You are here

Fibroblast growth factor mutants having improved functional half-life and methods of their use

Title: Fibroblast growth factor mutants having improved functional half-life and methods of their use.
0 views
0 downloads
Name(s): Blaber, Michael, inventor
Lee, Jihun, inventor
Type of Resource: text
Genre: Utility
Text
Date Created: 2015-01-09
Date Issued: 2016-10-18
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Mutant fibroblast growth factor (FGF) proteins having a polypeptide sequence with a high sequence identity to proteins encoded by members of the Fgf-1 subfamily of genes from a mammalian species, such as human, and with a specific amino acid substitution of an alanine at a position corresponding to amino acid position 66 of human FGF-1 with a cysteine and/or a specific amino acid substitution of a phenylalanine at a position corresponding to amino acid position 132 of human FGF-1 with a tryptophan (based on the 140 amino acid numbering scheme of human FGF-1) are provided. Other amino acid mutations or substitutions may be combined. Polynucleotide sequences encoding the mutant FGF proteins and host cells containing such polynucleotide sequences are provided. Methods of administering a mutant FGF protein to an individual to treat an ischemic condition or disease or a wound or tissue injury are also provided.
Identifier: FSU_uspto_9469680 (IID), 9469680 (patent number), 941193 (inventor key), 14/593107 (app id), 6c9256d97d167832cbab694dc904bd27 (assignee id)
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_uspto_9469680
Use and Reproduction: Copyright not evaluated
Owner Institution: FSU

Choose the citation style.
Fibroblast growth factor mutants having improved functional half-life and methods of their use. (2016). Fibroblast growth factor mutants having improved functional half-life and methods of their use. Retrieved from http://purl.flvc.org/fsu/fd/FSU_uspto_9469680