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- Title
- Evaluating Disinhibition and Decision-making Using a BART Task.
- Creator
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Bowns, Rachel
- Abstract/Description
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The present study assessed decision-making in a Balloon Analogue Risk Task as related to Triarchic Psychopathy Measure disinhibition. This study used two versions of the BART task, an automatic and a manual task. Paired samples t-tests were used to evaluate differences in participant responses between-tasks, as well as within-tasks after win trials and after loss trials. Repeated measures ANOVAs were used to assess effects of tasks and previous trial outcome on number of pumps and inter-pump...
Show moreThe present study assessed decision-making in a Balloon Analogue Risk Task as related to Triarchic Psychopathy Measure disinhibition. This study used two versions of the BART task, an automatic and a manual task. Paired samples t-tests were used to evaluate differences in participant responses between-tasks, as well as within-tasks after win trials and after loss trials. Repeated measures ANOVAs were used to assess effects of tasks and previous trial outcome on number of pumps and inter-pump-interval (IPI) as well as interactions with TriPM disinhibition. Further exploratory analyses were conducted to assess for similar interactions with TriPM boldness. TriPM disinhibition was only found to impact the number of pumps or IPI in the manual task. Both TriPM disinhibition and TriPM boldness were found to have unique impacts on the number of pumps after win and after loss in the manual task. These results suggest that TriPM disinhibition may impact behavior on tasks which require slowed, multi-step decision making.
Show less - Date Issued
- 2019-12-05
- Identifier
- FSU_libsubv1_scholarship_submission_1575565934_18576552
- Format
- Thesis
- Title
- Age, growth, and maturity of the gafftopsail catfish, Bagre marinus, in Northwest Florida.
- Creator
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Miguez, Joseph Simonet
- Abstract/Description
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The gafftopsail catfish, Bagre marinus, is a particularly abundant species of marine, mouthbrooding catfish found throughout the Gulf of Mexico. In this study, the age, growth, and maturity of this species was determined for a population within Apalachicola Bay, a large highly productive estuary in Northwest Florida designated as a National Estuarine Research Reserve. New age, growth, and maturity data presented for B. marinus is relevant as the continued exploitation of highly sought-after...
Show moreThe gafftopsail catfish, Bagre marinus, is a particularly abundant species of marine, mouthbrooding catfish found throughout the Gulf of Mexico. In this study, the age, growth, and maturity of this species was determined for a population within Apalachicola Bay, a large highly productive estuary in Northwest Florida designated as a National Estuarine Research Reserve. New age, growth, and maturity data presented for B. marinus is relevant as the continued exploitation of highly sought-after species in the Gulf of Mexico is likely to lead to the development of a fishery targeting B. marinus similar to the marine catfish fisheries of Central and South America. A total of 235 specimens were sampled in this study between April 2018 to August 2019. Age determination through use of counting the growth bands of lapillal otoliths yielded an age range of 1 to 25 years old for females and 1 to 14 years old for males. Growth was modeled with five different length-at-age models with sexes being modeled independently. Akaike information criterion corrected for a small sample size (AICc) was used to directly compare models and determine most appropriate model for the data presented. For females in this study it was found that the two three-parameter von Bertanlanffy growth models (k = 0.171 0.015, L∞ = 515.03 7.50 mm (fork length, FL)) yielded the best fits for the length at age data of the females with strong support also for the Gompertz model (k = 0.217 0.016, L∞ = 507.84 6.37 mm (FL)). For males in this study, all models excluding the two-parameter von Bertanlanffy growth model exhibited comparable fits of the data with the logistic model yielding the best fit for males (k = 0.429 0.056, L∞ = 470.31 11.55 mm (FL)). Maturity ogives calculated within this study suggest that age-at-maturity was 3 years old for females and 2 years old for males. Age and growth results in this study differed from those estimated for other populations of B. marinus in the Gulf of Mexico.
Show less - Date Issued
- 2019-12-04
- Identifier
- FSU_libsubv1_scholarship_submission_1575488199_9b0508c4
- Format
- Thesis
- Title
- Capturing the Disruption in the Circadian Clock During Carcinogenesis Using a Simplified Quantitative Framework.
- Creator
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Murray, Tyson Todd
- Abstract/Description
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The circadian rhythm is important for the regulation of many cellular functions in mammals. Central control of the circadian rhythm is located in the suprachiasmatic nucleus in the hypothalamus; however, individual peripheral cells also have a similar circadian clock. The disruption of these cellular clocks have been implicated in the development of cancers and other metabolic and behavioral disorders. Over 95% of breast cancers have a disturbance in the core circadian clock protein, Period....
Show moreThe circadian rhythm is important for the regulation of many cellular functions in mammals. Central control of the circadian rhythm is located in the suprachiasmatic nucleus in the hypothalamus; however, individual peripheral cells also have a similar circadian clock. The disruption of these cellular clocks have been implicated in the development of cancers and other metabolic and behavioral disorders. Over 95% of breast cancers have a disturbance in the core circadian clock protein, Period. Specifically noted in the composition proteins Period1 (Per1), Period2 (Per2), Period3 (Per3), or Cryptochrome (Cry). These changes are highly correlated with methylation of the Per or Cry promoters and are thought to enhance carcinogenesis. One of the mechanisms of carcinogenesis may be through interactions with p53, a known tumor suppressor, and Per2. However, both Per1 and Per3 have also been implicated in carcinogenesis though their mechanisms are less well studied. Per1 is found to have a role in the cell division cycle and sensitizes cells for apoptosis induced by DNA damage. Per3 is located in a frequently deleted genetic region of ER+ breast cancers. A model has been developed that captures the behavior of the circadian rhythm at the peripheral cellular level in silico focusing on the four genes outlined above. This model is based on the biological interactions of each gene and data collected on the expression of the four proteins.
Show less - Date Issued
- 2019-11-18
- Identifier
- FSU_libsubv1_scholarship_submission_1575655981_7ea67fec
- Format
- Thesis
- Title
- Economic Globalization and Within-Country Income Inequality.
- Creator
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Nicolai, Kevin
- Abstract/Description
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Using year to year OLS, pooled OLS, and fixed effects models, it is found that economic globalization, as measured by rates of international trade and foreign direct investment, does not have a statistically significant relationship with within-country income inequality.
- Date Issued
- 2019-11-15
- Identifier
- FSU_libsubv1_scholarship_submission_1574363661_17abdb28
- Format
- Thesis
- Title
- Effect of Mild Traumatic Brain Injury in a Model of Attention Deficit Hyperactivity Disorder.
- Creator
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Cea Salazar, Valentina Isidora
- Abstract/Description
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Attention Deficit Hyperactivity Disorder (ADHD) can interfere with daily life due to inattention, impulsivity, and hyperactivity. Mild traumatic brain injury (mTBI), or concussion, can cause a number of post-concussive symptoms such as depression, anxiety, and headaches. Repetitive concussion appears to have more severe consequences. We hypothesized that repetitive concussion exacerbates the behaviors associated with ADHD or vice versa. To test this hypothesis four groups of mice were used: 1...
