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Title: Acute BDNF treatment upregulates GluR1-SAP97 and GluR2-GRIP1 interactions: implications for sustained AMPA receptor expression..
Creator: Jourdi, Hussam, Kabbaj, Mohamed
Abstract/Description: Brain-derived neurotrophic factor (BDNF) plays several prominent roles in synaptic plasticity and in learning and memory formation. Reduced BDNF levels and altered BDNF signaling have been reported in several brain diseases and behavioral disorders, which also exhibit reduced levels of AMPAr subunits. BDNF treatment acutely regulates AMPA receptor expression and function, including synaptic AMPAr subunit trafficking, and implicates several well defined signaling molecules that are required to...
Show moreBrain-derived neurotrophic factor (BDNF) plays several prominent roles in synaptic plasticity and in learning and memory formation. Reduced BDNF levels and altered BDNF signaling have been reported in several brain diseases and behavioral disorders, which also exhibit reduced levels of AMPAr subunits. BDNF treatment acutely regulates AMPA receptor expression and function, including synaptic AMPAr subunit trafficking, and implicates several well defined signaling molecules that are required to elicit long term potentiation and depression (LTP and LTD, respectively). Long term encoding of synaptic events, as in long term memory formation, requires AMPAr stabilization and maintenance. However, factors regulating AMPAr stabilization in neuronal cell membranes and synaptic sites are not well characterized. In this study, we examine the effects of acute BDNF treatment on levels of AMPAr-associated scaffolding proteins and on AMPAr subunit-scaffolding protein interactions. We also examine the effects of BDNF-dependent enhanced interactions between AMPAr subunits with their specific scaffolding proteins on the accumulation of both types of proteins. Our results show that acute BDNF treatment upregulates the interactions between AMPAr subunits (GluR1 and GluR2) with their scaffold proteins SAP97 and GRIP1, respectively, leading to prolonged increased accumulation of both categories of proteins, albeit with distinct mechanisms for GluR1 and GluR2. Our findings reveal a new role for BDNF in the long term maintenance of AMPA receptor subunits and associated scaffolding proteins at synapses and further support the role of BDNF as a key regulator of synaptic consolidation. These results have potential implications for recent findings implicating BDNF and AMPAr subunits in various brain diseases and behavioral disorders.
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Date Issued: 2013-01-01
Identifier: FSU_pmch_23460828, 10.1371/journal.pone.0057124, PMC3584105, 23460828, 23460828, PONE-D-12-38051
Format: Citation

Title: Activation Profiles of Human Kallikrein-Related Peptidases by Proteases of the Thrombostasis Axis.
Creator: Yoon, Hyesook, Blaber, Sachiko, Evans, D., Trim, Julie, Juliano, Maria, Scarisbrick, Isobel, Blaber, Michael
Abstract/Description: The human kallikrein-related peptidases (KLKs) comprise 15 members (KLK1-15) and are the single largest family of serine proteases. The KLKs are utilized, or proposed, as clinically important biomarkers and therapeutic targets of interest in cancer and neurodegenerative disease. All KLKs appear to be secreted as inactive pro-forms (pro-KLKs) that are activated extracellularly by specific proteolytic release of their N-terminal pro-peptide. This processing is a key step in the regulation of...
Show moreThe human kallikrein-related peptidases (KLKs) comprise 15 members (KLK1-15) and are the single largest family of serine proteases. The KLKs are utilized, or proposed, as clinically important biomarkers and therapeutic targets of interest in cancer and neurodegenerative disease. All KLKs appear to be secreted as inactive pro-forms (pro-KLKs) that are activated extracellularly by specific proteolytic release of their N-terminal pro-peptide. This processing is a key step in the regulation of KLK function. Much recent work has been devoted to elucidating the potential for activation cascades between members of the KLK family, with physiologically relevant KLK regulatory cascades now described in skin desquamation and semen liquefaction. Despite this expanding knowledge of KLK regulation, details regarding the potential for functional intersection of KLKs with other regulatory proteases are essentially unknown. To elucidate such interaction potential, we have characterized the ability of proteases associated with thrombostasis to hydrolyze the pro-peptide sequences of the KLK family using a previously described pro-KLK fusion protein system. A subset of positive hydrolysis results were subsequently quantified with proteolytic assays using intact recombinant pro-KLK proteins. Pro-KLK6 and 14 can be activated by both plasmin and uPA, with plasmin being the best activator of pro-KLK6 identified to date. Pro-KLK11 and 12 can be activated by a broad-spectrum of thrombostasis proteases, with thrombin exhibiting a high degree of selectivity for pro-KLK12. The results show that proteases of the thrombostasis family can efficiently activate specific pro-KLKs, demonstrating the potential for important regulatory interactions between these two major protease families.
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Date Issued: 2008
Identifier: FSU_migr_biomed_faculty_publications-0009
Format: Citation

Title: Adding Stable Carbon Isotopes Improves Model Representation Of The Role Of Microbial Communities In Peatland Methane Cycling.
Creator: Deng, Jia, McCalley, Carmody K., Frolking, Steve, Chanton, Jeff, Crill, Patrick, Varner, Ruth, Tyson, Gene, Rich, Virginia, Hines, Mark, Saleska, Scott R., Li, Changsheng
Abstract/Description: Climate change is expected to have significant and uncertain impacts on methane (CH4) emissions from northern peatlands. Biogeochemical models can extrapolate site-specificCH(4) measurements to larger scales and predict responses of CH4 emissions to environmental changes. However, these models include considerable uncertainties and limitations in representing CH4 production, consumption, and transport processes. To improve predictions of CH4 transformations, we incorporated acetate and stable...
Show moreClimate change is expected to have significant and uncertain impacts on methane (CH4) emissions from northern peatlands. Biogeochemical models can extrapolate site-specificCH(4) measurements to larger scales and predict responses of CH4 emissions to environmental changes. However, these models include considerable uncertainties and limitations in representing CH4 production, consumption, and transport processes. To improve predictions of CH4 transformations, we incorporated acetate and stable carbon (C) isotopic dynamics associated with CH4 cycling into a biogeochemistry model, DNDC. By including these new features, DNDC explicitly simulates acetate dynamics and the relative contribution of acetotrophic and hydro-genotrophic methanogenesis (AM and HM) to CH4 production, and predicts the C isotopic signature (delta C-13) in soil C pools and emitted gases. When tested against biogeochemical and microbial community observations at two sites in a zone of thawing permafrost in a subarctic peatland in Sweden, the new formulation substantially improved agreement with CH4 production pathways and delta C-13 in emitted CH4 (delta C-13-CH4), a measure of the integrated effects of microbial production and consumption, and of physical transport. We also investigated the sensitivity of simulated delta C-13-CH4 to C isotopic composition of substrates and, to fractionation factors for CH4 production (alpha(AM) and alpha(HM)), CH4 oxidation (alpha(MO)), and plant-mediated CH4 transport (alpha(TP)). The sensitivity analysis indicated that the delta C-13-CH4 is highly sensitive to the factors associated with microbial metabolism (alpha(AM), alpha(HM), and alpha(MO)). The model framework simulating stable C isotopic dynamics provides a robust basis for better constraining and testing microbial mechanisms in predicting CH4 cycling in peatlands.
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Date Issued: 2017-06
Identifier: FSU_libsubv1_wos_000406239300036, 10.1002/2016MS000817
Format: Citation

Title: Adapting to Change: Administrators' Perceptions of the Second Year of Developmental Education Reform in the Florida College System.
Creator: Hu, Shouping, Richard, Keith, Woods, Chenoa S., Nix, Samantha, Tandberg, David, Park, Toby, Bertrand Jones, Tamara
Abstract/Description: The Center for Postsecondary Success at Florida State University has been studying the implementation and outcomes of SB 1720 since its initial implementation by surveying campus leaders across the FCS. This report explores the third set of surveys, administered in spring of 2016. This survey focused on changes the colleges made between the first and second years of implementation of SB 1720.
Date Issued: 2016-07-01
Identifier: FSU_libsubv1_scholarship_submission_1485301022
Format: Citation

Title: Activation of Metabotropic Glutamate Receptors Regulates Ribosomes of Cochlear Nucleus Neurons.
Creator: Hyson, Richard, Carzoli, Kathryn
Abstract/Description: The brain stem auditory system of the chick is an advantageous model for examining changes that occur as a result of deafness. Elimination of acoustic input through cochlear ablation results in the eventual death of approximately 30% of neurons in the chick cochlear nucleus, nucleus magnocellularis (NM). One early change following deafness is an alteration in NM ribosomes, evidenced both by a decrease in protein synthesis and reduction in antigenicity for Y10B, a monoclonal antibody that...
Show moreThe brain stem auditory system of the chick is an advantageous model for examining changes that occur as a result of deafness. Elimination of acoustic input through cochlear ablation results in the eventual death of approximately 30% of neurons in the chick cochlear nucleus, nucleus magnocellularis (NM). One early change following deafness is an alteration in NM ribosomes, evidenced both by a decrease in protein synthesis and reduction in antigenicity for Y10B, a monoclonal antibody that recognizes a ribosomal epitope. Previous studies have shown that mGluR activation is necessary to maintain Y10B antigenicity and NM viability. What is still unclear, however, is whether or not mGluR activation is sufficient to prevent deafness-induced changes in these neurons, or if other activity-dependent factors are also necessary. The current study investigated the ability of mGluR activation to regulate cochlear nucleus ribosomes in the absence of auditory nerve input. In vitro methods were employed to periodically pressure eject glutamate or mGluR agonists over neurons on one side of a slice preparation leaving the opposite side of the same slice untreated. Immunohistochemistry was then performed using Y10B in order to assess ribosomal changes. Application of glutamate and both group I and II selective mGluR agonists effectively rescued ribosomal antigenicity on the treated side of the slice in comparison to ribosomes on the untreated side. These findings suggest that administration of mGluR agonists is sufficient to reduce the early interruption of normal ribosomal integrity that is typically seen following loss of auditory nerve activity.
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Date Issued: 2014-10-21
Identifier: FSU_libsubv1_scholarship_submission_1475086818, 10.1371/journal.pone.0111243
Format: Citation

Title: Acute exercise with whole-body vibration decreases wave reflection and leg arterial stiffness.
Creator: Figueroa, Arturo, Vicil, Florence, Sanchez-Gonzalez, Marcos A
Abstract/Description: Whole-body vibration exercise (WBV) acutely decreases brachial-ankle pulse wave velocity (baPWV), an index of systemic arterial stiffness. However, the effect of WBV on segmental PWV and aortic hemodynamics is unknown. We examined the acute effects of WBV on arterial function. Fifteen young men performed ten 1-min sets of static squat with WBV (40 Hz, 1 mm, 5.37 G) and without WBV (no-WBV). Brachial and aortic blood pressure (BP), heart rate (HR), augmentation index (AIx), baPWV, carotid...
Show moreWhole-body vibration exercise (WBV) acutely decreases brachial-ankle pulse wave velocity (baPWV), an index of systemic arterial stiffness. However, the effect of WBV on segmental PWV and aortic hemodynamics is unknown. We examined the acute effects of WBV on arterial function. Fifteen young men performed ten 1-min sets of static squat with WBV (40 Hz, 1 mm, 5.37 G) and without WBV (no-WBV). Brachial and aortic blood pressure (BP), heart rate (HR), augmentation index (AIx), baPWV, carotid-femoral PWV (cfPWV), and femoral-ankle (faPWV), were recorded before and 5, 15, and 30 min after both trials. Brachial and aortic SBP (P < 0.01), and HR (P < 0.01) were increased only at 5 min after both exercise trials. AIx was elevated through the recovery after no-WBV while decreased at 15 and 30 min after WBV exercise. FaPWV was decreased (P < 0.01) at 5 min after both trials, but returned to baseline at 15 min after no-WBV exercise and was maintained decreased at 15 and 30 min after WBV exercise. There were no significant changes in brachial and aortic diastolic BP, cfPWV and baPWV after both trials. Our findings indicate that regardless of WBV, static squat causes a small transient increase in hemodynamic responses during early recovery. WBV counteracts the increase in AIx induced by static squat and reduces wave reflection magnitude through a local effect on arterial stiffness.
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Date Issued: 2011-01-01
Identifier: FSU_pmch_22254186, PMC3253511, 22254186, 22254186
Format: Citation

