Search results

Title: The "Demand Side" of General Education - A Review of the Literature: Technical Report Number 11.
Creator: Reardon, Robert C, Lenz, Janet G, Sampson, James P, Johnston, Joseph S, Kramer, Gary L
Abstract/Description: Much of the literature in general education is focused on the design or contents of the program, or the "supply side," while little attention has been given to students' understandings of and attitudes toward general education, the "demand side." This paper reviews literature on the "demand side" of general education by first providing a brief synopsis of the notion of general education and recent recommendations for reform, and next summarizing research on student knowledge of and attitudes...
Show moreMuch of the literature in general education is focused on the design or contents of the program, or the "supply side," while little attention has been given to students' understandings of and attitudes toward general education, the "demand side." This paper reviews literature on the "demand side" of general education by first providing a brief synopsis of the notion of general education and recent recommendations for reform, and next summarizing research on student knowledge of and attitudes toward higher education and general education. Because of the paucity of "demand side" research, the paper shifts focus to processes used in higher education to affect demand side questions, including teaching, recruitment and admissions, orientation, academic and career advising, and course scheduling. The paper ends with conclusions on the importance of attending to "demand side" issues in the improvement of general education programs.
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Date Issued: 1990-07-01
Identifier: FSU_libsubv1_scholarship_submission_1525887098_ce56a520, 10.17125/fsu.1525887098
Format: Citation

Title: "Poverty Porn": The Narratives of INGO Media Campaigns.
Creator: Costner, Monique, Kohli, Tanu
Abstract/Description: International non-governmental organizations (INGOs) have different strategies of raising awareness and funds for their causes. Sometimes however, these strategies can rely on the use of stereotypical or dehumanizing depictions of people from the developing world. We have all seen the images of hungry children with bloated stomachs, presumably from some African or Asian country. To what extent do these narratives present a grossly simplified version of the struggles people in poverty face?...
Show moreInternational non-governmental organizations (INGOs) have different strategies of raising awareness and funds for their causes. Sometimes however, these strategies can rely on the use of stereotypical or dehumanizing depictions of people from the developing world. We have all seen the images of hungry children with bloated stomachs, presumably from some African or Asian country. To what extent do these narratives present a grossly simplified version of the struggles people in poverty face? The term “poverty porn” has been coined to describe these kinds of shock-based images which reduce people to their vulnerability and helplessness. Narratives within INGO media campaigns can either contribute to, or combat stereotypical images of developing regions. The first section of this research will discuss representations of people from developing regions. Second, the research will examine strategies employed in several digital-based INGO media campaigns through their use of visual and verbal tools. Third, the research will analyze the ethical nature of media campaigns which contribute to or combat stereotypes. It is important for international non-governmental organizations and those within the field of international development to consider how communication strategies impact the understanding we have of developing regions. This research aims to look critically at INGO communications and provide best practices for organizations constructing their own media campaigns.
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Date Issued: 2018-05-04
Identifier: FSU_libsubv1_scholarship_submission_1525459187_d84adacc
Format: Citation

Title: "Poverty Porn": The Narratives of INGO Media Campaigns.
Creator: Costner, Monique, Kohli, Tanu
Abstract/Description: International non-governmental organizations (INGOs) have different strategies of raising awareness and funds for their causes. Sometimes however, these strategies can rely on the use of stereotypical or dehumanizing depictions of people from the developing world. We have all seen the images of hungry children with bloated stomachs, presumably from some African or Asian country. To what extent do these narratives present a grossly simplified version of the struggles people in poverty face?...
Show moreInternational non-governmental organizations (INGOs) have different strategies of raising awareness and funds for their causes. Sometimes however, these strategies can rely on the use of stereotypical or dehumanizing depictions of people from the developing world. We have all seen the images of hungry children with bloated stomachs, presumably from some African or Asian country. To what extent do these narratives present a grossly simplified version of the struggles people in poverty face? The term “poverty porn” has been coined to describe these kinds of shock-based images which reduce people to their vulnerability and helplessness. Narratives within INGO media campaigns can either contribute to, or combat stereotypical images of developing regions. The first section of this research will discuss representations of people from developing regions. Second, the research will examine strategies employed in several digital-based INGO media campaigns through their use of visual and verbal tools. Third, the research will analyze the ethical nature of media campaigns which contribute to or combat stereotypes. It is important for international non-governmental organizations and those within the field of international development to consider how communication strategies impact the understanding we have of developing regions. This research aims to look critically at INGO communications and provide best practices for organizations constructing their own media campaigns.
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Date Issued: 2018-05-04
Identifier: FSU_libsubv1_scholarship_submission_1525459546_a796c8ef
Format: Citation

Title: "Waiting to Fail" Redux: Understanding Inadequate Response to Intervention..
Creator: Al Otaiba, Stephanie, Wagner, Richard K, Miller, Brett
Abstract/Description: This introduction to the special issue provides an overview of the promise, but also the ongoing challenges, related to Response to Intervention (RTI) as a means of both prevention and identification of reading disabilities. We conclude by describing the articles in this special issue and considering their implications for future research.
Date Issued: 2014-08-01
Identifier: FSU_pmch_25422530, 10.1177/0731948714525622, PMC4240019, 25422530, 25422530
Format: Citation

Title: 1.1-billion-year-old Porphyrins Establish A Marine Ecosystem Dominated By Bacterial Primary Producers.
Creator: Gueneli, N., McKenna, A. M., Ohkouchi, N., Boreham, C. J., Beghin, J., Javaux, E. J., Brocks, J. J.
Abstract/Description: The average cell size of marine phytoplankton is critical for the flow of energy and nutrients from the base of the food web to higher trophic levels. Thus, the evolutionary succession of primary producers through Earth's history is important for our understanding of the radiation of modern protists similar to 800 million years ago and the emergence of eumetazoan animals similar to 200 million years later. Currently, it is difficult to establish connections between primary production and the...
Show moreThe average cell size of marine phytoplankton is critical for the flow of energy and nutrients from the base of the food web to higher trophic levels. Thus, the evolutionary succession of primary producers through Earth's history is important for our understanding of the radiation of modern protists similar to 800 million years ago and the emergence of eumetazoan animals similar to 200 million years later. Currently, it is difficult to establish connections between primary production and the proliferation of large and complex organisms because the mid-Proterozoic (similar to 1,800-800 million years ago) rock record is nearly devoid of recognizable phytoplankton fossils. We report the discovery of intact porphyrins, the molecular fossils of chlorophylls, from 1,100-million-year-old marine black shales of the Taoudeni Basin (Mauritania), 600 million years older than previous findings. The porphyrin nitrogen isotopes (delta N-15(por) = 5.6-10.2 parts per thousand) are heavier than in younger sedimentary sequences, and the isotopic offset between sedimentary bulk nitrogen and porphyrins (epsilon(por) = -5.1 to -0.5 parts per thousand) points to cyanobacteria as dominant primary producers. Based on fossil carotenoids, anoxygenic green (Chlorobiacea) and purple sulfur bacteria (Chromatiaceae) also contributed to photosynthate. The low epsilon(por) values, in combination with a lack of diagnostic eukaryotic steranes in the time interval of 1,600-1,000 million years ago, demonstrate that algae played an insignificant role in mid-Proterozoic oceans. The paucity of algae and the small cell size of bacterial phytoplankton may have curtailed the flow of energy to higher trophic levels, potentially contributing to a diminished evolutionary pace toward complex eukaryotic ecosystems and large and active organisms.
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Date Issued: 2018-07-24
Identifier: FSU_libsubv1_wos_000439574700004, 10.1073/pnas.1803866115
Format: Citation

Title: The 2.8 Angstrom Electron Microscopy Structure Of Adeno-associated Virus-dj Bound By A Heparinoid Pentasaccharide.
Creator: Xie, Qing, Spear, John M., Noble, Alex J., Sousa, Duncan R., Meyer, Nancy L., Davulcu, Omar, Zhang, Fuming, Linhardt, Robert J., Stagg, Scott M., Chapman, Michael S.
Abstract/Description: Atomic structures of adeno-associated virus (AAV)-DJ, alone and in complex with fondaparinux, have been determined by cryoelectron microscopy at 3 angstrom resolution. The gene therapy vector, AAV-DJ, is a hybrid of natural serotypes that was previously derived by directed evolution, selecting for hepatocyte entry and resistance to neutralization by human serum. The structure of AAV-DJ differs from that of parental serotypes in two regions where neutralizing antibodies bind, so immune escape...
Show moreAtomic structures of adeno-associated virus (AAV)-DJ, alone and in complex with fondaparinux, have been determined by cryoelectron microscopy at 3 angstrom resolution. The gene therapy vector, AAV-DJ, is a hybrid of natural serotypes that was previously derived by directed evolution, selecting for hepatocyte entry and resistance to neutralization by human serum. The structure of AAV-DJ differs from that of parental serotypes in two regions where neutralizing antibodies bind, so immune escape appears to have been the primary driver of AAV-DJ's directed evolution. Fondaparinux is an analog of cell surface heparan sulfate to which several AAVs bind during entry. Fondaparinux interacts with viral arginines at a known heparin binding site, without the large conformational changes whose presence was controversial in low-resolution imaging of AAV2-heparin complexes. The glycan density suggests multimodal binding that could accommodate sequence variation and multivalent binding along a glycan polymer, consistent with a role in attachment, prior to more specific interactions with a receptor protein mediating entry.
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Date Issued: 2017-06
Identifier: FSU_libsubv1_wos_000406299600001, 10.1016/j.omtm.2017.02.004
Format: Citation

Title: The 2.8 Å Electron Microscopy Structure of Adeno-Associated Virus-DJ Bound by a Heparinoid Pentasaccharide.
Creator: Xie, Qing, Spear, John M, Noble, Alex J, Sousa, Duncan R, Meyer, Nancy L, Davulcu, Omar, Zhang, Fuming, Linhardt, Robert J, Stagg, Scott M, Chapman, Michael S
Abstract/Description: Atomic structures of adeno-associated virus (AAV)-DJ, alone and in complex with fondaparinux, have been determined by cryoelectron microscopy at 3 Å resolution. The gene therapy vector, AAV-DJ, is a hybrid of natural serotypes that was previously derived by directed evolution, selecting for hepatocyte entry and resistance to neutralization by human serum. The structure of AAV-DJ differs from that of parental serotypes in two regions where neutralizing antibodies bind, so immune escape appears...
Show moreAtomic structures of adeno-associated virus (AAV)-DJ, alone and in complex with fondaparinux, have been determined by cryoelectron microscopy at 3 Å resolution. The gene therapy vector, AAV-DJ, is a hybrid of natural serotypes that was previously derived by directed evolution, selecting for hepatocyte entry and resistance to neutralization by human serum. The structure of AAV-DJ differs from that of parental serotypes in two regions where neutralizing antibodies bind, so immune escape appears to have been the primary driver of AAV-DJ's directed evolution. Fondaparinux is an analog of cell surface heparan sulfate to which several AAVs bind during entry. Fondaparinux interacts with viral arginines at a known heparin binding site, without the large conformational changes whose presence was controversial in low-resolution imaging of AAV2-heparin complexes. The glycan density suggests multi-modal binding that could accommodate sequence variation and multivalent binding along a glycan polymer, consistent with a role in attachment, prior to more specific interactions with a receptor protein mediating entry.
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Date Issued: 2017-03-08
Identifier: FSU_pmch_28480299, 10.1016/j.omtm.2017.02.004, PMC5415311, 28480299, 28480299, S2329-0501(17)30044-X
Format: Citation