Show moreAttention Deficit Hyperactivity Disorder (ADHD) can interfere with daily life due to inattention, impulsivity, and hyperactivity. Mild traumatic brain injury (mTBI), or concussion, can cause a number of post-concussive symptoms such as depression, anxiety, and headaches. Repetitive concussion appears to have more severe consequences. We hypothesized that repetitive concussion exacerbates the behaviors associated with ADHD or vice versa. To test this hypothesis four groups of mice were used: 1) mice that received anesthesia only (control), 2) mice exposed to nicotine in their drinking water during gestation and throughout the pre-weaning period (ADHD), 3) mice that received one concussion per day for five days under anesthesia at approximately 60 days of age (mTBI), and 4) ADHD mice that received a 5 concussions (ADHD+ mTBI). The n for each group was 8-12. Behavioral testing for attention, depression, anxiety, spatial working memory, and recognition memory was conducted before and after TBI was performed. mTBI caused short term attention deficits, but did not exacerbate attention deficits associated with ADHD. mTBI also did not exacerbate deficient in spatial working memory associated with ADHD. However, the combination of ADHD and mTBI resulted in depression that was not seen independently in either model, suggesting a synergistic effect of ADHD and mTBI on depression that should be the focus of future work.
Show less - Date Issued
- 2019-11-04
- Identifier
- FSU_libsubv1_scholarship_submission_1556327928_c2e19c25
- Format
- Thesis
- Title
- Serial Implantation Study of NICD Induced Tumor in Drosophila.
- Creator
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Portilla, Juan-Martin
- Abstract/Description
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Thanks to both the homology of crucial cancer related genes between Drosophila melanogaster and humans, along with easily manipulatable gene expression of D. melanogaster; the fly is aphenomenal model to study cancer. The recent discovery of a new tumor model in the Drosophila salivary gland imaginal ring has allowed for the enhanced characterization of this tumor via its implantation into host flies. Utilizing this implantation technique, we deduced the initial overgrowths true tumorigenic...
Show moreThanks to both the homology of crucial cancer related genes between Drosophila melanogaster and humans, along with easily manipulatable gene expression of D. melanogaster; the fly is aphenomenal model to study cancer. The recent discovery of a new tumor model in the Drosophila salivary gland imaginal ring has allowed for the enhanced characterization of this tumor via its implantation into host flies. Utilizing this implantation technique, we deduced the initial overgrowths true tumorigenic potential, along with quantifying a metastasis-like phenotype. By serially implanting the tumor into new hosts periodically, the progression and evolution of this tumor has been tracked using single cell RNA sequencing, antibody staining, electron microscopy, and the continued quantification of metastasis-like phenotype. Along with the pursuit of the establishment of a cell line, this study aims to better characterize this tumor and elucidate the characteristics of an initially weakly metastatic tumor’s descent into elevated malignancy.
Show less - Date Issued
- 2019-11-04
- Identifier
- FSU_libsubv1_scholarship_submission_1556555204_4f13c38e
- Format
- Thesis
- Title
- Relationship Between Parenting Styles and Dissociative Symptoms in Children Between 6 and 8 Years-Old.
- Creator
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Cormier, Caeli Virginia
- Abstract/Description
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Parenting styles are known to influence a child’s development, the present study investigates the relationship between parenting factors and child dissociative symptoms. Seventy parents and their children were participants in this study. Schludermann and Schludermann’s Child Report of Parent Behavior Inventory and Putman and colleagues’ Child Dissociative Checklist were measures used in the study. A simultaneous regression suggests that parental psychological control was predictive of child...
Show moreParenting styles are known to influence a child’s development, the present study investigates the relationship between parenting factors and child dissociative symptoms. Seventy parents and their children were participants in this study. Schludermann and Schludermann’s Child Report of Parent Behavior Inventory and Putman and colleagues’ Child Dissociative Checklist were measures used in the study. A simultaneous regression suggests that parental psychological control was predictive of child dissociative symptoms, while parental firmness inversely predicted child dissociative symptoms. Results suggest that parental factors may be influential on the development of dissociative symptoms in children.
Show less - Date Issued
- 2019-10-13
- Identifier
- FSU_libsubv1_scholarship_submission_1570977679_f1d40382
- Format
- Thesis
- Title
- The Essentials of Mukashibanashi: A study of motifs & morals in Japanese folk tales.
- Creator
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Wadhams, Erin
- Abstract/Description
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In order to construct a compelling story, it is always important to have a map for guidance. When the story in question is a folk tale from Japan, it is especially important to have an accurate guide, collected and distilled from a study of the body of works in the field—both scholarly and creative—in order to construct a story that is authentic. My final piece follows the general plot structure of Japanese folk tales, contains several common motifs, expresses moral values that are typical of...
Show moreIn order to construct a compelling story, it is always important to have a map for guidance. When the story in question is a folk tale from Japan, it is especially important to have an accurate guide, collected and distilled from a study of the body of works in the field—both scholarly and creative—in order to construct a story that is authentic. My final piece follows the general plot structure of Japanese folk tales, contains several common motifs, expresses moral values that are typical of Japanese folk tales and, of course is written in Japanese, utilizing grammatical structures essential to folk tales. While existing works on Japanese folk tales seek to categorize them or examine certain individual elements such as the “heavenly wife” motif or the nature of animals within the folk tales, I have created a piece and accompanying guide that acts as a broader survey of what makes up a Japanese folk tale that can be applicable to most existing tales and help non-specialists and foreign readers understand the essential parts of mukashibanashi. In order to construct an authentic folk tale of my own, I integrated four types of research that allowed me to examine structure, motifs, moral lessons, and grammar and language. I built upon Alan Miller’s study of the plot structure of the “heavenly wife” tales in order to create a general plot progression applicable across a broad range of Japanese folk tales. Using Yanagita Kunio and Seki Keigo’s indices of folk tales, I was able to determine common motifs across a broad array of folk tales. I synthesized work by Nelly Tchalakova and Motoko Fujihiro Huthwaite on ethic norms in Japanese folk literature to create an index of common moral values and lessons that appear in folk tales. Finally, by reading the both original and translated texts of a selection of folk tales, I was able to identify important grammatical trends and make determinations about readership demographic and language expectations for my own work. Using this body of research, I was able to write an original folk tale that is an average of my findings on these four topics.
Show less - Date Issued
- 2019-09-18
- Identifier
- FSU_libsubv1_scholarship_submission_1556306620_82268d7b
- Format
- Thesis
- Title
- Oxytocin and metabolic tissue: An analysis of OXTR in skeletal muscle and lipid size and density in surrounding adipose tissue.
- Creator
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Aiken, Romy Maxine, Greenwood, Maria, Hammock, Elizabeth
- Abstract/Description
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The neuropeptide oxytocin (OXT) is most commonly associated with parturition, lactation, and social behavior but also modulates eating behaviors and homeostatic metabolic processes. Existing research relating metabolic disorders to OXT suggest a role for OXT in regulating the physiology of metabolic tissues. The implications of this role are relevant to Prader-Willi Syndrome (PWS), a genetic disorder which includes a deficit of OXT-producing neurons in the paraventricular nucleus of the...