Title: Adaptation of Florida’s Urban Infrastructure to Climate Change.
Creator: Bloetscher, Frederick, Hoermann, Serena, Berry, Leonard
Abstract/Description: This chapter looks at how the impacts of climate change affect different parts of Florida. With more than 1500 miles of coastline that contains numerus differences in character between the state’s southern-most point in the Florida Keys to the northwest Florida Panhandle and northeast Florida in Jacksonville, it is easy to see why areas across the state are not all the same; temperature, rainfall rates, and even the potential for sea level rise can vary significantly depending on what part of...
Show moreThis chapter looks at how the impacts of climate change affect different parts of Florida. With more than 1500 miles of coastline that contains numerus differences in character between the state’s southern-most point in the Florida Keys to the northwest Florida Panhandle and northeast Florida in Jacksonville, it is easy to see why areas across the state are not all the same; temperature, rainfall rates, and even the potential for sea level rise can vary significantly depending on what part of the state one is in. For example, southeast Florida and the Tampa Bay area are already dealing with sea level rise issues, but there is much work to be done in order to assess the risks and help identify potential solutions. Efforts to adapt to rising seas will need to draw upon prior research and current work to develop tool box strategies that involve the hard and soft components. A background of impacts to water resources (less rainfall has been detected) will be discussed.
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Date Issued: 2017-11-29
Identifier: FSU_libsubv1_scholarship_submission_1515510253_5d0b606b, 10.17125/fci2017.ch11
Format: Citation

Title: Acute and timing effects of beta-hydroxy-beta-methylbutyrate (HMB) on indirect markers of skeletal muscle damage.
Creator: Wilson, Jacob M, Kim, Jeong-Su, Lee, Sang-Rok, Rathmacher, John A, Dalmau, Brett, Kingsley, J Derek, Koch, Heather, Manninen, Anssi H, Saadat, Raz, Panton, Lynn B
Abstract/Description: While chronic β-Hydroxy β-Methylbutyrate (HMB) supplementation (≥ 2 wk) lowers exercise induced muscle damage, its acute or timing effects have not been examined. The purpose of this study was to investigate the acute and timing effects of oral HMB supplementation on serum creatine kinase (CK), lactate dehydrogenase (LDH), muscle soreness, and maximal voluntary contraction (MVC). Sixteen non-resistance trained men (22 ± 2 yrs) were assigned to HMB-Pre or HMB-Post groups. In a crossover design...
Show moreWhile chronic β-Hydroxy β-Methylbutyrate (HMB) supplementation (≥ 2 wk) lowers exercise induced muscle damage, its acute or timing effects have not been examined. The purpose of this study was to investigate the acute and timing effects of oral HMB supplementation on serum creatine kinase (CK), lactate dehydrogenase (LDH), muscle soreness, and maximal voluntary contraction (MVC). Sixteen non-resistance trained men (22 ± 2 yrs) were assigned to HMB-Pre or HMB-Post groups. In a crossover design, all subjects performed 55 maximal eccentric knee extension/flexion contractions on 2 occasions on either the right or left leg. HMB-Pre (N = 8) randomly received 3 grams of either a placebo or HMB before and a placebo after exercise. HMB-Post (N = 8) received a placebo before and either 3 grams of HMB or a placebo after exercise. Muscle damage tests were recorded before, at 8, 24, 48, and 72 hrs post exercise. There was a reduction in MVC and an increase in soreness in the quadriceps and hamstrings following exercise (p < 0.001). Although HMB-Pre approached significance in attenuating soreness for the quadriceps (p = 0.07), there was no time x group effect. Serum indices of damage increased, peaking at 48 hrs for CK (773%) (p < 0.001) and 72 hrs for LDH (180%) (p < 0.001). While there were no time x group effects of HMB on CK and LDH, post hoc analysis revealed that only HMB-Pre showed no significant increase in LDH levels following exercise. Our findings suggest no clear acute or timing effects of HMB supplementation. However, consuming HMB before exercise appeared to prevent increases in LDH.
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Date Issued: 2009-02-04
Identifier: FSU_pmch_19193206, 10.1186/1743-7075-6-6, PMC2642830, 19193206, 19193206, 1743-7075-6-6
Format: Citation

Title: Addressing Disparities in Academic Medicine: What of the Minority Tax?.
Creator: Rodriguez, Jose, Campbell, Kendall, Pololi, Linda
Abstract/Description: Background The proportion of black, Latino, and Native American faculty in U.S. academic medical centers has remained almost unchanged over the last 20 years. Some authors credit the "minority tax"—the burden of extra responsibilities placed on minority faculty in the name of diversity. This tax is in reality very complex, and a major source of inequity in academic medicine. Discussion The “minority tax” is better described as an Underrepresented Minority in Medicine (URMM) faculty...
Show moreBackground The proportion of black, Latino, and Native American faculty in U.S. academic medical centers has remained almost unchanged over the last 20 years. Some authors credit the "minority tax"—the burden of extra responsibilities placed on minority faculty in the name of diversity. This tax is in reality very complex, and a major source of inequity in academic medicine. Discussion The “minority tax” is better described as an Underrepresented Minority in Medicine (URMM) faculty responsibility disparity. This disparity is evident in many areas: diversity efforts, racism, isolation, mentorship, clinical responsibilities, and promotion. Summary The authors examine the components of the URMM responsibility disparity and use information from the medical literature and from human resources to suggest practical steps that can be taken by academic leaders and policymakers to move toward establishing faculty equity and thus increase the numbers of black, Latino, and Native American faculty in academic medicine.
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Date Issued: 2015-02-01
Identifier: FSU_libsubv1_scholarship_submission_1474988014, 10.1186/s12909-015-0290-9
Format: Citation

Title: An investigation of the association of genetic susceptibility risk with somatic mutation burden in breast cancer.
Creator: Zhu, Bin, Mukherjee, Anwesha, Machiela, Mitchell J., Song, Lei, Hua, Xing, Shi, Jianxin, Garcia-Closas, Montserrat, Chanock, Stephen J., Chatterjee, Nilanjan
Abstract/Description: Background: Genome-wide association studies have reported nearly 100 common germline susceptibility loci associated with the risk for breast cancer. Tumour sequencing studies have characterised somatic mutation profiles in breast cancer patients. The relationship between breast cancer susceptibility loci and somatic mutation patterns in breast cancer remains largely unexplored. Methods: We used single-nucleotide polymorphism (SNP) genotyping array data and tumour exome sequencing data...
Show moreBackground: Genome-wide association studies have reported nearly 100 common germline susceptibility loci associated with the risk for breast cancer. Tumour sequencing studies have characterised somatic mutation profiles in breast cancer patients. The relationship between breast cancer susceptibility loci and somatic mutation patterns in breast cancer remains largely unexplored. Methods: We used single-nucleotide polymorphism (SNP) genotyping array data and tumour exome sequencing data available from 638 breast cancer patients of European ancestry from The Cancer Genome Atlas (TCGA) project. We analysed both genotype data and, when necessary, imputed genotypes for 90 known breast cancer susceptibility loci. We performed linear regression models to investigate possible associations between germline risk variants with total somatic mutation count (TSMC), as well as specific mutation types. We examined individual SNP genotypes, as well as a multi-SNP polygenic risk score (PRS). Models were statistically adjusted for age at diagnosis, stage, oestrogen-receptor (ER) and progesterone-receptor (PR) status of breast cancer. We also performed stratified analyses by ER and PR status. Results: We observed a significant inverse association (P = 8.75 x 10(-6); FDR = 0.001) between the risk allele in rs2588809 of the gene RAD51B and TSMC across all breast cancer patients, for both ER+ and ER- tumours. This association was also evident for different types of mutations. The PRS analysis for all patients, with or without rs2588809, showed a significant inverse association (P = 0.01 and 0.04, respectively) with TSMC. This inverse association was significant in ER+ patients with the ER+-specific PRS (P = 0.02), but not among ER- patients for the ER--specific PRS (P = 0.39). Conclusions: We observed an inverse association between common germline risk variants and TSMC, which, if confirmed, could provide new insights into how germline variation informs our understanding of somatic mutation patterns in breast cancer.
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Date Issued: 2016-09
Identifier: FSU_libsubv1_wos_000384570600016, 10.1038/bjc.2016.223
Format: Citation

Title: An improved smaller biotin ligase for BioID proximity labeling.
Creator: Kim, Dae In, Jensen, Samuel C., Noble, Kyle A., Birendra, K. C., Roux, Kenneth H., Motamedchaboki, Khatereh, Roux, Kyle J.
Abstract/Description: The BioID method uses a promiscuous biotin ligase to detect protein-protein associations as well as proximate proteins in living cells. Here we report improvements to the BioID method centered on BioID2, a substantially smaller promiscuous biotin ligase. BioID2 enables more-selective targeting of fusion proteins, requires less biotin supplementation, and exhibits enhanced labeling of proximate proteins. Thus BioID2 improves the efficiency of screening for protein-protein associations. We also...
Show moreThe BioID method uses a promiscuous biotin ligase to detect protein-protein associations as well as proximate proteins in living cells. Here we report improvements to the BioID method centered on BioID2, a substantially smaller promiscuous biotin ligase. BioID2 enables more-selective targeting of fusion proteins, requires less biotin supplementation, and exhibits enhanced labeling of proximate proteins. Thus BioID2 improves the efficiency of screening for protein-protein associations. We also demonstrate that the biotinylation range of BioID2 can be considerably modulated using flexible linkers, thus enabling application-specific adjustment of the biotin-labeling radius.
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Date Issued: 2016-04-15
Identifier: FSU_libsubv1_wos_000375753600003, 10.1091/mbc.E15-12-0844
Format: Citation

Title: An Electrochemical Approach To Measuring Oxidative Stability Of Solid Polymer Electrolytes For Lithium Batteries.
Creator: Hallinan, Daniel T., Rausch, Alexander, McGill, Brandon
Abstract/Description: Polymer electrolytes are an interesting class of electrolytes that hold promise for safer, flexible, high-energy batteries. Block copolymer electrolytes that contain polystyrene, poly(ethylene oxide) (PEO) and lithium bis-trifluoromethanesulfonimide salt (LiTFSI) are compatible with lithium metal. However, the compatibility of PEO-based electrolyte with advanced lithium positive electrodes has not been conclusively demonstrated. Therefore, oxidative stability of PEO+LiTFSI and the block...
Show morePolymer electrolytes are an interesting class of electrolytes that hold promise for safer, flexible, high-energy batteries. Block copolymer electrolytes that contain polystyrene, poly(ethylene oxide) (PEO) and lithium bis-trifluoromethanesulfonimide salt (LiTFSI) are compatible with lithium metal. However, the compatibility of PEO-based electrolyte with advanced lithium positive electrodes has not been conclusively demonstrated. Therefore, oxidative stability of PEO+LiTFSI and the block copolymer electrolyte with common current collectors and against inert working electrodes have been investigated electrochemically. The solid nature of these polymer electrolytes is a challenge for electrochemical investigations, since most electrochemical experiments have been designed for liquid electrolyte. In order to quantitatively evaluate polymer electrolyte stability, an electrochemical approach especially designed for solid electrolytes is presented. This approach uses a set of linear sweep voltammograms from different, large overpotentials to open circuit voltage, which the authors term variable reverse linear sweep voltammetry. By allowing the cell to relax between each polarization, the first data points of each voltammogram are not mass transfer limited. This yields current versus overpotential data that can be analyzed with a kinetic model, such as the Butler-Volmer model. The block copolymer electrolyte has been found to be quite stable to electrochemical oxidation, up to 5 V at 40 degrees C. The degradation reaction has been found to be slow with large thermal activation energy. (C) 2016 Elsevier Ltd. All rights reserved.
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Date Issued: 2016-11-02
Identifier: FSU_libsubv1_wos_000384873600005, 10.1016/j.ces.2016.06.054
Format: Citation

Title: An Unusual Inverted Saline Microbial Mat Community in an Interdune Sabkha in the Rub' al Khali (the Empty Quarter), United Arab Emirates.
Creator: McKay, Christopher P., Rask, Jon C., Detweiler, Angela M., Bebout, Brad M., Everroad, R. Craig, Lee, Jackson Z., Chanton, Jeffrey P., Mayer, Marisa H., Caraballo, Adrian A. L.,...
Show moreMcKay, Christopher P., Rask, Jon C., Detweiler, Angela M., Bebout, Brad M., Everroad, R. Craig, Lee, Jackson Z., Chanton, Jeffrey P., Mayer, Marisa H., Caraballo, Adrian A. L., Kapili, Bennett, Al-Awar, Meshgan, Al-Farraj, Asma
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Abstract/Description: Salt flats (sabkha) are a recognized habitat for microbial life in desert environments and as analogs of habitats for possible life on Mars. Here we report on the physical setting and microbiology of interdune sabkhas among the large dunes in the Rub' al Khali (the Empty Quarter) in Liwa Oasis, United Arab Emirates. The salt flats, composed of gypsum and halite, are moistened by relatively fresh ground water. The result is a salinity gradient that is inverted compared to most salt flat...
Show moreSalt flats (sabkha) are a recognized habitat for microbial life in desert environments and as analogs of habitats for possible life on Mars. Here we report on the physical setting and microbiology of interdune sabkhas among the large dunes in the Rub' al Khali (the Empty Quarter) in Liwa Oasis, United Arab Emirates. The salt flats, composed of gypsum and halite, are moistened by relatively fresh ground water. The result is a salinity gradient that is inverted compared to most salt flat communities with the hypersaline layer at the top and freshwater layers below. We describe and characterize a rich photosynthetically-based microbial ecosystem that is protected from the arid outside environment by a translucent salt crust. Gases collected from sediments under shallow ponds in the sabkha contain methane in concentrations as high as 3400 ppm. The salt crust could preserve biomarkers and other evidence for life in the salt after it dries out. Chloride-filled depressions have been identified on Mars and although surface flow of water is unlikely on Mars today, ground water is possible. Such a near surface system with modern groundwater flowing under ancient salt deposits could be present on Mars and could be accessed by surface rovers.
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Date Issued: 2016-03-16
Identifier: FSU_libsubv1_wos_000372574900036, 10.1371/journal.pone.0150342
Format: Citation

