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Infiltration of Identical T Cell Repertoires in Multiple Organs with Autoimmunity in NOD Mice
Title
Infiltration of Identical T Cell Repertoires in Multiple Organs with Autoimmunity in NOD Mice.
Creator
Look, Sydney, Landry, Laurie, Williams, Theodore, Delong, Thomas, Haskins, Kathryn, Nakayama, Maki
Abstract/Description
Patients with one autoimmune disease, such as type 1 diabetes, are at a higher risk for developing additional autoimmune disease(s) than healthy individuals. Similarly, NOD mice spontaneously develop autoimmune diabetes and Sjögren’s syndrome. In addition to a genetic predisposition, we hypothesized that T cells activated in a primary organ may play a role in the development of secondary autoimmune diseases. To determine if and how often identical T cells infiltrate multiple targeted organs...
Show morePatients with one autoimmune disease, such as type 1 diabetes, are at a higher risk for developing additional autoimmune disease(s) than healthy individuals. Similarly, NOD mice spontaneously develop autoimmune diabetes and Sjögren’s syndrome. In addition to a genetic predisposition, we hypothesized that T cells activated in a primary organ may play a role in the development of secondary autoimmune diseases. To determine if and how often identical T cells infiltrate multiple targeted organs and whether the infiltration is antigen-specific, we analyzed T cell receptor (TCR) repertoires in pancreatic islets, salivary glands, and peripheral blood of NOD mice and tested reactivity of dual-infiltrating TCRs to these tissues. Salivary glands contained a higher frequency of overlapping TCR sequences with islets than peripheral blood (32.4 ± 11.3% with islets v.s. 13.1 ± 2.7% with peripheral blood, p=0.03). In addition, the single cell TCR analysis identified identical TCR pairs at the nucleotide level including a second alpha/beta sequence in both islets and salivary glands, indicating the presence of T cells derived from same monoclonal T cells in these organs. Six out of 7 TCRs found in both islets and salivary glands responded to islets but not to salivary glands. In conclusion, we demonstrated the significant proportion of identical T cells infiltrating pancreatic islets and salivary glands in NOD mice. However, the current study does not support the concept that T cells in an affected organ migrate to another due to antigen specificity.
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Date Issued
2016-11-14
Identifier
FSU_libsubv1_scholarship_submission_1479090170
Format
Citation
Team Clinic
Title
Team Clinic: A Group Approach to Care for Youth with Type 1 Diabetes.
Creator
Driscoll, Kimberly, Raymond, Jennifer, McClain, Megan Rose
Abstract/Description
Achieving adequate glycemic control in youth with type 1 diabetes (T1D) is poor as patients’ transition from pediatric to adult care. Shared medical appointments have shown to improve health outcomes and increase patient and provider satisfaction. Team Clinic is an innovative clinical care model that uses shared medical appointments and group sessions to provide developmentally targeted care to youth with T1D and their parents to maximize support. Through shared medical appointments, group...
Show moreAchieving adequate glycemic control in youth with type 1 diabetes (T1D) is poor as patients’ transition from pediatric to adult care. Shared medical appointments have shown to improve health outcomes and increase patient and provider satisfaction. Team Clinic is an innovative clinical care model that uses shared medical appointments and group sessions to provide developmentally targeted care to youth with T1D and their parents to maximize support. Through shared medical appointments, group sessions, and problem-solving interventions, Team Clinic aims to improve patient glycemic control; decrease patient stress; improve parent, provider, and patient satisfaction; and improve clinic efficiency. This randomized controlled trial enrolled 300 participants, middle and high school aged youth, with T1D and their parents who were either randomized to either routine care (i.e., no intervention) or intervention for four clinic visits occurring every 3 months. For those in the intervention group, youth are initially seen independently with a T1D provider for a routine physical exam. Then, youth and parents are separated into youth and parent groups aimed at increasing T1D knowledge, setting goals, and problem-solving common T1D challenges. After approximately one hour, youth and parents reconnect for a 20-30 minute appointment with their T1D provider. The intervention and data collection are ongoing.
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Date Issued
2016-10-13
Identifier
FSU_libsubv1_scholarship_submission_1478545073
Format
Citation
Where's the Food? Refining Food Desert Measures to More Accurately Reflect Local Access to Healthy Food and Incidence of Diet-Related Disease Deaths
Title
Where's the Food? Refining Food Desert Measures to More Accurately Reflect Local Access to Healthy Food and Incidence of Diet-Related Disease Deaths.
Creator
Wilson, Kellie O'Dare, Fazio, Michael, Morgan, Derek, Bloechle, Amber, Vinci, Debra, Gutierrez, Anasuya
Abstract/Description
Food is not optional. While Florida approximates the national average for household food insecurity, this number varies considerably by county. However, all counties in the Northwest Florida panhandle region experience food insecurity rates higher than both national and state averages. Although food insecurity is a complex issue caused by various factors, the problem is primarily driven by poverty and lack of local access to food (commonly known as “food deserts”). Furthermore, while...
Show moreFood is not optional. While Florida approximates the national average for household food insecurity, this number varies considerably by county. However, all counties in the Northwest Florida panhandle region experience food insecurity rates higher than both national and state averages. Although food insecurity is a complex issue caused by various factors, the problem is primarily driven by poverty and lack of local access to food (commonly known as “food deserts”). Furthermore, while virtually all experts in human nutrition agree that adequate consumption of fresh fruits and vegetables (FFV) is integral to a healthy diet and increased longevity, families living in food deserts experience severely restricted access to these items in particular. Given the relationship between lack of access to FFV and increased diet-related morbidity, this study employed quantitative and geospatial methods to examine the distribution of local food retailers that (1) offered a full service selection of FFV and (2) accepted SNAP payments, and examined the rate of diet-related deaths at the census tract level in Escambia and Santa Rosa counties. This study found a strong, positive correlation between number of non-full service food retailers (convenience, corner stores) and each form of diet related deaths. The higher the number of non full service stores per tract, the more diet related deaths. In addition, the strongest relationship is observed between diabetes and number of non-FFV retailers.
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Date Issued
2016-09-01
Identifier
FSU_libsubv1_scholarship_submission_1481210152
Format
Citation