Search results

Title: The effects of exogenous cannabinoids on body weight loss within the activity-based anorexia paradigm in female rats.
Creator: Moran, Anne, Eckel, Lisa, Ogden, Sean
Date Issued: 2017-04-28
Identifier: FSU_libsubv1_scholarship_submission_1493403152
Format: Thesis

Title: Setting Hollywood Ablaze: Remembering and Depicting Women Spies in Popular Media.
Creator: McGuyre, Haley
Abstract/Description: This project will inspect the history of remembrance of female allied spies during the Second World War through media. Here, spying refers both to intelligence gathering, espionage, and sabotage. Comparing movies such as Charlotte Gray (2001), Carve Her Name with Pride (1958) Casino Royale (2006), and Les Femmes de l’Ombre (2008) with the lives of real female spies such as Noor Inayat Khan, Gertrude Sanford-Legendre, Katherine Keene, and Violette Szabo, this paper will explore the...
Show moreThis project will inspect the history of remembrance of female allied spies during the Second World War through media. Here, spying refers both to intelligence gathering, espionage, and sabotage. Comparing movies such as Charlotte Gray (2001), Carve Her Name with Pride (1958) Casino Royale (2006), and Les Femmes de l’Ombre (2008) with the lives of real female spies such as Noor Inayat Khan, Gertrude Sanford-Legendre, Katherine Keene, and Violette Szabo, this paper will explore the discrepancies between images and realities, focusing on the tropes of the Madonna and the Whore. Due to the lack of coverage spies in general receive in the historiography of World War II, many people outside of academia become exposed to spies via Hollywood. Here, I will discuss how this type of exposure changes how we as a society think of espionage both in the past and the present. Depictions of other eras of espionage will also receive some discussion, in order to better understand the effects of popular media covering female espionage during World War II.
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Date Issued: 2017-04-28
Identifier: FSU_libsubv1_scholarship_submission_1493409617
Format: Thesis

Title: Turning Towards Zion: An Analysis of the Development of Attitudes Towards Israel of American Reform Jews in the Wake of Israel's War of 1967 Through Examination of the Yearbooks of the Central Conference of American Rabbis.
Creator: Friedman, Micah Roberts
Date Issued: 2017-04-28
Identifier: FSU_libsubv1_scholarship_submission_1493412163
Format: Thesis

Title: Singing Ebola: Music, Media, and the Politics of Participation in West Africa.
Creator: Rivera, Michael Perez
Abstract/Description: Throughout the 2014 Ebola outbreak in West Africa, local musicians composed and performed music to combat mistrust of and misinformation surrounding the disease. Many artists participated in Ebola music campaigns live and online, either through independent projects or through funding by the government or non-governmental organizations (NGOs). Previous research on public health music suggests that when musicians are sponsored by these Western-based NGOs, their creative processes become...
Show moreThroughout the 2014 Ebola outbreak in West Africa, local musicians composed and performed music to combat mistrust of and misinformation surrounding the disease. Many artists participated in Ebola music campaigns live and online, either through independent projects or through funding by the government or non-governmental organizations (NGOs). Previous research on public health music suggests that when musicians are sponsored by these Western-based NGOs, their creative processes become entangled with larger development agendas, many of which implement neoliberal capitalist ideologies rooted in globalization and neocolonialism (Morin 2012; Pier 2015). I argue that in spite of these transient financial opportunities presented by Western aid projects, local independent initiatives offer a valuable yet overlooked method of knowledge dissemination, demonstrating great opportunity to promote local arts familiar to indigenous communities. Drawing on lyrical and structural analysis of Internet songs, as well as participant-observation of concerts and oral history collection with local musicians in Conakry, Guinea, I deconstruct how these artists and production teams responded to the Ebola crisis while seeking to preserve their sociocultural identities in an increasingly globalized world.
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Date Issued: 2017-04-28
Identifier: FSU_libsubv1_scholarship_submission_1493410536
Format: Thesis

Title: Prevalence of and Risk Factors for Food Addiction Among University Students.
Creator: Coel, Mikaela Lee, Maier, Haiyan, Spicer, Maria, Kearley, Mark
Abstract/Description: The primary goal of this study was to assess the prevalence of food addiction and to determine risk factors for food addiction among college students. Data was collected at Florida State University (FSU) via a self-monitored survey modified from the Yale Food Addiction Scale 2.0. The correlations between food addiction and body mass index (BMI), academic year, living situations, the presence of a meal plan, and a history of dieting were analyzed. The results of the study showed that 18.7% of...
Show moreThe primary goal of this study was to assess the prevalence of food addiction and to determine risk factors for food addiction among college students. Data was collected at Florida State University (FSU) via a self-monitored survey modified from the Yale Food Addiction Scale 2.0. The correlations between food addiction and body mass index (BMI), academic year, living situations, the presence of a meal plan, and a history of dieting were analyzed. The results of the study showed that 18.7% of college students have food addiction, and that obese students as well as students that have a history of dieting are more likely to have food addiction than their peers.
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Date Issued: 2017-04-28
Identifier: FSU_libsubv1_scholarship_submission_1493411576
Format: Thesis

Title: Exploring Predictors of Mobile Device Usage and Proficiency Among Older Adults.
Creator: Champagne, Kimberly J., Boot, Walter
Abstract/Description: Technology adoption rates of older adults typically lag behind those of their younger counterparts; a digital divide. This is unfortunate because technology has many potential benefits for older people. Among older adults, attitudes and cognitive abilities predict computer and Internet adoption, use, and proficiency. However, an important trend over the past two decades has been the rise of mobile computing (specifically with respect to smartphones and tablet computers). High quality...
Show moreTechnology adoption rates of older adults typically lag behind those of their younger counterparts; a digital divide. This is unfortunate because technology has many potential benefits for older people. Among older adults, attitudes and cognitive abilities predict computer and Internet adoption, use, and proficiency. However, an important trend over the past two decades has been the rise of mobile computing (specifically with respect to smartphones and tablet computers). High quality interactions with mobile technology critically depend upon individuals’ technology proficiency, making it important to understand how mobile device proficiency might be anticipated. This paper explored predictors of mobile device proficiency among older adults (65+) using a dataset from a cognitive intervention study that included 60 participants. Measures of computer and mobile device proficiency were obtained. Demographic variables and assessments of reasoning ability, processing speed, and executive control were collected and explored as predictors of mobile device proficiency. Even within this older adult sample, mobile device proficiency was related to age, but contrary to predictions, cognition was not significantly related to mobile device proficiency; the strongest predictor of mobile device proficiency was computer proficiency. This implies some transfer of proficiency from one technology platform to another. These results have implications for predicting quality technology interactions given the link between interaction quality and technology proficiency.
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Date Issued: 2017-04-28
Identifier: FSU_libsubv1_scholarship_submission_1493411889
Format: Thesis

Title: UASt-Gal4 System: Determining Why It Fails to Function in Germline Cells.
Creator: Moreno, Henry
Date Issued: 2017-04-28
Identifier: FSU_libsubv1_scholarship_submission_1493409678
Format: Thesis