Title: Absence Of Dirac States In Baznbi2 Induced By Spin-orbit Coupling.
Creator: Ren, Weijun, Wang, Aifeng, Graf, D., Liu, Yu, Zhang, Zhidong, Yin, Wei-Guo, Petrovic, C.
Abstract/Description: We report magnetotransport properties of BaZnBi2 single crystals. Whereas electronic structure features Dirac states, such states are removed from the Fermi level by spin-orbit coupling (SOC) and consequently electronic transport is dominated by the small hole and electron pockets. Our results are consistent with not only three-dimensional, but also with quasi-two-dimensional portions of the Fermi surface. The SOC-induced gap in Dirac states is much larger when compared to isostructural...
Show moreWe report magnetotransport properties of BaZnBi2 single crystals. Whereas electronic structure features Dirac states, such states are removed from the Fermi level by spin-orbit coupling (SOC) and consequently electronic transport is dominated by the small hole and electron pockets. Our results are consistent with not only three-dimensional, but also with quasi-two-dimensional portions of the Fermi surface. The SOC-induced gap in Dirac states is much larger when compared to isostructural SrMnBi2. This suggests that not only long-range magnetic order, but also mass of the alkaline-earth atoms A in ABX(2) (A = alkaline-earth, B = transition-metal, and X = Bi/Sb) are important for the presence of low-energy states obeying the relativistic Dirac equation at the Fermi surface.
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Date Issued: 2018-01-22
Identifier: FSU_libsubv1_wos_000423341500001, 10.1103/PhysRevB.97.035147
Format: Citation

Title: Academic Achievement Among Juvenile Detainees.
Creator: Grigorenko, Elena L, Macomber, Donna, Hart, Lesley, Naples, Adam, Chapman, John, Geib, Catherine F, Chart, Hilary, Tan, Mei, Wolhendler, Baruch, Wagner, Richard
Abstract/Description: The literature has long pointed to heightened frequencies of learning disabilities (LD) within the population of law offenders; however, a systematic appraisal of these observations, careful estimation of these frequencies, and investigation of their correlates and causes have been lacking. Here we present data collected from all youth (1,337 unique admissions, mean age 14.81, 20.3% females) placed in detention in Connecticut (January 1, 2010-July 1, 2011). All youth completed a computerized...
Show moreThe literature has long pointed to heightened frequencies of learning disabilities (LD) within the population of law offenders; however, a systematic appraisal of these observations, careful estimation of these frequencies, and investigation of their correlates and causes have been lacking. Here we present data collected from all youth (1,337 unique admissions, mean age 14.81, 20.3% females) placed in detention in Connecticut (January 1, 2010-July 1, 2011). All youth completed a computerized educational screener designed to test a range of performance in reading (word and text levels) and mathematics. A subsample (n = 410) received the Wide Range Achievement Test, in addition to the educational screener. Quantitative (scale-based) and qualitative (grade-equivalence-based) indicators were then analyzed for both assessments. Results established the range of LD in this sample from 13% to 40%, averaging 24.9%. This work provides a systematic exploration of the type and severity of word and text reading and mathematics skill deficiencies among juvenile detainees and builds the foundation for subsequent efforts that may link these deficiencies to both more formal, structured, and variable definitions and classifications of LD, and to other types of disabilities (e.g., intellectual disability) and developmental disorders (e.g., ADHD) that need to be conducted in future research.
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Date Issued: 2015-07-01
Identifier: FSU_pmch_24064502, 10.1177/0022219413500991, PMC5064284, 24064502, 24064502, 0022219413500991
Format: Citation

Title: Academic Leadership Programs in the United States.
Creator: Guthrie, Kathy L., Teig, Trisha S., Hu, Pei
Abstract/Description: This research report examines 1,558 academic leadership programs in the United States. Findings include an overview of the leadership degree types, institutional affiliation, state and regional breakdown, and specific courses commonly found in academic leadership programs.
Date Issued: 2018-05-01
Identifier: FSU_libsubv1_scholarship_submission_1568233387_693853db
Format: Citation

Title: Academic Responding During Instruction and Reading Outcomes for Kindergarten Students At-risk for Reading Difficulties.
Creator: Wanzek, Jeanne, Roberts, Greg, Al Otaiba, Stephanie
Abstract/Description: The purpose of this study was to investigate the academic responding of students at-risk for reading difficulties in beginning reading instruction. Opportunities for kindergarten students at-risk for reading difficulties to respond academically during teacher-facilitated reading instruction in the general education classroom were examined in relation to student reading achievement as well as social behaviors. Student academic responding during teacher-facilitated instruction significantly...
Show moreThe purpose of this study was to investigate the academic responding of students at-risk for reading difficulties in beginning reading instruction. Opportunities for kindergarten students at-risk for reading difficulties to respond academically during teacher-facilitated reading instruction in the general education classroom were examined in relation to student reading achievement as well as social behaviors. Student academic responding during teacher-facilitated instruction significantly predicted end of year reading achievement. Teacher perceptions of students' social skills (positive correlation) and problem behaviors (negative correlation) were significantly correlated with academic responding. When academic responding and teacher perceptions of social behaviors were examined together, only teacher perceptions of academic competence and problem behaviors predicted spring outcomes.
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Date Issued: 2014-01-01
Identifier: FSU_pmch_24665162, 10.1007/s11145-013-9433-8, PMC3961576, 24665162, 24665162
Format: Citation

Title: Accurate Identification of Unknown and Known Metabolic Mixture Components by Combining 3D NMR with Fourier Transform Ion Cyclotron Resonance Tandem Mass Spectrometry.
Creator: Wang, Cheng, He, Lidong, Li, Da-Wei, Bruschweiler-Li, Lei, Marshall, Alan G, Brüschweiler, Rafael
Abstract/Description: Metabolite identification in metabolomics samples is a key step that critically impacts downstream analysis. We recently introduced the SUMMIT NMR/mass spectrometry (MS) hybrid approach for the identification of the molecular structure of unknown metabolites based on the combination of NMR, MS, and combinatorial cheminformatics. Here, we demonstrate the feasibility of the approach for an untargeted analysis of both a model mixture and E. coli cell lysate based on 2D/3D NMR experiments in...
Show moreMetabolite identification in metabolomics samples is a key step that critically impacts downstream analysis. We recently introduced the SUMMIT NMR/mass spectrometry (MS) hybrid approach for the identification of the molecular structure of unknown metabolites based on the combination of NMR, MS, and combinatorial cheminformatics. Here, we demonstrate the feasibility of the approach for an untargeted analysis of both a model mixture and E. coli cell lysate based on 2D/3D NMR experiments in combination with Fourier transform ion cyclotron resonance MS and MS/MS data. For 19 of the 25 model metabolites, SUMMIT yielded complete structures that matched those in the mixture independent of database information. Of those, seven top-ranked structures matched those in the mixture, and four of those were further validated by positive ion MS/MS. For five metabolites, not part of the 19 metabolites, correct molecular structural motifs could be identified. For E. coli, SUMMIT MS/NMR identified 20 previously known metabolites with three or more H spins independent of database information. Moreover, for 15 unknown metabolites, molecular structural fragments were determined consistent with their spin systems and chemical shifts. By providing structural information for entire metabolites or molecular fragments, SUMMIT MS/NMR greatly assists the targeted or untargeted analysis of complex mixtures of unknown compounds.
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Date Issued: 2017-10-06
Identifier: FSU_pmch_28795575, 10.1021/acs.jproteome.7b00457, PMC5663437, 28795575, 28795575
Format: Citation

$Acoustic wave absorption as a probe of dynamical geometrical response of fractional quantum Hall liquids$

Title: Acoustic wave absorption as a probe of dynamical geometrical response of fractional quantum Hall liquids.
Creator: Yang, Kun
Abstract/Description: We show that an acoustic crystalline wave gives rise to an effect similar to that of a gravitational wave to an electron gas. Applying this idea to a two-dimensional electron gas in the fractional quantum Hall regime, this allows for experimental study of its intra-Landau level dynamical response in the long-wavelength limit. To study such response we generalize Haldane's geometrical description of fractional quantum Hall states to situations where the external metric is time dependent. We...
Show moreWe show that an acoustic crystalline wave gives rise to an effect similar to that of a gravitational wave to an electron gas. Applying this idea to a two-dimensional electron gas in the fractional quantum Hall regime, this allows for experimental study of its intra-Landau level dynamical response in the long-wavelength limit. To study such response we generalize Haldane's geometrical description of fractional quantum Hall states to situations where the external metric is time dependent. We show that such time-dependent metric (generated by acoustic wave) couples to collective modes of the system, including a quadrapolar mode at long wavelength, and magnetoroton at finite wavelength. Energies of these modes can be revealed in spectroscopic measurements, controlled by strain-induced Fermi velocity anisotropy. We argue that such geometrical probe provides a potentially highly useful alternative probe of quantum Hall liquids, in addition to the usual electromagnetic response.
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Date Issued: 2016-04-15
Identifier: FSU_libsubv1_wos_000374297500001, 10.1103/PhysRevB.93.161302
Format: Citation

Title: Acquiring Science and Social Studies Knowledge in Kindergarten Through Fourth Grade: Conceptualization, Design, Implementation, and Efficacy Testing of Content-Area Literacy Instruction (CALI)..
Creator: Dombek, Jennifer, Crowe, Elizabeth C, Spencer, Mercedes, Tighe, Elizabeth L, Coffinger, Sean, Zargar, Elham, Wood, Taffeta, Petscher, Yaacov
Abstract/Description: With national focus on reading and math achievement, science and social studies have received less instructional time. Yet, accumulating evidence suggests that content knowledge is an important predictor of proficient reading. Starting with a design study, we developed Content Area Literacy Instruction (CALI), as an individualized (or personalized) instructional program for kindergarteners through fourth graders to build science and social studies knowledge. We developed CALI to be...
Show moreWith national focus on reading and math achievement, science and social studies have received less instructional time. Yet, accumulating evidence suggests that content knowledge is an important predictor of proficient reading. Starting with a design study, we developed Content Area Literacy Instruction (CALI), as an individualized (or personalized) instructional program for kindergarteners through fourth graders to build science and social studies knowledge. We developed CALI to be implemented in general education classrooms, over multiple iterations (n=230 students), using principles of design-based implementation research. The aims were to develop CALI as a usable and feasible instructional program that would, potentially, improve science and social studies knowledge, and could be implemented during the literacy block without negatively affecting students' reading gains (i.e., no opportunity cost). We then evaluated the efficacy of CALI in a randomized controlled field trial with 418 students in kindergarten through fourth grade. Results reveal that CALI demonstrates promise as a useable and feasible instructional individualized general education program, and is efficacious in improving social studies (=2.2) and science (=2.1) knowledge, with some evidence of improving oral and reading comprehension skills (=.125).
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Date Issued: 2017-04-01
Identifier: FSU_pmch_28479610, 10.1037/edu0000128, PMC5415842, 28479610, 28479610
Format: Citation