Title: An Efficient And Long-time Accurate Third-order Algorithm For The Stokes-darcy System.
Creator: Chen, Wenbin, Gunzburger, Max, Sun, Dong, Wang, Xiaoming
Abstract/Description: A third-order in time numerical IMEX-type algorithm for the Stokes-Darcy system for flows in fluid saturated karst aquifers is proposed and analyzed. A novel third-order Adams-Moulton scheme is used for the discretization of the dissipative term whereas a third-order explicit Adams-Bashforth scheme is used for the time discretization of the interface term that couples the Stokes and Darcy components. The scheme is efficient in the sense that one needs to solve, at each time step, decoupled...
Show moreA third-order in time numerical IMEX-type algorithm for the Stokes-Darcy system for flows in fluid saturated karst aquifers is proposed and analyzed. A novel third-order Adams-Moulton scheme is used for the discretization of the dissipative term whereas a third-order explicit Adams-Bashforth scheme is used for the time discretization of the interface term that couples the Stokes and Darcy components. The scheme is efficient in the sense that one needs to solve, at each time step, decoupled Stokes and Darcy problems. Therefore, legacy Stokes and Darcy solvers can be applied in parallel. The scheme is also unconditionally stable and, with a mild time-step restriction, long-time accurate in the sense that the error is bounded uniformly in time. Numerical experiments are used to illustrate the theoretical results. To the authors' knowledge, the novel algorithm is the first third-order accurate numerical scheme for the Stokes-Darcy system possessing its favorable efficiency, stability, and accuracy properties.
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Date Issued: 2016-12
Identifier: FSU_libsubv1_wos_000386770800006, 10.1007/s00211-015-0789-3
Format: Citation

Title: Analysis of Competition in the Defense Industrial Base: An F-22 case study.
Creator: King, David, Driessnack, John D.
Abstract/Description: Consolidation of the defense industrial base has led to concerns about whether enough competition exists between remaining firms to maintain needed cost reduction and innovation. We examine competition in the U.S. defense industrial base by performing an in-depth case study of Lockheed Martin and the F-22 program that considers multiple tiers of the industrial base. We find that defense firm specialization has led to outsourcing practices and arguably a more robust U.S. defense industrial...
Show moreConsolidation of the defense industrial base has led to concerns about whether enough competition exists between remaining firms to maintain needed cost reduction and innovation. We examine competition in the U.S. defense industrial base by performing an in-depth case study of Lockheed Martin and the F-22 program that considers multiple tiers of the industrial base. We find that defense firm specialization has led to outsourcing practices and arguably a more robust U.S. defense industrial base. Implications for government policy are identified.
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Date Issued: 2006-08-07
Identifier: FSU_libsubv1_scholarship_submission_1511885036_50505685, 10.1093/cep/by1014
Format: Citation

Title: Analysis methods for characterizing salinity variability from multivariate time series applied to the Apalachicola Bay estuary.
Creator: Morey, Steven, Dukhovskoy, Dmitry
Abstract/Description: Statistical analysis methods are developed to quantify the impacts of multiple forcing variables on the hydrographic variability within an estuary instrumented with an enduring observational system. The methods are applied to characterize the salinity variability within Apalachicola Bay, a shallow multiple-inlet estuary along the northeastern Gulf of Mexico coast. Thirteen-year multivariate time series collected by the National Estuary Research Reserve at three locations within the bay are...
Show moreStatistical analysis methods are developed to quantify the impacts of multiple forcing variables on the hydrographic variability within an estuary instrumented with an enduring observational system. The methods are applied to characterize the salinity variability within Apalachicola Bay, a shallow multiple-inlet estuary along the northeastern Gulf of Mexico coast. Thirteen-year multivariate time series collected by the National Estuary Research Reserve at three locations within the bay are analyzed to determine how the estuary responds to variations in external forcing mechanisms, such as freshwater discharge, precipitation, tides and local winds, at multiple time scales. The analysis methods are used to characterize the estuarine variability under differing flow regimes of the Apalachicola River, a managed waterway, with particular focus on extreme events and scales of variability that are critical to local ecosystems. Multivariate statistical models are applied that describe the salinity response to winds from multiple directions, river flow, and precipitation at daily, weekly, and monthly time scales to understand the response of the estuary under different climate regimes. Results show that the salinity is particularly sensitive to river discharge and wind magnitude and direction, with local precipitation being largely unimportant. Applying statistical analyses with conditional sampling quantifies how the likelihoods of high salinity and long duration high salinity events, conditions of critical importance to estuarine organisms, change given the state of the river flow. Intraday salinity range is shown to be negatively correlated with the salinity, and correlated with river discharge rate.
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Date Issued: 2012
Identifier: FSU_migr_coaps_pubs-0047, 10.1175/JTECH-D-11-00136.1
Format: Citation

Title: Bacterial community diversity of the deep-sea octocoral .
Creator: Kellogg, Christina A, Ross, Steve W, Brooke, Sandra D
Abstract/Description: Compared to tropical corals, much less is known about deep-sea coral biology and ecology. Although the microbial communities of some deep-sea corals have been described, this is the first study to characterize the bacterial community associated with the deep-sea octocoral, . Samples from five colonies of were collected from Baltimore Canyon (379-382 m depth) in the Atlantic Ocean off the east coast of the United States of America. DNA was extracted from the coral samples and 16S rRNA gene...
Show moreCompared to tropical corals, much less is known about deep-sea coral biology and ecology. Although the microbial communities of some deep-sea corals have been described, this is the first study to characterize the bacterial community associated with the deep-sea octocoral, . Samples from five colonies of were collected from Baltimore Canyon (379-382 m depth) in the Atlantic Ocean off the east coast of the United States of America. DNA was extracted from the coral samples and 16S rRNA gene amplicons were pyrosequenced using V4-V5 primers. Three samples sequenced deeply (>4,000 sequences each) and were further analyzed. The dominant microbial phylum was Proteobacteria, but other major phyla included Firmicutes and Planctomycetes. A conserved community of bacterial taxa held in common across the three colonies was identified, comprising 68-90% of the total bacterial community depending on the coral individual. The bacterial community of does not appear to include the genus , which has been found previously to be the dominant bacterial associate in several temperate and tropical gorgonians. Inferred functionality suggests the possibility of nitrogen cycling by the core bacterial community.
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Date Issued: 2016-09-29
Identifier: FSU_pmch_27703865, 10.7717/peerj.2529, PMC5047221, 27703865, 27703865, 2529
Format: Citation

Title: Regulated large-scale nucleosome density patterns and precise nucleosome positioning correlate with V(D)J recombination.
Creator: Pulivarthy, Sandhya R, Lion, Mattia, Kuzu, Guray, Matthews, Adam G W, Borowsky, Mark L, Morris, John, Kingston, Robert E, Dennis, Jonathan H, Tolstorukov, Michael Y, Oettinger,...
Show morePulivarthy, Sandhya R, Lion, Mattia, Kuzu, Guray, Matthews, Adam G W, Borowsky, Mark L, Morris, John, Kingston, Robert E, Dennis, Jonathan H, Tolstorukov, Michael Y, Oettinger, Marjorie A
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Abstract/Description: We show that the physical distribution of nucleosomes at antigen receptor loci is subject to regulated cell type-specific and lineage-specific positioning and correlates with the accessibility of these gene segments to recombination. At the Ig heavy chain locus (IgH), a nucleosome in pro-B cells is generally positioned over each IgH variable (VH) coding segment, directly adjacent to the recombination signal sequence (RSS), placing the RSS in a position accessible to the recombination...
Show moreWe show that the physical distribution of nucleosomes at antigen receptor loci is subject to regulated cell type-specific and lineage-specific positioning and correlates with the accessibility of these gene segments to recombination. At the Ig heavy chain locus (IgH), a nucleosome in pro-B cells is generally positioned over each IgH variable (VH) coding segment, directly adjacent to the recombination signal sequence (RSS), placing the RSS in a position accessible to the recombination activating gene (RAG) recombinase. These changes result in establishment of a specific chromatin organization at the RSS that facilitates accessibility of the genomic DNA for the RAG recombinase. In contrast, in mouse embryonic fibroblasts the coding segment is depleted of nucleosomes, which instead cover the RSS, thereby rendering it inaccessible. Pro-T cells exhibit a pattern intermediate between pro-B cells and mouse embryonic fibroblasts. We also find large-scale variations of nucleosome density over hundreds of kilobases, delineating chromosomal domains within IgH, in a cell type-dependent manner. These findings suggest that developmentally regulated changes in nucleosome location and occupancy, in addition to the known chromatin modifications, play a fundamental role in regulating V(D)J recombination. Nucleosome positioning-which has previously been observed to vary locally at individual enhancers and promoters-may be a more general mechanism by which cells can regulate the accessibility of the genome during development, at scales ranging from several hundred base pairs to many kilobases.
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Date Issued: 2016-10-18
Identifier: FSU_pmch_27698124, 10.1073/pnas.1605543113, PMC5081657, 27698124, 27698124, 1605543113
Format: Citation

Title: Dual Detection System for Simultaneous Measurement of Intracellular Fluorescent Markers and Cellular Secretion.
Creator: Yi, Lian, Bandak, Basel, Wang, Xue, Bertram, Richard, Roper, Michael G
Abstract/Description: Glucose-stimulated insulin secretion from pancreatic β-cells within islets of Langerhans plays a critical role in maintaining glucose homeostasis. Although this process is essential for maintaining euglycemia, the underlying intracellular mechanisms that control it are still unclear. To allow simultaneous correlation between intracellular signal transduction events and extracellular secretion, an analytical system was developed that integrates fluorescence imaging of intracellular probes with...
Show moreGlucose-stimulated insulin secretion from pancreatic β-cells within islets of Langerhans plays a critical role in maintaining glucose homeostasis. Although this process is essential for maintaining euglycemia, the underlying intracellular mechanisms that control it are still unclear. To allow simultaneous correlation between intracellular signal transduction events and extracellular secretion, an analytical system was developed that integrates fluorescence imaging of intracellular probes with high-speed automated insulin immunoassays. As a demonstration of the system, intracellular [Ca] ([Ca]) was measured by imaging Fura-2 fluorescence simultaneously with insulin secretion from islets exposed to elevated glucose levels. Both [Ca] and insulin were oscillatory during application of 10 mM glucose with temporal and quantitative profiles similar to what has been observed elsewhere. In previous work, sinusoidal glucose levels have been used to test the entrainment of islets while monitoring either [Ca] or insulin levels; using this newly developed system, we show unambiguously that oscillations of both [Ca] and insulin release are entrained to oscillatory glucose levels and that the temporal correlation of these are maintained throughout the experiment. It is expected that the developed analytical system can be expanded to investigate a number of other intracellular messengers in islets or other stimulus-secretion pathways in different cells.
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Date Issued: 2016-11-01
Identifier: FSU_pmch_27712062, 10.1021/acs.analchem.6b02404, PMC5089909, 27712062, 27712062
Format: Citation

Title: Protein folding, binding, and droplet formation in cell-like conditions.
Creator: Qin, Sanbo, Zhou, Huan-Xiang
Abstract/Description: The many bystander macromolecules in the crowded cellular environments present both steric repulsion and weak attraction to proteins undergoing folding or binding and hence impact the thermodynamic and kinetic properties of these processes. The weak but nonrandom binding with bystander macromolecules may facilitate subcellular localization and biological function. Weak binding also leads to the emergence of a protein-rich droplet phase, which has been implicated in regulating a variety of...
Show moreThe many bystander macromolecules in the crowded cellular environments present both steric repulsion and weak attraction to proteins undergoing folding or binding and hence impact the thermodynamic and kinetic properties of these processes. The weak but nonrandom binding with bystander macromolecules may facilitate subcellular localization and biological function. Weak binding also leads to the emergence of a protein-rich droplet phase, which has been implicated in regulating a variety of cellular functions. All these important problems can now be addressed by realistic modeling of intermolecular interactions. Configurational sampling of concentrated protein solutions is an ongoing challenge.
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Date Issued: 2017-04-01
Identifier: FSU_pmch_27771543, 10.1016/j.sbi.2016.10.006, PMC5397379, 27771543, 27771543, S0959-440X(16)30169-5
Format: Citation