Title: Places of Personal Past: Recollecting Memories Through a Landscape.
Creator: Mago, Karina Raquel
Abstract/Description: For my Honors project, I created a series of paintings that seek to depict the scene of some of my most pivotal memories in a way that maintains both the location of the landscape, and the events that occurred within that landscape, vague and undisclosed. I distill the elements of each landscape, abstracting it into an assortment of basic forms and colors. The objective is to depict an unknown yet familiar space, a scene that can transport any individual into introspective analysis. I believe...
Show moreFor my Honors project, I created a series of paintings that seek to depict the scene of some of my most pivotal memories in a way that maintains both the location of the landscape, and the events that occurred within that landscape, vague and undisclosed. I distill the elements of each landscape, abstracting it into an assortment of basic forms and colors. The objective is to depict an unknown yet familiar space, a scene that can transport any individual into introspective analysis. I believe that by painting these vacant spaces, I created a platform onto which a viewer could project their own experiences and recollections. Within this paper I aim to situate my paintings within a contemporary framework, while referencing theoretical psychological academic writings and historical references. Through a formal analysis, I will explain how elements such as color, perspective, surface, and materiality play a role within the conceptual idea of the work. I place my paintings within an academic context by examining some of the psychological literature that address autobiographical memory, memory creation, recollection, and inherent bias of memory. Last, I will explain how the work is in dialogue with other artists and how their work influenced this series. I believe that by understanding the way in which memory has been examined so far through an academic lens, I can better illustrate memories and how they work. I hope to create a series of landscapes that catapult the viewer into an introspective journey.
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Date Issued: 2017-04-28
Identifier: FSU_libsubv1_scholarship_submission_1493410418
Format: Thesis

Title: Behavioral Implications of Growth and Destiny Beliefs in Romantic Relationships.
Creator: Montalvo, Shae, McNulty, James, Hicks, Lindsey
Abstract/Description: This study tested the association between romantic partners’ growth beliefs and their use of negative direct communication strategies, rather than negative indirect communication strategies, when discussing problems in their relationship. Because of the benefits associated with the use of direct strategies when discussing relationship problems (i.e., clarification of the problem, motivation to resolve problem), we predicted that spouses with growth beliefs would be more likely to use direct...
Show moreThis study tested the association between romantic partners’ growth beliefs and their use of negative direct communication strategies, rather than negative indirect communication strategies, when discussing problems in their relationship. Because of the benefits associated with the use of direct strategies when discussing relationship problems (i.e., clarification of the problem, motivation to resolve problem), we predicted that spouses with growth beliefs would be more likely to use direct communication strategies during conflict discussions. Ultimately, we predicted that the use of direct communication strategies would result in higher relationship satisfaction for spouses with a growth mindset. These predictions were tested using a behavioral study of 120 couples, during which newlywed spouses reported their implicit theories about relationships and participated in conflict discussions. Moderated mediational analyses revealed that spouses with growth beliefs (compared to spouses with destiny beliefs) were not more likely to employ direct communication strategies during conflict discussions. Moreover, the use of direct strategies did not account for any differences in relationship satisfaction between partners with fixed and growth mindsets.
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Date Issued: 2017-04-28
Identifier: FSU_libsubv1_scholarship_submission_1493410662
Format: Thesis

Title: What Predicts the Moralized Perception of Self-Sacrifice?: Clarifying the Roles of Fusion and Moral Dilemma Decision-Making.
Creator: Polacek, David Aaron
Abstract/Description: Why do people sacrifice themselves for others? According to identity fusion theory, people are most willing to sacrifice themselves to save others when they experience a visceral sense of oneness with the group. This entails strong emotional concern for group member well-being. Conversely, people low in fusion may still occasionally choose to sacrifice for the group, but not for emotional reasons—instead, because they endorse abstract generalized utilitarian ethical principles that require...
Show moreWhy do people sacrifice themselves for others? According to identity fusion theory, people are most willing to sacrifice themselves to save others when they experience a visceral sense of oneness with the group. This entails strong emotional concern for group member well-being. Conversely, people low in fusion may still occasionally choose to sacrifice for the group, but not for emotional reasons—instead, because they endorse abstract generalized utilitarian ethical principles that require people to maximize overall outcomes for others regardless of group membership. Although initial evidence supports this claim, it is restricted to self-report measures. The current work applies process dissociation to assess individual differences in affective reactions to harm and cognitive evaluations of outcomes on classic moral dilemmas where harming a stranger saves other strangers. I will examine whether these processes predict the moralized perception of self-sacrifice.
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Date Issued: 2017-04-28
Identifier: FSU_libsubv1_scholarship_submission_1493681737
Format: Thesis

Title: Story Language: Macrostructure Development in Preschool Children.
Creator: Smith, Kelly Ann
Abstract/Description: This project investigated how macrostructure story language use varies among 3-to-5- year-old preschool children when told to retell the story “Billy Bear & the Balloon”. The goal was to see what macrostructure elements children this age use in their story retellings, and furthermore, at what frequency they use them. This was done by having the participants each watch the short movie “Billy Bear & the Balloon”, then retell the story while the clinician collected their language sample using a...
Show moreThis project investigated how macrostructure story language use varies among 3-to-5- year-old preschool children when told to retell the story “Billy Bear & the Balloon”. The goal was to see what macrostructure elements children this age use in their story retellings, and furthermore, at what frequency they use them. This was done by having the participants each watch the short movie “Billy Bear & the Balloon”, then retell the story while the clinician collected their language sample using a simple recording device. The language samples were then transcribed and coded for each macrostructure element being investigated. Upon examination of their coded language samples, it became clear that there is a potential relationship between both story language use and age, and story language use and gender. This research highlights the importance of awareness of story language use norms, particularly as dependent on both age and gender, as deviation from the norm could indicate a potential language impairment that needs to be addressed in clinical therapy.
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Date Issued: 2017-04-28
Identifier: FSU_libsubv1_scholarship_submission_1493397560
Format: Thesis

Title: Dietary Protein Intake and Body Composition in Pre and Postmenopausal Women.
Creator: Leonard, Joseph, Panton, Lynn, Shattinger, Christopher, Artese, Ashley
Date Issued: 2017-04-28
Identifier: FSU_libsubv1_scholarship_submission_1493391454
Format: Thesis

Title: Phonetic pre-training of non-native speech learning in older adults.
Creator: Hayes, Lydia Faith
Date Issued: 2017-04-28
Identifier: FSU_libsubv1_scholarship_submission_1493395271
Format: Thesis

Title: A Contemporary Creative Approach to the Philosophy of the Absurd.
Creator: Gomez, Noah Glenn
Date Issued: 2017-04-28
Identifier: FSU_libsubv1_scholarship_submission_1493400357
Format: Thesis

Title: Investigating How Water Type and Temperature Affect Fitness of Freshwater Pulmonate, Physella hendersoni.
Creator: Fourqurean, Virginia Leigh
Date Issued: 2017-04-28
Identifier: FSU_libsubv1_scholarship_submission_1493400648
Format: Thesis