Title: Across the tree of life, radiation resistance is governed by antioxidant Mn, gauged by paramagnetic resonance.
Creator: Sharma, Ajay, Gaidamakova, Elena K, Grichenko, Olga, Matrosova, Vera Y, Hoeke, Veronika, Klimenkova, Polina, Conze, Isabel H, Volpe, Robert P, Tkavc, Rok, Gostinčar, Cene, Gunde...
Show moreSharma, Ajay, Gaidamakova, Elena K, Grichenko, Olga, Matrosova, Vera Y, Hoeke, Veronika, Klimenkova, Polina, Conze, Isabel H, Volpe, Robert P, Tkavc, Rok, Gostinčar, Cene, Gunde-Cimerman, Nina, DiRuggiero, Jocelyne, Shuryak, Igor, Ozarowski, Andrew, Hoffman, Brian M, Daly, Michael J
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Abstract/Description: Despite concerted functional genomic efforts to understand the complex phenotype of ionizing radiation (IR) resistance, a genome sequence cannot predict whether a cell is IR-resistant or not. Instead, we report that absorption-display electron paramagnetic resonance (EPR) spectroscopy of nonirradiated cells is highly diagnostic of IR survival and repair efficiency of DNA double-strand breaks (DSBs) caused by exposure to gamma radiation across archaea, bacteria, and eukaryotes, including fungi...
Show moreDespite concerted functional genomic efforts to understand the complex phenotype of ionizing radiation (IR) resistance, a genome sequence cannot predict whether a cell is IR-resistant or not. Instead, we report that absorption-display electron paramagnetic resonance (EPR) spectroscopy of nonirradiated cells is highly diagnostic of IR survival and repair efficiency of DNA double-strand breaks (DSBs) caused by exposure to gamma radiation across archaea, bacteria, and eukaryotes, including fungi and human cells. IR-resistant cells, which are efficient at DSB repair, contain a high cellular content of manganous ions (Mn) in high-symmetry (H) antioxidant complexes with small metabolites (e.g., orthophosphate, peptides), which exhibit narrow EPR signals (small zero-field splitting). In contrast, Mn ions in IR-sensitive cells, which are inefficient at DSB repair, exist largely as low-symmetry (L) complexes with substantially broadened spectra seen with enzymes and strongly chelating ligands. The fraction of cellular Mn present as H-complexes (H-Mn), as measured by EPR of live, nonirradiated Mn-replete cells, is now the strongest known gauge of biological IR resistance between and within organisms representing all three domains of life: Antioxidant H-Mn complexes, not antioxidant enzymes (e.g., Mn superoxide dismutase), govern IR survival. As the pool of intracellular metabolites needed to form H-Mn complexes depends on the nutritional status of the cell, we conclude that IR resistance is predominantly a metabolic phenomenon. In a cross-kingdom analysis, the vast differences in taxonomic classification, genome size, and radioresistance between cell types studied here support that IR resistance is not controlled by the repertoire of DNA repair and antioxidant enzymes.
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Date Issued: 2017-10-31
Identifier: FSU_pmch_29042516, 10.1073/pnas.1713608114, PMC5676931, 29042516, 29042516, 1713608114
Format: Citation

Title: Adaptation of Florida’s Urban Infrastructure to Climate Change.
Creator: Bloetscher, Frederick, Hoermann, Serena, Berry, Leonard
Abstract/Description: This chapter looks at how the impacts of climate change affect different parts of Florida. With more than 1500 miles of coastline that contains numerus differences in character between the state’s southern-most point in the Florida Keys to the northwest Florida Panhandle and northeast Florida in Jacksonville, it is easy to see why areas across the state are not all the same; temperature, rainfall rates, and even the potential for sea level rise can vary significantly depending on what part of...
Show moreThis chapter looks at how the impacts of climate change affect different parts of Florida. With more than 1500 miles of coastline that contains numerus differences in character between the state’s southern-most point in the Florida Keys to the northwest Florida Panhandle and northeast Florida in Jacksonville, it is easy to see why areas across the state are not all the same; temperature, rainfall rates, and even the potential for sea level rise can vary significantly depending on what part of the state one is in. For example, southeast Florida and the Tampa Bay area are already dealing with sea level rise issues, but there is much work to be done in order to assess the risks and help identify potential solutions. Efforts to adapt to rising seas will need to draw upon prior research and current work to develop tool box strategies that involve the hard and soft components. A background of impacts to water resources (less rainfall has been detected) will be discussed.
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Date Issued: 2017-11-29
Identifier: FSU_libsubv1_scholarship_submission_1515510253_5d0b606b, 10.17125/fci2017.ch11
Format: Citation

Title: Adapting to Change: Administrators' Perceptions of the Second Year of Developmental Education Reform in the Florida College System.
Creator: Hu, Shouping, Richard, Keith, Woods, Chenoa S., Nix, Samantha, Tandberg, David, Park, Toby, Bertrand Jones, Tamara
Abstract/Description: The Center for Postsecondary Success at Florida State University has been studying the implementation and outcomes of SB 1720 since its initial implementation by surveying campus leaders across the FCS. This report explores the third set of surveys, administered in spring of 2016. This survey focused on changes the colleges made between the first and second years of implementation of SB 1720.
Date Issued: 2016-07-01
Identifier: FSU_libsubv1_scholarship_submission_1485301022
Format: Citation

Title: Adiabatic Sweep Cross-polarization Magic-angle-spinning Nmr Of Half-integer Quadrupolar Spins.
Creator: Wi, Sungsool, Kim, Chul, Schurko, Robert, Frydman, Lucio
Abstract/Description: The use of frequency-swept radiofrequency (rf) pulses for enhancing signals in the magic-angle spinning (MAS) spectra of half-integer quadrupolar nuclides was explored. The broadband adiabatic inversion cross-polarization magic-angle spinning (BRAIN-CPMAS) method, involving an adiabatic inversion pulse on the S-channel and a simultaneous rectangular spin-lock pulse on the I-channel (H-1), was applied to I (1/2) -> S(3/2) systems. Optimal BRAIN-CPMAS matching conditions were found to involve...
Show moreThe use of frequency-swept radiofrequency (rf) pulses for enhancing signals in the magic-angle spinning (MAS) spectra of half-integer quadrupolar nuclides was explored. The broadband adiabatic inversion cross-polarization magic-angle spinning (BRAIN-CPMAS) method, involving an adiabatic inversion pulse on the S-channel and a simultaneous rectangular spin-lock pulse on the I-channel (H-1), was applied to I (1/2) -> S(3/2) systems. Optimal BRAIN-CPMAS matching conditions were found to involve low rf pulse strengths for both the I- and S-spin channels. At these low and easily attainable rf field strengths, level-crossing events among the energy levels |3/2 >, |1/2 >, | -1/2 >, | - 3/2 > that are known to complicate the CPMAS of quadrupolar nuclei, are mostly avoided. Zero- and double-quantum polarization transfer modes, akin to those we have observed for 1(1/2) -> S(1/2) polarization transfers, were evidenced by these analyses even in the presence of the quadrupolar interaction. H-1-Na-23 and H-1-B-11 BRAIN-CPMAS conditions were experimentally explored on model compounds by optimizing the width of the adiabatic sweep, as well as the rf pulse powers of the H-1 and Na-23/B-11 channels, for different MAS rates. The experimental data obtained on model compounds containing spin-3/2 nuclides, matched well predictions from numerical simulations and from an average Hamiltonian theory model. Extensions to half-integer spin nuclides with higher spins and potential applications of this BRAIN-CPMAS approach are discussed. (C) 2017 Elsevier Inc. All rights reserved.
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Date Issued: 2017-04
Identifier: FSU_libsubv1_wos_000399861500017, 10.1016/j.jmr.2017.02.021
Format: Citation

Title: Advanced (Measurement) Applications of Curriculum-based Measurement in Reading.
Creator: Petscher, Yaacov M., Cummings, Kelli, Biancarosa, Gina, Fien, Hank
Abstract/Description: The purpose of this article is to provide a commentary on the current state of several measurement issues pertaining to curriculum-based measures of reading (R-CBM1). We begin by providing an overview of the utility of R-CBM, followed by a presentation of five specific measurements considerations: 1) the reliability of R-CBM oral reading fluency, 2) issues pertaining to form effects, 3) the generalizability of scores from R-CBM, 4) measurement error, and 5) linearity of growth in R-CBM. We...
Show moreThe purpose of this article is to provide a commentary on the current state of several measurement issues pertaining to curriculum-based measures of reading (R-CBM1). We begin by providing an overview of the utility of R-CBM, followed by a presentation of five specific measurements considerations: 1) the reliability of R-CBM oral reading fluency, 2) issues pertaining to form effects, 3) the generalizability of scores from R-CBM, 4) measurement error, and 5) linearity of growth in R-CBM. We then conclude with a presentation of the purpose for this issue and broadly introduce the articles in the special issue. Because oral reading fluency is one of the most common measures of R-CBM, much of the review is focused on this particular type of assessment; however, the issues presented extend to other assessments of R-CBM.
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Date Issued: 2013
Identifier: FSU_migr_fcrr-pubs-0001, 10.1177/1534508412461434
Format: Citation

Title: Advanced (Measurement) Applications of Curriculum-Based Measurement in Reading.
Creator: Petscher, Yaacov, Cummings, Kelli Dawn, Biancarosa, Gina, Fien, Hank
Abstract/Description: The purpose of this article is to provide a commentary on the current state of several measurement issues pertaining to curriculum-based measures of reading (R-CBM). We begin by providing an overview of the utility of R-CBM, followed by a presentation of five specific measurements considerations: 1) the reliability of R-CBM oral reading fluency, 2) issues pertaining to form effects, 3) the generalizability of scores from R-CBM, 4) measurement error, and 5) linearity of growth in R-CBM. We...
Show moreThe purpose of this article is to provide a commentary on the current state of several measurement issues pertaining to curriculum-based measures of reading (R-CBM). We begin by providing an overview of the utility of R-CBM, followed by a presentation of five specific measurements considerations: 1) the reliability of R-CBM oral reading fluency, 2) issues pertaining to form effects, 3) the generalizability of scores from R-CBM, 4) measurement error, and 5) linearity of growth in R-CBM. We then conclude with a presentation of the purpose for this issue and broadly introduce the articles in the special issue. Because oral reading fluency is one of the most common measures of R-CBM, much of the review is focused on this particular type of assessment; however, the issues presented extend to other assessments of R-CBM.
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Date Issued: 2013-03-01
Identifier: FSU_pmch_26346551, 10.1177/1534508412461434, PMC4557774, 26346551, 26346551
Format: Citation