Show moreThe neuropeptide oxytocin (OXT) is most commonly associated with parturition, lactation, and social behavior but also modulates eating behaviors and homeostatic metabolic processes. Existing research relating metabolic disorders to OXT suggest a role for OXT in regulating the physiology of metabolic tissues. The implications of this role are relevant to Prader-Willi Syndrome (PWS), a genetic disorder which includes a deficit of OXT-producing neurons in the paraventricular nucleus of the hypothalamus, obesity, hypotonia, and hyperphagia. The purpose of this study is to assess the presence of oxytocin receptors (OXTR) in the skeletal muscles of neonatal OXTR wildtype and knockout mice and consider genotype-dependent differences in surrounding adipose tissue. Image analysis for OXTR in muscle was performed on archived autoradiographic samples and associated anatomical cresyl violet stains from 20 μm sagittal slices of postnatal day 0 (P0) whole body OXTR wild-type (WT) and OXTR knock-out (KO) mice. Quantification of radioligand binding in regions of interest (forelimb, hindlimb, and masseter muscles) revealed higher OXTR binding in OXTR-KO males than wildtype males across regions while OXTR-WT females demonstrate higher binding across regions than wildtype males. BODIPY lipid staining of neonatal OXTR-WT and OXTR-KO mice suggest density of lipid droplets in adipose tissue above forelimb does not differ between knock-outs and wildtypes. Failed immunofluorescence staining of EGFP-OXTR transgene positive and negative P0 mice fixed with liquid and vapor paraformaldehyde (PFA) prompted investigation of vapor fixation protocol to optimize endogenous fluorescence. Endogenous fluorescence in trigeminal ganglion of OXTR-EGFP transgene positive and negative mice fixed for varying incubation periods was inconclusive and requires further investigation.
Show less - Date Issued
- 2019-08-02
- Identifier
- FSU_libsubv1_scholarship_submission_1564745984_47eee70d
- Format
- Thesis
- Title
- Development of a Novel In Vitro Brain Tumor Model for Ultra-High Field Magnetic Resonance.
- Creator
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Kynast, Nicholas M.
- Abstract/Description
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Glioma is a common form of brain cancer, with over 20,000 new cases each year. As is the problem with many fast-growing cancers, the development of drug resistance is a major obstacle to treatment. While we have previously developed an in vivo, sodium MR-based, non-invasive imaging biomarker that permits the detection and monitoring of chemoresistance, the study of the mechanisms of chemoresistance would be significantly enhanced by the development of an MR-compatible model of chemoresistance...
Show moreGlioma is a common form of brain cancer, with over 20,000 new cases each year. As is the problem with many fast-growing cancers, the development of drug resistance is a major obstacle to treatment. While we have previously developed an in vivo, sodium MR-based, non-invasive imaging biomarker that permits the detection and monitoring of chemoresistance, the study of the mechanisms of chemoresistance would be significantly enhanced by the development of an MR-compatible model of chemoresistance. Thus, the goal of this project was to develop an in vitro model of glioma that can be evaluated in real-time by sodium MR using the 900 MHz, 21.1 Tesla magnet at the National High Magnetic Field Laboratory. The studies reported in this thesis outline our initial steps to the development of not only a model that is compatible with ultra-high field strength MR, but one that can be subjected to chemotherapeutic agents while undergoing both sodium and diffusion MR.
Show less - Date Issued
- 2019-07-26
- Identifier
- FSU_libsubv1_scholarship_submission_1564162212_b8279510
- Format
- Thesis
- Title
- The Legislative Effectiveness of Women Under Gender Quotas: Argentina Before and After Quota Implementation.
- Creator
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Cake, Hannah Rae
- Abstract/Description
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In the field of politics and gender, political scientists have been keenly interested in legislative gender quotas: how they are adopted, how they place women into positions of power, and whether they change the descriptive, substantive, and formal representation of women. In this paper, I expand upon previous research by assessing the legislative effectiveness of women under gender quotas. I examine the legislative effectiveness of male and female Members of Congress (MCs) in the Argentine...
Show moreIn the field of politics and gender, political scientists have been keenly interested in legislative gender quotas: how they are adopted, how they place women into positions of power, and whether they change the descriptive, substantive, and formal representation of women. In this paper, I expand upon previous research by assessing the legislative effectiveness of women under gender quotas. I examine the legislative effectiveness of male and female Members of Congress (MCs) in the Argentine Senate and the Chamber of Deputies as defined by their ability to pass legislation both before and after the implementation of a national legislative gender quota. Contrary to much of the previous literature, I find that both before and after gender quota implementation, women MCs appear to surpass male MCs in their legislative effectiveness.
Show less - Date Issued
- 2019-07-26
- Identifier
- FSU_libsubv1_scholarship_submission_1564169854_8d8cfc1d
- Format
- Thesis
- Title
- Preparation of High Quality Junctions on SmB6 for Planar Tunneling Spectroscopy.
- Creator
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Sittler, Jennifer Ann
- Abstract/Description
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Samarium hexaboride (SmB6) belongs to an interesting class of quantum matter known as topological Kondo insulators. To investigate its detailed topological nature, we have adopted planar tunneling spectroscopy. Tunnel junctions were made by oxidizing the SmB6 crystal itself for a barrier and evaporating strips of Pb as counter-electrodes. When superconducting Pb is used as a counter-electrode, the tunneling conductance spectra of high quality junctions revealed asymmetrical coherence peaks as...
Show moreSamarium hexaboride (SmB6) belongs to an interesting class of quantum matter known as topological Kondo insulators. To investigate its detailed topological nature, we have adopted planar tunneling spectroscopy. Tunnel junctions were made by oxidizing the SmB6 crystal itself for a barrier and evaporating strips of Pb as counter-electrodes. When superconducting Pb is used as a counter-electrode, the tunneling conductance spectra of high quality junctions revealed asymmetrical coherence peaks as well as an additional peak at ~ 5 mV. These features were attributed to inelastic tunneling processes involving the emission and absorption of spin excitons [1,2]. Improving the junction quality even further would allow for measurements of the second harmonic, which may reveal detailed information about the spin excitons. In this work, the effects of two different surface cleaning methods, plasma cleaning and ion beam etching, are investigated. Although the junction quality is also shown to depend heavily on the plasma oxidation conditions, the surface cleaning step was shown to be essential and both methods were able to produce conductance spectra with the expected SmB6 features. Comparing the data to simulations based on the Blonder-Tinkham-Klapwijk model, several junctions were shown to have a weak barrier strength. Additionally, these same junctions typically had higher junction resistances. Such seemingly contradictory observations may be explained by considering a barrier containing layers of suboxides in addition to the stoichiometric oxide, B2O3. [1] W. K. Park, L. Sun, A. Noddings, D. -J. Kim, Z. Fisk, and L. H. Greene, P. Natl. Acad. Sci. USA 13, 6599 (2016). [2] L. Sun, D. -J. Kim, Z. Fisk, and W. K. Park, Phys. Rev. B. 95, 195129 (2017).
