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Alternative Folding Nuclei Definitions Facilitate the Evolution of a Symmetric Protein Fold from a Smaller Peptide Motif

Title: Alternative Folding Nuclei Definitions Facilitate the Evolution of a Symmetric Protein Fold from a Smaller Peptide Motif.
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Name(s): Longo, Liam, author
Lee, Jihun, author
Tenorio, Connie, author
Blaber, Michael, author
Type of Resource: text
Genre: text
Date Issued: 2013-10-17
Physical Form: computer
Physical Form: online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Protein 3° structure symmetry is a defining feature of nearly a third of protein folds and is generally thought to result from a combination of gene duplication, fusion, and truncation events. Such events represent major replication errors, involving substantial alteration of protein 3° structure as well as causing regions of exact repeating 1° structure, both of which are generally considered deleterious to protein folding. Thus, the prevalence of symmetric protein folds is counterintuitive and suggests a specific, yet unexplained, robustness. Using a designed β-trefoil protein, we show that purely symmetric 1° structure enables utilization of alternative definitions of the critical folding nucleus in response to gross structural rearrangement. Thus, major replication errors producing 1° structure symmetry can conserve foldability. The results provide an explanation for the prevalence of symmetric protein folds, and highlight a critical role for 1° structure symmetry in protein evolution.
Identifier: FSU_libsubv1_scholarship_submission_1456501539 (IID), 10.1016/j.str.2013.09.003 (DOI)
Keywords: Protein folding, Protein evolution, Folding nucleus, Protein design
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_libsubv1_scholarship_submission_1456501539
Owner Institution: FSU
Is Part Of: Structure.
Issue: iss. 11, vol. 21

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Longo, L., Lee, J., Tenorio, C., & Blaber, M. (2013). Alternative Folding Nuclei Definitions Facilitate the Evolution of a Symmetric Protein Fold from a Smaller Peptide Motif. Structure. Retrieved from http://purl.flvc.org/fsu/fd/FSU_libsubv1_scholarship_submission_1456501539