Title: Advanced Reading Comprehension Expectations in Secondary School: Considerations for Students with Emotional or Behavior Disorders..
Creator: Ciullo, Stephen, Ortiz, Miriam B, Al Otaiba, Stephanie, Lane, Kathleen Lynne
Abstract/Description: The debate around recent implementation of the Common Core Standards (CCSS) has perplexed many policy makers, practitioners, and researchers; yet there remains broad agreement for the need to improve reading outcomes and college and career readiness for all students, including students with disabilities. One of the most vulnerable populations with disabilities in terms of college and career readiness is students with emotional disorders (ED). A considerable percentage of students with ED...
Show moreThe debate around recent implementation of the Common Core Standards (CCSS) has perplexed many policy makers, practitioners, and researchers; yet there remains broad agreement for the need to improve reading outcomes and college and career readiness for all students, including students with disabilities. One of the most vulnerable populations with disabilities in terms of college and career readiness is students with emotional disorders (ED). A considerable percentage of students with ED encounter unfavorable academic and long-term outcomes, often due to reading difficulties and behavioral variables that impede learning. To date, the impact of rising expectations in reading on the education of students with ED has been absent from this conversation about CCSS. In this article, we consider the implications of new reading expectations in the critical period of Grades 6-12 for students with ED. First, we summarize grade level expectations of the standards. Then, we describe the characteristics and underachievement of students with ED. Next, we evaluate challenges in meeting the expectations based on extant research, and provide recommendations for practice based on the intervention literature. We conclude by prioritizing a research and policy agenda that advocates for increasing the likelihood of success in reading for students with ED in middle school and high school.
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Date Issued: 2016-06-01
Identifier: FSU_pmch_27403040, 10.1177/1044207315604365, PMC4937879, 27403040, 27403040
Format: Citation

Title: Advancing NMDA Receptor Physiology by Integrating Multiple Approaches.
Creator: Zhou, Huan-Xiang, Wollmuth, Lonnie P
Abstract/Description: NMDA receptors (NMDARs) are ion channels activated by the excitatory neurotransmitter glutamate and are essential to all aspects of brain function, including learning and memory formation. Missense mutations distributed throughout NMDAR subunits have been associated with an array of neurological disorders. Recent structural, functional, and computational studies have generated many insights into the activation process connecting glutamate binding to ion-channel opening, which is central to...
Show moreNMDA receptors (NMDARs) are ion channels activated by the excitatory neurotransmitter glutamate and are essential to all aspects of brain function, including learning and memory formation. Missense mutations distributed throughout NMDAR subunits have been associated with an array of neurological disorders. Recent structural, functional, and computational studies have generated many insights into the activation process connecting glutamate binding to ion-channel opening, which is central to NMDAR physiology and pathophysiology. The field appears poised for breakthroughs, including the exciting prospect of resolving the conformations and energetics of elementary steps in the activation process, and atomic-level modeling of the effects of missense mutations on receptor function. The most promising strategy going forward is through strong integration of multiple approaches.
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Date Issued: 2017-03-01
Identifier: FSU_pmch_28187950, 10.1016/j.tins.2017.01.001, PMC5339030, 28187950, 28187950, S0166-2236(17)30002-4
Format: Citation

Title: Age, Growth, and Reproductive Biology of Cownose Rays in Chesapeake Bay.
Creator: Fisher, Robert, Call, Garrett, Grubbs, Dean
Abstract/Description: The Cownose Ray Rhinoptera bonasus is an opportunistic predator of benthic invertebrates and has had a long history of negative interactions with commercial shellfish industries. Most recently, Cownose Rays have been implicated in negatively affecting the recovery of bay scallop Argopecten irradians stocks in North Carolina and oyster restoration and commercial aquaculture efforts in Chesapeake Bay. A mitigation attempt to decrease predation on shellfish has resulted in an unregulated fishery...
Show moreThe Cownose Ray Rhinoptera bonasus is an opportunistic predator of benthic invertebrates and has had a long history of negative interactions with commercial shellfish industries. Most recently, Cownose Rays have been implicated in negatively affecting the recovery of bay scallop Argopecten irradians stocks in North Carolina and oyster restoration and commercial aquaculture efforts in Chesapeake Bay. A mitigation attempt to decrease predation on shellfish has resulted in an unregulated fishery for Cownose Rays. Cownose Ray life history suggests that they are highly susceptible to overexploitation. We determined age, growth, and size at maturity for Cownose Rays collected in Chesapeake Bay. In total, 694 rays were used for the study: 246 males ranging in size from 30.0 to 98.0 cm disc width (DW) and 448 females ranging from 30.0 to 110.5 cm DW. The oldest individual observed was a female (107 cm DW) estimated at age 21. Our data suggested that Cownose Rays grow considerably faster during the first few years than has been previously reported, thus producing higher estimates of the growth coefficient k. The best-fit growth models (three-parameter von Bertalanffy models) estimated k-values of 0.2741 for males and 0.1931 for females. The large sample size and inclusion ofmany older animals (n = 119 rays over age 10) resulted in theoreticalmaximum size estimates that matched the observed sizes well. The median size at 50% maturity was 85–86 cm DW for males and females (corresponding to ages of ∼6–7 for males and ∼7–8 for females). Fecundity in Cownose Rays was typically one embryo per mature female, with a gestation period of 11–12 months. Our study confirms that the Cownose Ray is a K-selected species with late maturity, long gestation, and low reproductive potential, indicating that it could be highly susceptible to overexploitation.
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Date Issued: 2013
Identifier: FSU_migr_marinelab_pubs-0003, 10.1080/19425120.2013.812587
Format: Citation

Title: Age-related changes of gene expression in the neocortex: preliminary data on RNA-Seq of the transcriptome in three functionally distinct cortical areas..
Creator: Naumova, Oksana Yu, Palejev, Dean, Vlasova, Natalia V, Lee, Maria, Rychkov, Sergei Yu, Babich, Olga N, M Vaccarino, Flora, Grigorenko, Elena L
Abstract/Description: The study of gene expression (i.e., the study of the transcriptome) in different cells and tissues allows us to understand the molecular mechanisms of their differentiation, development and functioning. In this article, we describe some studies of gene-expression profiling for the purposes of understanding developmental (age-related) changes in the brain using different technologies (e.g., DNA-Microarray) and the new and increasingly popular RNA-Seq. We focus on advancements in studies of...
Show moreThe study of gene expression (i.e., the study of the transcriptome) in different cells and tissues allows us to understand the molecular mechanisms of their differentiation, development and functioning. In this article, we describe some studies of gene-expression profiling for the purposes of understanding developmental (age-related) changes in the brain using different technologies (e.g., DNA-Microarray) and the new and increasingly popular RNA-Seq. We focus on advancements in studies of gene expression in the human brain, which have provided data on the structure and age-related variability of the transcriptome in the brain. We present data on RNA-Seq of the transcriptome in three distinct areas of the neocortex from different ages: mature and elderly individuals. We report that most age-related transcriptional changes affect cellular signaling systems, and, as a result, the transmission of nerve impulses. In general, the results demonstrate the high potential of RNA-Seq for the study of distinctive features of gene expression among cortical areas and the changes in expression through normal and atypical development of the central nervous system.
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Date Issued: 2012-11-01
Identifier: FSU_pmch_23062308, 10.1017/S0954579412000818, PMC3539811, 23062308, 23062308, S0954579412000818
Format: Citation

Title: Aggression and Violence in Sport: Moving Beyond the Debate..
Creator: Sacks, David N, Petscher, Yaacov, Stanley, Christopher T, Tenenbaum, Gershon
Abstract/Description: This paper is the latest in a series of articles published in The Sport Psychologist in recent years on aggression and violence in sport (Kerr, 1999, 2002; Tenenbaum, Sacks, Miller, Golden, & Doolin, 2000; Tenenbaum, Stewart, Singer, & Duda, 1997). While these respective articles have presented dissenting views on the nature and prevention of aggression and violence in sport, the present paper proposes that much of the apparent disagreement is semantic in nature. Thus, this paper begins by...
Show moreThis paper is the latest in a series of articles published in The Sport Psychologist in recent years on aggression and violence in sport (Kerr, 1999, 2002; Tenenbaum, Sacks, Miller, Golden, & Doolin, 2000; Tenenbaum, Stewart, Singer, & Duda, 1997). While these respective articles have presented dissenting views on the nature and prevention of aggression and violence in sport, the present paper proposes that much of the apparent disagreement is semantic in nature. Thus, this paper begins by clarifying some definitional issues before specifying both areas of agreement and continued dissention among recent authors. Major emphases in this paper include the importance of adopting preventative rather than reactive measures to reduce the dangers associated with aggression and violence in sport, as well as the manner in which adult sport norms affect youth sport environments. In addition, several broader issues, which have emerged from these recent published debates, are presented for future consideration.
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Date Issued: 2003-01-01
Identifier: FSU_pmch_26855638, 10.1080/1612197X.2003.9671710, PMC4743757, 26855638, 26855638
Format: Citation

Title: Aging Effect Of Zylon.
Creator: Niu, Rongmei, Han, Ke, Walsh, Robert P., Buchholz, Kyle, Goddard, Robert E., Besara, Tiglet, Siegrist, Theo M.
Abstract/Description: Zylon fibers, which are made of high-strength polymer, are used at the National High Magnetic Field Laboratory for structural reinforcement of high field pulsed magnet coils. Most polymers are subject to chain scission, which is the result of aging degradation of the fibers in the absence of chemical agent. We studied chain scission of Zylon fibers stored with and without visible light. No mechanical strength degradation was found in Zylon stored without exposure to visible light for 8 years....
Show moreZylon fibers, which are made of high-strength polymer, are used at the National High Magnetic Field Laboratory for structural reinforcement of high field pulsed magnet coils. Most polymers are subject to chain scission, which is the result of aging degradation of the fibers in the absence of chemical agent. We studied chain scission of Zylon fibers stored with and without visible light. No mechanical strength degradation was found in Zylon stored without exposure to visible light for 8 years. Prolonged exposure to lab-lighting rendered formation of surface defects, resulting in reduction in mechanical strength.
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Date Issued: 2018-04
Identifier: FSU_libsubv1_wos_000422810000001, 10.1109/TASC.2017.2783362
Format: Citation