Show less - Date Issued
- 2019-07-24
- Identifier
- FSU_libsubv1_scholarship_submission_1564022158_f4b80854
- Format
- Thesis
- Title
- Prejudicial Processing: An Investigation of the Role of Prejudice and Bias on the Fluency Effect.
- Creator
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Cryderman, Jacob Joseph
- Abstract/Description
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The present study examines the fluency effect and factors which may influence its prevalence. The fluency effect is a phenomenon first reported by Keysar (2010) that purports that people attribute less believability to those with accented speech as opposed to those with native accents, despite the content of speech being identical. The fluency effect is thought to be due to language processing efficiency alone, rather than to any influence outside of the language processing system. This claim...
Show moreThe present study examines the fluency effect and factors which may influence its prevalence. The fluency effect is a phenomenon first reported by Keysar (2010) that purports that people attribute less believability to those with accented speech as opposed to those with native accents, despite the content of speech being identical. The fluency effect is thought to be due to language processing efficiency alone, rather than to any influence outside of the language processing system. This claim, however, is untested. The present study first replicates the experiment conducted by Keysar (2010) where participants were asked to listen to trivia facts and indicate whether they are true or false. Participants were then asked to complete measures for additional potential influencing factors. The additional factors of interest for this project are the prejudicial views and biases of the participants as measured by the Feeling Thermometer and the Implicit Association Test respectively. In contrast to earlier work, this study showed no evidence of a fluency effect. The study also showed no evidence that prejudices and biases affected the participants’ responses to statements by different speakers.
Show less - Date Issued
- 2019-07-22
- Identifier
- FSU_libsubv1_scholarship_submission_1563819521_5dbb1081
- Format
- Thesis
- Title
- End of Year Spending: The Use-It or Lose-It Dilemma: A Case Study of the U.S. Department of State's Costly Habit.
- Creator
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Pimentel Marte, Omar Jose
- Abstract/Description
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The use-it or lose-it dilemma has haunted the expiring budget fiscal year spending model since its inception. The United States Government, specifically the U.S. Department of State*, has consistently performed as a last-minute budget spender and arguably reliant on this habit. This research project incorporates thousands of federal contracts that have been made public from the U.S. Department of State thanks to the efforts of OpenTheBooks.com. By submitting countless Freedom of Information...
Show moreThe use-it or lose-it dilemma has haunted the expiring budget fiscal year spending model since its inception. The United States Government, specifically the U.S. Department of State*, has consistently performed as a last-minute budget spender and arguably reliant on this habit. This research project incorporates thousands of federal contracts that have been made public from the U.S. Department of State thanks to the efforts of OpenTheBooks.com. By submitting countless Freedom of Information Act requests, the organization has compiled this data for general distribution. This study focuses on the expenditures incurred by the U. S. Department of State to observe, recognize, and highlight the trends that most commonly occur as the fiscal year comes to a close. My project provides pertinent information about where there may be potential for a policy shift to address use-it or lose-it in our government – hopefully, one day, saving taxpayers billions of dollars.
Show less - Date Issued
- 2019-07-17
- Identifier
- FSU_libsubv1_scholarship_submission_1564511782_3e1e8774
- Format
- Thesis
- Title
- Evaluating worry controllability, physiological arousal, and working memory through a worry induction task.
- Creator
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Gorday, Julia Ylan
- Abstract/Description
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Background: Pathological worry is considered to be excessive, pervasive, and uncontrollable; which has been found to be a transdiagnostic factor related to other conditions including anxiety, depression, and suicidality. Worry controllability specifically was related to each of these conditions. However, more research is needed to better understand the role perceived controllability of worry plays. The present study aimed to examine perceived controllability of worry and its influences on...
Show moreBackground: Pathological worry is considered to be excessive, pervasive, and uncontrollable; which has been found to be a transdiagnostic factor related to other conditions including anxiety, depression, and suicidality. Worry controllability specifically was related to each of these conditions. However, more research is needed to better understand the role perceived controllability of worry plays. The present study aimed to examine perceived controllability of worry and its influences on physiological responses and working memory before and after a novel worry induction task.Methods: Participants were 105 individuals (75.2% female, 24.8% male), aged 18 to 60 years (M = 21.26 , SD = 7.70). Participants completed a two-part study where they were randomized into a worry induction or control group. All participants completed measurements of self-report, skin conductance level, working memory, and executive functioning. Participants in the experimental group underwent a personalized worry induction task, as opposed to a neutral task (control group). Results: Results indicated that the worry induction task induced a greater negative affect in the experimental condition, compared to the control group. Further results indicated that there were no significant relationships between physiological arousal, executive functioning, or working memory with experimental group; moreover, these relationships were not moderated by worry controllability. Limitations: This study was underpowered, utilized a cross-sectional design, and did not collect clinical diagnostic information.Conclusions: Overall, those who experienced the worry induction task showed no significant differences in physiological arousal, executive functioning, or working memory as compared to those in the control condition, regardless of their perceived ability to control their own worries. Future studies should recruit a larger, clinical sample of participants and utilize a mixed-methods approach to symptom assessment.
Show less - Date Issued
- 2019-07-08
- Identifier
- FSU_libsubv1_scholarship_submission_1563986084_04d1bb90
- Format
- Thesis
- Title
- An Analysis of ERK/RSK Activation of Kaposi’s Sarcoma-Associated Herpesvirus ORF45 Homologues.
- Creator
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Brown, Miranda J
- Abstract/Description
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Kaposi’s Sarcoma Herpesvirus (KSHV) is an oncogenic virus that causes human malignancies, including Kaposi Sarcoma, multicentric castleman disease, and primary effusion lymphoma. KSHV is a gammaherpes virus of the genus Rhadinovirus, which all contain tegument proteins. KSHV ORF45 is one such protein that is critical in production of viral progeny during lytic replication, and is an immediate early gene in viral infection. The ORF45 protein of gammaherpesvirinae has multiple functions,...
Show moreKaposi’s Sarcoma Herpesvirus (KSHV) is an oncogenic virus that causes human malignancies, including Kaposi Sarcoma, multicentric castleman disease, and primary effusion lymphoma. KSHV is a gammaherpes virus of the genus Rhadinovirus, which all contain tegument proteins. KSHV ORF45 is one such protein that is critical in production of viral progeny during lytic replication, and is an immediate early gene in viral infection. The ORF45 protein of gammaherpesvirinae has multiple functions, including inhibition of IRF-7 and prolonged activation of the MAPK/ERK pathways. In KSHV, ORF45 can activate extracellular signal-regulated kinase (ERK) and p90 ribosomal kinase (RSK) to form a complex with pERK and pRSK to prolong their phosphorylation and their abilities to transcribe DNA for viral progeny. In order to better understand the functions of ORF45, we are interested in exploring the ability of other gammaherpes homologues of KSHV ORF45 to activate ERK and RSK. In addition, we wish to better understand how the ability to activate ERK and RSK relates to the amino acid sequence of each homologue, and how expression of pERK and pRSK correlates to phylogeny. By comparing homologues’ amino acid sequences and activation, further insight into the important process of how KSHV replicates in the cell can lead to future studies on how to prevent the formation of viral progeny in live hosts such as humans. We found that activation of ERK and RSK, and therefore levels of pERK and pRSK, varies greatly between different homologues of KSHV ORF45. In addition, levels of pERK and pRSK do have some correlation to differences in the amino acid sequences of ERK and RSK binding sites of ORF45. Lastly, we observed that closely related homologues on the phylogenetic tree have similar levels of phosphorylated ERK and RSK, demonstrating a pattern between ancestry and ability to form pERK and pRSK complexes.