Title: Self-Fertilization and Inbreeding in the Simultaneous Hermaphrodite Bugula neritina.
Creator: Zubek, Zachary Andrew
Abstract/Description: Plants and animals that are simultaneous hermaphrodites and have short dispersal distances have a high potential for inbreeding. Simultaneous hermaphrodites have the potential to self-fertilize, and short dispersal distances increase the chance of mating with kin. Hermaphroditism, self-fertilization, and inbreeding have been studied extensively in plants, but very little is known about the extent to which they increase or decrease fitness in animals. In particular, the degree to which...
Show morePlants and animals that are simultaneous hermaphrodites and have short dispersal distances have a high potential for inbreeding. Simultaneous hermaphrodites have the potential to self-fertilize, and short dispersal distances increase the chance of mating with kin. Hermaphroditism, self-fertilization, and inbreeding have been studied extensively in plants, but very little is known about the extent to which they increase or decrease fitness in animals. In particular, the degree to which bryozoans produce viable offspring through self-fertilization or other forms of inbreeding remains unresolved. Therefore, I assessed the patterns and consequences of larval settlement and inbreeding in Bugula neritina, an arborescent marine bryozoan. The overall research objective was to examine the consequences of mating with self, kin, and unrelated individuals through manipulative laboratory experiments where colonies were reared in the lab with different mating partners. There were three treatments: 1) a dish with a single settler (solitary treatment), 2) a dish with settlers from parents collected within 3m of each other (near treatment), and 3) a dish with two settlers from parents collected within 300m of each other (far treatment). There were no differences in the growth rate of colonies between the treatments after two weeks, but colonies in the solitary treatment were larger than in the near and far treatments after seven weeks. The proportion of colonies with unfertilized ovicells, and the total number of unfertilized ovicells per colony, at week seven did not differ between treatments, suggesting that zooids had become female and were capable of supporting an embryo. However, colonies grown in isolation never produced fertilized ovicells, but colonies grown with another colony produced fertilized ovicells and viable offspring (i.e., a next generation of settlers). Based on this evidence, it was concluded that B. neritina does not self-fertilize. Furthermore, short dispersal distances (~3m) in the field might not have negative effects on subsequent mating success in the population studied. An important next step is to repeat this experiment and genotype both parents and offspring to determine whether self-fertilization occurs in the paired colonies, as might occur if extrinsic sperm cues trigger sperm release. Together, these results contribute to a better understanding of mating systems in sessile marine invertebrates.
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Date Issued: 2017-04-28
Identifier: FSU_libsubv1_scholarship_submission_1493398780
Format: Thesis

Title: A Cross-Sectional Analysis of Body Composition and Function in Pre-Frail and Frail Older Adults.
Creator: Chanin, Marisa
Date Issued: 2017-04-28
Identifier: FSU_libsubv1_scholarship_submission_1493400519
Format: Thesis

Title: Twitter Content for Depression Advocacy and Awareness.
Creator: Ramsier, Leah Eryn
Abstract/Description: Depression is a mental health issue that negatively impacts quality of life. Social media are a popular way to discuss topics with a broad audience, and they can be used to raise awareness and spread information. This study focuses on the platform Twitter, researching the content in the hashtag #depression from October 2nd, 2016 to January 10th, 2017. It used exploratory social network analysis to find patterns in the social networks within the hashtag. It also used a survey to find which co...
Show moreDepression is a mental health issue that negatively impacts quality of life. Social media are a popular way to discuss topics with a broad audience, and they can be used to raise awareness and spread information. This study focuses on the platform Twitter, researching the content in the hashtag #depression from October 2nd, 2016 to January 10th, 2017. It used exploratory social network analysis to find patterns in the social networks within the hashtag. It also used a survey to find which co-occurring hashtags Twitter users are most interested in and are perceived as being most related to depression. The study found hashtags co-occurring with #depression and visualized the structure of the hashtag, mention, and retweet social networks within #depression. It also found which popular co-occurring hashtags were most interesting to Twitter users (#love, #exercise, and #treatment) and which popular co-occurring hashtags were perceived by Twitter users as most relevant to #depression (#depression, #dépression, #mentalhealth, #mentalillness, and #mindfulness).
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Date Issued: 2017-04-28
Identifier: FSU_libsubv1_scholarship_submission_1493389864
Format: Thesis

Title: Malleability of Measures of Cognitive Ability.
Creator: Bayles, Megan Ashley
Abstract/Description: “Brain training” claims have been the subject of many recent investigations. Proponents of brain training believe that practicing simple cognitive exercises or gamified versions of these exercises can result in improvements not just to the practiced task, but to other tasks and abilities as well. This has been termed “transfer of training.” For example, Jaeggi, Buschkuehl, Jonides, and Perrig (2008) have claimed that since working memory is vital to the performance of many different tasks,...
Show more“Brain training” claims have been the subject of many recent investigations. Proponents of brain training believe that practicing simple cognitive exercises or gamified versions of these exercises can result in improvements not just to the practiced task, but to other tasks and abilities as well. This has been termed “transfer of training.” For example, Jaeggi, Buschkuehl, Jonides, and Perrig (2008) have claimed that since working memory is vital to the performance of many different tasks, practicing working memory tasks can result in generalizable benefits. To test this idea, they had some participants practice working memory tasks while other participants received no training. At the end of the study, those participants who practiced the working memory task (a dual-N back task, to be described later) improved on two measures of fluid intelligence (Gf) while the control group did not. This finding received a great deal of attention due to previously accepted assumptions that Gf is static and cannot be improved. Similarly, Dahlin, Nyberg, Bäckman, and Neely (2008) found evidence for transfer of training as long as the practiced task and the transfer task appeared to share common neural circuits. In this fMRI study, practicing one working memory tasked improved the performance of other tasks to the extent that the practiced task and the transfer tasked relied on the striatum. Based on these and other results, some scientists argue that training can target certain cognitive abilities and neural circuits, resulting in the improved performance of other tasks that depend on overlapping abilities and circuits.
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Date Issued: 2017-04-28
Identifier: FSU_libsubv1_scholarship_submission_1493396860
Format: Thesis

Title: Working memory effects on non-native speech learning by older adults.
Creator: Weiner, Jessica
Date Issued: 2017-04-28
Identifier: FSU_libsubv1_scholarship_submission_1493395097
Format: Thesis

Title: Graphics Processing Unit Accelerated Variational Two-Electron Reduced-Density-Matrix-Driven Complete Active Space Self-Consistent Field Methods.
Creator: Koulias, Lauren Nicole
Date Issued: 2017-04-28
Identifier: FSU_libsubv1_scholarship_submission_1493396642
Format: Thesis

Title: Modification of Exosomes by Epstein-Barr Virus Oncoprotein LMP1.
Creator: Kosteilc, Marius Mathew
Abstract/Description: Epstein Barr virus (EBV) is a human herpesvirus that is carried by 90% percent of adults and can cause Hodgkin's and Burkitt's lymphoma among other cancers. EBV hijacks the machinery of the host cell in order to produce proteins, DNA, RNAs, and viral particles. In context of cancer, EBV has been shown to regulate cell migration, metastasis, and cell proliferation. The EBV oncoprotein Latent Membrane Protein 1, LMP1, has been found in the extracellular vesicles of endosomal origin called...
Show moreEpstein Barr virus (EBV) is a human herpesvirus that is carried by 90% percent of adults and can cause Hodgkin's and Burkitt's lymphoma among other cancers. EBV hijacks the machinery of the host cell in order to produce proteins, DNA, RNAs, and viral particles. In context of cancer, EBV has been shown to regulate cell migration, metastasis, and cell proliferation. The EBV oncoprotein Latent Membrane Protein 1, LMP1, has been found in the extracellular vesicles of endosomal origin called exosomes secreted by cancer cells latently infected with EBV. Secretion of LMP1 and other viral factors from cells is a possible way to manipulate the physiology of nearby cells. Previous proteomic analyses of exosomes from latently infected lymphoma cell lines found numerous proteins to be altered due to EBV infection with many of the changes correlating with LMP1 expression in the exosome producing cells. Therefore, our hypothesis is that LMP1 is a major driver of the components and functions of exosomes released from infected cells. To test this, we purified exosomes from the conditioned media of cells expressing LMP1 using polyethylene glycol precipitation combined with Optiprep density gradients. The purified exosomes proteins were then solubilized, separated by SDS-PAGE, and digested by in-gel trypsin digestion. The resulting peptides were identified via liquid chromatography combined with electron spray ionization mass spectrometry and relative quantities of proteins were determined by spectral count-based quantitative proteomics. Differentially expressed proteins were then confirmed by western blot analysis. Overall, this study provides a better understanding of the contributions of LMP1 expression to exosome content that may be important for EBV oncogenesis.
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Date Issued: 2017-04-28
Identifier: FSU_libsubv1_scholarship_submission_1493404754
Format: Thesis

