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Functional Intersection of the Kallikrein-Related Peptidases (KLKs) and Thrombostasis Axis

Title: Functional Intersection of the Kallikrein-Related Peptidases (KLKs) and Thrombostasis Axis.
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Name(s): Blaber, Michael, author
Yoon, Hyesook, 1975-, author
Juliano, Maria, author
Scarisbrick, Isobel, author
Blaber, Sachiko, author
Type of Resource: text
Genre: text
Issuance: serial
Date Issued: 2010
Physical Form: computer
Physical Form: online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: A large body of emerging evidence indicates a functional interaction between the kallikrein-related peptidases (KLKs) and proteases of the thrombostasis axis. These interactions appear relevant for both normal health as well as pathologies associated with inflammation, tissue injury, and remodeling. Regulatory interactions between the KLKs and thrombostasis proteases could impact several serious human diseases, including neurodegeneration and cancer. The emerging network of specific interactions between these two protease families appears to be complex, and much work remains to elucidate it. Complete understanding how this functional network resolves over time, given specific initial conditions, and how it might be controllably manipulated, will probably contribute to the emergence of novel diagnostics and therapeutic agents for major diseases.
Identifier: FSU_migr_biomed_faculty_publications-0018 (IID)
Keywords: activation cascade, kallikrein, kallikrein-related peptidase (KLK), plasmin, thrombogenesis, thrombolysis, thrombostasis
Uncontrolled subjects: Angiostatins, Animals, Enzyme Activation, Humans, Kallikreins, Protease Inhibitors, Receptors, Proteinase-Activated, Thrombosis
Note: Originally published in Biological Chemistry.
Citation: Blaber, M., Yoon, H., Juliano, M.A., Scarisbrick, I.A., and Blaber, S.I. (2010). Functional intersection of the Kallikrein-related peptidases (KLKs) and thrombostasis axis. Biological Chemistry 391, 311-320.
Subject(s): Biochemistry
Biophysics
Molecular biology
Cytology
Developmental biology
Clinical biochemistry
Medical sciences
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_migr_biomed_faculty_publications-0018
Owner Institution: FSU
Is Part of Series: Department of Biomedical Sciences Faculty Publications.
Is Part Of: Biological Chemistry.
Issue: 4, 391