Title: An S116R Phosphorylation Site Mutation in Human Fibroblast Growth Factor-1 Differentially Affects Mitogenic and Glucose-Lowering Activities.
Creator: Xia, Xue, Kumru, Ozan S, Blaber, Sachiko I, Middaugh, C Russell, Li, Ling, Ornitz, David M, Suh, Jae Myoung, Atkins, Annette R, Downes, Michael, Evans, Ronald M, Tenorio, Connie...
Show moreXia, Xue, Kumru, Ozan S, Blaber, Sachiko I, Middaugh, C Russell, Li, Ling, Ornitz, David M, Suh, Jae Myoung, Atkins, Annette R, Downes, Michael, Evans, Ronald M, Tenorio, Connie A, Bienkiewicz, Ewa, Blaber, Michael
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Abstract/Description: Fibroblast growth factor-1 (FGF-1), a potent human mitogen and insulin sensitizer, signals through both tyrosine kinase receptor-mediated autocrine/paracrine pathways as well as a nuclear intracrine pathway. Phosphorylation of FGF-1 at serine 116 (S116) has been proposed to regulate intracrine signaling. Position S116 is located within a ∼17 amino acid C-terminal loop that contains a rich set of functional determinants including heparin∖heparan sulfate affinity, thiol reactivity, nuclear...
Show moreFibroblast growth factor-1 (FGF-1), a potent human mitogen and insulin sensitizer, signals through both tyrosine kinase receptor-mediated autocrine/paracrine pathways as well as a nuclear intracrine pathway. Phosphorylation of FGF-1 at serine 116 (S116) has been proposed to regulate intracrine signaling. Position S116 is located within a ∼17 amino acid C-terminal loop that contains a rich set of functional determinants including heparin∖heparan sulfate affinity, thiol reactivity, nuclear localization, pharmacokinetics, functional half-life, nuclear ligand affinity, stability, and structural dynamics. Mutational targeting of specific functionality in this region without perturbing other functional determinants is a design challenge. S116R is a non-phosphorylatable variant present in bovine FGF-1 and other members of the human FGF family. We show that the S116R mutation in human FGF-1 is accommodated with no perturbation of biophysical or structural properties, and is therefore an attractive mutation with which to elucidate the functional role of phosphorylation. Characterization of S116R shows reduction in NIH 3T3 fibroblast mitogenic stimulation, increase in fibroblast growth factor receptor-1c activation, and prolonged duration of glucose lowering in ob/ob hyperglycemic mice. A novel FGF-1/fibroblast growth factor receptor-1c dimerization interaction combined with non-phosphorylatable intracrine signaling is hypothesized to be responsible for these observed functional effects.
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Date Issued: 2016-12-01
Identifier: FSU_pmch_27773526, 10.1016/j.xphs.2016.09.005, PMC5310217, 27773526, 27773526, S0022-3549(16)41698-9
Format: Citation

Title: Glucose Oscillations Can Activate an Endogenous Oscillator in Pancreatic Islets.
Creator: McKenna, Joseph P, Dhumpa, Raghuram, Mukhitov, Nikita, Roper, Michael G, Bertram, Richard
Abstract/Description: Pancreatic islets manage elevations in blood glucose level by secreting insulin into the bloodstream in a pulsatile manner. Pulsatile insulin secretion is governed by islet oscillations such as bursting electrical activity and periodic Ca2+ entry in β-cells. In this report, we demonstrate that although islet oscillations are lost by fixing a glucose stimulus at a high concentration, they may be recovered by subsequently converting the glucose stimulus to a sinusoidal wave. We predict with...
Show morePancreatic islets manage elevations in blood glucose level by secreting insulin into the bloodstream in a pulsatile manner. Pulsatile insulin secretion is governed by islet oscillations such as bursting electrical activity and periodic Ca2+ entry in β-cells. In this report, we demonstrate that although islet oscillations are lost by fixing a glucose stimulus at a high concentration, they may be recovered by subsequently converting the glucose stimulus to a sinusoidal wave. We predict with mathematical modeling that the sinusoidal glucose signal's ability to recover islet oscillations depends on its amplitude and period, and we confirm our predictions by conducting experiments with islets using a microfluidics platform. Our results suggest a mechanism whereby oscillatory blood glucose levels recruit non-oscillating islets to enhance pulsatile insulin output from the pancreas. Our results also provide support for the main hypothesis of the Dual Oscillator Model, that a glycolytic oscillator endogenous to islet β-cells drives pulsatile insulin secretion.
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Date Issued: 2016-10-27
Identifier: FSU_pmch_27788129, 10.1371/journal.pcbi.1005143, PMC5082885, 27788129, 27788129, PCOMPBIOL-D-16-00306
Format: Citation

Title: Parasite stress and pathogen avoidance relate to distinct dimensions of political ideology across 30 nations.
Creator: Tybur, Joshua M, Inbar, Yoel, Aarøe, Lene, Barclay, Pat, Barlow, Fiona Kate, de Barra, Mícheál, Becker, D Vaughn, Borovoi, Leah, Choi, Incheol, Choi, Jong An, Consedine, Nathan...
Show moreTybur, Joshua M, Inbar, Yoel, Aarøe, Lene, Barclay, Pat, Barlow, Fiona Kate, de Barra, Mícheál, Becker, D Vaughn, Borovoi, Leah, Choi, Incheol, Choi, Jong An, Consedine, Nathan S, Conway, Alan, Conway, Jane Rebecca, Conway, Paul, Adoric, Vera Cubela, Demirci, Dilara Ekin, Fernández, Ana María, Ferreira, Diogo Conque Seco, Ishii, Keiko, Jakšić, Ivana, Ji, Tingting, van Leeuwen, Florian, Lewis, David M G, Li, Norman P, McIntyre, Jason C, Mukherjee, Sumitava, Park, Justin H, Pawlowski, Boguslaw, Petersen, Michael Bang, Pizarro, David, Prodromitis, Gerasimos, Prokop, Pavol, Rantala, Markus J, Reynolds, Lisa M, Sandin, Bonifacio, Sevi, Bariş, De Smet, Delphine, Srinivasan, Narayanan, Tewari, Shruti, Wilson, Cameron, Yong, Jose C, Žeželj, Iris
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Abstract/Description: People who are more avoidant of pathogens are more politically conservative, as are nations with greater parasite stress. In the current research, we test two prominent hypotheses that have been proposed as explanations for these relationships. The first, which is an intragroup account, holds that these relationships between pathogens and politics are based on motivations to adhere to local norms, which are sometimes shaped by cultural evolution to have pathogen-neutralizing properties. The...
Show morePeople who are more avoidant of pathogens are more politically conservative, as are nations with greater parasite stress. In the current research, we test two prominent hypotheses that have been proposed as explanations for these relationships. The first, which is an intragroup account, holds that these relationships between pathogens and politics are based on motivations to adhere to local norms, which are sometimes shaped by cultural evolution to have pathogen-neutralizing properties. The second, which is an intergroup account, holds that these same relationships are based on motivations to avoid contact with outgroups, who might pose greater infectious disease threats than ingroup members. Results from a study surveying 11,501 participants across 30 nations are more consistent with the intragroup account than with the intergroup account. National parasite stress relates to traditionalism (an aspect of conservatism especially related to adherence to group norms) but not to social dominance orientation (SDO; an aspect of conservatism especially related to endorsements of intergroup barriers and negativity toward ethnic and racial outgroups). Further, individual differences in pathogen-avoidance motives (i.e., disgust sensitivity) relate more strongly to traditionalism than to SDO within the 30 nations.
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Date Issued: 2016-11-01
Identifier: FSU_pmch_27791090, 10.1073/pnas.1607398113, PMC5098626, 27791090, 27791090, 1607398113
Format: Citation

Title: Unidirectional allostery in the regulatory subunit RIα facilitates efficient deactivation of protein kinase A.
Creator: Guo, Cong, Zhou, Huan-Xiang
Abstract/Description: The holoenzyme complex of protein kinase A is in an inactive state; activation involves ordered cAMP binding to two tandem domains of the regulatory subunit and release of the catalytic subunit. Deactivation has been less studied, during which the two cAMPs unbind from the regulatory subunit to allow association of the catalytic subunit to reform the holoenzyme complex. Unbinding of the cAMPs appears ordered as indicated by a large difference in unbinding rates from the two sites, but the...
Show moreThe holoenzyme complex of protein kinase A is in an inactive state; activation involves ordered cAMP binding to two tandem domains of the regulatory subunit and release of the catalytic subunit. Deactivation has been less studied, during which the two cAMPs unbind from the regulatory subunit to allow association of the catalytic subunit to reform the holoenzyme complex. Unbinding of the cAMPs appears ordered as indicated by a large difference in unbinding rates from the two sites, but the cause has remained elusive given the structural similarity of the two tandem domains. Even more intriguingly, NMR data show that allosteric communication between the two domains is unidirectional. Here, we present a mechanism for the unidirectionality, developed from extensive molecular dynamics simulations of the tandem domains in different cAMP-bound forms. Disparate responses to cAMP releases from the two sites (A and B) in conformational flexibility and chemical shift perturbation confirmed unidirectional allosteric communication. Community analysis revealed that the A-site cAMP, by forming across-domain interactions, bridges an essential pathway for interdomain communication. The pathway is impaired when this cAMP is removed but remains intact when only the B-site cAMP is removed. Specifically, removal of the A-site cAMP leads to the separation of the two domains, creating room for binding the catalytic subunit. Moreover, the A-site cAMP, by maintaining interdomain coupling, retards the unbinding of the B-site cAMP and stalls an unproductive pathway of cAMP release. Our work expands the perspective on allostery and implicates functional importance for the directionality of allostery.
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Date Issued: 2016-11-01
Identifier: FSU_pmch_27791125, 10.1073/pnas.1610142113, PMC5098638, 27791125, 27791125, 1610142113
Format: Citation

Title: Magnetic phase diagram of underdoped YBaCuO inferred from torque magnetization and thermal conductivity.
Creator: Yu, Fan, Hirschberger, Max, Loew, Toshinao, Li, Gang, Lawson, Benjamin J, Asaba, Tomoya, Kemper, J B, Liang, Tian, Porras, Juan, Boebinger, Gregory S, Singleton, John, Keimer,...
Show moreYu, Fan, Hirschberger, Max, Loew, Toshinao, Li, Gang, Lawson, Benjamin J, Asaba, Tomoya, Kemper, J B, Liang, Tian, Porras, Juan, Boebinger, Gregory S, Singleton, John, Keimer, Bernhard, Li, Lu, Ong, N Phuan
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Abstract/Description: Strong evidence for charge-density correlation in the underdoped phase of the cuprate YBaCuO was obtained by NMR and resonant X-ray scattering. The fluctuations were found to be enhanced in strong magnetic fields. Recently, 3D charge-density-wave (CDW) formation with long-range order (LRO) was observed by X-ray diffraction in [Formula: see text] 15 T. To elucidate how the CDW transition impacts the pair condensate, we have used torque magnetization to 45 T and thermal conductivity [Formula:...
Show moreStrong evidence for charge-density correlation in the underdoped phase of the cuprate YBaCuO was obtained by NMR and resonant X-ray scattering. The fluctuations were found to be enhanced in strong magnetic fields. Recently, 3D charge-density-wave (CDW) formation with long-range order (LRO) was observed by X-ray diffraction in [Formula: see text] 15 T. To elucidate how the CDW transition impacts the pair condensate, we have used torque magnetization to 45 T and thermal conductivity [Formula: see text] to construct the magnetic phase diagram in untwinned crystals with hole density = 0.11. We show that the 3D CDW transitions appear as sharp features in the susceptibility and [Formula: see text] at the fields [Formula: see text] and [Formula: see text], which define phase boundaries in agreement with spectroscopic techniques. From measurements of the melting field [Formula: see text] of the vortex solid, we obtain evidence for two vortex solid states below 8 K. At 0.5 K, the pair condensate appears to adjust to the 3D CDW by a sharp transition at 24 T between two vortex solids with very different shear moduli. At even higher (41 T), the second vortex solid melts to a vortex liquid which survives to fields well above 41 T. de Haas-van Alphen oscillations appear at fields 24-28 T, below the lower bound for the upper critical field [Formula: see text].
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Date Issued: 2016-11-08
Identifier: FSU_pmch_27791146, 10.1073/pnas.1612591113, PMC5111645, 27791146, 27791146, 1612591113
Format: Citation