Show less - Date Issued
- 2019-05-07
- Identifier
- FSU_libsubv1_scholarship_submission_1557282997_781f22dc
- Format
- Thesis
- Title
- Women in the Age of the Hundred Years War.
- Creator
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Cannon, Jonathan William
- Abstract/Description
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This paper is an analysis on the autonomy and depiction of women in the Later Middle Ages. It will cover a period of over a hundred years with specific attention paid to the literature in this time period, which will be further supported by secondary sources to resolve gaps of knowledge. This was also the period in which the Hundred Years War (1337-1453) was waged and from where the English and French case studies of this paper originate. This century is important for context in the Later...
Show moreThis paper is an analysis on the autonomy and depiction of women in the Later Middle Ages. It will cover a period of over a hundred years with specific attention paid to the literature in this time period, which will be further supported by secondary sources to resolve gaps of knowledge. This was also the period in which the Hundred Years War (1337-1453) was waged and from where the English and French case studies of this paper originate. This century is important for context in the Later Middle Ages as this was a point in history that had a number of key events such as the Black Death as well as being one of the best preserved in terms of sources available.What this paper uncovered was that while in the Later Middle Ages women from both upper and lower classes were able to a certain extent act as independent agents; this was not reflected in the contemporary literature until towards the end of this period. By the end of this period however there was an increasing number of women that were detailed and credited for their actions without being compared to their male relatives, as being described as virtuous (as opposed to evil) because of their feminine traits, and that more classes of women were being represented within the literature.
Show less - Date Issued
- 2019-05-03
- Identifier
- FSU_libsubv1_scholarship_submission_1557433266_a2827df1
- Format
- Thesis
- Title
- Influence of Trait and State Anxiety on Visual Signal Detection.
- Creator
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Carbello, Destiny
- Abstract/Description
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Anxiety pathology has been associated with hyperactivity and differences in perception of sensory stimuli. Anxiety may impact how well the perceiver can block out irrelevant or repeated stimuli, or respond when a target image is presented. Previous studies have focused on anxious individuals favor in detecting threatening stimuli. The current study looks to understand sensory events with the absence of a threat and the relation between visual signal detection, trait anxiety, and state anxiety...
Show moreAnxiety pathology has been associated with hyperactivity and differences in perception of sensory stimuli. Anxiety may impact how well the perceiver can block out irrelevant or repeated stimuli, or respond when a target image is presented. Previous studies have focused on anxious individuals favor in detecting threatening stimuli. The current study looks to understand sensory events with the absence of a threat and the relation between visual signal detection, trait anxiety, and state anxiety. Typically, visual signals are detected when a stimulus is presented. However, individuals with anxiety pathology have shown a deficiency in their ability to accurately detect signals. Male and female undergraduate students will take part in a 3-stimuli oddball task, mood ratings, and experience an anxiety induction paradigm to tease apart these potential effects. Results showed the interaction of state and BIS on d’ was insignificant (F(1,21) = 2.682, p=.11). However, the interaction of state and BIS on d’ showed a medium, positive trend (r=.34) suggesting that subject higher on the BIS scale had an improvement on their visual signal detection. Additionally, the mean false alarm rate decreased pre (M = 5.65, SD = 8.13) to post (M = 3.47, SD = 3.86), suggesting that subject improved on ignoring distractors once induced with a state of anxiety.
Show less - Date Issued
- 2019-05-02
- Identifier
- FSU_libsubv1_scholarship_submission_1556816751_434b005d
- Format
- Thesis
- Title
- Understanding my Heritage Through the Deconstruction of Social Dance: With a Focus on Cuban Salsa (Casino).
- Creator
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Cobblah Gutierrez, Melissa
- Abstract/Description
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This research consists of an exploration and deconstruction of the Cuban dance form casino as a solo practice, to continue the investigation and development of my choreographic process while simultaneously understanding better my roots as a Cuban native. Another point of interest is to have a better understanding of the connection that can exist between social and concert dance. One of the main objectives is to start provoking and inciting more discussions about this dance genre that has...
Show moreThis research consists of an exploration and deconstruction of the Cuban dance form casino as a solo practice, to continue the investigation and development of my choreographic process while simultaneously understanding better my roots as a Cuban native. Another point of interest is to have a better understanding of the connection that can exist between social and concert dance. One of the main objectives is to start provoking and inciting more discussions about this dance genre that has played such a significant role in the Cuban population, throughout time. Eventually this could inspire others to go further in the study and deconstruction of this rich form that is vaguely researched and written about.This project is done to satisfy the Honors in the Major program requirement.
Show less - Date Issued
- 2019-05-01
- Identifier
- FSU_libsubv1_scholarship_submission_1556739102_88669087
- Format
- Thesis
- Title
- Dissecting KSHV ORF45 Functional Domains In The Antagonism Of The Host Antiviral Innate Immune Response.
- Creator
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Taylor, Michael Evan
- Abstract/Description
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Kaposi’s Sarcoma-associated Herpesvirus is a ɣ-herpesvirus known to cause 3 types of human cancers. Herpesviruses are effective at bypassing the host innate immune system. Recent studies have revealed the role of caspases, critical apoptotic proteins, in the inhibition of the innate immune response through cleavage of dsDNA pattern recognition receptors (PRRs) and associated pathway proteins. Extracellular Signal-Regulated Kinase (ERK/MAPK) is known to upregulate apoptotic conditions when its...
Show moreKaposi’s Sarcoma-associated Herpesvirus is a ɣ-herpesvirus known to cause 3 types of human cancers. Herpesviruses are effective at bypassing the host innate immune system. Recent studies have revealed the role of caspases, critical apoptotic proteins, in the inhibition of the innate immune response through cleavage of dsDNA pattern recognition receptors (PRRs) and associated pathway proteins. Extracellular Signal-Regulated Kinase (ERK/MAPK) is known to upregulate apoptotic conditions when its expression or activation is uncontrolled. KSHV tegument and immediate-early protein ORF45 is important for the sustained activation of ERK and RSK and the optimal production of infectious progeny. In this work, I reveal that KSHV ORF45 progresses SLK and HEK293 cells to intrinsic apoptosis, however, the related HEK293T cells are found to be resistant to ORF45 toxicity. Interestingly, the related MHV68 ORF45 is not toxic in all cell types tested, as a result MHV68 ORF45 may prove to be a valuable control to further elucidate the mechanism of toxicity. Using internal deletion mutants, I show that overexpression of KSHV ORF45 progresses cells to intrinsic apoptosis due to the sustained activation of ERK and RSK. Further, show that caspase cleavage, downstream of KSHV ORF45 ERK/RSK toxicity, cleaves proteins of the cGAS dsDNA sensing pathway to reduce the upregulation of Interferons consistent with previous literature.