Title: Exploring Room Rate Dispersion in Hotels Across Channels.
Creator: Luberto, Eric
Abstract/Description: This study examines room rate dispersion in hotels across 60 booking days and between the direct and indirect channels. The researcher utilized a stratified sampling method to create a sample of 700 hotels within the United States. With assistance from TravelClick, the researcher acquired room rates from these hotels. To obtain results, repeated-measures ANOVA was run to test main channel effect, two-way interaction, and three-way interaction. The findings indicated a significant effect for...
Show moreThis study examines room rate dispersion in hotels across 60 booking days and between the direct and indirect channels. The researcher utilized a stratified sampling method to create a sample of 700 hotels within the United States. With assistance from TravelClick, the researcher acquired room rates from these hotels. To obtain results, repeated-measures ANOVA was run to test main channel effect, two-way interaction, and three-way interaction. The findings indicated a significant effect for days, days x class, days x channel and days x channel x class. It was also found that price parity exists between the direct and indirect channels. However, by examining each hotel class, it was determined that price dispersion is prominently present across booking days. At 14 days prior to arrival, price dispersion was found to be the highest. These results have managerial implications for hotel revenue managers. Our results clearly indicate that room rates differ depending on the class of the hotel and the amount of booking days prior to arrival. In developing their pricing strategies, they must be conscious of this information and manage their channels and room rates accordingly.
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Date Issued: 2017-04-28
Identifier: FSU_libsubv1_scholarship_submission_1493411178
Format: Thesis

Title: Seasonal changes in male size and alternative mating tactics in sailfin mollies (Poecilia latipinna).
Creator: Arriola Mendieta, Ivonne, Lange, Elizabeth C., Hughes, Kimberly A.
Abstract/Description: In many taxa, individuals display discrete variation in both morphology and behavior. Although these “alternative tactics” are relatively common, their maintenance within populations has yet to be adequately explained. A first step in addressing this question is to describe how behavior changes within a population over time. Sailfin mollies (Poecilia latipinna) are a livebearing fish that show extreme variation in mature male size and reproductive behavior. Adult male size is genetically...
Show moreIn many taxa, individuals display discrete variation in both morphology and behavior. Although these “alternative tactics” are relatively common, their maintenance within populations has yet to be adequately explained. A first step in addressing this question is to describe how behavior changes within a population over time. Sailfin mollies (Poecilia latipinna) are a livebearing fish that show extreme variation in mature male size and reproductive behavior. Adult male size is genetically determined but highly variable within populations, and reproductive behavior covaries with genetically-determined size. Large males display courtship behavior, small males use sneaking behavior, and males in the middle of the size distribution exhibit behavioral plasticity that depends on the social context. Large males also mature more slowly than small males, so the size distribution of adult males within a population can vary dramatically over time. To determine if temporal variation and behavioral plasticity could play a role in maintaining these polymorphisms, we asked if individual male behavior covaries with the male body size distribution across seasons within a population. We censused the population and recorded the size of males, females and juveniles monthly from February 2015 to January 2017. A subset of males, from fish censused in June and October 2015-2016, was brought to the lab to assess reproductive behavior towards a receptive female. We found that the male size distribution varied seasonally; males were largest in the fall and winter, and smallest in late spring and summer. Standard length and its interaction with season significantly affected the male rate of courtship displays, but not sneaking behavior or gonoporal nibbles. This result suggests that changes in individual male behavior track the male size distribution within populations, recapitulating a pattern that has been shown across populations.
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Date Issued: 2017-04-28
Identifier: FSU_libsubv1_scholarship_submission_1493399548
Format: Thesis

Title: Legality, Ethics and Memory: The Role of American Physicians in Post-WWII Germany.
Creator: Abel, Liesa A.
Abstract/Description: This thesis addresses the responses and subsequent roles of American military physicians in Post- WWII Germany, from March 1945 to January 1950. Physician roles include medical practice both within and outside of their specialties, hospital administration, and work in Prisoner of War (POW) and Displaced Persons (DP) camps. Physicians treated trauma in their patients but also experienced trauma themselves; they also wrestled with conflicting feelings toward German civilians and former Nazis....
Show moreThis thesis addresses the responses and subsequent roles of American military physicians in Post- WWII Germany, from March 1945 to January 1950. Physician roles include medical practice both within and outside of their specialties, hospital administration, and work in Prisoner of War (POW) and Displaced Persons (DP) camps. Physicians treated trauma in their patients but also experienced trauma themselves; they also wrestled with conflicting feelings toward German civilians and former Nazis. Explored here are altruistic motives of physicians who treated POWs and DPs, as well as a contemporary assessment of the significance of their work.
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Date Issued: 2017-04-28
Identifier: FSU_libsubv1_scholarship_submission_1493385335
Format: Thesis

Title: The Inherent Absense of Feminist Values in Cosmopolitan, the "Women's Magazine," and How the Publication's Shift from Print to Online Publishing is Saving Their Feminist Readership.
Creator: Swantek, Samantha
Date Issued: 2017-04-28
Identifier: FSU_libsubv1_scholarship_submission_1493425446
Format: Thesis

Title: The role of compatibility in determining the costs and benefits of polyandry in the broadcast spawning urchin Lytechinus variegatus.
Creator: Betters, Melissa
Abstract/Description: When females mate with multiple males is a phenomenon known as polyandry. This is a strategy of sexual reproduction that presents both costs and benefits to female fitness. Mating with multiple males may maximize sperm availability and increase the likelihood of encountering a high-quality male. On the other hand, sperm may become overwhelming and result in polyspermy. With increasing mates, female could increase the risk of encountering low-quality males as well. The research presented in...
Show moreWhen females mate with multiple males is a phenomenon known as polyandry. This is a strategy of sexual reproduction that presents both costs and benefits to female fitness. Mating with multiple males may maximize sperm availability and increase the likelihood of encountering a high-quality male. On the other hand, sperm may become overwhelming and result in polyspermy. With increasing mates, female could increase the risk of encountering low-quality males as well. The research presented in this paper examined how these costs and benefits could potentially affect the fitness of individuals within a broadcast spawning population of marine urchins, Lytechinus variegatus. These organisms release their gametes into the water column, where fertilization occurs externally. This study attempted to examine how fertilization success was affected, if at all, by a female’s eggs encountering sperm from two different males in the water column rather than just one. Urchin color was also controlled for in order to see whether it may be used as a proxy for gametic compatibility between individuals. The data suggested that by pooling males together in the water column, rather than mating with one male at a time, the efficiency of fertilization increased. Therefore, it took less sperm to reach the same fertilization success when males were pooled together than when they were kept apart. Though assortative mating based on color was predicted, the data only showed evidence of this during the trials in which males were pooled together. When females were presented with a single male, male and female identity were instead the best predictors of compatibility.
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Date Issued: 2017-04-28
Identifier: FSU_libsubv1_scholarship_submission_1493414146
Format: Thesis

