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Activation profiles of human kallikrein-related peptidases by matrix metalloproteinases.

Title: Activation profiles of human kallikrein-related peptidases by matrix metalloproteinases.
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Name(s): Yoon, Hyesook, author
Blaber, Sachiko I, author
Li, Wu, author
Scarisbrick, Isobel A, author
Blaber, Michael, author
Type of Resource: text
Genre: journal article
text
Date Issued: 2013-01-01
Physical Form: computer
Physical Form: online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: The 15 human kallikrein-related peptidases (KLKs) are clinically important biomarkers and therapeutic targets of interest in inflammation, cancer, and neurodegenerative disease. KLKs are secreted as inactive pro-forms (pro-KLKs) that are activated extracellularly by specific proteolytic release of their amino-terminal pro-peptide, and this is a key step in their functional regulation. Physiologically relevant KLK regulatory cascades of activation have been described in skin desquamation and semen liquefaction, and work by a large number of investigators has elucidated pairwise and autolytic activation relationships among the KLKs with the potential for more extensive activation cascades. More recent work has asked whether functional intersection of KLKs with other types of regulatory proteases exists. Such studies show a capacity for members of the thrombostasis axis to act as broad activators of pro-KLKs. In the present report, we ask whether such functional intersection is possible between the KLKs and the members of the matrix metalloproteinase (MMP) family by evaluating the ability of the MMPs to activate pro-KLKs. The results identify MMP-20 as a broad activator of pro-KLKs, suggesting the potential for intersection of the KLK and MMP axes under pathological dysregulation of MMP-20 expression.
Identifier: FSU_pmch_23241590 (IID), 10.1515/hsz-2012-0249 (DOI), PMC3709557 (PMCID), 23241590 (RID), 23241590 (EID), /j/bchm.2013.394.issue-1/hsz-2012-0249/hsz-2012-0249.xml (PII)
Grant Number: R01 DE015821, R01 NS052741, 1R01NS052741-01A2, 2R01DE015821
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709557.
Subject(s): Enzyme Activation
Humans
Hydrolysis
Kallikreins/metabolism
Matrix Metalloproteinase 20/metabolism
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_pmch_23241590
Owner Institution: FSU
Is Part Of: Biological chemistry.
1437-4315
Issue: iss. 1, vol. 394

Choose the citation style.
Yoon, H., Blaber, S. I., Li, W., Scarisbrick, I. A., & Blaber, M. (2013). Activation profiles of human kallikrein-related peptidases by matrix metalloproteinases. Biological Chemistry. Retrieved from http://purl.flvc.org/fsu/fd/FSU_pmch_23241590