Show less - Date Issued
- 2019-04-29
- Identifier
- FSU_libsubv1_scholarship_submission_1556304000_6d91358a
- Format
- Thesis
- Title
- Phronesis as Authorial Know-how: A Play on the Art of Living a Well Written Story.
- Creator
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Carpenter, Jennifer
- Abstract/Description
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A Letter to the Audience Before I draw the curtain and release the philosophical coddiwomple that follows, I would like to take this time to reflect on its coming to be and, hopefully, explain myself to the audience. A preemptive rundown and a warning (or two) of what this project is meant to be--and why I've chosen to write it in this way--will be helpful in understanding what’s going on. To start, I’d like to ward off any high expectations for traditional order or strict structure to my...
Show moreA Letter to the Audience Before I draw the curtain and release the philosophical coddiwomple that follows, I would like to take this time to reflect on its coming to be and, hopefully, explain myself to the audience. A preemptive rundown and a warning (or two) of what this project is meant to be--and why I've chosen to write it in this way--will be helpful in understanding what’s going on. To start, I’d like to ward off any high expectations for traditional order or strict structure to my creative project: I make no claim to the exactness or completeness to the words written here. Of course I suppose my argument could have been made by writing a regular paper, and probably with less words at that, and, to justify this piece of thoughtful whimsy, I’ll start by answering this obvious question that the reader might find themselves asking--why didn't I? It's a fair question. There are so many ways I would like to address this question, but I’ll try to constrain myself to the most topical. First, in the most blunt way: I've get lyrically restless writing philosophy in the prescribed formats and sometimes adhering to strict contextual expectations can restrict the writer on a thoughtful quest. I long for the days when philosophers were allowed a bit of creative freedom in getting their thoughts out there; mostly relying on their own thinking and just writing it in the way they wanted. I feel restrained by rules of philosophical writing, at times, and I think this subject beckons for me to stretch my imagination and ignore (for the moment) the need to follow a certain path of inquiry. This reason, for the unorthodox method that I take, address the less than straightforward way I go about putting forth my case: lives are not straightforward. Nothing about by subject is straightforward. Our lives, conduct and even characters are barely legible to us. Once more, our thoughts are not like he standard philosophical paper--not really. Academic papers (strictly academic) are crafted y stepping outside oneself to edit. Our thoughts do not chug along like a train down one track, at least mine do not. It's more like flying a kite. I have this idea, storytelling as the art of living, and I release it letting the thought mingle with my other beliefs, desires, and goals. The control I have the kite is minimal, just a flimsy piece of plastic and a big of string. Every once in a while a gust of whimsy blows by and takes my kid away, then, I have to slowly gain back control by guiding into a better position. As the reader will experience in the arupt way in which conversations end and begin. It will help to see this piece as the writing process of what would be philosophy paper, refined for presentation. I wanted to represent this attitude in the setting of the lay, thus, I set my scene within the mind of a student reading Aristotle with my interlocutors being character manifestations of our student's different perspectives. Her multitudes, if you will, come together to interpret Aristotle's lesson for living well as a lesson in writing well; with one of them further arguing that his lesson is taught to convince us that is self-authorship is what makes a life well lived. As our student reads the relevant passages from Aristotle, lachessi presents her authorial analogy to the group: showing how authorship is practical wisdom and how this take on wisdom better informs us as to what happy people are doing. After Which the collective discusses Lachesis Second claim, that, Aristotle is telling us to become the author of our own stories. Finding the form that best fit the matter at hand is not an easy task; I struggled to find an appropriate vessel for discussion the art of living as the art of storytelling. I needed a narrative form, that relies on heavy dialogue, and one that would allow for me to incorporate quotes from the nicomachean ethics in a way that wouldn't interrupt the flow. I, also, wanted a writing style that could allow be to sway a bit from the course, in a relevant manner. A stage play is the practical choice for m project mostly because of its dialog aspect; and the organization's of acts and scene help to keep the dialogues as individual conversations that go together, yet, do not exactly merge seamlessly from topic to topic. This type allows me to connect Aristotle's Phronimos to the well written author and discuss how she embodies the notion of authoring her one's own life.
Show less - Date Issued
- 2019-04-27
- Identifier
- FSU_libsubv1_scholarship_submission_1524861087_cd109dd1
- Format
- Thesis
- Title
- Virtual Reality and the Digital Divide.
- Creator
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Dilanchian, Andrew Taylor
- Abstract/Description
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Each year, more innovative, and often more complicated, technology is released. While this poses little threat to most of the younger population (because of technology designers’ habit of catering to younger consumers, among other reasons), many older adults continue to play “catch-up” as they struggle to decipher newer devices. This situation is commonly referred to as the “digital divide.” This divide permeates into entertainment technology as well; the Entertainment Software Association ...
Show moreEach year, more innovative, and often more complicated, technology is released. While this poses little threat to most of the younger population (because of technology designers’ habit of catering to younger consumers, among other reasons), many older adults continue to play “catch-up” as they struggle to decipher newer devices. This situation is commonly referred to as the “digital divide.” This divide permeates into entertainment technology as well; the Entertainment Software Association (2017) reports that forty-six percent of gamers are younger adults (18-49) while only twenty-six percent are older adults (50+). Within the domain of gaming, even less is known about older adults’ adoption, perception of, and attitudes toward Virtual Reality gaming, and potential usability issues that might impact use and adoption. With that, this study is designed to examine how older adults compare to younger adults when using virtual reality, a relatively novel entertainment technology, and to determine how the novelty of this technology might impact age differences in factors that shape Virtual Reality (VR) use. We recruited twenty younger adults (18-29) as well as twenty older adults (65+). Each participant experienced the same virtual experiences using the HTC Vive. Of primary interest are the following factors: perceived realism of the virtual space, involvement in the virtual environment, general presence, and spatial presence. We were also interested in the perceived usability of the virtual reality system and any factors that would negatively affect the participant’s experience (i.e., frustration, mental, temporal, and physical demand, cyber sickness, etc.). We found that older and younger adults had generally similar experiences. Older adults, in some instances, experienced greater immersion and presence. Surprisingly, cyber sickness, which was expected to be a problem based on previous research, was low, and significantly lower for older adults.
Show less - Date Issued
- 2019-04-26
- Identifier
- FSU_libsubv1_scholarship_submission_1556133089_b1c0e18c
- Format
- Thesis
- Title
- Chernobyl: The Legasov Syndrome.
- Creator
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Blackwill, Colby
- Abstract/Description
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Through a series of short stories, interview transcripts, and a documentary film. The experience of Chernobyl and its affect on the concept of "home" is examined. This thesis includes a number of critiques of current art which covers Chernobyl and offers a more human and moral example.
- Date Issued
- 2019-04-26
- Identifier
- FSU_libsubv1_scholarship_submission_1556289216_502edb85
- Format
- Thesis
- Title
- Finite Jellium for Plasmonic Nanoparticles.
