You are here

Functional intersection of the kallikrein-related peptidases (KLKs) and thrombostasis axis.

Title: Functional intersection of the kallikrein-related peptidases (KLKs) and thrombostasis axis.
0 views
0 downloads
Name(s): Blaber, Michael, author
Yoon, Hyesook, author
Juliano, Maria A, author
Scarisbrick, Isobel A, author
Blaber, Sachiko I, author
Type of Resource: text
Genre: journal article
text
Date Issued: 2010-04-01
Physical Form: computer
Physical Form: online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: A large body of emerging evidence indicates a functional interaction between the kallikrein-related peptidases (KLKs) and proteases of the thrombostasis axis. These interactions appear relevant for both normal health as well as pathologies associated with inflammation, tissue injury, and remodeling. Regulatory interactions between the KLKs and thrombostasis proteases could impact several serious human diseases, including neurodegeneration and cancer. The emerging network of specific interactions between these two protease families appears to be complex, and much work remains to elucidate it. Complete understanding how this functional network resolves over time, given specific initial conditions, and how it might be controllably manipulated, will probably contribute to the emergence of novel diagnostics and therapeutic agents for major diseases.
Identifier: FSU_pmch_20128685 (IID), 10.1515/BC.2010.024 (DOI), PMC3047482 (PMCID), 20128685 (RID), 20128685 (EID)
Grant Number: R01 NS052741, R01 NS052741-03, R15 NS057771, R15 NS057771-01
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3047482.
Subject(s): Angiostatins/chemistry
Angiostatins/metabolism
Animals
Enzyme Activation
Humans
Kallikreins/metabolism
Protease Inhibitors/metabolism
Receptors, Proteinase-Activated/metabolism
Thrombosis/metabolism
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_pmch_20128685
Owner Institution: FSU
Is Part Of: Biological chemistry.
1437-4315
Issue: iss. 4, vol. 391

Choose the citation style.
Blaber, M., Yoon, H., Juliano, M. A., Scarisbrick, I. A., & Blaber, S. I. (2010). Functional intersection of the kallikrein-related peptidases (KLKs) and thrombostasis axis. Biological Chemistry. Retrieved from http://purl.flvc.org/fsu/fd/FSU_pmch_20128685