Title: Viral recombination blurs taxonomic lines: examination of single-stranded DNA viruses in a wastewater treatment plant..
Creator: Pearson, Victoria M, Caudle, S Brian, Rokyta, Darin R
Abstract/Description: Understanding the structure and dynamics of microbial communities, especially those of economic concern, is of paramount importance to maintaining healthy and efficient microbial communities at agricultural sites and large industrial cultures, including bioprocessors. Wastewater treatment plants are large bioprocessors which receive water from multiple sources, becoming reservoirs for the collection of many viral families that infect a broad range of hosts. To examine this complex collection...
Show moreUnderstanding the structure and dynamics of microbial communities, especially those of economic concern, is of paramount importance to maintaining healthy and efficient microbial communities at agricultural sites and large industrial cultures, including bioprocessors. Wastewater treatment plants are large bioprocessors which receive water from multiple sources, becoming reservoirs for the collection of many viral families that infect a broad range of hosts. To examine this complex collection of viruses, full-length genomes of circular ssDNA viruses were isolated from a wastewater treatment facility using a combination of sucrose-gradient size selection and rolling-circle amplification and sequenced on an Illumina MiSeq. Single-stranded DNA viruses are among the least understood groups of microbial pathogens due to genomic biases and culturing difficulties, particularly compared to the larger, more often studied dsDNA viruses. However, the group contains several notable well-studied examples, including agricultural pathogens which infect both livestock and crops ( and ), and model organisms for genetics and evolution studies (). Examination of the collected viral DNA provided evidence for 83 unique genotypic groupings, which were genetically dissimilar to known viral types and exhibited broad diversity within the community. Furthermore, although these genomes express similarities to known viral families, such as , , and , many are so divergent that they may represent new taxonomic groups. This study demonstrated the efficacy of the protocol for separating bacteria and large viruses from the sought after ssDNA viruses and the ability to use this protocol to obtain an in-depth analysis of the diversity within this group.
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Date Issued: 2016-10-18
Identifier: FSU_pmch_27781171, 10.7717/peerj.2585, PMC5075696, 27781171, 27781171, 2585
Format: Citation

Title: Intrinsic and extrinsic pinning in NdFeAs(O,F): vortex trapping and lock-in by the layered structure..
Creator: Tarantini, C, Iida, K, Hänisch, J, Kurth, F, Jaroszynski, J, Sumiya, N, Chihara, M, Hatano, T, Ikuta, H, Schmidt, S, Seidel, P, Holzapfel, B, Larbalestier, D C
Abstract/Description: Fe-based superconductors (FBS) present a large variety of compounds whose properties are affected to different extents by their crystal structures. Amongst them, the REFeAs(O,F) (RE1111, RE being a rare-earth element) is the family with the highest critical temperature T but also with a large anisotropy and Josephson vortices as demonstrated in the flux-flow regime in Sm1111 (T ∼ 55 K). Here we focus on the pinning properties of the lower-T Nd1111 in the flux-creep regime. We demonstrate that...
Show moreFe-based superconductors (FBS) present a large variety of compounds whose properties are affected to different extents by their crystal structures. Amongst them, the REFeAs(O,F) (RE1111, RE being a rare-earth element) is the family with the highest critical temperature T but also with a large anisotropy and Josephson vortices as demonstrated in the flux-flow regime in Sm1111 (T ∼ 55 K). Here we focus on the pinning properties of the lower-T Nd1111 in the flux-creep regime. We demonstrate that for H//c critical current density J at high temperatures is dominated by point-defect pinning centres, whereas at low temperatures surface pinning by planar defects parallel to the c-axis and vortex shearing prevail. When the field approaches the ab-planes, two different regimes are observed at low temperatures as a consequence of the transition between 3D Abrikosov and 2D Josephson vortices: one is determined by the formation of a vortex-staircase structure and one by lock-in of vortices parallel to the layers. This is the first study on FBS showing this behaviour in the full temperature, field, and angular range and demonstrating that, despite the lower T and anisotropy of Nd1111 with respect to Sm1111, this compound is substantially affected by intrinsic pinning generating a strong ab-peak in J.
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Date Issued: 2016-10-26
Identifier: FSU_pmch_27782196, 10.1038/srep36047, PMC5080545, 27782196, 27782196, srep36047
Format: Citation

Title: Insomnia and suicide-related behaviors: A multi-study investigation of thwarted belongingness as a distinct explanatory factor..
Creator: Chu, Carol, Hom, Melanie A, Rogers, Megan L, Stanley, Ian H, Ringer-Moberg, Fallon B, Podlogar, Matthew C, Hirsch, Jameson K, Joiner, Thomas E
Abstract/Description: Insomnia is a robust correlate of suicidal ideation and behavior. Preliminary research has identified thwarted belongingness (c.f. social disconnection) as an explanatory link between insomnia and suicidal ideation. This study replicates and extends previous findings using both cross-sectional and longitudinal designs in four demographically diverse samples. Additionally, the specificity of thwarted belongingness was evaluated by testing anxiety as a rival mediator. Self-report measures of...
Show moreInsomnia is a robust correlate of suicidal ideation and behavior. Preliminary research has identified thwarted belongingness (c.f. social disconnection) as an explanatory link between insomnia and suicidal ideation. This study replicates and extends previous findings using both cross-sectional and longitudinal designs in four demographically diverse samples. Additionally, the specificity of thwarted belongingness was evaluated by testing anxiety as a rival mediator. Self-report measures of insomnia symptoms, thwarted belongingness, suicidal ideation and behavior, and anxiety were administered in four adult samples: 469 undergraduate students, 352 psychiatric outpatients, 858 firefighters, and 217 primary care patients. More severe insomnia was associated with more severe thwarted belongingness and suicidality. Thwarted belongingness significantly accounted for the association between insomnia and suicidality, cross-sectionally and longitudinally, beyond anxiety. Notably, findings supported the specificity of thwarted belongingness: anxiety did not significantly mediate the association between insomnia and suicidality, and insomnia did not mediate the relation between thwarted belongingness and suicidality. This study relied solely on self-report measures. Future studies incorporating objective sleep measurements are needed. Findings underscore the utility of assessing and addressing sleep disturbances and social disconnection to reduce suicide risk.
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Date Issued: 2017-01-15
Identifier: FSU_pmch_27770645, 10.1016/j.jad.2016.08.065, PMC5154904, 27770645, 27770645, S0165-0327(16)31130-2
Format: Citation

Title: A Value Proposition For Early Physical Therapist Management Of Neck Pain: A Retrospective Cohort Analysis.
Creator: Horn, Maggie E., Brennan, Gerard P., George, Steven Z., Harman, Jeffrey S., Bishop, Mark D.
Abstract/Description: Background: Neck pain is one of the most common reasons for entry into the healthcare system. Recent increases in healthcare utilization and medical costs have not correlated with improvements in health. Therefore there is a need to identify management strategies for neck pain that are effective for the patient, cost efficient for the payer and provided at the optimal time during an episode of neck pain. Methods: One thousand five hundred thirty-one patients who underwent physical therapist...
Show moreBackground: Neck pain is one of the most common reasons for entry into the healthcare system. Recent increases in healthcare utilization and medical costs have not correlated with improvements in health. Therefore there is a need to identify management strategies for neck pain that are effective for the patient, cost efficient for the payer and provided at the optimal time during an episode of neck pain. Methods: One thousand five hundred thirty-one patients who underwent physical therapist management with a primary complaint of non-specific neck pain from January 1, 2008 to December 31, 2012 were identified from the Rehabilitation Outcomes Management System (ROMS) database at Intermountain Healthcare. Patients reporting duration of symptoms less than 4 weeks were designated as undergoing "early" management and patients with duration of symptoms greater than 4 weeks were designated as receiving "delayed" management. These groups were compared using binary logistic regression to examine odds of achieving Minimal Clinically Important Difference (MCID) on the Neck Disability Index (NDI) and Numerical Pain Rating Scale (NPRS). Separate generalized linear modeling examined the effect of timing of physical therapist management on the metrics of value and efficiency. Results: Patients who received early physical therapist management had increased odds of achieving MCID on the NDI (aOR = 2.01, 95 % CI 1.57, 2.56) and MCID on the NPRS (aOR = 1.82, 95 % CI 1.42, 2.38), when compared to patients receiving delayed management. Patients who received early management demonstrated the greatest value in decreasing disability with a 2.27 percentage point change in NDI score per 100 dollars, best value in decreasing pain with a 0.38 point change on the NPRS per 100 dollars. Finally, patients receiving early management were managed more efficiently with a 3.44 percentage point change in NDI score per visit and 0.57 point change in NPRS score per visit. Conclusions: These findings suggest that healthcare systems that provide pathways for patients to receive early physical therapist management of neck pain may realize improved patient outcomes, greater value and higher efficiency in decreasing disability and pain compared to delayed management. Further research is needed to confirm this assertion.
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Date Issued: 2016-07-12
Identifier: FSU_libsubv1_wos_000379459400004, 10.1186/s12913-016-1504-5
Format: Citation

Title: The ABC's of math: A genetic analysis of mathematics and its links with reading ability and general cognitive ability.
Creator: Hart, Sara, Petrill, Stephen, Thompson, Lee, Plomin, Robert
Abstract/Description: The goal of this first major report from the Western Reserve Reading Project Math component is to explore the etiology of the relationship among tester-administered measures of mathematics ability, reading ability and general cognitive ability. Data are available on 314 pairs of monozygotic and same-sex dizygotic twins analyzed across five waves of assessment. Univariate analyses provide a range of estimates of genetic (h²=.00-.63) and shared environmental influences (c²=.15-.52) across math...
Show moreThe goal of this first major report from the Western Reserve Reading Project Math component is to explore the etiology of the relationship among tester-administered measures of mathematics ability, reading ability and general cognitive ability. Data are available on 314 pairs of monozygotic and same-sex dizygotic twins analyzed across five waves of assessment. Univariate analyses provide a range of estimates of genetic (h²=.00-.63) and shared environmental influences (c²=.15-.52) across math calculation, fluency and problem solving measures. Multivariate analyses indicate genetic overlap between math problem solving with general cognitive ability and reading, whereas math fluency shares significant genetic overlap with reading fluency and general cognitive ability. Further, math fluency has unique genetic influences. In general, math ability has shared environmental overlap with general cognitive ability and decoding. These results indicate that aspects of math that include problem solving have different genetic and environmental influences than math calculation. Moreover, math fluency, a timed measure of calculation, is the only measured math ability with unique genetic influences.
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Date Issued: 2009
Identifier: FSU_migr_psy_faculty_publications-0008, 10.1037/a0015115
Format: Citation

Title: A review of multimodel superensemble forecasting for weather, seasonal climate, and hurricanes.
Creator: Krishnamurti, T. N., Kumar, V., Simon, A., Bhardwaj, A., Ghosh, T., Ross, R.
Abstract/Description: This review provides a summary of work in the area of ensemble forecasts for weather, climate, oceans, and hurricanes. This includes a combination of multiple forecast model results that does not dwell on the ensemble mean but uses a unique collective bias reduction procedure. A theoretical framework for this procedure is provided, utilizing a suite of models that is constructed from the well-known Lorenz low-order nonlinear system. A tutorial that includes a walk-through table and...
Show moreThis review provides a summary of work in the area of ensemble forecasts for weather, climate, oceans, and hurricanes. This includes a combination of multiple forecast model results that does not dwell on the ensemble mean but uses a unique collective bias reduction procedure. A theoretical framework for this procedure is provided, utilizing a suite of models that is constructed from the well-known Lorenz low-order nonlinear system. A tutorial that includes a walk-through table and illustrates the inner workings of the multimodel superensemble's principle is provided. Systematic errors in a single deterministic model arise from a host of features that range from the model's initial state (data assimilation), resolution, representation of physics, dynamics, and ocean processes, local aspects of orography, water bodies, and details of the land surface. Models, in their diversity of representation of such features, end up leaving unique signatures of systematic errors. The multimodel superensemble utilizes as many as 10 million weights to take into account the bias errors arising from these diverse features of multimodels. The design of a single deterministic forecast models that utilizes multiple features from the use of the large volume of weights is provided here. This has led to a better understanding of the error growths and the collective bias reductions for several of the physical parameterizations within diverse models, such as cumulus convection, planetary boundary layer physics, and radiative transfer. A number of examples for weather, seasonal climate, hurricanes and sub surface oceanic forecast skills of member models, the ensemble mean, and the superensemble are provided.
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Date Issued: 2016-06
Identifier: FSU_libsubv1_wos_000385716900003, 10.1002/2015RG000513
Format: Citation

Title: A new Arctic hadrosaurid from the Prince Creek Formation (lower Maastrichtian) of northern Alaska.
Creator: Mori, Hirotsugu, Druckenmiller, Patrick S., Erickson, Gregory M.
Abstract/Description: The Liscomb bonebed in the Price Creek Formation of northern Alaska has produced thousands of individual bones of a saurolophine hadrosaurid similar to Edmontosaurus; however, the specific identity of this taxon has been unclear, in part because the vast majority of the remains represent immature individuals. In this study, we address the taxonomic status of the Alaskan material through a comparative and quantitative morphological analysis of juvenile as well several near adult-sized...
Show moreThe Liscomb bonebed in the Price Creek Formation of northern Alaska has produced thousands of individual bones of a saurolophine hadrosaurid similar to Edmontosaurus; however, the specific identity of this taxon has been unclear, in part because the vast majority of the remains represent immature individuals. In this study, we address the taxonomic status of the Alaskan material through a comparative and quantitative morphological analysis of juvenile as well several near adult-sized specimens with particular reference to the two known species of Edmontosaurus, as well as a cladistic analysis using two different matrices for Hadrosauroidea. In the comparative morphological analysis, we introduce a quantitative method using bivariate plots to address ontogenetic variation. Our comparative anatomical analysis reveals that the Alaskan saurolophine possesses a unique suite of characters that distinguishes it from Edmontosaurus, including a premaxillary circumnarial ridge that projects posterolaterally without a premaxillary vestibular promontory, a shallow groove lateral to the posterodorsal premaxillary foramen, a relatively narrow jugal process of the postorbital lacking a postorbital pocket, a relatively tall maxilla, a relatively gracile jugal, a more strongly angled posterior margin of the anterior process of the jugal, wide lateral exposure of the quadratojugal, and a short symphyseal process of the dentary. The cladistic analyses consistently recover the Alaskan saurolophine as the sister taxon to Edmontosaurus annectens + Edmontosaurus regalis. This phylogenetic assessment is robust even when accounting for ontogenetically variable characters. Based on these results, we erect a new taxon, Ugrunaaluk kuukpikensis gen. et sp. nov. that contributes to growing evidence for a distinct, early Maastrichtian Arctic dinosaur community that existed at the northernmost extent of Laramidia during the Late Cretaceous.
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Date Issued: 2016
Identifier: FSU_libsubv1_wos_000371323000002, 10.4202/app.00152.2015
Format: Citation

