significantly less likely to develop long-lasting humoral immune responses to DENV, as measured in healthy annual serum samples (79.7% vs 47.8%; P < .001). Humoral immunity was associated with viral load at presentation: 40 of 43 patients (93.0%) with a viral load ≥7.0 log10 copies/mL serum developed the expected rise in anti-DENV antibodies in annual samples versus 13 of 68 (19.1%) patients with a viral load below this level (P < .001). Antibody responses to DENV-positive C cases differ from responses to classic symptomatic dengue. These findings have important implications for DENV transmission modeling, immunology, and epidemiologic surveillance.
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Date Issued: 2017-06-15
Identifier: FSU_pmch_28863466, 10.1093/infdis/jix195, PMC5853235, 28863466, 28863466, 3747427
Format: Citation

Title: Do the 'brain dead' merely appear to be alive?.
Creator: Nair-Collins, Michael, Miller, Franklin G
Abstract/Description: The established view regarding 'brain death' in medicine and medical ethics is that patients determined to be dead by neurological criteria are dead in terms of a biological conception of death, not a philosophical conception of personhood, a social construction or a legal fiction. Although such individuals show apparent signs of being alive, in reality they are (biologically) dead, though this reality is masked by the intervention of medical technology. In this article, we argue that an...
Show moreThe established view regarding 'brain death' in medicine and medical ethics is that patients determined to be dead by neurological criteria are dead in terms of a biological conception of death, not a philosophical conception of personhood, a social construction or a legal fiction. Although such individuals show apparent signs of being alive, in reality they are (biologically) dead, though this reality is masked by the intervention of medical technology. In this article, we argue that an appeal to the distinction between appearance and reality fails in defending the view that the 'brain dead' are dead. Specifically, this view relies on an inaccurate and overly simplistic account of the role of medical technology in the physiology of a 'brain dead' patient. We conclude by offering an explanation of why the conventional view on 'brain death', though mistaken, continues to be endorsed in light of its connection to organ transplantation and the dead donor rule.
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Date Issued: 2017-11-01
Identifier: FSU_pmch_28848063, 10.1136/medethics-2016-103867, PMC5749302, 28848063, 28848063, medethics-2016-103867
Format: Citation

Title: Germline Silencing Of Uast Depends On The Pirna Pathway.
Creator: Huang, Yi-Chun, Moreno, Henry, Row, Sarayu, Jia, Dongyu, Deng, Wu-Min
Date Issued: 2018-05-20
Identifier: FSU_libsubv1_wos_000437352900005, 10.1016/j.jgg.2018.04.005
Format: Citation

Title: Non-complicit: Revisiting Hans Asperger’s Career in Nazi-era Vienna.
Creator: Falk, Dean
Abstract/Description: Recent allegations that pediatrician Hans Asperger legitimized Nazi policies, including forced sterilization and child euthanasia, are refuted with newly translated and chronologically-ordered information that takes into account Hitler’s deceptive ‘halt’ to the T4 euthanasia program in 1941. It is highly unlikely that Asperger was aware of the T4 program when he referred Herta Schreiber to Am Spiegelgrund or when he mentioned that institution 4 months later on the medical chart of another ...
Show moreRecent allegations that pediatrician Hans Asperger legitimized Nazi policies, including forced sterilization and child euthanasia, are refuted with newly translated and chronologically-ordered information that takes into account Hitler’s deceptive ‘halt’ to the T4 euthanasia program in 1941. It is highly unlikely that Asperger was aware of the T4 program when he referred Herta Schreiber to Am Spiegelgrund or when he mentioned that institution 4 months later on the medical chart of another (unrelated) girl, Elisabeth Schreiber. Asperger campaigned vigorously from 1938 to 1943 to have his specialization, Curative Education, take priority in the diagnosis and treatment of disabled children over other fields that promoted Nazi racial hygiene policies. He neither disparaged his patients nor was he sexist. By 1938, he had identified the essentials of Asperger syndrome and described an unnamed boy whom he later profiled (as Ernst K.) in 1944. Rather than doing ‘thin’ research, Asperger made discoveries that were prescient, and some of his activities conformed to definitions of “individual resistance.”
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Date Issued: 2019-03-18
Identifier: FSU_libsubv1_scholarship_submission_1553010792_32fb0055, 10.1007/s10803-019-03981-7
Format: Citation