Title: The Relation Between Efficiency of Executive Function Involved in Running and Behaviors During Training and Competition.
Creator: Puig Kreis, Maria Mercedes
Date Issued: 2017-04-28
Identifier: FSU_libsubv1_scholarship_submission_1493412321
Format: Thesis

Title: Second Shell [FE4S4] Ligands in Sulfite Reductase Hemoprotein.
Creator: Cepeda, Marisa Raquel
Abstract/Description: Assimilatory sulfite reductase is an iron metalloenzyme found in Escherichia coli capable of reducing sulfite to sulfide through a six electron transfer reduction. Within this complex, eight flavoproteins transfer electrons to four hemoproteins that contain the active site. We are interested in determining a mechanism for this electron transfer and designed point variants F437A, M444A, and T477A to test whether they are potential electron acceptors on SiRHP. To probe this question,...
Show moreAssimilatory sulfite reductase is an iron metalloenzyme found in Escherichia coli capable of reducing sulfite to sulfide through a six electron transfer reduction. Within this complex, eight flavoproteins transfer electrons to four hemoproteins that contain the active site. We are interested in determining a mechanism for this electron transfer and designed point variants F437A, M444A, and T477A to test whether they are potential electron acceptors on SiRHP. To probe this question, complementation assays, activity assays, and electron paramagnetic resonance (EPR) spectroscopy were used to determine each residue’s involvement and structural importance to the complex. Activity assays showed that point mutagenesis of residue M444 decreased activity within the holoenzyme while electron paramagnetic resonance experiments showed that T477 may play an important structural role. Gel shift assays and x-ray crystallography will be used to further explore these questions related to how E. coli perpetuates sulfur’s bio-geo cycle in environments that lack sulfide.
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Date Issued: 2017-04-28
Identifier: FSU_libsubv1_scholarship_submission_1493407839
Format: Thesis

Title: A Search for Quantum Black Hole Production in Proton-Proton Collisions at sqrt(s) = 13 TeV Requiring Two High Energy Photons.
Creator: Tolbert, Steven William
Abstract/Description: This thesis searches for new physics at CMS in the form of microscopic black hole production at a minimum threshold of formation of 2.0 TeV. This analysis will examine data from Run II of the LHC with center-of-mass energy sqrt(s)=13 TeV, and an integrated luminosity of 12.9 +- 0.8 fb^-1. This is the first analysis to search for microscopic black hole production with the requirement of two high pT photons in the final state. After modeling backgrounds through low jet multiplicity control...
Show moreThis thesis searches for new physics at CMS in the form of microscopic black hole production at a minimum threshold of formation of 2.0 TeV. This analysis will examine data from Run II of the LHC with center-of-mass energy sqrt(s)=13 TeV, and an integrated luminosity of 12.9 +- 0.8 fb^-1. This is the first analysis to search for microscopic black hole production with the requirement of two high pT photons in the final state. After modeling backgrounds through low jet multiplicity control regions, no statistically significant excess is found in the signal region.
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Date Issued: 4/28/2017
Identifier: FSU_libsubv1_scholarship_submission_1493408195
Format: Thesis

Title: Women Warriors: Defending Aizu During the Boshin War (1868-1869).
Creator: Trumble, Erin
Abstract/Description: The role of 19th century Japanese women is often misinterpreted by the West. While the late Tokugawa period was certainly a patriarchy, women of the samurai class were commonly taught how to wield weapons and defend their homes. This is particularly evident in the Battle of Aizu Wakamatsu during the Boshin War where women were very active in the fighting. This study hopes to understand the culture around these women at the time of the battle, and also look at their place in contemporary...
Show moreThe role of 19th century Japanese women is often misinterpreted by the West. While the late Tokugawa period was certainly a patriarchy, women of the samurai class were commonly taught how to wield weapons and defend their homes. This is particularly evident in the Battle of Aizu Wakamatsu during the Boshin War where women were very active in the fighting. This study hopes to understand the culture around these women at the time of the battle, and also look at their place in contemporary popular culture. To investigate this, I have gathered and read secondary sources regarding women in Japan and their role among warriors. In addition, I traveled to Japan to find primary sources and to visit sites pertinent to my research, such as the Tsurugajo Castle in Aizu Wakamatsu. I have also begun reading the translation of the memoirs of one of the women who fought at Aizu, Yamamoto Yaeko. To learn of their portrayal in popular culture, I have read a manga and watched a Taiga Drama, both of which focus on telling the story of Yamamoto Yaeko. Thus far, my research demonstrates that it was fairly common for women of the samurai class to learn martial arts. However, it was less common that they would participate in actual battles and the women of Aizu and others like them appear to be the exception to the rule.
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Date Issued: 2017-04-27
Identifier: FSU_libsubv1_scholarship_submission_1493409157
Format: Thesis

Title: Exploring the Influence of Digital Media on the Automotive Industry.
Creator: Scherer, Amanda Nicole
Abstract/Description: The author presents a literature review and analysis of the influence of digital media on the automotive industry. Since the beginning of the automotive industry in the 1890s and the introduction of the first affordable Model T automobile by Henry Ford in 1908, the automotive industry has experienced exponential growth from a few hundred sales the first few years to the current sales volume of approximately 75 million automobiles sold worldwide each year. For the first one hundred years, the...
Show moreThe author presents a literature review and analysis of the influence of digital media on the automotive industry. Since the beginning of the automotive industry in the 1890s and the introduction of the first affordable Model T automobile by Henry Ford in 1908, the automotive industry has experienced exponential growth from a few hundred sales the first few years to the current sales volume of approximately 75 million automobiles sold worldwide each year. For the first one hundred years, the automotive industry relied on traditional media such as print publications including newspapers, magazines, and brochures, analog television, radio, and billboards as the primary means of information and communication distribution to the public. With the emergence of computers, the Internet, mobile devices, and web browsers, the automotive industry has made a dramatic shift from utilizing traditional media to reach consumers and has pivoted to embrace digital media (new media). Websites, blogs, social media, smart phone apps, computer multimedia, online databases, video games, and augmented reality allow companies to reach and interact with consumers as digital content is rapidly and easily accessed using digital devices and offers on-demand availability through the Internet. The search methodology for this paper was performed primarily using automotive industry sources, the Internet, Florida State University library, Google Scholar, and a variety of online research tools. In searching for how traditional and digital media have influenced the automotive industry, a clear trend emerged after 1995 which involved how consumers utilize computers and the Internet to assist them in seeking automobile information. Currently, approximately 90% of adults use the Internet, 60% of adults own a smartphone such as an Apple iPhone, and over 70% of adults use online resources for research and information. The author discovered that traditional media sources have declined in importance as consumers now rely on digital media sources such as Google, automotive review websites, social media, blogs, YouTube, automotive manufacturer websites, and smartphone apps as their primary source of automotive information. As individuals add to the worldwide wealth of knowledge and experience via user generated content social media resources such as Facebook, Instagram, and automotive blogs, the automotive industry will continue to shift their resources away from traditional media sources and focus more on digital media to include current and future trends to reach new consumers and serve their existing customers.
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Date Issued: 2017-04-27
Identifier: FSU_libsubv1_scholarship_submission_1493345144
Format: Thesis