Title: A new robust oxygen-temperature sensor for aquatic eddy covariance measurements.
Creator: Berg, Peter, Koopmans, Dirk J., Huettel, Markus, Li, Hua, Mori, Kosuke, Wueest, Alfred
Abstract/Description: The fragility of thin Clark-type glass microelectrodes used in aquatic eddy covariance measurements of benthic oxygen fluxes is a challenge when using this powerful technique. This study presents a new fast-responding dual oxygen-temperature sensor for eddy covariance measurements that is far more robust. Response time tests in the lab, where the sensor was inserted from air into water, revealed 90% response times of 0.51 s and 0.34 s for oxygen and temperature measurements, respectively. In...
Show moreThe fragility of thin Clark-type glass microelectrodes used in aquatic eddy covariance measurements of benthic oxygen fluxes is a challenge when using this powerful technique. This study presents a new fast-responding dual oxygen-temperature sensor for eddy covariance measurements that is far more robust. Response time tests in the lab, where the sensor was inserted from air into water, revealed 90% response times of 0.51 s and 0.34 s for oxygen and temperature measurements, respectively. In wave tank tests, the new sensor showed no stirring sensitivity in contrast to Clark-type microelectrodes. Other tests in a flume and in a particle-free water tank revealed how close the sensor can be positioned to the measuring volume of the Acoustic Doppler Velocimeter without disturbing velocity recordings. In field tests at river sites, all > 24 h, the new sensor recorded high-quality eddy covariance data for the entire deployment. Similar positive results were obtained in deployments at a marine site with unidirectional current flow overlaid with minor wave action. Concurrently deployed eddy covariance systems based on the new sensor and a traditional Clark-type microelectrode revealed that they recorded statistically equivalent fluxes and similar velocity-oxygen cospectra until the microelectrode broke after 2 h. The significant increase in robustness of the new sensor was achieved by relying on a larger sensor tip. This put some constrains on how the sensor should be deployed and fluxes extracted, but given the substantial gain in performance, it is a viable alternative for eddy covariance measurements in many aquatic environments.
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Date Issued: 2016-03
Identifier: FSU_libsubv1_wos_000372701900001, 10.1002/lom3.10071
Format: Citation

Title: A route for a strong increase of critical current in nanostrained iron-based superconductors.
Creator: Ozaki, Toshinori, Wu, Lijun, Zhang, Cheng, Jaroszynski, Jan, Si, Weidong, Zhou, Juan, Zhu, Yimei, Li, Qiang
Abstract/Description: The critical temperature T-c and the critical current density J(c) determine the limits to large-scale superconductor applications. Superconductivity emerges at T-c. The practical current-carrying capability, measured by J(c), is the ability of defects in superconductors to pin the magnetic vortices, and that may reduce T-c. Simultaneous increase of T-c and J(c) in superconductors is desirable but very difficult to realize. Here we demonstrate a route to raise both T-c and J(c) together in...
Show moreThe critical temperature T-c and the critical current density J(c) determine the limits to large-scale superconductor applications. Superconductivity emerges at T-c. The practical current-carrying capability, measured by J(c), is the ability of defects in superconductors to pin the magnetic vortices, and that may reduce T-c. Simultaneous increase of T-c and J(c) in superconductors is desirable but very difficult to realize. Here we demonstrate a route to raise both T-c and J(c) together in iron-based superconductors. By using low-energy proton irradiation, we create cascade defects in FeSe0.5Te0.5 films. T-c is enhanced due to the nanoscale compressive strain and proximity effect, whereas J(c) is doubled under zero field at 4.2 K through strong vortex pinning by the cascade defects and surrounding nanoscale strain. At 12 K and above 15 T, one order of magnitude of J(c) enhancement is achieved in both parallel and perpendicular magnetic fields to the film surface.
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Date Issued: 2016-10-06
Identifier: FSU_libsubv1_wos_000385556300001, 10.1038/ncomms13036
Format: Citation

Title: A novel molecular approach for tracing terrigenous dissolved organic matter into the deep ocean.
Creator: Medeiros, Patricia M., Seidel, Michael, Niggemann, Jutta, Spencer, Robert G. M., Hernes, Peter J., Yager, Patricia L., Miller, William L., Dittmar, Thorsten, Hansell, Dennis A.
Abstract/Description: Marine dissolved organic matter (DOM) contains one of the largest exchangeable organic carbon pools on Earth. Riverine input represents an important source of DOM to the oceans, yet much remains to be learned about the fate of the DOM linking terrestrial to oceanic carbon cycles through rivers at the global scale. Here we use ultrahigh-resolution mass spectrometry to identify 184 molecular formulae that are indicators of riverine inputs (referred to as t-Peaks) and to track their distribution...
Show moreMarine dissolved organic matter (DOM) contains one of the largest exchangeable organic carbon pools on Earth. Riverine input represents an important source of DOM to the oceans, yet much remains to be learned about the fate of the DOM linking terrestrial to oceanic carbon cycles through rivers at the global scale. Here we use ultrahigh-resolution mass spectrometry to identify 184 molecular formulae that are indicators of riverine inputs (referred to as t-Peaks) and to track their distribution in the deep North Atlantic and North Pacific Oceans. The t-Peaks were found to be enriched in the Amazon River, to be highly correlated with known tracers of terrigenous input, and to be observed in all samples from four different rivers characterized by vastly different landscapes and vegetation coverage spanning equatorial (Amazon and Congo), subtropical (Altamaha), and Arctic (Kolyma) regions. Their distribution reveals that terrigenous organic matter is injected into the deep ocean by the global meridional overturning circulation, indicating that a fraction of the terrigenous DOM introduced by rivers contributes to the DOM pool observed in the deep ocean and to the storage of terrigenous organic carbon. This novel molecular approach can be used to further constrain the transfer of DOM from land to sea, especially considering that Fourier transform ion cyclotron resonance mass spectrometer analysis is becoming increasingly frequent in studies characterizing the molecular composition of DOM in lakes, rivers, and the ocean.
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Date Issued: 2016-05
Identifier: FSU_libsubv1_wos_000379949100005, 10.1002/2015GB005320
Format: Citation

Title: Analytical Electrochemical Impedance Modeling of Li-air Batteries Under D.C. Discharge.
Creator: Andrei, Petru, Zheng, Jim, Mehta, M., Mixon, G.
Abstract/Description: An analytical impedance model and a small-signal equivalent circuit are derived for the impedance spectra of Li-air batteries with porous cathodes. The model takes into consideration the effects of the oxygen diffusion, double layer, and faradaic processes in the cathode and can be applied to Li-air batteries with organic and aqueous electrolytes operating under d.c. discharge. It is shown that the cathode of Li-air batteries can create two slightly asymmetrical semicircles on the Nyquist...
Show moreAn analytical impedance model and a small-signal equivalent circuit are derived for the impedance spectra of Li-air batteries with porous cathodes. The model takes into consideration the effects of the oxygen diffusion, double layer, and faradaic processes in the cathode and can be applied to Li-air batteries with organic and aqueous electrolytes operating under d.c. discharge. It is shown that the cathode of Li-air batteries can create two slightly asymmetrical semicircles on the Nyquist diagram: one at low frequencies, where the oxygen diffusion dominates the operation of the cell and one at medium frequencies due to the combined effects of the double-layer capacitance and faradaic processes. The second semicircle becomes negligibly small at low values of the cathode width or oxygen concentration. Both semicircles can degenerate into one large semicircle when the double layer capacitance is large enough and masks the effects of the faradaic processes, which happens at large values of the specific area of the cathode and double layer capacitance, or when the oxygen diffusion coefficient in the electrolyte is relatively large. They also degenerate into one semicircle when the porosity is decreased, for instance during the final period of the discharge of Li-air batteries with organic electrolyte, when the cathode is partly clogged with the deposit reaction products. The elements of the small-signal equivalent circuit are expressed in terms of the oxygen diffusion coefficient, oxygen concentration, discharge current, and other material and kinetic parameters, which make our model instrumental for extracting information about the material structure, reaction processes, and diffusion in the cathode. Based on the derived analytical results, we also propose a method to extract the effective value of the oxygen diffusion coefficient and reaction rate constant from the experimental impedance spectra of the cells. A simplified small-signal equivalent circuit model is also presented. This model contains only elementary components such as resistors and capacitors and can be implemented numerically in circuit simulators.
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Date Issued: 2013
Identifier: FSU_migr_ece_faculty_publications-0013, 10.1149/2.046311jes
Format: Citation

Title: Analytical Results on the Role of Flexibility in Flapping Propulsion.
Creator: Moore, Nicholas
Abstract/Description: Wing or fin flexibility can dramatically affect the performance of flying and swimming animals. Both laboratory experiments and numerical simulations have been used to study these effects, but analytical results are notably lacking. Here, we develop small-amplitude theory to model a flapping wing that pitches passively due to a combination of wing compliance, inertia and fluid forces. Remarkably, we obtain a class of exact solutions describing the wing's emergent pitching motions, along with...
Show moreWing or fin flexibility can dramatically affect the performance of flying and swimming animals. Both laboratory experiments and numerical simulations have been used to study these effects, but analytical results are notably lacking. Here, we develop small-amplitude theory to model a flapping wing that pitches passively due to a combination of wing compliance, inertia and fluid forces. Remarkably, we obtain a class of exact solutions describing the wing's emergent pitching motions, along with expressions for how thrust and efficiency are modified by compliance. The solutions recover a range of realistic behaviours and shed new light on how flexibility can aid performance, the importance of resonance, and the separate roles played by wing and fluid inertia. The simple robust estimates afforded by our theory may prove valuable even in situations where details of the flapping motion and wing geometry differ.
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Date Issued: 2014
Identifier: FSU_migr_math_faculty_publications-0002, 10.1017/jfm.2014.533
Format: Citation