Title: Agreement Among Traditional and RTI-based Definitions of Reading-Related Learning Disability with Preschool Children.
Creator: Milburn, Trelani F, Lonigan, Christopher J, Allan, Darcey M, Phillips, Beth M
Abstract/Description: To investigate approaches for identifying young children who may be at risk for later reading-related learning disabilities, this study compared the use of four contemporary methods of indexing learning disability (LD) with older children (i.e., IQ-achievement discrepancy, low achievement, low growth, and dual-discrepancy) to determine risk status with a large sample of 1,011 preschoolers. These children were classified as at risk or not using each method across three early-literacy skills (i...
Show moreTo investigate approaches for identifying young children who may be at risk for later reading-related learning disabilities, this study compared the use of four contemporary methods of indexing learning disability (LD) with older children (i.e., IQ-achievement discrepancy, low achievement, low growth, and dual-discrepancy) to determine risk status with a large sample of 1,011 preschoolers. These children were classified as at risk or not using each method across three early-literacy skills (i.e., language, phonological awareness, print knowledge) and at three levels of severity (i.e., 5th, 10th, 25th percentiles). Chance-corrected affected-status agreement (CCASA) indicated poor agreement among methods with rates of agreement generally decreasing with greater levels of severity for both single- and two-measure classification, and agreement rates were lower for two-measure classification than for single-measure classification. These low rates of agreement between conventional methods of identifying children at risk for LD represent a significant impediment for identification and intervention for young children considered at-risk.
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Date Issued: 2017-04-01
Identifier: FSU_pmch_28670102, 10.1016/j.lindif.2017.03.011, PMC5489126, 28670102, 28670102
Format: Citation

Title: AIM2 inflammasome activation and regulation: A structural perspective..
Creator: Wang, Bing, Yin, Qian
Abstract/Description: Absent in melanoma 2 (AIM2) inflammasome is a multi-protein platform that recognizes aberrant cytoplasmic dsDNA and induces cytokine maturation, release and pyroptosis. It is composed of AIM2, apoptosis-associated speck-like protein containing a CARD (ASC), and caspase-1. Recent X-ray crystallographic and high resolution cryo-electron microscopic (cryo-EM) studies have revealed a series of structures in AIM2 inflammasome activation and regulation. One prominent feature common in multiple...
Show moreAbsent in melanoma 2 (AIM2) inflammasome is a multi-protein platform that recognizes aberrant cytoplasmic dsDNA and induces cytokine maturation, release and pyroptosis. It is composed of AIM2, apoptosis-associated speck-like protein containing a CARD (ASC), and caspase-1. Recent X-ray crystallographic and high resolution cryo-electron microscopic (cryo-EM) studies have revealed a series of structures in AIM2 inflammasome activation and regulation. One prominent feature common in multiple steps is the assembly of high-order structures, especially helical filaments nucleated by upstream molecules, rather than stoichiometric complexes. In this review, we track the AIM2 inflammasome activation process step by step, using high-resolution structures to illustrate the overall architecture of AIM2 inflammasome and its assembly and regulatory mechanisms.
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Date Issued: 2017-12-01
Identifier: FSU_pmch_28813641, 10.1016/j.jsb.2017.08.001, PMC5733693, 28813641, 28813641, S1047-8477(17)30132-6
Format: Citation

Title: Allele-specific Control Of Replication Timing And Genome Organization During Development.
Creator: Rivera-Mulia, Juan Carlos, Dimond, Andrew, Vera, Daniel, Trevilla-Garcia, Claudia, Sasaki, Takayo, Zimmerman, Jared, Dupont, Catherine, Gribnau, Joost, Fraser, Peter, Gilbert,...
Show moreRivera-Mulia, Juan Carlos, Dimond, Andrew, Vera, Daniel, Trevilla-Garcia, Claudia, Sasaki, Takayo, Zimmerman, Jared, Dupont, Catherine, Gribnau, Joost, Fraser, Peter, Gilbert, David M.
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Abstract/Description: DNA replication occurs in a defined temporal order known as the replication-timing (RT) program. RT is regulated during development in discrete chromosomal units, coordinated with transcriptional activity and 3D genome organization. Here, we derived distinct cell types from F1 hybrid musculus x castaneus mouse crosses and exploited the high single-nucleotide polymorphism (SNP) density to characterize allelic differences in RT (Repli-seq), genome organization (Hi-C and promoter-capture Hi-C),...
Show moreDNA replication occurs in a defined temporal order known as the replication-timing (RT) program. RT is regulated during development in discrete chromosomal units, coordinated with transcriptional activity and 3D genome organization. Here, we derived distinct cell types from F1 hybrid musculus x castaneus mouse crosses and exploited the high single-nucleotide polymorphism (SNP) density to characterize allelic differences in RT (Repli-seq), genome organization (Hi-C and promoter-capture Hi-C), gene expression (total nuclear RNA-seq), and chromatin accessibility (ATAC-seq). We also present HARP, a new computational tool for sorting SNPs in phased genomes to efficiently measure allele-specific genome-wide data. Analysis of six different hybrid mESC clones with different genomes (C57BL/ 6,129 /sv, and CAST/ Ei), parental configurations, and gender revealed significant RT asynchrony between alleles across similar to 12% of the autosomal genome linked to subspecies genomes but not to parental origin, growth conditions, or gender. RT asynchrony in mESCs strongly correlated with changes in Hi-C compartments between alleles but not as strongly with SNP density, gene expression, imprinting, or chromatin accessibility. We then tracked mESC RT asynchronous regions during development by analyzing differentiated cell types, including extraembryonic endoderm stem (XEN) cells, four male and female primary mouse embryonic fibroblasts (MEFs), and neural precursor cells (NPCs) differentiated in vitro from mESCs with opposite parental configurations. We found that RT asynchrony and allelic discordance in Hi-C compartments seen in mESCs were largely lost in all differentiated cell types, accompanied by novel sites of allelic asynchrony at a considerably smaller proportion of the genome, suggesting that genome organization of homologs converges to similar folding patterns during cell fate commitment.
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Date Issued: 2018-06-01
Identifier: FSU_libsubv1_wos_000436084800005, 10.1101/gr.232561.117
Format: Citation

Title: Allosteric activation of SENP1 by SUMO1 β-grasp domain involves a dock-and-coalesce mechanism.
Creator: Guo, Jingjing, Zhou, Huan-Xiang
Abstract/Description: Small ubiquitin-related modifiers (SUMOs) are conjugated to proteins to regulate a variety of cellular processes. SENPs are cysteine proteases with a catalytic center located within a channel between two subdomains that catalyzes SUMO C-terminal cleavage for processing of SUMO precursors and de-SUMOylation of target proteins. The β-grasp domain of SUMOs binds to an exosite cleft, and allosterically activates SENPs via an unknown mechanism. Our molecular dynamics simulations showed that...
Show moreSmall ubiquitin-related modifiers (SUMOs) are conjugated to proteins to regulate a variety of cellular processes. SENPs are cysteine proteases with a catalytic center located within a channel between two subdomains that catalyzes SUMO C-terminal cleavage for processing of SUMO precursors and de-SUMOylation of target proteins. The β-grasp domain of SUMOs binds to an exosite cleft, and allosterically activates SENPs via an unknown mechanism. Our molecular dynamics simulations showed that binding of the β-grasp domain induces significant conformational and dynamic changes in SENP1, including widening of the exosite cleft and quenching of nanosecond dynamics in all but a distal region. A dock-and-coalesce mechanism emerges for SENP-catalyzed SUMO cleavage: the wedging of the β-grasp domain enables the docking of the proximal portion of the C-terminus and the strengthened cross-channel motional coupling initiates inter-subdomain correlated motions to allow for the distal portion to coalesce around the catalytic center.
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Date Issued: 2016-08-31
Identifier: FSU_pmch_27576863, 10.7554/eLife.18249, PMC5030089, 27576863, 27576863
Format: Citation

Title: Alumina Particle Reinforced Cu Matrix Conductors.
Creator: Han, Ke, Goddard, Robert E., Toplosky, Vince, Niu, Rongmei, Lu, Jun, Walsh, Robert
Abstract/Description: The high strength conductors used in pulsed magnets in the US National HighMagnetic Field Laboratory (MagLab) are manufactured from Cu matrix composites. One of the composites is made from particle-reinforced Cu. The fabrication of these composite conductors requires high deformation strain, which creates high densities of dislocations and reduced particle spacing. Both mechanical strength and electrical conductivity can be predicted from particle spacing and dislocation density. When...
Show moreThe high strength conductors used in pulsed magnets in the US National HighMagnetic Field Laboratory (MagLab) are manufactured from Cu matrix composites. One of the composites is made from particle-reinforced Cu. The fabrication of these composite conductors requires high deformation strain, which creates high densities of dislocations and reduced particle spacing. Both mechanical strength and electrical conductivity can be predicted from particle spacing and dislocation density. When dislocation density reaches a certain value, the particle size, distribution, and shape become important to mechanical properties. We studied the particle size, distribution, and shape in high-strength conductors with respect to the properties of the conductors. The two most important factors related to the above parameters were dislocations near the interface between particle and matrix and stress concentration near the particles. By engineering these variations, the properties of the conductors can be optimized. This paper reports our understanding of the relationship between critical properties and particle distribution in composite conductors for high field pulsed magnets.
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Date Issued: 2018-04
Identifier: FSU_libsubv1_wos_000427621000001, 10.1109/TASC.2018.2795587
Format: Citation

Title: Amount of Time in Print Reading in General Education Kindergarten Classrooms: What Does It Look Like for Students At-risk for Reading Difficulties?.
Creator: Kent, Shawn C, Wanzek, Jeanne, Al Otaiba, Stephanie
Abstract/Description: The purpose of this study was to examine the amount of time spent actively engaged in reading sounds, words, and connected text for students at-risk for reading difficulties in the first formal grade of reading instruction, kindergarten. Observational data of 109 kindergarten students at high-risk for later reading difficulties were collected during general education reading instruction across the school year. Findings revealed students read orally for just over 1 minute during their reading...
Show moreThe purpose of this study was to examine the amount of time spent actively engaged in reading sounds, words, and connected text for students at-risk for reading difficulties in the first formal grade of reading instruction, kindergarten. Observational data of 109 kindergarten students at high-risk for later reading difficulties were collected during general education reading instruction across the school year. Findings revealed students read orally for just over 1 minute during their reading instruction with approximately equal time spent reading sounds, words, or connected text. Implications of these results for early reading instruction and intervention for students at-risk for reading difficulties or disabilities are presented.
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Date Issued: 2012-05-01
Identifier: FSU_pmch_23087545, 10.1111/j.1540-5826.2012.00351.x, PMC3475198, 23087545, 23087545
Format: Citation