Title: Implementing Bootstrap Resampling for Sequential Process Monitoring of Functional Data.
Creator: Archer, Andrew J.
Abstract/Description: In many fields of statistical research, statisticians are challenged in producing risk limited, bias controlled data near instantaneously. For instance, in the area of signal detection, there exists a need to process mass quantities of data in a short time frame while simultaneously detecting the time at which a change in the process occurs. This has been a daunting task for many analytics professionals. Hawkins et al. (2003) outlined the traditional implementation of control charts for...
Show moreIn many fields of statistical research, statisticians are challenged in producing risk limited, bias controlled data near instantaneously. For instance, in the area of signal detection, there exists a need to process mass quantities of data in a short time frame while simultaneously detecting the time at which a change in the process occurs. This has been a daunting task for many analytics professionals. Hawkins et al. (2003) outlined the traditional implementation of control charts for process monitoring. Charts including the cumulative sum and exponentially weighted moving average control chart were introduced as standard methods for identifying and monitoring process shifts. Unfortunately, these methods are limited by the need to estimate parameters, or are limited by simplifying parameters and known error distributions. To confront this challenge, we propose the use of a nonparametric method for process modeling of functional data that incorporates a variety of resampling methods.
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Date Issued: 2017-04-27
Identifier: FSU_libsubv1_scholarship_submission_1493346509
Format: Thesis

Title: Homotopy Type Theory, Univalent Foundation, and Binary Trees.
Creator: Beauvile, Robed
Date Issued: 2017-04-27
Identifier: FSU_libsubv1_scholarship_submission_1493325849
Format: Thesis

Title: The History of Britain and the European Union.
Creator: Crenshaw, Alexandra Marie
Date Issued: 2017-04-27
Identifier: FSU_libsubv1_scholarship_submission_1493330474
Format: Thesis

Title: The Effects of Sex, Handedness, and Additional Morphological Features on the Chela Crushing Force of Callinectes Sapidus.
Creator: Martin, Drew Michael
Abstract/Description: This study investigated the relationships between the brachyuran Callinectes sapidus chela bite force and morphological features, consisting of carapace width, propodus length, propodus width, propodus height, and area of the adductor apodeme. Over the course of about seven months, Atlantic blue crabs were collected and observed for morphometric measurements and other characteristics, such as sex and handedness. In addition, chela bite force was quantified for each claw using a bite force...
Show moreThis study investigated the relationships between the brachyuran Callinectes sapidus chela bite force and morphological features, consisting of carapace width, propodus length, propodus width, propodus height, and area of the adductor apodeme. Over the course of about seven months, Atlantic blue crabs were collected and observed for morphometric measurements and other characteristics, such as sex and handedness. In addition, chela bite force was quantified for each claw using a bite force transducer. Using single linear regression analyses and the Akaike information criterion (AIC), the relationships of chela crushing force and morphological features were examined. When the maximum force values and the morphological values of both crusher and cutter chelae were combined within the same dataset, propodus height was determined to have the strongest correlation with maximum crushing force. However, when data from crusher and cutter chelae were examined separately, the best predictor of maximum crushing force was found to be propodus width. Analysis of covariance (ANCOVA) statistics were utilized to determine whether maximum crushing forces significantly differed between right and left handed crabs, crusher and cutter chelae, and males and females. Force did not significantly differ between male and female chelae of the same propodus width, but did significantly differ between crusher and cutter chelae. There was a significant interaction between handedness and claw type (P < 0.001); right-handed crabs generated higher crushing claw force; handedness was not apparent in cutter claws. All C. sapidus reared individuals have been previously found to exhibit a right-handed crusher and left-handed cutter layout; however, when the crusher is lost, the left cutter transitions to a new crusher. The results of the significant interaction of chela type and handedness suggests that transitioned crushers exert a lesser force than an original right-handed crusher of the same size. The largest chela bite force recorded in this study was a considerable 291.62 Newtons of force, exceeding any maximum crushing force measurements documented in previous literature and establishing a new upper limit of the crushing force C. sapidus could produce.
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Date Issued: 2017-04-27
Identifier: FSU_libsubv1_scholarship_submission_1493334856
Format: Thesis

Title: Water Waves Over a Step: Experiments, Simulations, and Freak Events.
Creator: Bolles, Craig Tyler
Abstract/Description: This thesis presents an investigation on the effect of variable topography on surface gravity wave statistics. We focus our attention to the simplest case of variable topography, a piece-wise constant bottom with only two depths. We use a well known semi-analytical solution method for such a topographic profile to calculate surface statistics. In the course of implementation, we saw it fit to provide a convergence analysis for the method not yet seen in any literature. We then consider waves...
Show moreThis thesis presents an investigation on the effect of variable topography on surface gravity wave statistics. We focus our attention to the simplest case of variable topography, a piece-wise constant bottom with only two depths. We use a well known semi-analytical solution method for such a topographic profile to calculate surface statistics. In the course of implementation, we saw it fit to provide a convergence analysis for the method not yet seen in any literature. We then consider waves randomly generated on the deep side of a deep to shallow bathymetry profile with a fixed set of statistics and observe how these statistics change with depth using both experiments and simulations. Our findings confirm the role of nonlinear topographic induced instabilities in the generation of 'freak' waves in the vicinity of the depth change.
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Date Issued: 2017-04-27
Identifier: FSU_libsubv1_scholarship_submission_1493325467
Format: Thesis

Title: Public Private Partnerships and the Advent of 2008.
Creator: Cramer, Holly Ann
Abstract/Description: In the transportation industry it has become increasingly common to use public private partnerships as a method for funding, designing, and managing transportation infrastructure. Though the concept was hardly discussed in the United States throughout the 20th century, since the Great Recession that took hold in 2008, public private partnerships have become heavily legislated and regulated in an unprecedented manner to not only encourage their use but also so that many states may ensure...
Show moreIn the transportation industry it has become increasingly common to use public private partnerships as a method for funding, designing, and managing transportation infrastructure. Though the concept was hardly discussed in the United States throughout the 20th century, since the Great Recession that took hold in 2008, public private partnerships have become heavily legislated and regulated in an unprecedented manner to not only encourage their use but also so that many states may ensure strict guidelines of their application so as to not risk any public losses. Increases in overall public private partnership enabling policies and the simultaneous introduction of new regulations have been the primary affects of the financial crisis on the alternative transportation financing option.
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Date Issued: 2017-04-27
Identifier: FSU_libsubv1_scholarship_submission_1493311467
Format: Thesis