Title: Angular Decay Coefficients Of J/psi Mesons At Forward Rapidity From P Plus P Collisions At Root S=510 Gev.
Creator: Adare, A., Aidala, C., Ajitanand, N. N., Akiba, Y., Akimoto, R., Alfred, M., Andrieux, V., Aoki, K., Apadula, N., Aramaki, Y., Asano, H., Atomssa, E. T., Awes, T. C., Ayuso, C.,...
Show moreAdare, A., Aidala, C., Ajitanand, N. N., Akiba, Y., Akimoto, R., Alfred, M., Andrieux, V., Aoki, K., Apadula, N., Aramaki, Y., Asano, H., Atomssa, E. T., Awes, T. C., Ayuso, C., Azmoun, B., Babintsev, V., Bai, M., Bandara, N. S., Bannier, B., Barish, K. N., Bathe, S., Bazilevsky, A., Beaumier, M., Beckman, S., Belmont, R., Berdnikov, A., Berdnikov, Y., Black, D., Blau, D. S., Boer, M., Bok, J. S., Bownes, E. K., Boyle, K., Brooks, M. L., Bryslawskyj, J., Buesching, H., Bumazhnov, V., Butler, C., Campbell, S., Roman, V. Canoa, Cervantes, R., Chen, C.-H., Chi, C. Y., Chiu, M., Choi, I. J., Choi, J. B., Chujo, T., Citron, Z., Connors, M., Cronin, N., Csanad, M., Csorgo, T., Danley, T. W., Datta, A., Daugherity, M. S., David, G., DeBlasio, K., Dehmelt, K., Denisov, A., Deshpande, A., Desmond, E. J., Ding, L., Dion, A., Dixit, D., Do, J. H., Drees, A., Drees, K. A., Dumancic, M., Durham, J. M., Durum, A., Dusing, J. P., Elder, T., Enokizono, A., En'yo, H., Esumi, S., Fadem, B., Fan, W., Feege, N., Fields, D. E., Finger, M., Finger, M., Fokin, S. L., Frantz, J. E., Franz, A., Frawley, A. D., Fukuda, Y., Gal, C., Gallus, P., Garg, P., Ge, H., Giordano, F., Glenn, A., Goto, Y., Grau, N., Greene, S. V., Perdekamp, M. Grosse, Gu, Y., Gunji, T., Guragain, H., Hachiya, T., Haggerty, J. S., Hahn, K. I., Hamagaki, H., Hamilton, H. F., Han, S. Y., Hanks, J., Hasegawa, S., Haseler, T. O. S., He, X., Hemmick, T. K., Hill, J. C., Hill, K., Hollis, R. S., Homma, K., Hong, B., Hoshino, T., Hotvedt, N., Huang, J., Huang, S., Ikeda, Y., Imai, K., Imazu, Y., Imrek, J., Inaba, M., Iordanova, A., Isenhower, D., Ito, Y., Ivanishchev, D., Jacak, B. V., Jeon, S. J., Jezghani, M., Ji, Z., Jia, J., Jiang, X., Johnson, B. M., Joo, E., Joo, K. S., Jorjadze, V., Jouan, D., Jumper, D. S., Kang, J. H., Kang, J. S., Kapukchyan, D., Karthas, S., Kawall, D., Kazantsev, A. V., Kempel, T., Key, J. A., Khachatryan, V., Khanzadeev, A., Kihara, K., Kim, C., Kim, D. H., Kim, D. J., Kim, E.-J., Kim, H.-J., Kim, M., Kim, M. H., Kim, Y. K., Kimball, M. L., Kincses, D., Kistenev, E., Klatsky, J., Kleinjan, D., Kline, P., Koblesky, T., Kofarago, M., Koster, J., Kotler, J. R., Kotov, D., Kudo, S., Kurita, K., Kurosawa, M., Kwon, Y., Lacey, R., Lajoie, J. G., Lallow, E. O., Lebedev, A., Lee, K. B., Lee, S., Lee, S. H., Leitch, M. J., Leitgab, M., Leung, Y. H., Lewis, N. A., Li, X., Lim, S. H., Liu, L. D., Liu, M. X., Loggins, V.-R., Loggins, V.-R., Lovasz, K., Lynch, D., Majoros, T., Makdisi, Y. I., Makek, M., Malaev, M., Manion, A., Manko, V. I., Mannel, E., Masuda, H., McCumber, M., McGaughey, P. L., McGlinchey, D., McKinney, C., Meles, A., Mendez, A. R., Mendoza, M., Meredith, B., Miake, Y., Mignerey, A. C., Mihalik, D. E., Miller, A. J., Milov, A., Mishra, D. K., Mitchell, J. T., Mitsuka, G., Miyasaka, S., Mizuno, S., Montuenga, P., Moon, T., Morrison, D. P., Morrow, S. I. M., Moukhanova, T. V., Murakami, T., Murata, J., Mwai, A., Nagai, K., Nagamiya, S., Nagashima, K., Nagashima, T., Nagle, J. L., Nagy, M. I., Nakagawa, I., Nakagomi, H., Nakano, K., Nattrass, C., Netrakanti, P. K., Nihashi, M., Niida, T., Nouicer, R., Novak, T., Novitzky, N., Novotny, R., Nyanin, A. S., O'Brien, E., Ogilvie, C. A., Koop, J. D. Orjuela, Osborn, J. D., Oskarsson, A., Ottino, G. J., Ozawa, K., Pak, R., Pantuev, V., Papavassiliou, V., Park, J. S., Park, S., Pate, S. F., Patel, L., Patel, M., Peng, J.-C., Peng, W., Perepelitsa, D. V., Perera, G. D. N., Peressounko, D. Yu, PerezLara, C. E., Perry, J., Petti, R., Phipps, M., Pinkenburg, C., Pinson, R., Pisani, R. P., Press, C. J., Pun, A., Purschke, M. L., Rak, J., Ravinovich, I., Read, K. F., Reynolds, D., Riabov, V., Riabov, Y., Richford, D., Rinn, T., Riveli, N., Roach, D., Rolnick, S. D., Rosati, M., Rowan, Z., Rubin, J. G., Runchey, J., Safonov, A. S., Saito, N., Sakaguchi, T., Sako, H., Samsonov, V., Sarsour, M., Sato, K., Sato, S., Sawada, S., Schaefer, B., Schmoll, B. K., Sedgwick, K., Seele, J., Seidl, R., Sen, A., Seto, R., Sett, P., Sexton, A., Sharma, D., Shein, I., Shibata, T.-A., Shigaki, K., Shimomura, M., Shioya, T., Shukla, P., Sickles, A., Silva, C. L., Silva, J. A., Silvermyr, D., Singh, B. K., Singh, C. P., Singh, V., Slunecka, M., Smith, K. L., Snowball, M., Soltz, R. A., Sondheim, W. E., Sorensen, S. P., Sourikova, I. V., Stankus, P. W., Stepanov, M., Stien, H., Stoll, S. P., Sugitate, T., Sukhanov, A., Sumita, T., Sun, J., Syed, S., Sziklai, J., Takahara, A., Takeda, A., Taketani, A., Tanida, K., Tannenbaum, M. J., Tarafdar, S., Taranenko, A., Tarnai, G., Tieulent, R., Timilsina, A., Todoroki, T., Tomasek, M., Torii, H., Towell, C. L., Towell, M., Towell, R., Towell, R. S., Tserruya, I., Ueda, Y., Ujvari, B., van Hecke, H. W., Vargyas, M., Vazquez-Carson, S., Velkovska, J., Virius, M., Vrba, V., Vukman, N., Vznuzdaev, E., Wang, X. R., Wang, Z., Watanabe, D., Watanabe, Y., Watanabe, Y. S., Wei, F., Whitaker, S., Wolin, S., Wong, C. P., Woody, C. L., Wysocki, M., Xia, B., Xu, C., Xu, Q., Xue, L., Yalcin, S., Yamaguchi, Y. L., Yamamoto, H., Yanovich, A., Yin, P., Yoo, J. H., Yoon, I., Younus, I., Yu, H., Yushmanov, I. E., Zajc, W. A., Zelenski, A., Zharko, S., Zou, L.
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Abstract/Description: We report the first measurement of the full angular distribution for inclusive J/psi -> mu(+)mu(-) decays in p + p collisions at root s = 510 GeV. The measurements are made for J/psi transverse momentum 2
Show moreWe report the first measurement of the full angular distribution for inclusive J/psi -> mu(+)mu(-) decays in p + p collisions at root s = 510 GeV. The measurements are made for J/psi transverse momentum 2 < p(T) < 10 GeV /c and rapidity 1.2 < y < 2.2 in the Helicity, Collins-Soper, and Gottfried-Jackson reference frames. In all frames the polar coefficient lambda theta is strongly negative at low p(T) and becomes close to zero at high p(T), while the azimuthal coefficient lambda phi is close to zero at low p(T), and becomes slightly negative at higher p(T). The frame-independent coefficient lambda is strongly negative at all p(T) in all frames. The data are compared to the theoretical predictions provided by nonrelativistic quantum chromodynamics models.
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Date Issued: 2017-05-08
Identifier: FSU_libsubv1_wos_000401231900001, 10.1103/PhysRevD.95.092003
Format: Citation

Title: Anatomy and Osteohistology of the basal hadrosaurid dinosaur Eotrachodon from the uppermost Santonian (Cretaceous) of southern appalachia.
Creator: Prieto-Marquez, Albert, Erickson, Gregory M., Ebersole, Jun A.
Abstract/Description: The cranial and postcranial anatomy of the basal hadrosaurid dinosaur Eotrachodon orientalis, from the uppermost Santonian of southern Appalachia (southeastern U.S.A.), is described in detail. This animal is the only known pre-Campanian non-lambeosaurine hadrosaurid, and the most complete hadrosauroid known from Appalachia. E. orientalis possesses a mosaic of plesiomorphic and derived characters in the context of Hadrosauroidea. Characters shared with basal hadrosauroids include a short and...
Show moreThe cranial and postcranial anatomy of the basal hadrosaurid dinosaur Eotrachodon orientalis, from the uppermost Santonian of southern Appalachia (southeastern U.S.A.), is described in detail. This animal is the only known pre-Campanian non-lambeosaurine hadrosaurid, and the most complete hadrosauroid known from Appalachia. E. orientalis possesses a mosaic of plesiomorphic and derived characters in the context of Hadrosauroidea. Characters shared with basal hadrosauroids include a short and sloping maxillary ectopterygoid shelf, caudally prominent maxillary jugal process, one functional tooth per alveolus on the maxillary occlusal plane, a jugal rostral process with a shallow caudodorsal margin and medioventrally facing articular facet, a vertical dentary coronoid process with a poorly expanded apex, and tooth crowns with accessory ridges. Derived characters shared with other hadrosaurids include a circumnarial depression compartmented into three fossae (as in brachylophosaurins and Edmontosaurus), a thin everted premaxillary oral margin (as in Gryposaurus, Prosaurolophus, and Saurolophus), and a maxilla with a deep and rostrocaudally extensive rostrodorsal region with a steeply sloping premaxillary margin (as in Gryposaurus). Eotrachodon orientalis differs primarily from the other hadrosauroid from the Mooreville Chalk of Alabama, Lophorhothon atopus, in having a slender and crestless nasal whose caudodorsal margin is not invaded by the circumnarial depression. Hadrosaurus foulkii, the only other known hadrosaurid from Appalachia, is distinct from E. orientalis in having dentary teeth lacking accessory ridges and a dorsally curved shaft of the ischium. A histological section of the tibia of the E. orientalis holotype (MSC 7949) suggests that this individual was actively growing at the time of death and, thus, had the potential to become a larger animal later in development.
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Date Issued: 2016-04-14
Identifier: FSU_libsubv1_wos_000374374200003, 10.7717/peerj.1872
Format: Citation

Title: Anchored Enrichment Dataset For True Flies (order Diptera) Reveals Insights Into The Phylogeny Of Flower Flies (family Syrphidae).
Creator: Young, Andrew Donovan, Lemmon, Alan R., Skevington, Jeffrey H., Mengual, Ximo, Stahls, Gunilla, Reemer, Menno, Jordaens, Kurt, Kelso, Scott, Lemmon, Emily Moriarty, Hauser,...
Show moreYoung, Andrew Donovan, Lemmon, Alan R., Skevington, Jeffrey H., Mengual, Ximo, Stahls, Gunilla, Reemer, Menno, Jordaens, Kurt, Kelso, Scott, Lemmon, Emily Moriarty, Hauser, Martin, De Meyer, Marc, Misof, Bernhard, Wiegmann, Brian M.
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Abstract/Description: Background: Anchored hybrid enrichment is a form of next-generation sequencing that uses oligonucleotide probes to target conserved regions of the genome flanked by less conserved regions in order to acquire data useful for phylogenetic inference from a broad range of taxa. Once a probe kit is developed, anchored hybrid enrichment is superior to traditional PCR-based Sanger sequencing in terms of both the amount of genomic data that can be recovered and effective cost. Due to their incredibly...
Show moreBackground: Anchored hybrid enrichment is a form of next-generation sequencing that uses oligonucleotide probes to target conserved regions of the genome flanked by less conserved regions in order to acquire data useful for phylogenetic inference from a broad range of taxa. Once a probe kit is developed, anchored hybrid enrichment is superior to traditional PCR-based Sanger sequencing in terms of both the amount of genomic data that can be recovered and effective cost. Due to their incredibly diverse nature, importance as pollinators, and historical instability with regard to subfamilial and tribal classification, Syrphidae (flower flies or hoverflies) are an ideal candidate for anchored hybrid enrichment-based phylogenetics, especially since recent molecular phylogenies of the syrphids using only a few markers have resulted in highly unresolved topologies. Over 6200 syrphids are currently known and uncovering their phylogeny will help us to understand how these species have diversified, providing insight into an array of ecological processes, from the development of adult mimicry, the origin of adult migration, to pollination patterns and the evolution of larval resource utilization. Results: We present the first use of anchored hybrid enrichment in insect phylogenetics on a dataset containing 30 flower fly species from across all four subfamilies and 11 tribes out of 15. To produce a phylogenetic hypothesis, 559 loci were sampled to produce a final dataset containing 217,702 sites. We recovered a well resolved topology with bootstrap support values that were almost universally >95 %. The subfamily Eristalinae is recovered as paraphyletic, with the strongest support for this hypothesis to date. The ant predators in the Microdontinae are sister to all other syrphids. Syrphinae and Pipizinae are monophyletic and sister to each other. Larval predation on soft-bodied hemipterans evolved only once in this family. Conclusions: Anchored hybrid enrichment was successful in producing a robustly supported phylogenetic hypothesis for the syrphids. Subfamilial reconstruction is concordant with recent phylogenetic hypotheses, but with much higher support values. With the newly designed probe kit this analysis could be rapidly expanded with further sampling, opening the door to more comprehensive analyses targeting problem areas in syrphid phylogenetics and ecology.
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Date Issued: 2016-06-29
Identifier: FSU_libsubv1_wos_000378675500003, 10.1186/s12862-016-0714-0
Format: Citation