Title: Analysis methods for characterizing salinity variability from multivariate time series applied to the Apalachicola Bay estuary.
Creator: Morey, Steven, Dukhovskoy, Dmitry
Abstract/Description: Statistical analysis methods are developed to quantify the impacts of multiple forcing variables on the hydrographic variability within an estuary instrumented with an enduring observational system. The methods are applied to characterize the salinity variability within Apalachicola Bay, a shallow multiple-inlet estuary along the northeastern Gulf of Mexico coast. Thirteen-year multivariate time series collected by the National Estuary Research Reserve at three locations within the bay are...
Show moreStatistical analysis methods are developed to quantify the impacts of multiple forcing variables on the hydrographic variability within an estuary instrumented with an enduring observational system. The methods are applied to characterize the salinity variability within Apalachicola Bay, a shallow multiple-inlet estuary along the northeastern Gulf of Mexico coast. Thirteen-year multivariate time series collected by the National Estuary Research Reserve at three locations within the bay are analyzed to determine how the estuary responds to variations in external forcing mechanisms, such as freshwater discharge, precipitation, tides and local winds, at multiple time scales. The analysis methods are used to characterize the estuarine variability under differing flow regimes of the Apalachicola River, a managed waterway, with particular focus on extreme events and scales of variability that are critical to local ecosystems. Multivariate statistical models are applied that describe the salinity response to winds from multiple directions, river flow, and precipitation at daily, weekly, and monthly time scales to understand the response of the estuary under different climate regimes. Results show that the salinity is particularly sensitive to river discharge and wind magnitude and direction, with local precipitation being largely unimportant. Applying statistical analyses with conditional sampling quantifies how the likelihoods of high salinity and long duration high salinity events, conditions of critical importance to estuarine organisms, change given the state of the river flow. Intraday salinity range is shown to be negatively correlated with the salinity, and correlated with river discharge rate.
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Date Issued: 2012
Identifier: FSU_migr_coaps_pubs-0047, 10.1175/JTECH-D-11-00136.1
Format: Citation

Title: An Analysis of the Localization Feature of Two Computer-Assisted Career Guidance Systems - DISCOVER and SIGI PLUS: Technical Report No. 14.
Creator: Lenz, Janet G, Leierer, Stephen J, Reardon, Robert C, Sampson, James P
Abstract/Description: This report describes the efforts of the Career Center at Florida State University to implement the localization options in the DISCOVER and SIGI PLUS computer-assisted career guidance (CACG) systems in 1991-1992. A review of the literature and current use of localization suggested that it is a complex, underutilized extension of CACG software. Use of the localization feature raises issues about the nature of the desired client outcomes, the type of information to be included, the processes...
Show moreThis report describes the efforts of the Career Center at Florida State University to implement the localization options in the DISCOVER and SIGI PLUS computer-assisted career guidance (CACG) systems in 1991-1992. A review of the literature and current use of localization suggested that it is a complex, underutilized extension of CACG software. Use of the localization feature raises issues about the nature of the desired client outcomes, the type of information to be included, the processes and costs for installing and using the feature, and who in the organization should be responsible. To determine what types of information to include in localization, career advising staff were surveyed, two staff meetings were held, and user feedback on the two CACG systems were examined. It was decided to emphasize local information that would accomplish the goals of (1) providing instructions to improve client interaction with the CACGS and reduce client confusion, and (2) linking clients with other Career Center resources and activities. Primary localization efforts were directed toward DISCOVER because the software design was more compatible with the two program goals noted above. This report includes a discussion of project findings in relation to localization issues, i.e., clarifying the purposes of localization, the influences of system design on localization functioning, the impact of localization on CACG system effects, and the impact of localization on staffing and training. The report concludes with a review of implications for practitioners and system developers of the study of CACG system localization features.
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Date Issued: 1992-06-22
Identifier: FSU_libsubv1_scholarship_submission_1525888624_5df96194, 10.17125/fsu.1525888624
Format: Citation

Title: Anisotropic Antiferromagnetic Order In The Spin-orbit Coupled Trigonal-lattice Ca2sr2iro6.
Creator: Sheng, Jieming, Ye, Feng, Hoffmann, Christina, Cooper, Valentino R., Okamoto, Satoshi, Terzic, Jasminka, Zheng, Hao, Zhao, Hengdi, Cao, G.
Abstract/Description: We used single-crystal x-ray and neutron diffraction to investigate the crystal and magnetic structures of trigonal lattice iridate Ca2Sr2IrO6. The crystal structure is determined to be R (3) over bar with two distinct Ir sites. The system exhibits long-range antiferromagnetic order below T-N = 13.1 K. The magnetic wave vector is identified as (0,0.5,1) with ferromagnetic coupling along the a axis and antiferromagnetic correlation along the b axis. Spins align dominantly within the basal...
Show moreWe used single-crystal x-ray and neutron diffraction to investigate the crystal and magnetic structures of trigonal lattice iridate Ca2Sr2IrO6. The crystal structure is determined to be R (3) over bar with two distinct Ir sites. The system exhibits long-range antiferromagnetic order below T-N = 13.1 K. The magnetic wave vector is identified as (0,0.5,1) with ferromagnetic coupling along the a axis and antiferromagnetic correlation along the b axis. Spins align dominantly within the basal plane along the [1,2,0] direction and tilt 34 degrees toward the c axis. The ordered moment is 0.66(3) mu(B) /Tr, larger than other iridates where iridium ions form corner- or edge-sharing IrO6 octahedral networks. The tilting angle is reduced to approximate to 19 degrees when a magnetic field of 4.9 T is applied along the c axis. Density functional theory calculations confirm that the experimentally determined magnetic configuration is the most probable ground state with an insulating gap similar to 0.5 eV.
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Date Issued: 2018-06-11
Identifier: FSU_libsubv1_wos_000434761900004, 10.1103/PhysRevB.97.235116
Format: Citation

Title: Annual Review: A Content Analysis of Career Development Theory, Research, and Practice – 2013.
Creator: Sampson, Jr., James P, Hou, Pei-Chun, Kronholz, Julia F., Dozier, V. Casey, McClain, Mary-Catherine, Buzzetta, Mary, Pawley, Elizabeth K., Finklea, Jane T., Peterson, Gary W.,...
Show moreSampson, Jr., James P, Hou, Pei-Chun, Kronholz, Julia F., Dozier, V. Casey, McClain, Mary-Catherine, Buzzetta, Mary, Pawley, Elizabeth K., Finklea, Jane T., Peterson, Gary W., Lenz, Janet G., Reardon, Robert C., Osborn, Debra S., Hayden, Seth C. W., Colvin, Gloria P., Kennelly, Emily L.
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Abstract/Description: This annual review of the career counseling and development literature presents a content analysis of refereed journal articles published in 2013. Four research questions guided the analysis: (a) What content topics were included in career development articles published in refereed journals in 2013?, (b) To what extent are theory, research, and practice integrated in career development articles published in refereed journals in 2013?, (c) What variation exists in the characteristics of career...
Show moreThis annual review of the career counseling and development literature presents a content analysis of refereed journal articles published in 2013. Four research questions guided the analysis: (a) What content topics were included in career development articles published in refereed journals in 2013?, (b) To what extent are theory, research, and practice integrated in career development articles published in refereed journals in 2013?, (c) What variation exists in the characteristics of career development articles published in refereed journals in 2013?, and (d) What variation exists in the content included in theory, research, and practice articles? A total of 360 unique topics were identified in 357 articles from 24 journals. Results indicated that topic content in journals evolved slowly with limited integration of theory, research, and practice. Implications are suggested for: (a) future topic content, (b) better integration of theory, research, and practice, (c) education and training, (d) journal editorial policy, and (e) future content analyses of journal articles.
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Date Issued: 2014-12-01
Identifier: FSU_libsubv1_scholarship_submission_1613240259_e579bd27, 10.1002/j.2161-0045.2014.00085.x
Format: Citation

Title: Anomalous Thermal Conductivity And Magnetic Torque Response In The Honeycomb Magnet Alpha-rucl3.
Creator: Leahy, Ian A., Pocs, Christopher A., Siegfried, Peter E., Graf, David, Do, S.-H., Choi, Kwang-Yong, Normand, B., Lee, Minhyea
Abstract/Description: We report on the unusual behavior of the in-plane thermal conductivity. and torque tau response in the Kitaev-Heisenberg material alpha-RuCl3. kappa shows a striking enhancement with linear growth beyond H = 7 T, where magnetic order disappears, while t for both of the in-plane symmetry directions shows an anomaly at the same field. The temperature and field dependence of kappa are far more complex than conventional phonon and magnon contributions, and require us to invoke the presence of...
Show moreWe report on the unusual behavior of the in-plane thermal conductivity. and torque tau response in the Kitaev-Heisenberg material alpha-RuCl3. kappa shows a striking enhancement with linear growth beyond H = 7 T, where magnetic order disappears, while t for both of the in-plane symmetry directions shows an anomaly at the same field. The temperature and field dependence of kappa are far more complex than conventional phonon and magnon contributions, and require us to invoke the presence of unconventional spin excitations whose properties are characteristic of a field-induced spin-liquid phase related to the enigmatic physics of the Kitaev model in an applied magnetic field.
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Date Issued: 2017-05-05
Identifier: FSU_libsubv1_wos_000400673100007, 10.1103/PhysRevLett.118.187203
Format: Citation

Title: Anomalously Large Resistance At The Charge Neutrality Point In A Zero-gap Inas/gasb Bilayer.
Creator: Yu, W., Clerico, V., Hernandez Fuentevilla, C., Shi, X., Jiang, Y., Saha, D., Lou, W. K., Chang, K., Huang, D. H., Gumbs, G., Smirnov, D., Stanton, C. J., Jiang, Z., Bellani, V....
Show moreYu, W., Clerico, V., Hernandez Fuentevilla, C., Shi, X., Jiang, Y., Saha, D., Lou, W. K., Chang, K., Huang, D. H., Gumbs, G., Smirnov, D., Stanton, C. J., Jiang, Z., Bellani, V., Meziani, Y., Diez, E., Pan, W., Hawkins, S. D., Klem, J. F.
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Abstract/Description: We report here our recent electron transport results in spatially separated two-dimensional electron and hole gases with nominally degenerate energy subbands, realized in an InAs(10 nm)/GaSb(5 nm) coupled quantum well. We observe a narrow and intense maximum (similar to 500 k Omega) in the four-terminal resistivity in the charge neutrality region, separating the electron-like and hole-like regimes, with a strong activated temperature dependence above T = 7 Kand perfect stability against...
Show moreWe report here our recent electron transport results in spatially separated two-dimensional electron and hole gases with nominally degenerate energy subbands, realized in an InAs(10 nm)/GaSb(5 nm) coupled quantum well. We observe a narrow and intense maximum (similar to 500 k Omega) in the four-terminal resistivity in the charge neutrality region, separating the electron-like and hole-like regimes, with a strong activated temperature dependence above T = 7 Kand perfect stability against quantizing magnetic fields. We discuss several mechanisms for that unexpectedly large resistance in this zero-gap semi-metal system including the formation of an excitonic insulator state.
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Date Issued: 2018-05-31
Identifier: FSU_libsubv1_wos_000433958500005, 10.1088/1367-2630/aac595
Format: Citation