Title: North Atlantic and Northeast Pacific Tropical Cyclone Intensity Comparison Using Integrated Kinetic Energy.
Creator: Carstens, Jacob
Abstract/Description: The Integrated Kinetic Energy (IKE) of tropical cyclones (TCs) in the Northeast Pacific (NEP) basin is computed from the Extended Best Track Dataset from 2004-2013. Analysis of extreme terciles is conducted based on the IKE values of the TCs and compared with those of the North Atlantic (AL) basin. Analysis reveals that large (small) IKE TCs in the NEP basin are generally in the open waters (closer to coast), have their genesis closer to the equator (more latitudinal diversity), have a more...
Show moreThe Integrated Kinetic Energy (IKE) of tropical cyclones (TCs) in the Northeast Pacific (NEP) basin is computed from the Extended Best Track Dataset from 2004-2013. Analysis of extreme terciles is conducted based on the IKE values of the TCs and compared with those of the North Atlantic (AL) basin. Analysis reveals that large (small) IKE TCs in the NEP basin are generally in the open waters (closer to coast), have their genesis closer to the equator (more latitudinal diversity), have a more zonal motion of TC (meridional component of motion is significant), and prevalent in the later part of the season (no preferred time of the season). The comparison with the TCs of the AL basin reveals qualitatively similar characteristics of the extreme terciles based on their IKE values. However, there are salient differences in the IKE characteristics of TCs between the two basins, which are highlighted by the contrast in the rainfall volumes within the gale strength wind radii of the TCs. The TCs of the NEP basin carry much lower rainfall volumes than their AL counterparts, in addition to generally having lower IKE. Furthermore, we have developed a linear regression equation to predict the rainfall volume of the TC from its IKE value. This equation tends to predict rainfall volume reasonably well from IKE in a perfect prognostic approach, with some subtle differences in its performance between the two basins.
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Date Issued: 2017-04-27
Identifier: FSU_libsubv1_scholarship_submission_1493267526
Format: Thesis

Title: No Money, No Problem: A PR Template for Nonprofits.
Creator: Hudson, Malory Ann
Abstract/Description: The purpose of this research was to uncover patterns and information that would assist in the creation of a preliminary public relations template for nonprofit organizations. The goal was to provide a guideline for nonprofits to effectively utilize when needing public relations. The research employed two surveys for the study. The initial survey targeted PR professionals, and was created to investigate patterns in nonprofit PR implementation. The second survey questioned the general public,...
Show moreThe purpose of this research was to uncover patterns and information that would assist in the creation of a preliminary public relations template for nonprofit organizations. The goal was to provide a guideline for nonprofits to effectively utilize when needing public relations. The research employed two surveys for the study. The initial survey targeted PR professionals, and was created to investigate patterns in nonprofit PR implementation. The second survey questioned the general public, and worked to understand how audiences use social and traditional media. The data was analyzed using the Statistical Package for the Social Sciences (SPSS) software. From the results, several patterns in PR methods were discovered, along with greater understanding of the general public’s usage of media outlets. The research concluded with five guiding steps to effective nonprofit PR implementation – (1) understand why the nonprofit organization is utilizing PR, (2) create key messages, (3) understand the competition, (4) understand the obstacles (5) know the media outlets most employed by target audience.
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Date Issued: 2017-04-27
Identifier: FSU_libsubv1_scholarship_submission_1493298308
Format: Thesis

Title: Analyzing the Relationship Between Vocabulary Size and the Duration and Accuracy of Response of English Learners.
Creator: Timm, Catherine Christine
Abstract/Description: English Learners with slow vocabulary development take longer to comprehend text than English-speaking monolinguals. This is a significant problem for many students who are learning English as a second language and it is important that we best assist English Learners to prevent delays within the classroom. The purpose of this study is to analyze how children’s vocabulary size correlates with the duration and accuracy of their response. This study analyzes 20 students ages 5-6, and uses eye...
Show moreEnglish Learners with slow vocabulary development take longer to comprehend text than English-speaking monolinguals. This is a significant problem for many students who are learning English as a second language and it is important that we best assist English Learners to prevent delays within the classroom. The purpose of this study is to analyze how children’s vocabulary size correlates with the duration and accuracy of their response. This study analyzes 20 students ages 5-6, and uses eye tracking technology to measure response time. Contrary to previous studies, a correlation between vocabulary size and duration of response was not found. Our findings did show a correlation between vocabulary size and accuracy of response, and English Learners portrayed a stronger performance than English-speaking monolinguals on the eye tracking task. Through these findings, we are better able to understand the impact of vocabulary size on English Learners to aid English Learners academically and socially.
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Date Issued: 2017-04-27
Identifier: FSU_libsubv1_scholarship_submission_1493304250
Format: Thesis

Title: Relations Among Narrative Lexical Diversity and Expressive/ Receptive Vocabulary of Young English Learners.
Creator: De Novi, Natasha
Abstract/Description: English learner students are a growing population within the United States public school system. These students are seen to consistently score lower on educational assessments compared to their English-speaking monolingual peers. However, many assessments tests used are standardized tests that were norm-referenced on an English-speaking monolingual population. Consequently, language differences are often considered language deficits due to a lack of understanding about language development...
Show moreEnglish learner students are a growing population within the United States public school system. These students are seen to consistently score lower on educational assessments compared to their English-speaking monolingual peers. However, many assessments tests used are standardized tests that were norm-referenced on an English-speaking monolingual population. Consequently, language differences are often considered language deficits due to a lack of understanding about language development among ELs. The purpose of this study was to learn more about the developmental patterns and relationships among ELs’ narratives and vocabulary skills to ensure accurate assessment and academic success. Twelve Spanish-speaking ELs and nine English-speaking monolinguals in Kindergarten produced a narrative retell and received expressive/ receptive vocabulary scores. The number of different words (NDW) in the narrative samples was compared to all participants’ English-only expressive/ receptive vocabulary and the ELs’ conceptual expressive/ receptive vocabulary. The results revealed a significant relationship between NDW in the narratives and English-only expressive vocabulary. Further research would be beneficial to better understand the relationship between ELs’ narratives and vocabulary skills to help support accurate assessments among ELs.
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Date Issued: 2017-04-27
Identifier: FSU_libsubv1_scholarship_submission_1493303099
Format: Thesis

Title: Historical Trends in Molecular Clock Dating Estimates of Divergence Dates in Published Studies.
Creator: Sabra, Rachael
Date Issued: 2017-04-27
Identifier: FSU_libsubv1_scholarship_submission_1493325638
Format: Thesis

Title: Institutional Persistence: Colonial Legacies and Corruption.
Creator: Joseph, Joan Vicki
Abstract/Description: Extant research on the enduring effects of colonialism overestimate the effect of national colonial identities. I introduce a more conceptually sound measure of colonialism that observes variation within—instead of between—colonial empires, departing from standard practice in the literature. I present a typology that differentiates between settler colonialism and mercantilism and argue that these differences have important explanatory power for the observed variation in present-day corruption...
Show moreExtant research on the enduring effects of colonialism overestimate the effect of national colonial identities. I introduce a more conceptually sound measure of colonialism that observes variation within—instead of between—colonial empires, departing from standard practice in the literature. I present a typology that differentiates between settler colonialism and mercantilism and argue that these differences have important explanatory power for the observed variation in present-day corruption. To account for a possible source of endogeneity, I isolate latitude as an exogenous component of states’ history and exploit differences in latitude as an instrument for my typology.
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Date Issued: 2017-04-27
Identifier: FSU_libsubv1_scholarship_submission_1524852570_c340ed40
Format: Thesis