- Creator
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Gibney, Daniel Patrick
- Abstract/Description
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Restricted Hartree-Fock (RHF) theory has been used to investigate the optical properties of cubic nanoparticles, which can serve as a model for plasmonic nanoparticles, using a finite jellium model. Optical investigations were carried out using real-time time-dependent Hartree-Fock theory and configuration interaction with single excitations for validation against each other. An investigation was also carried out to determine the effect that the spatial symmetry of the system plays in the...
Show moreRestricted Hartree-Fock (RHF) theory has been used to investigate the optical properties of cubic nanoparticles, which can serve as a model for plasmonic nanoparticles, using a finite jellium model. Optical investigations were carried out using real-time time-dependent Hartree-Fock theory and configuration interaction with single excitations for validation against each other. An investigation was also carried out to determine the effect that the spatial symmetry of the system plays in the computational effort required to generate the necessary one and two electron integrals. Additionally, the spatial symmetry was investigated for its effect on the computational effort required to solve the ground state RHF equations. Throughout these investigations, convergence of the ground state was difficult to achieve and care must be taken even after convergence to ensure that the calculations have found the ground state.
Show less - Date Issued
- 2019-04-26
- Identifier
- FSU_libsubv1_scholarship_submission_1556287475_fdaecf89
- Format
- Thesis
- Title
- An Analysis of Maize Remains from Unit 258N 472E at San Luis de Talimali (8Le4).
- Creator
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Townsend, Taylor
- Abstract/Description
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What cultigens of maize were grown at San Luis de Talimali? What was their dietary importance to the mission’s inhabitants? Who cooked with the maize- just the Apalachee who grew the crops or the Spanish as well? What role did maize play in the blending of Apalachee and Spanish cultures during the mission period in La Florida? Maize was a staple of the Apalachee diet, and were one of the plants heavily relied on by the Spanish upon their arrival in the new World. San Luis was one of the...
Show moreWhat cultigens of maize were grown at San Luis de Talimali? What was their dietary importance to the mission’s inhabitants? Who cooked with the maize- just the Apalachee who grew the crops or the Spanish as well? What role did maize play in the blending of Apalachee and Spanish cultures during the mission period in La Florida? Maize was a staple of the Apalachee diet, and were one of the plants heavily relied on by the Spanish upon their arrival in the new World. San Luis was one of the wealthiest Spanish missions in La Florida and played a crucial role in the success of the Mission system. The farms associated with San Luis produced a majority of foodstuffs for the rest of the province, however, modest archaeobotanical research has been conducted on the site. The results of this research will give a clearer picture of how maize was incorporated into Spanish foodways during the Mission Period. This will be done by analyzing flotation samples and floor deposits from a Spanish home and its surrounding area. This study will utilize flotation samples and general floor deposits excavated in Spring 2018 by Florida State University, and a foundational analysis, Plant Remains from Council House and Church Complex, conducted by C. Margaret Scarry in 1992 to identify the remains. The presence of maize will be quantified by variety, function, and location.
Show less - Date Issued
- 2019-04-26
- Identifier
- FSU_libsubv1_scholarship_submission_1556300772_5b7f95df
- Format
- Thesis
- Title
- Macroevolution of the Wings and Legs in Drosophila.
- Creator
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Murray, Connor Sean, Houle, David, Steppan, Scott, Beerli, Peter
- Abstract/Description
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I describe the interspecific variation of the wings and legs across 31 different species of Drosophila. This project is an expansion of previous work on the interspecific variation of Drosophila wings (Houle et al., 2017). I wanted to understand if the wings and legs have similar rates of evolution. Using the ordinations of the wing and leg traits, I saw the trend that similarly related taxa were grouped more closely together when using the wing traits. Phylogenetic heritability scores...
Show moreI describe the interspecific variation of the wings and legs across 31 different species of Drosophila. This project is an expansion of previous work on the interspecific variation of Drosophila wings (Houle et al., 2017). I wanted to understand if the wings and legs have similar rates of evolution. Using the ordinations of the wing and leg traits, I saw the trend that similarly related taxa were grouped more closely together when using the wing traits. Phylogenetic heritability scores indicated that the wing traits follow the phylogeny better than the leg traits. These two findings were indirect evidence that the rates of evolution are different between the two appendages. A phylogenetic mixed model found that the leg traits are evolving more rapidly than the wings. There may be several ecological or developmental explanations for these findings. This project has the potential to better describe how development affects the evolutionary rates of different appendages. More importantly, this document can provide some insight into how to compare the rates of divergence in an interspecific model system.
Show less - Date Issued
- 2019-04-26
- Identifier
- FSU_libsubv1_scholarship_submission_1556284711_ecafcb46
- Format
- Thesis
- Title
- Assessing the Impact of the Nordic Model of Combating Prostitution.
- Creator
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McConnell, Olivia
- Abstract/Description
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The purpose of this paper is to better understand the Nordic Model of combating prostitution, why it is controversial, and its impacts on human trafficking and society overall. In order to properly address these topics, I conducted an extensive literature review and traveled to Sweden and France, where the Nordic Model was implemented in 1999 and 2016 respectively. While in Sweden and France, I conducted interviews with individuals familiar with the model, its legal codes, and its...
Show moreThe purpose of this paper is to better understand the Nordic Model of combating prostitution, why it is controversial, and its impacts on human trafficking and society overall. In order to properly address these topics, I conducted an extensive literature review and traveled to Sweden and France, where the Nordic Model was implemented in 1999 and 2016 respectively. While in Sweden and France, I conducted interviews with individuals familiar with the model, its legal codes, and its implementation. These individuals included lawyers, public prosecutors, police officers, nongovernmental organizations, and government officials. In synthesizing the information gleaned from these interviews as well as the literature review, I attempt to identify the impact of the model as well as the greater debate surrounding the ethics of the model. Additionally, I address the beneficial aspects of the model as well as its weaknesses, using this information to inform my critique of the model and my policy proposals.This paper is divided into five sections. Section one discusses the international legal background of human trafficking policy; section two discusses the Nordic Model itself and its legal codification in the various countries that implement it; section three discusses the abolitionist philosophy that underlies the Nordic Model, delving into the arguments of both abolitionists and pro-sex worker groups; section four offers a critique of the model; and section five provides various recommendations to improve the model and better address human trafficking.In employing qualitative research methods, such as reviewing theoretical discussions , legislative history, media, and conducting interviews, I find that while the Nordic Model is certainly an innovative means of addressing human trafficking, it is far from a panacea. Ultimately, additional measures must be taken to promote a holistic approach to combatting international trafficking in persons.
Show less - Date Issued
- 2019-04-26
- Identifier
- FSU_libsubv1_scholarship_submission_1556296893_68da91b5
- Format
- Thesis
- Title
- Partible Citizenship: Transnational Discourses of Belonging in Tijuana's Deported Communities.
- Creator
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Dennis, Taegan
- Abstract/Description
-
US military veterans deported to their country of origin in Mexico argue that since they have served in the country’s military they have proven their right to citizenship and its state benefits, especially the ability to live permanently on the northern side of the US-Mexico border. In comparison, nonveteran deportees believe that they have a claim to residence because of the years spent in the US and the family ties developed there. Using interviews from both deported veterans and deported...
