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Fine-sampled Photographic Quantitation of Dermal Wound Healing Senescence in Aged BALB/cByJ Mice and Therapeutic Intervention with FGF-1

Title: Fine-sampled Photographic Quantitation of Dermal Wound Healing Senescence in Aged BALB/cByJ Mice and Therapeutic Intervention with FGF-1: Novel photographic quantitation of dermal healing.
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Name(s): Mellers, Alana, author
Tenorio, Connie, author
Lacatusu, Diana, author
Powell, Brett, author
Patel, Bhavi, author
Harper, Kathleen, author
Blaber, Michael, author
Type of Resource: text
Genre: Text
Working Paper
Date Issued: 2018-06-25
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Objective: Determine quantitative parameters of dermal wound healing senescence in aged BALB/cByJ mice (an important animal model of aging) and evaluate the potential for therapeutic intervention by fibroblast growth factor-1 (FGF-1). Approach: Utilize a novel, non-invasive, fine-sampled photographic methodology to quantify wound healing parameters for healing phases from wounding through to wound closure. Results: Parameters associated with key healing phases were quantified and compared for non-aged and aged cohorts of both sexes. The results identify a sexual dimorphism in dermal wound healing, with non-aged females exhibiting a greater overall healing efficiency compared to males. This enhanced healing in females, however, senesces with age such that healing parameters for aged males and females are statistically indistinguishable. Topical application of FGF-1 was identified as an effective therapeutic intervention to treat dermal healing senescence in aged females. Innovation: The FGF intervention is being analyzed using a new, recently published model. This approach significantly increases the amount of pre-clinical animal data obtainable in wound healing studies, minimizes cohort number compared to (lethal) histological studies, and permits a direct statistical comparison between different healing studies. Conclusion: Quantitative parameters of dermal wound healing, obtained from non-invasive fine-sampled photographic data, identify topical FGF-1 as an effective therapeutic to treat the senescence of dermal healing present in aged female BALB/cByJ mice. 
Identifier: FSU_libsubv1_scholarship_submission_1529889363_21ee7933 (IID)
Keywords: Animal model, inflammatory phase, proliferative phase, sexual dimorphism, splinted excision
Publication Note: pre-print
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_libsubv1_scholarship_submission_1529889363_21ee7933
Owner Institution: FSU
Is Part Of: Advances in Wound Care.

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Mellers, A., Tenorio, C., Lacatusu, D., Powell, B., Patel, B., Harper, K., & Blaber, M. (2018). Fine-sampled Photographic Quantitation of Dermal Wound Healing Senescence in Aged BALB/cByJ Mice and Therapeutic Intervention with FGF-1: Novel photographic quantitation of dermal healing. Advances In Wound Care. Retrieved from http://purl.flvc.org/fsu/fd/FSU_libsubv1_scholarship_submission_1529889363_21ee7933