Title: The Impact of Fusion Oncoprotein TCF3-PBX1 on Aberrant Replication Timing in Pediatric Acute Lymphoblastic Leukemia.
Creator: Somasundaram, Vivek
Abstract/Description: During S-phase of mitosis a cell must duplicate its genome before dividing. This process, referred to as DNA replication, occurs in a highly regulated and spatiotemporal manner in eukaryotic cells and is called the Replication Timing program. Moreover this process of Replication Timing (RT) is extensively conserved in eukaryotic cells, occurring in manner that is unique and specific to each cell type. In cells derived from disease states RT is perturbed, particularly in cancers, which have...
Show moreDuring S-phase of mitosis a cell must duplicate its genome before dividing. This process, referred to as DNA replication, occurs in a highly regulated and spatiotemporal manner in eukaryotic cells and is called the Replication Timing program. Moreover this process of Replication Timing (RT) is extensively conserved in eukaryotic cells, occurring in manner that is unique and specific to each cell type. In cells derived from disease states RT is perturbed, particularly in cancers, which have aberrant RT profiles that substantially deviate from healthy cell counterparts. One specific subtype of the blood cancer Leukemia, referred to as Acute Lymphoblastic Leukemia (ALL), is of particular interest as some of these cells have been shown to express a unique oncoprotein not found in healthy leukocytes. This protein is thought to play a key role in leukemogenesis, thus reducing its expression may in turn ameliorate some of aberrancies seen in leukemic RT profiles. This study will present a method for reducing expression of this oncoprotein in order to measure the necessity of the fusion oncoprotein for the altered RT seen in patients expressing this oncoprotein.
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Date Issued: 2017-04-27
Identifier: FSU_libsubv1_scholarship_submission_1493346648
Format: Thesis

Title: Characterization of small molecule inhibitors of Zika Virus infection.
Creator: Allen, Chase Terrance
Abstract/Description: Zika virus (ZIKV) is a mosquito-transmitted positive RNA sense virus that has spread rapidly in the past year, prompting the World Health Organization (WHO), on 1 February 2016, to announce that the association of Zika infection with clusters of microcephaly and other neurological disorders constituted a Public Health Emergency of International Concern1. The state of emergency eventually ended in November of 2016; however, given the global health concern posed by this virus, a large-scale...
Show moreZika virus (ZIKV) is a mosquito-transmitted positive RNA sense virus that has spread rapidly in the past year, prompting the World Health Organization (WHO), on 1 February 2016, to announce that the association of Zika infection with clusters of microcephaly and other neurological disorders constituted a Public Health Emergency of International Concern1. The state of emergency eventually ended in November of 2016; however, given the global health concern posed by this virus, a large-scale effort to identify drugs for treating ZIKV and combatting its continued spread is of utmost importance. There are currently no drugs or vaccines for the treatment or prevention of ZIKV infection, although at least one vaccine study is scheduled for stage II/IIb clinical trials. This vaccine is currently being developed by the National Institute of Allergy and Infectious Diseases (NIAID), a branch of the National Institutes of Health (NIH). Although this vaccine study is underway, it is still highly advantageous to have small molecule inhibitors because whether or not this vaccination will produce susceptibilities to secondary flavivirus infections is still unknown42. The urgency that this situation provides led us and others to look to test preexisting drugs for efficacy against ZIKV infection. In attempt to close this gap in treatment and prevention we, in collaboration with Dr. Wei Zheng and others at the National Center for Advanced Translational Sciences (NCATS), previously reported a screen of 6,000 compounds for anti-ZIKV activity. In this study, we identified several compounds with sub-micromolar anti-ZIKV activity in a cell-culture based model, including the FDA approved anthelmintic drug Niclosamide. Niclosamide proved to be capable of inhibiting ZIKV replication at ~0.2μM concentrations, in vitro, when added either before or after ZIKV exposure2. In order to pursue additional potential drugs, our collaborative efforts have, in total, screened over 80,000 compounds for anti-ZIKV activity. Of these, we have selected several compounds for characterization, based on multiple factors: initial antiviral activity in a ZIKV viral protein (non-structural protein 1) detection assay, cytotoxicity profiles, and US Food and Drug Administration (FDA) approval status or previous in vivo safety profiles via human clinical trials. Attempts to further characterize the anthelmintic drug Niclosamide as well as efforts to identify several more compounds for antiviral activity were explored in a cell culture based ZIKV model for efficacy against ZIKV infection and drug anti-ZIKV mechanism of action. My results demonstrate the efficacy of these screening techniques, identify potential compounds for anti-ZIKV drug development, and provide preliminary insights on the selected drug mechanisms of action.
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Date Issued: 2017-04-27
Identifier: FSU_libsubv1_scholarship_submission_1493319376
Format: Thesis

Title: Imagined Indigeneity: Portrait of Moctezuma and the Construction of Creole Identity.
Creator: Bias, Andrea Summer
Date Issued: 2017-04-26
Identifier: FSU_libsubv1_scholarship_submission_1493231251
Format: Thesis

Title: Scared to Death to Travel: A TMT Investigation.
Creator: Cervantes, Tabitha
Date Issued: 2017-04-26
Identifier: FSU_libsubv1_scholarship_submission_1493230244
Format: Thesis

Title: Analysis of Beta Decay Curves and Gamma-Ray Polarization from Compton Scattering Using C++ Programming.
Creator: Holt, Hannah Louise
Abstract/Description: One issue that arises when performing experimental nuclear physics research at different laboratories is the lack of ubiquity between programs that handle the output of the data acquisition systems. This paper presents two new C++ programs that were created specific to the XIA system at LeRoy Collins Research Laboratory. A program geared for the study of γ-ray polarization was designed and tested using data from excited Neon-20 γ emissions. Using the other new program to look at β decay, the...
Show moreOne issue that arises when performing experimental nuclear physics research at different laboratories is the lack of ubiquity between programs that handle the output of the data acquisition systems. This paper presents two new C++ programs that were created specific to the XIA system at LeRoy Collins Research Laboratory. A program geared for the study of γ-ray polarization was designed and tested using data from excited Neon-20 γ emissions. Using the other new program to look at β decay, the mean lifetime of Potassium-38 β+ decay was confirmed. Having these simple, yet specific, executables will allow individuals to study these topics in a more rigorous way.
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Date Issued: 2017-04-26
Identifier: FSU_libsubv1_scholarship_submission_1493351227
Format: Thesis

Title: Exploration of Deep Learning Methods for Vector Boson Fusion Event Discrimination.
Creator: Sanchez, Alejandro Mario
Abstract/Description: In the past, the discrimination of Higgs boson events from background events has been done with the introduction of clever variables to make discrimina- tion easier for machine learning methods. By using a complex neural network with two hidden layers and a stochastic optimizer algorithm called Adam, I can discriminate Higgs Boson events from non-Higgs events with a receiver oper- ating characteristic (ROC) score of 0.961 and a validation accuracy score of 94.4% using the raw data alone. I...
Show moreIn the past, the discrimination of Higgs boson events from background events has been done with the introduction of clever variables to make discrimina- tion easier for machine learning methods. By using a complex neural network with two hidden layers and a stochastic optimizer algorithm called Adam, I can discriminate Higgs Boson events from non-Higgs events with a receiver oper- ating characteristic (ROC) score of 0.961 and a validation accuracy score of 94.4% using the raw data alone. I also attempted to discriminate those Higgs events that were produced by the process of Vector Boson Fusion (VBF), and achieved a ROC score of 0.858 and a validation score of 79.7%. Although not as high a score as the Higgs/non-Higgs discrimination, the correct choice of raw data variables outperformed the historical clever variables used for this discrimination task. These results confirm something that it intuitively ob- vious, namely, that all the information about events is contained in the raw data and can be extracted directly with a sufficiently smart machine learning algorithm. A lot of time currently goes into designing clever variables for these purposes, but, in the future, computers will be able to discriminate with no need of these clever variables, allowing researchers to spend less time de- signing complicated, clever, variables and more time inventing better ways to analyze data for new physics.
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Date Issued: 2017-04-26
Identifier: FSU_libsubv1_scholarship_submission_1493403077
Format: Thesis

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