Show moreUS military veterans deported to their country of origin in Mexico argue that since they have served in the country’s military they have proven their right to citizenship and its state benefits, especially the ability to live permanently on the northern side of the US-Mexico border. In comparison, nonveteran deportees believe that they have a claim to residence because of the years spent in the US and the family ties developed there. Using interviews from both deported veterans and deported nonveterans living in Tijuana, Mexico, this project explores how deportees argue for their “repatriation” to be reunited with their family in the US, destabilizing US assumptions of citizenship as legal monolith. Parallelling Marilyn Strathern’s (1988) concept of partible personhood in Melanesian gift exchanges, deportees attempt to reproduce the citizen/state transaction with the US to builds relations in order to secure their return, refashioning reciprocal exchanges as moral debts between states and citizens. Deported veterans’ ability to organize transnationally and alter US law—all the while formally excluded from its democracy—demonstrates a transnational, partible citizenship that circulates via US militarism and excludes other members of Mexico’s repatriated people. This project examines discourses of belonging from both deported veterans and deported nonveterans to argue for a partible citizenship that circulates via transnational networks of care.
Show less - Date Issued
- 2019-04-26
- Identifier
- FSU_libsubv1_scholarship_submission_1556300894_b4880611
- Format
- Thesis
- Title
- Cell Growth and Differentiation of P19 Cells In a 3D Bioprinted Scaffold.
- Creator
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Drulias, Nicholas R.
- Abstract/Description
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Sodium alginate (A) and gelatin (G) based hydrogels are used extensively for biomedical applications to mimic the tissues and scaffolds in which cells are placed to differentiate. The rheological properties of the underlying hydrogel play an important part in cell encapsulation and differentiation and in one’s ability to process the gels into useful structures. Of particular interest is 3D printing hydrogels into scaffolds which mimic the external matrix of a certain cell line and still...
Show moreSodium alginate (A) and gelatin (G) based hydrogels are used extensively for biomedical applications to mimic the tissues and scaffolds in which cells are placed to differentiate. The rheological properties of the underlying hydrogel play an important part in cell encapsulation and differentiation and in one’s ability to process the gels into useful structures. Of particular interest is 3D printing hydrogels into scaffolds which mimic the external matrix of a certain cell line and still maintain cell viability. In this work we rheologically characterize hydrogels of alginate and gelatin with aim of 3D printing scaffolds for P19 muscle line. Pre and post chemical crosslinking rheological experiments were conducted on hydrogels to identify properties that effect print ability and print uniformity. Hydrogels were chemically crosslinked using CaCl2 and it was found that 2.5%(w/w) gelatin – 7.5%(w/w) alginate experienced the highest level of crosslinking. In addition, this composition experienced the highest level of printability and showed the most promise for cell culturing P19 in a 3D printed bio scaffold.
Show less - Date Issued
- 2019-04-26
- Identifier
- FSU_libsubv1_scholarship_submission_1556303687_ed3a1947
- Format
- Thesis
- Title
- GLP-1R Role in Cognition and Mood.
- Creator
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Henderson, Natalie Lynn
- Abstract/Description
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Major Depressive Disorder (MDD) is a common mental illness that produces cognitive deficits in patients, hindering affected individuals from performing daily life activities. In 2017, 17.3 million adults had at least one episode of major depression and more than half of these patients also experienced cognitive impairments (National Survey on Drug Use and Health). Current pharmacotherapies for MDD are somewhat effective at treating symptoms related to affect but are not effective in treating...
Show moreMajor Depressive Disorder (MDD) is a common mental illness that produces cognitive deficits in patients, hindering affected individuals from performing daily life activities. In 2017, 17.3 million adults had at least one episode of major depression and more than half of these patients also experienced cognitive impairments (National Survey on Drug Use and Health). Current pharmacotherapies for MDD are somewhat effective at treating symptoms related to affect but are not effective in treating the cognitive impairments associated with MDD. A promising answer to an effective antidepressant pharmacotherapy for both core mood and cognitive symptoms is being sought in glucagon-like peptide-1 receptor (GLP-1R) agonists. Activation of this receptors plays a role in some types of learning and memory and increases hippocampal neurogenesis, a critical component of antidepressant efficacy. We utilized Progressive Ratio (PR), Spatial and Novel Object Recognition (SNOR) and Location Discrimination (LD) tasks to investigate motivation, spatial learning and memory, respectively. We hypothesize that GLP-1R activation enhances execution of these tasks. Our results demonstrate that GLP-1R activation enhances cognitive performance in the LD task in a sex-dependent manner and spatial learning in the SNOR task. These data indicate that GLP-1R has potential to treat cognitive impairment associated with MDD, but its role in improving motivational and mood aspects of MDD requires further investigation.
Show less - Date Issued
- 2019-04-26
- Identifier
- FSU_libsubv1_scholarship_submission_1556303918_622ab141
- Format
- Thesis
- Title
- Setting a baseline: Interannual variability of carbonate parameters in the western South Pacific.
- Creator
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Dailey, Emily M
- Abstract/Description
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Surface water samples collected in the western South Pacific Ocean in the austral fall of 2015, 2016, 2017, and 2018, and were used to characterize the variability of carbonate parameters in the region. The main goals of the study were to: 1) Identify if there was significant spatial variability of calcite and aragonite saturation state between temperature-defined sub-regions, and, 2) Identify the magnitudes of and mechanisms behind inter-annual changes in calcite and aragonite saturation...
Show moreSurface water samples collected in the western South Pacific Ocean in the austral fall of 2015, 2016, 2017, and 2018, and were used to characterize the variability of carbonate parameters in the region. The main goals of the study were to: 1) Identify if there was significant spatial variability of calcite and aragonite saturation state between temperature-defined sub-regions, and, 2) Identify the magnitudes of and mechanisms behind inter-annual changes in calcite and aragonite saturation state within each sub-region over the 2015-2018 period. The carbonate parameters within the South Pacific Subtropical Gyre remained relatively constant from 2015 through 2018. The Chatham Rise and Subtropical Front region to the east of New Zealand experienced slight increases in temperature and pH over the study period. Between 2015 and 2016, and between 2017 and 2018, there were significant decreases in total alkalinity (TA), while between 2016 and 2017, TA increased. Calcite and aragonite saturation state increased over the four-year study period. Based on sensitivity test results, changes in pH and TA impacted calcite and aragonite state most significantly. To accommodate the opposite sense of change in pH and TA, Ihypothesize that there was a large amount of nitrate-supported photosynthesis by calcifying phytoplankton in 2015-2016 and in 2017-2018, specifically, by the coccolith, E. Huxleyi, a species prolific in this region, and that in the 2016-2017 period, there may have been nitrate-supported photosynthesis by non-calcifying phytoplankton driving the increase in both pH and TA.
Show less - Date Issued
- 2019-04-26
- Identifier
- FSU_libsubv1_scholarship_submission_1556308787_7a82f03c
- Format
- Thesis