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Mathematical Model for the Determination of Mouse Excisional Wound Healing Parameters from Photographic Data

Title: A Mathematical Model for the Determination of Mouse Excisional Wound Healing Parameters from Photographic Data.
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Name(s): Cogan, Nicholas G, author
Mellers, Alana, author
Patel, Bhavi, author
Powell, Brett, author
Aggarwal, Manu, author
Harper, Kathleen M, author
Blaber, Michael, author
Type of Resource: text
Genre: Text
Journal Article
Date Issued: 2018-04-17
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: We present a mathematical model to quantify parameters of mouse excisional wound healing from photographic data. The equation is a piecewise linear function in log scale that includes key parameters of initial wound radius (R0), an initial wound stasis phase (Ti), and time to wound closure (Tc); subsequently, these terms permit calculation of a latter active proliferative phase (Tp), and the healing rate (HR) during this active phase. A daily photographic record of wound healing (utilizing 6 mm diameter splinted excisional wounds) permits the necessary sampling for robust parameter refinement. When implemented with an automated nonlinear fitting routine, the healing parameters are determined in an operator-independent (i.e. unbiased) manner. The model was evaluated using photographic data from a splinted excisional surgical procedure involving several different mouse cohorts. Model fitting demonstrates excellent coefficients of determination (R2) in each case. The model thus permits quantitation of key parameters of excisional wound healing, from initial wounding through to wound closure, from photographic data.
Identifier: FSU_libsubv1_scholarship_submission_1522454139_52860c9c (IID), 10.1111/wrr.12634 (DOI)
Keywords: Splinted excision, Dermal healing, Inflammatory phase, Proliferative phase
Publication Note: This is an accepted article of Wound Repair and Regeneration. The publisher's version of record is available at https://doi.org/10.1111/wrr.12634.
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_libsubv1_scholarship_submission_1522454139_52860c9c
Owner Institution: FSU
Is Part Of: Wound Repair and Regeneration.

Choose the citation style.
Cogan, N. G., Mellers, A., Patel, B., Powell, B., Aggarwal, M., Harper, K. M., & Blaber, M. (2018). A Mathematical Model for the Determination of Mouse Excisional Wound Healing Parameters from Photographic Data. Wound Repair And Regeneration. Retrieved from http://purl.flvc.org/fsu/fd/FSU_libsubv1_scholarship_submission_1522454139_52860c9c