Title: Anxiety sensitivity profile: predictive and incremental validity..
Creator: Schmidt, Norman B, Keough, Meghan E, Timpano, Kiara R, Richey, J Anthony
Abstract/Description: Anxiety sensitivity (AS) is a well-researched risk factor for the development of anxiety psychopathology. AS is typically measured using the anxiety sensitivity index (ASI) but limitations have led to the creation of second generation measures of AS including the anxiety sensitivity profile (ASP). The ASP has not been used very extensively, however, and we believe this may be due to two important issues: (1) the ASP is lengthy, and (2) the predictive validity of the ASP is unexplored in...
Show moreAnxiety sensitivity (AS) is a well-researched risk factor for the development of anxiety psychopathology. AS is typically measured using the anxiety sensitivity index (ASI) but limitations have led to the creation of second generation measures of AS including the anxiety sensitivity profile (ASP). The ASP has not been used very extensively, however, and we believe this may be due to two important issues: (1) the ASP is lengthy, and (2) the predictive validity of the ASP is unexplored in relation to critical outcomes such as anxiety psychopathology. The purpose of the present report was to address these two issues. We evaluated whether an abbreviated form of the ASP was viable and also conducted tests of the scale's predictive validity. Findings suggest that a 22-item version of the ASP (i.e., ASP-22) is comparable to the original 60-item ASP. Moreover, the ASP-22 was predictive of anxious responding to a CO(2) challenge. In fact, the ASP-22 outperformed the ASI as a predictor of CO(2) reactivity. Also, the ASP-22 was a significant longitudinal predictor of incidence of Axis I diagnoses. In regard to predictive validity, the ASP-22 was comparable to the original ASP. In summary, the ASP-22 appears to represent a viable measure of AS that may complement the ASI.
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Date Issued: 2008-10-01
Identifier: FSU_pmch_18242951, 10.1016/j.janxdis.2007.12.003, PMC2600663, 18242951, 18242951, S0887-6185(07)00214-9
Format: Citation

Title: An Apparatus For Generation And Quantitative Measurement Of Homogeneous Isotropic Turbulence In He Ii.
Creator: Mastracci, Brian, Guo, Wei
Abstract/Description: The superfluid phase of helium-4, known as He II, exhibits extremely small kinematic viscosity and may be a useful tool for economically producing and studying high Reynolds number turbulent flow. Such applications are not currently possible because a comprehensive understanding of the complex two-fluid behavior of He II is lacking. This situation could be remedied by a systematic investigation of simple, well controlled turbulence that can be directly compared with theoretical models. To...
Show moreThe superfluid phase of helium-4, known as He II, exhibits extremely small kinematic viscosity and may be a useful tool for economically producing and studying high Reynolds number turbulent flow. Such applications are not currently possible because a comprehensive understanding of the complex two-fluid behavior of He II is lacking. This situation could be remedied by a systematic investigation of simple, well controlled turbulence that can be directly compared with theoretical models. To this end, we have developed a new apparatus that combines flow visualization with second sound attenuation to study turbulence in the wake of a mesh grid towed through a He II filled channel. One of three mesh grids (mesh number M = 3, 3.75, or 5 mm) can be pulled at speeds between 0.1 and 60 cm/s through a cast acrylic flow channel which has a 16 mm x 16mm cross section and measures 330 mm long. The motion of solidified deuterium tracer particles, with diameter of the order 1 mu m, in the resulting flow is captured by a high speed camera, and a particle tracking velocimetry algorithm resolves the Lagrangian particle trajectories through the turbulent flow field. A pair of oscillating superleak second sound transducers installed in the channel allows complementary measurement of vortex line density in the superfluid throughout the turbulent decay process. Success in early experiments demonstrates the effectiveness of both probes, and preliminary analysis of the data shows that both measurements strongly correlate with each other. Further investigations will provide comprehensive information that can be used to address open questions about turbulence in He II and move toward the application of this fluid to high Reynolds number fluid research. Published by AIP Publishing.
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Date Issued: 2018-01
Identifier: FSU_libsubv1_wos_000424022400070, 10.1063/1.4997735
Format: Citation

Title: An application of the elastic net for an endophenotype analysis.
Creator: Palejev, Dean, Hwang, Wookyeon, Landi, Nicole, Eastman, Maria, Frost, Stephen J, Fulbright, Robert K, Kidd, Judith R, Kidd, Kenneth K, Mason, Graeme F, Mencl, W Einar, Yrigollen...
Show morePalejev, Dean, Hwang, Wookyeon, Landi, Nicole, Eastman, Maria, Frost, Stephen J, Fulbright, Robert K, Kidd, Judith R, Kidd, Kenneth K, Mason, Graeme F, Mencl, W Einar, Yrigollen, Carolyn, Pugh, Kenneth R, Grigorenko, Elena L
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Abstract/Description: We provide an illustration of an application of the elastic net to a large number of common genetic variants in the context of the search for the genetic bases of an endophenotype conceivably related to individual differences in learning. GABA concentration in the occipital cortex, a critical area for reading, was obtained in a group (n = 76) of children aged 6-10 years. Two extreme groups, high and low, were selected for genotyping with the 650Y Illumina array chip (Ilmn650Y). An elastic net...
Show moreWe provide an illustration of an application of the elastic net to a large number of common genetic variants in the context of the search for the genetic bases of an endophenotype conceivably related to individual differences in learning. GABA concentration in the occipital cortex, a critical area for reading, was obtained in a group (n = 76) of children aged 6-10 years. Two extreme groups, high and low, were selected for genotyping with the 650Y Illumina array chip (Ilmn650Y). An elastic net approach was applied to the resulting SNP dataset; 100 SNPs were identified for each chromosome as "interesting" based on having the highest absolute value coefficients. The analyses highlighted chromosomes 15 and 20, which contained 55 candidate genes. The STRING partner analyses of the associated proteins pointed to a number of related genes, most notably, GABA and NTRK receptors.
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Date Issued: 2011-01-01
Identifier: FSU_pmch_21229297, 10.1007/s10519-011-9443-8, PMC3613288, 21229297, 21229297
Format: Citation

Title: An Applied Examination of Methods for Detecting Differential Distractor Functioning.
Creator: Koon, Sharon, Kamata, Akihito
Abstract/Description: This study applied the odds-ratio (Penfield, 2008), the multinomial logistic regression (Kato et al., 2009), and the standardised distractor analysis (Schmitt and Bleistein, 1987) methods in the examination of differential distractor functioning (DDF) effects. Using data from the administration of one statewide mathematics assessment, these methods were applied to provide insight into two research questions; 1) whether the magnitude and pattern of the DDF effect is constant across all methods...
Show moreThis study applied the odds-ratio (Penfield, 2008), the multinomial logistic regression (Kato et al., 2009), and the standardised distractor analysis (Schmitt and Bleistein, 1987) methods in the examination of differential distractor functioning (DDF) effects. Using data from the administration of one statewide mathematics assessment, these methods were applied to provide insight into two research questions; 1) whether the magnitude and pattern of the DDF effect is constant across all methods; 2) whether the pattern of DDF effects supports differential item functioning (DIF) findings. While some differences in results were found, all three methods present a viable option for use in improving test items included in statewide assessment programmes.
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Date Issued: 2013
Identifier: FSU_migr_fcrr-pubs-0005
Format: Citation

Title: Applying a Multiple Group Causal Indicator Modeling Framework to the Reading Comprehension Skills of Third, Seventh, and Tenth Grade Students.
Creator: Tighe, Elizabeth L, Wagner, Richard K, Schatschneider, Christopher
Abstract/Description: This study demonstrates the utility of applying a causal indicator modeling framework to investigate important predictors of reading comprehension in third, seventh, and tenth grade students. The results indicated that a 4-factor multiple indicator multiple indicator cause (MIMIC) model of reading comprehension provided adequate fit at each grade level. This model included latent predictor constructs of decoding, verbal reasoning, nonverbal reasoning, and working memory and accounted for a...
Show moreThis study demonstrates the utility of applying a causal indicator modeling framework to investigate important predictors of reading comprehension in third, seventh, and tenth grade students. The results indicated that a 4-factor multiple indicator multiple indicator cause (MIMIC) model of reading comprehension provided adequate fit at each grade level. This model included latent predictor constructs of decoding, verbal reasoning, nonverbal reasoning, and working memory and accounted for a large portion of the reading comprehension variance (73% to 87%) across grade levels. Verbal reasoning contributed the most unique variance to reading comprehension at all grade levels. In addition, we fit a multiple group 4-factor MIMIC model to investigate the relative stability (or variability) of the predictor contributions to reading comprehension across development (i.e., grade levels). The results revealed that the contributions of verbal reasoning, nonverbal reasoning, and working memory to reading comprehension were stable across the three grade levels. Decoding was the only predictor that could not be constrained to be equal across grade levels. The contribution of decoding skills to reading comprehension was higher in third grade and then remained relatively stable between seventh and tenth grade. These findings illustrate the feasibility of using MIMIC models to explain individual differences in reading comprehension across the development of reading skills.
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Date Issued: 2015-04-01
Identifier: FSU_pmch_25821346, 10.1007/s11145-014-9532-1, PMC4371741, 25821346, 25821346
Format: Citation

Title: Applying Automated Underway Ship Observations to Numerical Model Evaluation.
Creator: Smith, Shawn R., Briggs, Kristen, Lopez, Nicolas, Kourafalou, Vassiliki
Abstract/Description: Numerical models are used widely in the oceanic and atmospheric sciences to estimate and forecast conditions in the marine environment. Herein the application of in situ observations collected by automated instrumentation on ships at sampling rates
Show moreNumerical models are used widely in the oceanic and atmospheric sciences to estimate and forecast conditions in the marine environment. Herein the application of in situ observations collected by automated instrumentation on ships at sampling rates <= 5 min is demonstrated as a means to evaluate numerical model analyses. Specific case studies use near-surface ocean observations collected by a merchant vessel, an ocean racing yacht, and select research vessels to evaluate various ocean analyses from the Hybrid Coordinate Ocean Model (HYCOM). Although some specific differences are identified between the observations and numerical model analyses, the purpose of these comparisons is to demonstrate the value of high-sampling-rate in situ observations collected on ships for numerical model evaluation.
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Date Issued: 2016-03
Identifier: FSU_libsubv1_wos_000372785000001, 10.1175/JTECH-D-15-0052.1
Format: Citation