Title: Analysis of the Molecular Pathogenesis of Cardiomyopathy-Causing cTnT Mutants I79N, ΔE96, and ΔK210.
Creator: Bai, Fan, Caster, Hannah, Pinto, Jose, Kawai, Masataka
Abstract/Description: Three troponin T (TnT) mutants that cause hypertrophic, restrictive, and dilated cardiomyopathy (I79N, ΔE96, and ΔK210, respectively), were examined using the thin-filament extraction/reconstitution technique. Effects of Ca(2+), ATP, phosphate, and ADP concentrations on force and its transients were studied at 25°C. Maximal Ca(2+) tension (THC) and Ca(2+)-activatable tension (Tact), respectively, were similar among I79N, ΔE96, and WT, whereas ΔK210 led to a significantly lower THC (∼20% less)...
Show moreThree troponin T (TnT) mutants that cause hypertrophic, restrictive, and dilated cardiomyopathy (I79N, ΔE96, and ΔK210, respectively), were examined using the thin-filament extraction/reconstitution technique. Effects of Ca(2+), ATP, phosphate, and ADP concentrations on force and its transients were studied at 25°C. Maximal Ca(2+) tension (THC) and Ca(2+)-activatable tension (Tact), respectively, were similar among I79N, ΔE96, and WT, whereas ΔK210 led to a significantly lower THC (∼20% less) and Tact (∼25% less) than did WT. In pCa solution containing 8 mM Pi and ionic strength adjusted to 200 mM, the Ca(2+) sensitivity (pCa50) of I79N (5.63 ± 0.02) and ΔE96 (5.60 ± 0.03) was significantly greater than that of WT (5.45 ± 0.04), but the pCa50 of ΔK210 (5.54 ± 0.04) remained similar to that of WT. Five equilibrium constants were deduced using sinusoidal analysis. All three mutants showed significantly lower K0 (ADP association constant) and larger K4 (equilibrium constant of force generation step) relative to the corresponding values for WT. I79N and ΔK210 were associated with a K2 (equilibrium constant of cross-bridge detachment step) significantly lower than that of ΔE96 and WT. These results demonstrated that at pCa 4.66, the force/cross-bridge is ∼18% less in I79N and ∼41% less in ΔK210 than that in WT. These results indicate that the molecular pathogenesis of the cardiac TnT mutation-related cardiomyopathies is different for each mutation.
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Date Issued: 2013
Identifier: FSU_migr_biomed_faculty_publications-0051, 10.1016/j.bpj.2013.04.001
Format: Citation

Title: Analyzing Historical Impacts of Alsace, France.
Creator: Young, Shelby
Abstract/Description: This project explores the national identity of people of the Alsace region of France, which lies on the northeast border with Germany. This region alone contains six dialects that intertwine French and German. Germany defeated France and annexed Alsace in 1871, but the region returned to France following Germany’s defeat in World War I. The territory was then occupied by Germany and was officially part of the Greater German Reich, yet Alsace was never officially annexed back to Germany. The...
Show moreThis project explores the national identity of people of the Alsace region of France, which lies on the northeast border with Germany. This region alone contains six dialects that intertwine French and German. Germany defeated France and annexed Alsace in 1871, but the region returned to France following Germany’s defeat in World War I. The territory was then occupied by Germany and was officially part of the Greater German Reich, yet Alsace was never officially annexed back to Germany. The culture of this region is not only a mix of the two nationalities due to shifting national borders, but due to the land historically being a territory that is traded in treaties out of many wars, specifically World War I and II. By interviewing three generations of Alsatians, I sought to discover what national identity they maintain, as well as their perspectives on their regional history. This project is important because it is rooted it in an international debate of identity crisis, specifically national identity.
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Date Issued: 2017-10-02
Identifier: FSU_libsubv1_scholarship_submission_1534431707_8a7c2bb9
Format: Citation

Title: An Analysis of the Localization Feature of Two Computer-Assisted Career Guidance Systems - DISCOVER and SIGI PLUS: Technical Report No. 14.
Creator: Lenz, Janet G, Leierer, Stephen J, Reardon, Robert C, Sampson, James P
Abstract/Description: This report describes the efforts of the Career Center at Florida State University to implement the localization options in the DISCOVER and SIGI PLUS computer-assisted career guidance (CACG) systems in 1991-1992. A review of the literature and current use of localization suggested that it is a complex, underutilized extension of CACG software. Use of the localization feature raises issues about the nature of the desired client outcomes, the type of information to be included, the processes...
Show moreThis report describes the efforts of the Career Center at Florida State University to implement the localization options in the DISCOVER and SIGI PLUS computer-assisted career guidance (CACG) systems in 1991-1992. A review of the literature and current use of localization suggested that it is a complex, underutilized extension of CACG software. Use of the localization feature raises issues about the nature of the desired client outcomes, the type of information to be included, the processes and costs for installing and using the feature, and who in the organization should be responsible. To determine what types of information to include in localization, career advising staff were surveyed, two staff meetings were held, and user feedback on the two CACG systems were examined. It was decided to emphasize local information that would accomplish the goals of (1) providing instructions to improve client interaction with the CACGS and reduce client confusion, and (2) linking clients with other Career Center resources and activities. Primary localization efforts were directed toward DISCOVER because the software design was more compatible with the two program goals noted above. This report includes a discussion of project findings in relation to localization issues, i.e., clarifying the purposes of localization, the influences of system design on localization functioning, the impact of localization on CACG system effects, and the impact of localization on staffing and training. The report concludes with a review of implications for practitioners and system developers of the study of CACG system localization features.
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Date Issued: 1992-06-22
Identifier: FSU_libsubv1_scholarship_submission_1525888624_5df96194, 10.17125/fsu.1525888624
Format: Citation

Title: "It's Really Overwhelming": Parent And Service Provider Perspectives Of Parents Aging Out Of Foster Care.
Creator: Radey, Melissa, Schelbe, Lisa, McWey, Lenore M., Holtrop, Kendal, Canto, Angela I.
Abstract/Description: Rates of pregnancy and parenthood among current and former foster youth are two to three times higher than non-foster youth peers. Repeat pregnancies among young mothers aging out of foster care also occur at higher rates than peers not involved with the child welfare system. Furthermore, mothers aging out of foster care demonstrate high levels of parenting stress and risk for child maltreatment. Indeed, this population is in significant need of help; however, beyond anecdotal evidence,...
Show moreRates of pregnancy and parenthood among current and former foster youth are two to three times higher than non-foster youth peers. Repeat pregnancies among young mothers aging out of foster care also occur at higher rates than peers not involved with the child welfare system. Furthermore, mothers aging out of foster care demonstrate high levels of parenting stress and risk for child maltreatment. Indeed, this population is in significant need of help; however, beyond anecdotal evidence, little is known about the needs and day-to day experiences of this population. In order to tailor interventions to meet the needs of parents aging out, the perspectives of stakeholders must be taken into account. Using qualitative data gathered from separate small group interviews with parents aging out and service providers, this study examined participants' perceptions of parents' daily experiences, strengths, and needs. Findings indicated that parents aging out face overwhelming adversity and stress with little outside financial, emotional, or parenting support from family or friends. Yet, parents also expressed motivation to be good parents, resilience, and the desire to gain effective parenting skills. Although similar themes arose among parent and provider interviews, perceptions differed. Parents expressed hope and optimism in providing for their children while providers expressed systemic failure in preparing parents for independent living. Based on these findings, we conclude that parenting interventions specific to parents aging out may need to address three fundamental and key components: basic needs, social support, and effective parenting techniques. Published by Elsevier Ltd.
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Date Issued: 2016-08
Identifier: FSU_libsubv1_wos_000381171100001, 10.1016/j.childyouth.2016.05.013
Format: Citation

Title: "To Benefit the World by Whatever Means Possible": Adolescents' Constructions of Global Citizenship.
Creator: Myers, John
Abstract/Description: This article reports on the ways that 77 students in an international studies programme constructed meanings for global citizenship. The focus was on their personal meanings for the topic and how they articulated a global identity with their national civic beliefs. Data was collected from online discussion boards, written essays and 20 interviews. A key finding was that the students' political language for global citizenship, examined here in terms of purpose, membership and relationship with...
Show moreThis article reports on the ways that 77 students in an international studies programme constructed meanings for global citizenship. The focus was on their personal meanings for the topic and how they articulated a global identity with their national civic beliefs. Data was collected from online discussion boards, written essays and 20 interviews. A key finding was that the students' political language for global citizenship, examined here in terms of purpose, membership and relationship with national citizenship, was predominantly a moral commitment framed in universal language. A second finding was that the students understood global citizenship as a heterogeneous and complex affiliation shaped by a range of sources. The implication is that citizenship education emphasizing a narrow notion of patriotism may encourage students to disengage from civic life because it does not represent their lived experiences and identities. Insights for making citizenship education practices more inclusive are discussed., In this study, information about national identity and global citizenship were collected from 77 students enrolled in an international studies program through discussion boards, essays, and interviews. Results regarding global citizenship showed that participants’ language was often framed in moral and universal terms, and that students saw global citizenship as complex and drew from diverse sources to understand what it meant. The article also discussed how citizenship education needs to be broader and more inclusive than the traditional focus on patriotism.
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Date Issued: 2009
Identifier: FSU_migr_ste_faculty_publications-0007, 10.1080/01411920902989219
Format: Citation

Title: The "Demand Side" of General Education - A Review of the Literature: Technical Report Number 11.
Creator: Reardon, Robert C, Lenz, Janet G, Sampson, James P, Johnston, Joseph S, Kramer, Gary L
Abstract/Description: Much of the literature in general education is focused on the design or contents of the program, or the "supply side," while little attention has been given to students' understandings of and attitudes toward general education, the "demand side." This paper reviews literature on the "demand side" of general education by first providing a brief synopsis of the notion of general education and recent recommendations for reform, and next summarizing research on student knowledge of and attitudes...
Show moreMuch of the literature in general education is focused on the design or contents of the program, or the "supply side," while little attention has been given to students' understandings of and attitudes toward general education, the "demand side." This paper reviews literature on the "demand side" of general education by first providing a brief synopsis of the notion of general education and recent recommendations for reform, and next summarizing research on student knowledge of and attitudes toward higher education and general education. Because of the paucity of "demand side" research, the paper shifts focus to processes used in higher education to affect demand side questions, including teaching, recruitment and admissions, orientation, academic and career advising, and course scheduling. The paper ends with conclusions on the importance of attending to "demand side" issues in the improvement of general education programs.
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Date Issued: 1990-07-01
Identifier: FSU_libsubv1_scholarship_submission_1525887098_ce56a520, 10.17125/fsu.1525887098
Format: Citation

Title: "A Glimpse Into the Past": Communication, Cultural Tourism, and the Political Economy of Modern Gullah Preservation.
Creator: Graves, Brian
Date Issued: 2013-10-01
Identifier: FSU_libsubv1_scholarship_submission_1475787437
Format: Citation

Title: The "FSU Lives" Digitization Project.
Creator: Morris, Sammie, Smith, Plato
Abstract/Description: FSU Libraries Special Collections and Digital Library Center collaborated on development this presentation highlighting FSU Lives Class of 1955 digitization project along with digital preservation of faculty research as part of a guest lecture for Florida State University College of Communication & Information Spring 2011 Digital Libraries course (LIS5472) taught by Dr. Sanghee Oh.
Date Issued: 2011
Identifier: FSU_migr_digital_lib-0013
Format: Citation

Title: "Free to All": Library Publishing and the Challenge of Open Access.
Creator: Vandegrift, Micah, Bolick, Josh
Abstract/Description: There is a significant and important responsibility as libraries move into the role of publishing to retain our heritage of "access for all." Connecting and collaborating with colleagues in the publishing industry is essential, but should come with the understanding that the library as an organization is access-prone. This article discusses the complexities of navigating that relationship, and calls for libraries and publishers to embrace and respect the position from which we begin. Finally,...
Show moreThere is a significant and important responsibility as libraries move into the role of publishing to retain our heritage of "access for all." Connecting and collaborating with colleagues in the publishing industry is essential, but should come with the understanding that the library as an organization is access-prone. This article discusses the complexities of navigating that relationship, and calls for libraries and publishers to embrace and respect the position from which we begin. Finally, the article forecasts several possible characteristics of what "publishing" might look like if libraries press the principle of access in this growing area.
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Date Issued: 2014
Identifier: FSU_migr_library_faculty_publications-0011, 10.6084/m9.figshare.1088945
Format: Citation

Title: "Waiting to Fail" Redux: Understanding Inadequate Response to Intervention..
Creator: Al Otaiba, Stephanie, Wagner, Richard K, Miller, Brett
Abstract/Description: This introduction to the special issue provides an overview of the promise, but also the ongoing challenges, related to Response to Intervention (RTI) as a means of both prevention and identification of reading disabilities. We conclude by describing the articles in this special issue and considering their implications for future research.
Date Issued: 2014-08-01
Identifier: FSU_pmch_25422530, 10.1177/0731948714525622, PMC4240019, 25422530, 25422530
Format: Citation

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