Title: Framework Vs. Side-chain Amphidynamic Behaviour In Oligo-(ethylene Oxide) Functionalised Covalent-organic Frameworks.
Creator: Vazquez-Molina, Demetrius A., Pope, Giovanna M., Ezazi, Andrew A., Mendoza-Cortes, Jose L., Harper, James K., Uribe-Romo, Fernando J.
Abstract/Description: We present a family of covalent organic frameworks that have been functionalized with oligo-(ethylene oxide) chains of varying lengths. Because of the open structure of the COFs, the side chains do not interfere with their crystallization obtaining materials with predictable crystal structure. The difference in length of the side-chains allowed for the determination of amphidynamic behaviour with the use of C-13 solid-state NMR relaxation methods. Computational calculations further contribute...
Show moreWe present a family of covalent organic frameworks that have been functionalized with oligo-(ethylene oxide) chains of varying lengths. Because of the open structure of the COFs, the side chains do not interfere with their crystallization obtaining materials with predictable crystal structure. The difference in length of the side-chains allowed for the determination of amphidynamic behaviour with the use of C-13 solid-state NMR relaxation methods. Computational calculations further contribute to understanding the atomistic dynamic behaviour of the different atoms. This study demonstrates the ability to design complex behaviour in organic crystals.
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Date Issued: 2018-06-25
Identifier: FSU_libsubv1_wos_000436029000067, 10.1039/c8cc04292f
Format: Citation

Title: Aurora A Phosphorylation of YY1 during Mitosis Inactivates its DNA Binding Activity.
Creator: Alexander, Karen E, Rizkallah, Raed
Abstract/Description: Successful execution of mitotic cell division requires the tight synchronisation of numerous biochemical pathways. The underlying mechanisms that govern chromosome segregation have been thoroughly investigated. However, the mechanisms that regulate transcription factors in coordination with mitotic progression remain poorly understood. In this report, we identify the transcription factor YY1 as a novel mitotic substrate for the Aurora A kinase, a key regulator of critical mitotic events, like...
Show moreSuccessful execution of mitotic cell division requires the tight synchronisation of numerous biochemical pathways. The underlying mechanisms that govern chromosome segregation have been thoroughly investigated. However, the mechanisms that regulate transcription factors in coordination with mitotic progression remain poorly understood. In this report, we identify the transcription factor YY1 as a novel mitotic substrate for the Aurora A kinase, a key regulator of critical mitotic events, like centrosome maturation and spindle formation. Using in vitro kinase assays, we show that Aurora A directly phosphorylates YY1 at serine 365 in the DNA-binding domain. Using a new phospho-specific antibody, we show that YY1 phosphorylation at serine 365 occurs during mitosis, and that this phosphorylation is significantly reduced upon inhibition of Aurora A. Furthermore, we show, using electrophoretic mobility shift and chromatin immunoprecipitation assays, that phosphorylation of YY1 at this site abolishes its DNA binding activity in vitro and in vivo. In conformity with this loss of binding activity, phosphorylated YY1 also loses its transctivation ability as demonstrated by a luciferase reporter assay. These results uncover a novel mechanism that implicates Aurora A in the mitotic inactivation of transcription factors.
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Date Issued: 2017-08-30
Identifier: FSU_pmch_28855673, 10.1038/s41598-017-10935-5, PMC5577188, 28855673, 28855673, 10.1038/s41598-017-10935-5
Format: Citation

Title: Effects of pair bonding on parental behavior and dopamine activity in the nucleus accumbens in male prairie voles.
Creator: Lei, K, Liu, Y, Smith, A S, Lonstein, J S, Wang, Z
Abstract/Description: Male parental care is a vital behavior for the development as well as the physical and mental well-being of the young. However, little is known about the neurochemical regulation of male parental behavior, mainly due to the lack of appropriate animal models. In this study, we used the socially monogamous male prairie vole (Microtus ochrogaster) to investigate the effect of pair-bonding experience on paternal behavior and dopamine (DA) signaling in the nucleus accumbens (NAcc) in the brain. We...
Show moreMale parental care is a vital behavior for the development as well as the physical and mental well-being of the young. However, little is known about the neurochemical regulation of male parental behavior, mainly due to the lack of appropriate animal models. In this study, we used the socially monogamous male prairie vole (Microtus ochrogaster) to investigate the effect of pair-bonding experience on paternal behavior and dopamine (DA) signaling in the nucleus accumbens (NAcc) in the brain. We compared sexually naïve males with males that were pair bonded with a female for two weeks. Our data showed that pair-bonded males displayed enhanced paternal behavior, particularly in pup licking/grooming, associated with increased DA type-1 receptor (D1R) protein expression in the NAcc, compared to sexually naïve males. Site-specific brain microdialysis revealed a significant, but transient, increase in DA release in the NAcc associated with pup exposure in both groups of the males. Further, pharmacological blockade of D1R in the NAcc decreased pup licking/grooming in the pair-bonded males. Together, our data demonstrate that pair-bonding experience with a female facilitated male parental behavior via NAcc D1R mediation in male prairie voles.
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Date Issued: 2017-10-01
Identifier: FSU_pmch_28858415, 10.1111/ejn.13673, PMC5624856, 28858415, 28858415
Format: Citation

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