Title: Applying systems-level spectral imaging and analysis to reveal the organelle interactome.
Creator: Valm, Alex M, Cohen, Sarah, Legant, Wesley R, Melunis, Justin, Hershberg, Uri, Wait, Eric, Cohen, Andrew R, Davidson, Michael W, Betzig, Eric, Lippincott-Schwartz, Jennifer
Abstract/Description: The organization of the eukaryotic cell into discrete membrane-bound organelles allows for the separation of incompatible biochemical processes, but the activities of these organelles must be coordinated. For example, lipid metabolism is distributed between the endoplasmic reticulum for lipid synthesis, lipid droplets for storage and transport, mitochondria and peroxisomes for β-oxidation, and lysosomes for lipid hydrolysis and recycling. It is increasingly recognized that organelle contacts...
Show moreThe organization of the eukaryotic cell into discrete membrane-bound organelles allows for the separation of incompatible biochemical processes, but the activities of these organelles must be coordinated. For example, lipid metabolism is distributed between the endoplasmic reticulum for lipid synthesis, lipid droplets for storage and transport, mitochondria and peroxisomes for β-oxidation, and lysosomes for lipid hydrolysis and recycling. It is increasingly recognized that organelle contacts have a vital role in diverse cellular functions. However, the spatial and temporal organization of organelles within the cell remains poorly characterized, as fluorescence imaging approaches are limited in the number of different labels that can be distinguished in a single image. Here we present a systems-level analysis of the organelle interactome using a multispectral image acquisition method that overcomes the challenge of spectral overlap in the fluorescent protein palette. We used confocal and lattice light sheet instrumentation and an imaging informatics pipeline of five steps to achieve mapping of organelle numbers, volumes, speeds, positions and dynamic inter-organelle contacts in live cells from a monkey fibroblast cell line. We describe the frequency and locality of two-, three-, four- and five-way interactions among six different membrane-bound organelles (endoplasmic reticulum, Golgi, lysosome, peroxisome, mitochondria and lipid droplet) and show how these relationships change over time. We demonstrate that each organelle has a characteristic distribution and dispersion pattern in three-dimensional space and that there is a reproducible pattern of contacts among the six organelles, that is affected by microtubule and cell nutrient status. These live-cell confocal and lattice light sheet spectral imaging approaches are applicable to any cell system expressing multiple fluorescent probes, whether in normal conditions or when cells are exposed to disturbances such as drugs, pathogens or stress. This methodology thus offers a powerful descriptive tool and can be used to develop hypotheses about cellular organization and dynamics.
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Date Issued: 2017-06-01
Identifier: FSU_pmch_28538724, 10.1038/nature22369, PMC5536967, 28538724, 28538724, nature22369
Format: Citation

Title: Applying The Coastal And Marine Ecological Classification Standard (cmecs) To Nearshore Habitats In The Northeastern Gulf Of Mexico.
Creator: Kingon, Kelly
Abstract/Description: Many countries have classification standards for their environmental resources including criteria for classifying coastal and marine ecosystems. Until 2012, the United States just had a nationwide protocol for classifying terrestrial and aquatic habitats with no national standard for marine and most coastal habitats. In 2012 the Coastal and Marine Ecological Classification Standard (CMECS) was implemented to address this need. In the past, coastal and marine classifications were developed at...
Show moreMany countries have classification standards for their environmental resources including criteria for classifying coastal and marine ecosystems. Until 2012, the United States just had a nationwide protocol for classifying terrestrial and aquatic habitats with no national standard for marine and most coastal habitats. In 2012 the Coastal and Marine Ecological Classification Standard (CMECS) was implemented to address this need. In the past, coastal and marine classifications were developed at the regional or local level. Since its inception, the CMECS has not been applied in many geographic areas. My study was one of the first to apply the CMECS to the benthic habitats in the nearshore Northeastern Gulf of Mexico. Sidescan sonar mapping and dive surveys were completed at 33 sites at depths 10-23 m. Hardbottom and sand habitats characterized the study area, and the underwater surveys revealed hard corals, sponges, and macroalgae as the dominant taxa on the hardbottom. The CMECS was applied to the overall study area rather than each individual site or groups of similar sites because habitat and environmental characteristics, primarily outside the context of the CMECS, appeared to influence the distribution of taxa across sites more than the CMECS geoform, substrate, and water column components. The CMECS worked well for classifying the entire study area, but was not adequate for classifying the complex fine-scale habitats and temporal variations observed; modifications to the CMECS could help resolve these issues.
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Date Issued: 2018-01
Identifier: FSU_libsubv1_wos_000424119100022, 10.3390/geosciences8010022
Format: Citation

Title: Approximate Number Sense Shares Etiological Overlap with Mathematics and General Cognitive Ability.
Creator: Lukowski, Sarah L, Rosenberg-Lee, Miriam, Thompson, Lee A, Hart, Sara A, Willcutt, Erik G, Olson, Richard K, Petrill, Stephen A, Pennington, Bruce F
Abstract/Description: Approximate number sense (ANS), the ability to rapidly and accurately compare quantities presented non-symbolically, has been proposed as a precursor to mathematics skills. Earlier work reported low heritability of approximate number sense, which was interpreted as evidence that approximate number sense acts as a fitness trait. However, viewing ANS as a fitness trait is discordant with findings suggesting that individual differences in approximate number sense acuity correlate with...
Show moreApproximate number sense (ANS), the ability to rapidly and accurately compare quantities presented non-symbolically, has been proposed as a precursor to mathematics skills. Earlier work reported low heritability of approximate number sense, which was interpreted as evidence that approximate number sense acts as a fitness trait. However, viewing ANS as a fitness trait is discordant with findings suggesting that individual differences in approximate number sense acuity correlate with mathematical performance, a trait with moderate genetic effects. Importantly, the shared etiology of approximate number sense, mathematics, and general cognitive ability has remained unexamined. Thus, the etiology of approximate number sense and its overlap with math and general cognitive ability was assessed in the current study with two independent twin samples (N = 451 pairs). Results suggested that ANS acuity had moderate but significant additive genetic influences. ANS also had overlap with generalist genetic mechanisms accounting for variance and covariance in mathematics and general cognitive ability. Furthermore, ANS may have genetic factors unique to covariance with mathematics beyond overlap with general cognitive ability. Evidence across both samples was consistent with the proposal that the etiology of approximate number sense functions similar to that of mathematics and general cognitive skills.
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Date Issued: 2017-11-01
Identifier: FSU_pmch_29867283, 10.1016/j.intell.2017.08.005, PMC5982592, 29867283, 29867283
Format: Citation

Title: The arrested Agulhas retroflection.
Creator: Nof, Doron, Zharkov, Volodymyr, Ortiz, Joseph, Paldor, Nathan, Arruda, Wilton, Chassignet, E.
Abstract/Description: Paleoceanographic proxy data indicate that the Agulhas leakage into the South Atlantic was dramatically reduced during glacial times. In our former papers, we suggested that this was due to a northward shift of the zero wind stress curl that, in turn, forced the retroflection to occur farther north, where the slant of the coastline relative to the north is steep. In the present paper, we propose that strong westerlies (0.4 Pa, implying a wind speed of ~ 12 m s-1 at zero degrees centigrade),...
Show morePaleoceanographic proxy data indicate that the Agulhas leakage into the South Atlantic was dramatically reduced during glacial times. In our former papers, we suggested that this was due to a northward shift of the zero wind stress curl that, in turn, forced the retroflection to occur farther north, where the slant of the coastline relative to the north is steep. In the present paper, we propose that strong westerlies (0.4 Pa, implying a wind speed of ~ 12 m s-1 at zero degrees centigrade), which were supposedly common during glaciations, can also arrest the leakage. This arrest occurred because the wind stress opposed the momentum flux associated with the retroflection; such an arrest did not require the retroflection to shift in latitude. We use a simple, nonlinear, "reduced gravity" model to show analytically and numerically that, under the above conditions, the eastward wind stress compensates for the zonal westward flow-force associated with the retroflection, thus avoiding the development and shedding of rings. For a nearly zonal wall, westerly winds, and small upper layer thickness along the wall, the arresting wind stress is found, theoretically, to be, τx~0.042α3/2ρf[(2fQ)3/g']1/4 where α is twice the retroflection eddy vorticity, ρ the water density, and Q the Agulhas Current volume flux; the remaining notation is conventional.
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Date Issued: 2011
Identifier: FSU_migr_coaps_pubs-0053, 10.1357/002224011799849453
Format: Citation

Title: Assessing Crop Yield Simulations Driven By The Narccap Regional Climate Models In The Southeast United States.
Creator: Shin, D. W., Baigorria, Guillermo A., Romero, Consuelo C., Cocke, Steve, Oh, Ji-Hyun, Kim, Baek-Min
Abstract/Description: A set of the North American Regional Climate Change Assessment Program (NARCCAP) regional climate models is used in crop modeling systems to assess economically valuable agricultural production in the southeast United States, where weather/climate exerts strong impact on agriculture. The maize/peanut/ cotton yield amounts for the period of 1981-2003 are obtained in a regularly gridded (similar to 20km) southeast U.S. using (a) observed, (b) a reanalysis, and (c) the NARCCAP Phase I multimodel...
Show moreA set of the North American Regional Climate Change Assessment Program (NARCCAP) regional climate models is used in crop modeling systems to assess economically valuable agricultural production in the southeast United States, where weather/climate exerts strong impact on agriculture. The maize/peanut/ cotton yield amounts for the period of 1981-2003 are obtained in a regularly gridded (similar to 20km) southeast U.S. using (a) observed, (b) a reanalysis, and (c) the NARCCAP Phase I multimodel data set. It is shown that the regional-climate model-driven crop yield amounts are better simulated than the reanalysis-driven ones. Multimodel ensemble methods are then adopted to examine their usefulness in improving the simulation of regional crop yield amounts and are compared to each other. The bias-corrected or weighted composite methods combine the crop yield ensemble members better than the simple compositemethod. In general, the weighted ensemble crop yield simulations match marginally better with the observed-weather-driven yields compared to those of the other ensemble methods.
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Date Issued: 2017-03-16
Identifier: FSU_libsubv1_wos_000398064200002, 10.1002/2016JD025576
Format: Citation

Title: Assessing Early Elementary Students' Place Value Understanding: A Set of Interview Tasks.
Creator: Bray, Wendy S., Champagne, Zachary M., Blais, Tanya Vik, Schoen, Robert C.
Abstract/Description: This document contains a set of materials we created, selected, or adapted for the purpose of assessing children’s understanding of place value. These materials were sequenced to form a diagnostic assessment for use in a one-on-one, interview-type setting. The resulting collection of tasks and questions require approximately 20–30 minutes to administer with an individual child. The assessment is designed for diagnostic purposes. It is not intended to generate an achievement score.
Date Issued: 2017-06-30
Identifier: FSU_libsubv1_scholarship_submission_1510066800_57c75c1b, 10.17125/fsu.1510066800
Format: Citation

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